Steffen Christensen

Steffen Christensen
Aarhus University | AU · Department of Clinical Epidemiology

About

36
Publications
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2,266
Citations

Publications

Publications (36)
Article
Full-text available
Metformin has anti-inflammatory and anti-thrombotic effects that may improve the outcome of critical illness, but clinical data are limited. We examined the impact of preadmission metformin use on mortality among intensive care unit (ICU) patients with type 2 diabetes. We conducted this population-based cohort study among all persons admitted to th...
Article
Background: Data on the prognostic impact of diabetes and diabetic complications in intensive care unit (ICU) patients are limited and inconsistent. We, therefore, examined mortality in ICU patients with type 2 diabetes with and without pre-existing heart and kidney diseases compared with nondiabetic patients. Design: We conducted this populatio...
Article
Full-text available
Multiple sclerosis (MS) patients may be at increased risk of venous thromboembolism (VTE), but evidence is limited. To examine long-term risk of VTE among MS patients. We conducted a population-based cohort study among 17,418 Danish MS patients and 87,090 comparison cohort members from the general population. Data on MS, VTE and comorbidities were...
Article
Full-text available
Alcoholic patients comprise a large proportion of patients in intensive care units (ICUs). However, data are limited on the impact of alcoholism on mortality after intensive care. We conducted a cohort study among 16,848 first-time ICU patients between 2001 and 2007 to examine 30-day and 3-year mortality among alcoholic patients. Alcoholic patients...
Article
Full-text available
Physiology-based severity of illness scores are often used for risk adjustment in observational studies of intensive care unit (ICU) outcome. However, the complexity and time constraints of these scoring systems may limit their use in administrative databases. Comorbidity is a main determinant of ICU outcome, and comorbidity scores can be computed...
Article
Full-text available
The Charlson comorbidity index is often used to control for confounding in research based on medical databases. There are few studies of the accuracy of the codes obtained from these databases. We examined the positive predictive value (PPV) of the ICD-10 diagnostic coding in the Danish National Registry of Patients (NRP) for the 19 Charlson condit...
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Full-text available
Beta-blockers have cardioprotective, metabolic and immunomodulating effects that may be beneficial to patients in intensive care. We examined the association between preadmission beta-blocker use and 30-day mortality following intensive care. We identified 8,087 patients over age 45 admitted to one of three multidisciplinary intensive care units (I...
Article
We examined rates of first hospitalization for COPD, rates of 5-year mortality among patients hospitalized for COPD, and comparisons of mortality between COPD patients and a matched cohort free of COPD. We computed standardized rates of first COPD hospitalization. Using Cox regression, we compared 180- and 181-day to 5-year mortality among COPD pat...
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There are data to suggest that anemia is associated with increased mortality in patients with chronic obstructive pulmonary disease (COPD). In contrast, critically ill patients with low hemoglobin levels (4.3-5.5 mmol/L, 7.0-9.0 g/dL) in general do not appear to have a worsened clinical outcome. The effects of anemia in critically ill patients with...
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Full-text available
Patients with multiple sclerosis (MS) may have a higher risk of cardiovascular diseases (CVD) than the general population, but data are limited. We conducted a population-based cohort study involving Danish citizens diagnosed with MS (n = 13,963) from 1977 to 2006 and an age- and sex-matched population cohort (n = 66,407) using data on MS, arterial...
Article
Oral anticoagulant therapy with vitamin K antagonists is associated with an increased risk of bleeding, particularly gastrointestinal bleeding. It remains unclear, however, whether use of these medications is a risk factor for subarachnoid haemorrhage (SAH). We therefore examined the association between oral vitamin K antagonist use and risk of SAH...
Data
A. International Classification of Diseases (ICD)-10 Codes and Anatomical Therapeutic Chemical (ATC) prescription codes used for identification and classification of alcoholic patients. International Classification of Diseases (ICD)-10 codes and Anatomical Therapeutic Chemical (ATC) prescription codes used for identification and classification of a...
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Statins reduce risk of cardiovascular events and have beneficial pleiotropic effects; both may reduce mortality in critically ill patients. We examined whether statin use was associated with risk of death in general intensive care unit (ICU) patients. Cohort study of 12,483 critically ill patients > 45 yrs of age with a first-time admission to one...
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OBJECTIVE. Use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of upper gastrointestinal bleeding and this risk is amplified by concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs). The aim of the study was to examine the impact of SSRI use alone or in combination with NSAIDs on 30-day mortality after peptic ulcer...
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Glucocorticoid use is associated with increased risk of myocardial infarction, stroke, and heart failure, but data are limited on the risk of atrial fibrillation or flutter. We examined whether glucocorticoid use is associated with the risk of atrial fibrillation or flutter. For this population-based, case-control study, we identified all patients...
