Stefanie Mücke

Stefanie Mücke
Hannover Medical School | MHH · Hannover Unified Biobank

Doctor of Natural Sciences

About

11
Publications
1,012
Reads
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45
Citations
Additional affiliations
April 2022 - present
Hannover Medical School
Position
  • Project Manager
April 2020 - March 2022
Translational Alliance in Lower Saxony
Position
  • Scientific Officer
March 2016 - November 2019
Leibniz Universität Hannover
Position
  • Research Associate
Education
March 2016 - September 2020
Leibniz Universität Hannover
Field of study
  • Plant biotechnology & plant pathology
October 2013 - January 2016
Martin Luther University Halle-Wittenberg
Field of study
  • Plant genetics & plant pathology
October 2010 - September 2013
Martin Luther University Halle-Wittenberg
Field of study
  • Plant genetics & plant pathology

Publications

Publications (11)
Article
Full-text available
Rice-pathogenic Xanthomonas oryzae bacteria cause severe harvest loss and challenge a stable food supply. The pathogen virulence relies strongly on bacterial TALE (transcription activator-like effector) proteins that function as transcriptional activators inside the plant cell. To understand the plant targets of TALEs, we determined the genome sequ...
Article
Full-text available
Plant-pathogenic bacteria of the genus Xanthomonas use transcription activator-like effectors (TALEs) to induce gene expression in host plants and promote disease. Deciphering the code of TALE-DNA binding in 2009 was a milestone, which enabled researchers to predict TALE virulence targets and generate resistant plants with modern genome editing too...
Article
Full-text available
Plant-pathogenic Xanthomonas bacteria secrete transcription activator-like effectors (TALEs) into host cells, where they act as transcriptional activators on plant target genes to support bacterial virulence. TALEs have a unique modular DNA-binding domain composed of tandem repeats. Two amino acids within each tandem repeat, termed repeat-variable...
Article
Full-text available
Background The yield of many crop plants can be substantially reduced by plant-pathogenic Xanthomonas bacteria. The infection strategy of many Xanthomonas strains is based on transcription activator-like effectors (TALEs), which are secreted into the host cells and act as transcriptional activators of plant genes that are beneficial for the bacteri...
Article
Recent studies suggest that miRNA could serve as biomarkers in various human diseases. Since wet-lab experiments are expensive and time-consuming, computational techniques for miRNA-disease association prediction have attracted much attention in recent years. Data scarcity is one of the major challenges in building reliable machine learning models....
Preprint
Micro RNA or miRNA is a highly conserved class of non-coding RNA that plays an important role in many diseases. Identifying miRNA-disease associations can pave the way for better clinical diagnosis and finding potential drug targets. We propose a biologically-motivated data-driven approach for the miRNA-disease association prediction, which overcom...
Article
Full-text available
Transcription activator-like effectors (TALEs) are bacterial proteins with a programmable DNA-binding domain, which turned them into exceptional tools for biotechnology. TALEs contain a central array of consecutive 34 amino acid long repeats to bind DNA in a simple one-repeat-to-one-nucleotide manner. However, a few naturally occurring aberrant rep...
Preprint
Full-text available
The yield of many crop plants can be substantially reduced by plant-pathogenic Xanthomonas bacteria. The infection strategy of many Xanthomonas strains is based on transcription activator-like effectors (TALEs), which are secreted into the host cells and act as transcriptional activators of plant genes that are beneficial for the bacteria. The modu...
Preprint
Full-text available
Plant-pathogenic Xanthomonas bacteria secret transcription activator-like effectors (TALEs) into host cells, where they act as transcriptional activators on plant target genes to support bacterial virulence. TALEs have a unique modular DNA-binding domain composed of tandem repeats. Two amino acids within each tandem repeat, termed repeat-variable d...

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