Stefanie N. Taiclet- Bachelor of Science
- Laboratory Manager at University of Pittsburgh
Stefanie N. Taiclet
- Bachelor of Science
- Laboratory Manager at University of Pittsburgh
About
12
Publications
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Publications
Publications (12)
Background: Americans of African ancestry (AA) show disparities in ischemic stroke when compared to Euro-Americans: two-fold more stroke prevalence and mortality, greater stroke disability and post-stroke complications, and slower recovery. Thromboembolic ischemic stroke involves platelet hyperactivity, which stroke-related oxidative stress promote...
Sickle cell disease (SCD) is a monogenic disorder that results in chronic anemia and painful vaso-occlusive episodes. Chronic anemia increases the risk for development of chronic kidney disease, pulmonary hypertension, and stroke in SCD. The current standard of care therapy, hydroxyurea (HU), inhibits polymerization of abnormal hemoglobin S (HbS) b...
Triosephosphate isomerase deficiency (TPI Df) is a rare multisystem disorder with severe neuromuscular symptoms which arises exclusively from mutations within the TPI1 gene. Studies of TPI Df have been limited due to the absence of mammalian disease models and difficulties obtaining patient samples. Recently, we developed a novel murine model of TP...
Cystic fibrosis results from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel, ultimately leading to diminished transepithelial anion secretion and mucociliary clearance. CFTR correctors are therapeutics that restore the folding/trafficking of mutated CFTR to the plasma membrane. The large-conductance calciu...
Background:The growing epidemic of obesity is strongly linked to cardiovascular disease (CVD). Obesity leads to endothelial dysfunction, an instigating event that drives vascular injury and subsequent CVD, but the mechanisms by which obesity causes endothelial dysfunction remain unclear. Platelets circulate proximal to the endothelium and are tradi...
Purpose:
Lower urinary tract symptoms are known to significantly increase with age, negatively impacting quality of life and self-reliance. The urothelium fulfills crucial tasks, serving as a barrier protecting the underlying bladder tissue from the harsh chemical composition of urine, and exhibits signaling properties via the release of mediators...
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic voiding disorder that presents with pain in the urinary bladder and surrounding pelvic region. A growing body of evidence suggests that an increase in the permeability of the urothelium, the epithelial barrier that lines the interior of the bladder, contributes to the symptoms of IC/...
