Stefano Negrini

Stefano Negrini
Università degli Studi di Brescia | UNIBS · Department of Clinical and Experimental Sciences

MD, Associate Professor

About

608
Publications
235,936
Reads
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11,034
Citations
Additional affiliations
October 2011 - present
Università degli Studi di Brescia
October 2011 - present
Fondazione Don Carlo Gnocchi
Position
  • Rehabilitation Research Coordinator
October 2011 - present
Università degli Studi di Brescia
Position
  • Professor (Associate)

Publications

Publications (608)
Article
Full-text available
Purpose The association between idiopathic scoliosis (IS) and sports activities remains vague. We aimed to analyse their effect on full-time braced adolescents with IS. Methods We retrospectively recruited all the consecutive patients of a tertiary referral Institute of age ≥ 10 (adolescents), with a juvenile (JIS) or adolescent (AIS) IS diagnosis...
Article
Full-text available
This study aimed to assess the reliability of a qualitative scoring system based on the movement analysis of the spine in different populations and after usual care rehabilitative intervention. If proven true, the results could further future research development in quantitative indexes, leading to a possible subclassification of chronic low back p...
Article
Background Context Idiopathic scoliosis (IS) can significantly alter the quality of life of adolescents. Some of the available questionnaires in French measuring the quality of life in this population show weak psychometric properties. The newly developed Italian Spine Youth Quality of Life (ISYQOL) questionnaire promises better properties. Purpos...
Article
Objective This paper aims to describe the evidence on rehabilitation interventions for persons with spinal cord injury (SCI) identified in Cochrane Systematic Reviews (CSRs) selected for inclusion in the WHO PIR. Data Sources The CSRs search was led by Cochrane Rehabilitation team, using the tagging process, using the terms “spinal cord injury” an...
Article
Introduction: There is a global unmet need for rehabilitation to meet which the World Health Organization, in collaboration with Cochrane Rehabilitation, is developing the Package of Interventions for Rehabilitation with the aim of identifying rehabilitation interventions relevant to a range of key health conditions, including chronic obstructive...
Article
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Background: This review examined the effectiveness of behavioral interventions for adults with post-traumatic stress disorder (PTSD) triggered by physical injury or medical trauma. It discusses implications in support of rehabilitation management for COVID-19 survivors diagnosed with PTSD. Methods: This study adhered to the Preferred Reporting I...
Article
Full-text available
We introduced pelvis semi-rigid material (ethylene vinyl acetate) (Free-Pelvis) to improve the comfort and adaptability of very rigid braces (VRBs) for adolescents with idiopathic scoliosis (AIS), but this can also negatively impact the corrective forces on the trunk. Study Design: This was a matched retrospective cohort study. The inclusion criter...
Article
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Purpose The focus of SPINE20 is to develop evidence-based policy recommendations for the G20 countries to work with governments to reduce the burden of spine disease, and disability. Methods On September 17–18, 2021, SPINE20 held its annual meeting in Rome, Italy. Prior to the meeting, the SPINE20 created six proposed recommendations. These recomm...
Article
Since its foundation, Cochrane Rehabilitation has faced challenges with rehabilitation definitions because existing definitions did not indicate what rehabilitation includes and what it excludes. We aimed to develop a comprehensive and shared rehabilitation definition for research purposes to: (1) support the conduct of primary studies and systemat...
Article
Full-text available
Objective: Since its foundation, Cochrane Rehabilitation has faced challenges with rehabilitation definitions because existing definitions did not indicate what rehabilitation includes and what it excludes. We aimed to develop a comprehensive and shared rehabilitation definition for research purposes to: 1) support the conduct of primary studies a...
Article
Background: The World Health Organization has identified an unmet global need for rehabilitation interventions concerning 20 non-communicable diseases, traumatic brain injury included. This overview compiles and synthesizes the quality and quantity of available evidence on the effectiveness of rehabilitation interventions for traumatic brain injur...
Article
Spinal dysraphism (SD) or Spina bifida (SB) is a congenital deformity that results from embryonic neural tube closure failure during fetal development. This evidence-based position paper represents the official position of the European Union through the UEMS PRM Section. This paper aims to evaluate the role of the physical and rehabilitation medici...
Article
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Introduction: In experimental trials, new methods are tested against the 'best' or 'usual' care. To appraise control group (CG) interventions provided as "usual care", we focused on stroke as a leading cause of disability demanding rehabilitation as a complex intervention. Evidence acquisition: For this methodological appraisal, we conducted a s...
Article
Full-text available
Background: The Roussouly classification, based on the functional parameter sacral slope (SS), describes the normal sagittal balance in adults and has proved useful for surgery. Reference values in children should be defined, since they are an important treatment target of conservative treatment. Moreover, during growth, there are few correlations...
Article
Full-text available
Purpose In-brace radiograph of adolescents with idiopathic scoliosis (AIS) has been shown to reflect brace efficacy and the possibility of achieving curve correction. Conversely, the first out-of-brace radiograph could demonstrate the patient’s ability to maintain the correction. We aimed to determine which of the two radiographs is the best predic...
Article
Full-text available