Article
Systemic glucocorticoid use is associated with an increased risk for peptic ulcer bleeding (PUB); however, little is known about whether glucocorticoid use is associated with PUB outcome. We conducted a population-based cohort study to examine the association between preadmission use of systemic glucocorticoids and 30-day mortality following PUB. W...
Article
Randomized controlled trials (RCTs) have been considered the reference standard for evaluation of drug effects. Controversy exists concerning observational studies because of the lack of blinding and the risk of uncontrolled confounding. However, RCTs also have limitations, including short follow-up and relatively small study populations, which mak...
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To assess hospitalization rates (HR) for poisoning with heroin, methadone or strong analgesics and relate them to quantities of prescribed methadone and strong analgesics in Denmark between 1998 and 2004. Population-based ecological study. We extracted data on all emergency department visits and hospital admissions registered in the Danish National...
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Current data on incidence of interstitial lung diseases (ILDs) are sparse and concerns about an increasing trend have been raised. We examined incidence rates (IRs) of ILDs and changes in IRs between 1995 and 2005. All persons with a first-time hospital discharge or outpatient diagnosis of ILD were identified through the Danish National Registry of...
Data
Appendix. This appendix shows the ICD-10 codes used to identify patients with ILD.
Article
While some experimental and clinical research suggests that statins improve outcomes after severe infections, the evidence for pneumonia is conflicting. We examined whether preadmission statin use decreased risk of death, bacteremia, and pulmonary complications after pneumonia. We conducted a population-based cohort study of 29,900 adults hospitali...
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Full-text available
COPD is associated with an increased risk of peptic ulcer disease, but limited data exist on whether COPD influences short-term mortality among patients with bleeding and a perforated peptic ulcer. We examined the association between COPD and 30-day mortality following bleeding and perforation of a peptic ulcer. We identified all patients who had b...
Article
To assess the association between atrial fibrillation and flutter and use of bisphosphonates for osteoporosis among women. Population based case-control study, using medical databases from Denmark. Northern Denmark. 13 586 patients with atrial fibrillation and flutter and 68 054 population controls, all with complete hospital and prescription histo...
Article
What is already known about this subject: * Use of nonsteroidal anti-inflammatory drugs (NSAIDs) is a strong risk and prognostic factor for peptic ulcer perforation, and alternative analgesics are needed for high-risk patients. * Pain management guidelines propose tramadol as a treatment option for mild-to-moderate pain in patients at high risk of...
Article
Hospital standardised mortality ratios (HSMR) are widely used in quality improvement campaigns. No data exist on whether HSMR can be computed based on Danish administrative registries. We therefore used data from Danish registries to compute HSMRs. By linking hospital discharge registries with the Danish Civil Registration System, we identified 77...
Article
Intensive care contributes to a substantial part of health care expenses. Admission to intensive care units is associated with a high mortality rate and a high risk of long-term disability. Data from several studies suggest that suboptimal standards of intensive care are relatively common. Lack of knowledge regarding the use of intensive care and l...
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Full-text available
Mortality after perforated and bleeding peptic ulcer increases with age. Limited data exist on how the higher burden of comorbidity among elderly patients affects this association. We aimed to examine the association of age with short-term mortality after perforated and bleeding peptic ulcer and to determine the impact of comorbidity on this associ...
Article
Nonsteroidal anti-inflammatory drug (NSAID) use is a strong risk factor for peptic ulcer perforation, yet little is known about the outcome of this condition among NSAID users. We examined 30-day mortality after peptic ulcer perforation associated with the use of traditional NSAIDs and newer selective cyclo-oxygenase-2 (COX-2) inhibitors. We conduc...
Article
Full-text available
Diabetes may influence the outcome of complicated peptic ulcer disease, due to angiopathy, blurring of symptoms, and increased risk of sepsis. We examined whether diabetes increased 30-day mortality among Danish patients hospitalized with bleeding or perforated peptic ulcers. This population-based cohort study took place in the three Danish countie...

Projects

Project (1)
Project
This is a mulgtinational prospective observation study of consecutive (n=20 or 3 months) patients ≥ 80 admitted to the ICU. We will register usual ICU data, in particular on resource use (organ failure treatment) and outcome (30 days). Our aim is also to investigate the feasibility of a simple visual Frailty scale. The study is planned and conducted through the HSRO section in ESICM, and ESICM has endorsed the study. For those who want to know more, and hopefully participate: check http://www.esicm.org/research/eccrn/projects/ongoing-projects-endorsed Steering group: Hans Flaatten (N); Dylan-de Lange (NL); Bertrand Guidet (F); RuiMoreno (P) and Steffen Christensen (DK)