Stephan Gabet

University of Lille · Toxicology and Public Health

Purpose of review Stroke is the second leading cause of death worldwide, and exposure to particulate air pollution is now recognized as one of the major modifiable risk factors. However, air pollution can vary in terms of physicochemical composition and exposition specificities. Therefore, its relationships with stroke outcomes remain under intense...

Objective Cardiovascular diseases constitute, with around 19 million deaths per year, the leading cause of death in the world. The main controllable risk factors are malnutrition and smoking, but also lack of physical activity and air pollution, two factors directly linked to mobility. Noise and temperature can also be linked to mobility and cardio...

Background With the advent of the COVID-19 pandemic, in-person social interactions and opportunities for accessing resources that sustain health and well-being have drastically reduced. We therefore designed the pan-Canadian prospective COVID-19: HEalth and Social Inequities across Neighbourhoods (COHESION) cohort to provide a deeper understanding...

Background Relations between natural history of allergic sensitization and development of allergic diseases in childhood need to be clarified. Objectives This study aimed to identify patterns of allergic sensitization and of allergic morbidity during the first 8 years of life. Methods The study was conducted in the on-going population-based prospec...

A previous study reported positive associations of maternal urinary concentrations of triclosan, a synthetic phenol with widespread exposure in the general population, with placental DNA methylation of male fetuses. Given the high number of comparisons performed in -omic research, further studies were needed to validate and extend on these findings...

With the advent of the COVID-19 pandemic, in-person social interactions and opportunities for accessing resources that sustain health and well-being have drastically reduced. We therefore designed the pan-Canadian population-based prospective COVID-19: HEalth and Social Inequities across Neighbourhoods (COHESION) cohort to provide deeper understand...

Context Policies aiming at decreasing air pollutants (e.g., fine particulate matter, PM2.5) are often designed without targeting an explicit health benefit nor carrying out cost-benefit analyses. Methods We developed a transdisciplinary backward and forward approach at the conurbation level: from health objectives set by local decision-makers, we...

Background There is only scant evidence that air pollution increases the risk of breast cancer. Objectives We investigated this relationship for three air pollutants: nitrogen dioxide (NO2) and particulate matter with an aerodynamical diameter below 10 µm (PM10) and 2.5 µm (PM2.5). Methods We conducted a population-based case-control study on bre...

Background and aim: The epidemiological literature about the relationship of nitrogen dioxide (NO2) long-term exposure to breast cancer incidence has recently strongly evolved. We aimed to perform i) a meta-analysis of the studies considering this association, and, ii) using the dose-response function established, an assessment of the corresponding...

Background and aim: Public policies aiming at decreasing air pollutants such as fine particulate matter (PM2.5) are often designed without targeting an explicit health benefit and without carrying out cost-benefit analyses, therefore possibly limiting their adoption. We therefore developed a transdisciplinary backward and forward approach at the co...

Background: The epidemiological literature of associations between atmospheric pollutant exposure and breast cancer incidence has recently strongly evolved. Objectives: We aimed to perform a) a meta-analysis of studies considering this relationship, correcting for publication bias and taking menopausal status and cancer hormone responsiveness in...

Mobility is a major source of greenhouse gas emissions. At the same time, urban air pollution is a major public health issue in both North and South countries. This project aims to show the synergies between short-term public health issues related to pollution and the reduction of greenhouse gas emissions. MobilAir, in a fundamentally interdiscipli...

Background The natural history of allergic sensitization in childhood, and its impact on allergic disease development, needs to be clarified. This study aims to identify allergic sensitization and morbidity patterns during the first 8 years of life. Methods The study was conducted in the on-going population-based prospective Pollution and Asthma R...

Ultrafine particles (UFP, particulate matter PM<100 nm), through their small size, high number and surface area, and their chemical composition¹, can induce serious health effects². UFP are able to reach lung alveoli³ and are toxic through mechanisms of oxidative stress, cell signalling and activation, and release of mediators initiating inflammato...

Background Fine particulate matter (PM2.5) exposure entails large health effects in many urban areas. Public measures aiming at decreasing air pollution are often designed without targeting an explicit health benefit. Our objective was to investigate the health and economic benefits and the social inequalities in exposure resulting from several sce...

Background Natural course and co‐occurrence of asthma, eczema, and allergic rhinitis through childhood are still not fully documented. We aim to identify and characterize profiles based on the time course, severity, and apparent triggers of respiratory/allergy symptoms in school‐aged children. Methods Data on occurrence, severity, and triggers of...

The main aim of this study was to estimate how hypothetical scenarios of reduction of air pollution (focusing on PM2.5) levels in urban areas would translate in terms of health benefits such as avoided death cases, gain in life expectancy, and lung cancer and term low birth weight prevented cases as well as associated health costs. To inform about...

Rationale: Although the effects of traffic-related air pollution on respiratory exacerbations have been well documented, its impact on lung function in childhood remains unclear. Objectives: Our aim was to investigate the associations of prenatal, early, and lifetime traffic-related air pollution exposure with lung function at 8-9 years studying...

Contexte. Les premières années de vie apparaissent particulièrement propices au développement de la sensibilisation allergénique. Objectifs. Cette thèse vise à : i) décrire les profils de sensibilisation allergénique chez le nourrisson et l’enfant, ii) étudier l’association entre ces profils et la morbidité allergique et iii) identifier les facteur...

Introduction: Allergic sensitisation is poorly documented in infants. This study aims to provide new insights into allergic sensitisation patterns and related factors in infancy. Methods: This study concerns 1860 infants involved in a French population-based prospective birth cohort who had a standardised health examination when 18 month old. Sensi...

Highlights • Allergic sensitisation concerns 13.8% of infants as soon as 18 months of age. • Close exposure to cat allergens is strongly associated to aeroallergen sensitisation. • Introduction of meat after 6 months is negatively associated with food sensitisation. Background Allergic sensitisation is poorly documented in infants. This study ai...

Background: Profiles of allergic sensitisation are poorly documented in infancy. Relations between early sensitisation and allergic morbidity need to be clarified. Methods: This study dealt with children involved in the Pollution and Asthma Risk: an Infant Study (PARIS), a population-based prospective birth cohort. Allergic sensitisation to 12 f...

Poster Discussion Session