Purpose Studies have shown that bracing is an effective treatment for patients with idiopathic scoliosis. According to the current classification, almost all braces fall in the thoracolumbosacral orthosis (TLSO) category. Consequently, the generalization of scientific results is either impossible or misleading. This study aims to produce a classifi...
Article
Since its foundation, Cochrane Rehabilitation has faced challenges with rehabilitation definitions because existing definitions did not indicate what rehabilitation includes and what it excludes. We aimed to develop a comprehensive and shared rehabilitation definition for research purposes to: 1) support the conduct of primary studies and systemati...
Article
Full-text available
To facilitate the interaction between the health professional and the patient, a framework to guide the rehabilitation process is needed. This framework would encompass three interwoven aspects: the rehabilitation management plan, Individual Rehabilitation Project (IRP), and rehabilitation cycle(s). All three framework aspects focus on the patient...
Article
Aim: Identifying existing interventions for rehabilitation and related evidence presents a crucial step in developing the World Health Organization's (WHO) Package of Interventions for Rehabilitation. This paper reports the results of a systematic search that aimed to identify clinical practice guidelines (CPGs) relevant to the rehabilitation of p...
Chapter
The paper compares three assessment methods for the measurement of the trunk range of motion (ROM) in flexion-extension movements of subjects suspected of lumbar vertebrae instability (LVI). For five male adults affected by low-back pain and with morpho-dynamic prescription for suspected LVI, ROM was computed: from the analysis of morpho-dynamic ra...
Chapter
This paper presents a novel approach to support rehabilitation employing Action Observation Therapy (AOT), mixed reality (MR) and wearable technologies to foster common rehabilitative methods in restoring motor function. Here, the platform was specifically designed to support the standard physical treatments in post-stroke patients during upper lim...
Article
Background: Depression is very common in patients after a stroke and it can impact recovery. Objective: The Cochrane Review aimed to determine whether psychological therapy, pharmacological interventions, non-invasive brain stimulation, or their combination can prevent depression after stroke. Methods: The population addressed were patients wh...
Article
Full-text available
PurposeIn conservative early onset scoliosis treatment, interest in bracing is growing because repeated general anaesthesia (required by casting) has been questioned for possible brain damages. We aimed to check the results in the medium term of bracing, comparing idiopathic (IIS) to secondary (SIS) infantile scoliosis.Methods We performed a retros...
Article
Introduction: This paper updates and summarizes the current evidence informing rehabilitation of patients with COVID-19 and/or describing the consequences of the disease and its treatment. Evidence acquisition: Studies published from May 1st to June 30th, 2021 were selected, excluding descriptive studies and expert opinions. Papers were categori...
Article
Combining evidence-based medicine and shared decision making, current guidelines support an evidence-based personalised approach (EBPA) for idiopathic scoliosis in adolescents (AIS). EBPA is considered important for adolescents' compliance, which is particularly difficult in AIS. Benchmarking to existing Randomised Controlled Trials (RCTs) as parad...
Article
Full-text available
Purpose Adult scoliosis is sometimes associated with back pain and severe curves can progress over time. Despite scoliosis has been estimated to affect up to 68% of the population over 60, there is scant literature about conservative treatment for adult scoliosis. Recently, we tested a new brace designed to alleviate pain for adult patients with ch...
Article
Gait impairments are among the main issues for stroke survivors as they are often linked with a lack of endurance capacity, balance impairments and functional limitations. These conditions can be carefully assessed by combining an endurance capacity test, the 6-minute walk test (6MWT), with the analysis of gait performed by an inertial measurement...
Article
Purpose Responding to a recent editorial arguing against defining rehabilitation, we discuss the reasons for developing a classification of rehabilitation for research purposes, its philosophical background and some of the possible risks. Why define Science requires the definition and classification of phenomena to allow replication of experiments...
Conference Paper
A healthy mobility of the trunk plays a fundamental role in the activities of daily living. The flexion-extension movement is one of the main tasks evaluated in clinical practice to assess the functionality of the spine. Nevertheless, no fully shared methods are currently available for the clinician to perform quantitative evaluations on the moveme...
Article
Full-text available
Knee osteoarthritis (KOA) is a chronic progressive disease that can cause pain, functional impairment, and ultimately disability. A novel and promising therapeutic approach to KOA is the so-called regenerative medicine, a set of procedures designed to harness tissue regenerative capacity and optimize functional recovery. Increasing evidence points...
Article
A group of international researchers and editors summarize how (promptly and easily) an original manuscript can be written using certain tips and tricks. The authors guide novice colleagues with minimal experience using simple hints and straightforward advice in scholarly publishing. The main body of an original article is composed of four parts: I...
Article
Full-text available
Introduction: Fractures have been identified as one of the 20 major health conditions for the World Health Organization's (WHO) Package of Interventions for Rehabilitation (PIR) - that includes also the needs of children and youth. The identification of existing interventions for rehabilitation and related evidence is a crucial step along the deve...
Article
The development of high-quality research is desired in all healthcare fields. Experimental and nonexperimental designs are used to investigate the effect or association of an intervention and clinical or surrogate outcome. The aims of these methods are to improve knowledge and to develop new strategies to manage a disease or condition. Randomized c...
Article
Objective This study aims to describe “rapid living” systematic reviews, an innovative methodological design used to systematically synthesize emerging evidence in the field of rehabilitation during the COVID-19 pandemic. Study design and setting A methodological paper, with a formative approach to rapid living systematic reviews. Results Based o...
Article
Background: Multiple organ dysfunction syndrome, defined as altered organ function in critically ill patients, is a possible consequence of COVID-19. Investigating the current evidence is therefore crucial in this pandemic, as early rehabilitation could be effective for the functioning of patients with multiple organ failure. This rapid review ass...
Article
The World Health Organization (WHO) and Cochrane have been collaborating since long time. As a part of "Rehabilitation 2030: a call for action", WHO's Department of Noncommunicable Diseases is developing a Package of Rehabilitation Interventions (PRI) which provides a set of prioritized evidence-based interventions, along with resource requirements...
Article
Full-text available
Wearable devices are used in rehabilitation to provide biofeedback about biomechanical or physiological body parameters to improve outcomes in people with neurological diseases. This is a promising approach that influences motor learning and patients’ engagement. Nevertheless, it is not yet clear what the most commonly used sensor configurations ar...
Article
During its fourth year of existence, Cochrane Rehabilitation went on to promote evidence-informed health decision-making in rehabilitation. In 2020, the outbreak of the COVID-19 pandemic has made it necessary to alter priorities. In these challenging times, Cochrane Rehabilitation has firstly changed its internal organisation and established a new...
Article
Objective The aim of the present study was to identify, synthesize and categorize the methodological issues faced by the rehabilitation field. Data Sources A scoping review was conducted using studies identified in Medline, the Cochrane Library, EMBASE, Web of Science, Scopus, PEDro and Google Scholar up to August 2018. Study Selection We include...
Article
Objective to determine whether new tools and items have been developed to evaluate the risk of bias (RoB) and reporting of Randomized Controlled Trials (RCTs) in rehabilitation area; to determine which items are included in the existing reporting guidelines, and to create a matrix of items to report and conduct trials in rehabilitation as the first...
Article
Daily living activities and tasks like standing forward reaching present complex Anticipatory Postural Adjustments (APAs), and an objective, repeatable, subject- and task-dependent procedure to detect Voluntary Movements (VM) and APAs onsets is still missing. This paper proposes a new approach to the VMs study, based on a functional mechanical inte...
Article
The COVID-19 pandemic resulted in surge of research activity. Since its outset, efforts have been made to guide the rapid generation of research in medicine. There are gaps in some areas of rehabilitation research for patients with COVID-19. The development of a specific research framework might serve to help monitor the status of research (mapping...
Article
Objective To investigate the effects of continuous chest wall vibration (CCWV) with concurrent aerobic training in addition to a 4-week pulmonary rehabilitation program on dyspnea and functional exercise capacity in patients with chronic obstructive pulmonary disease (COPD). Design Randomized, single-blind, placebo-controlled trial. Setting The C...
Article
Retrospective chart audit. Firstly determining the prevalence of scoliosis in myelomeningocele (MMC) patients of the University Hospitals Leuven. Secondly analyzing whether there are differences concerning distribution of radiological level, ambulatory status, hydrocephalus, tethered cord, and syringomyelia in MMC patients with/without scoliosis. U...
Article
Objective To report the results of the systematic search performed to identify interventions and related evidence for rehabilitation of individuals with amputation based on the current evidence from Clinical Practice Guidelines (CPGs). Data sources Pubmed, Pedro, CINAHL, Embase, Google Scholar, and multiple guideline databases (date restriction 20...
Article
Full-text available
Although, biomarkers are regarded as an important tool for monitoring injury severity and treatment efficacy, and for predicting clinical evolution in many neurological diseases and disorders including spinal cord injury, there is still a lack of reliable biomarkers for the assessment of clinical course and patient outcome. In this study, a biologi...
Article
Full-text available
Background The identification of existing rehabilitation interventions and related evidence represents a crucial step along the development of the World Health Organization’s (WHO) Package of Interventions for Rehabilitation (PIR). The methods for such identification have been developed by the WHO Rehabilitation Programme and Cochrane Rehabilitatio...
Article
Full-text available
Objectives: The aim of this study was to compare the impact of fast-track rehabilitation (FTR) and conventional rehabilitation (CR) on early recovery pattern after fast-track surgery for knee arthroplasty and conventional total knee arthroplasty (TKA). Patients and methods: This prospective, case-control study included a total of 43 adult patien...
Article
Background: The term "rehabilitation" is heterogeneously used in the health context. Different interpretations can lead to disagreements, misunderstandings and different interpretations of what rehabilitation is between who provides it, who receives it and who studies it. The aim of this study was to conduct a terminological analysis of the differ...
Article
Background Evidence-based practice (EBP) is an essential element in the delivery of high-quality care and healthcare professionals make clinical decisions based on the best available research. Experts and international organisations have emphasised the need for healthcare professionals to possess adequate competencies for EBP. An EBP learning labor...