Stanley Ejike UkwuezeUniversity of Port Harcourt · Faculty of Pharmaceutical Sciences
Stanley Ejike Ukwueze
M. Pharm; PhD
About
41
Publications
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325
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Introduction
Pharmaceutical/drug quality control and Quality assurance, Pharmaceutical bio availability and generic substitutions. I also focus on natural product chemistry and product development.
Additional affiliations
December 2005 - June 2015
Education
September 2006 - January 2014
University of Nigeria Nsukka
Field of study
- Medicinal Chemistry
Publications
Publications (41)
Bioactivity-guided fractionation of methanol extract from the leaves of Psidium
guajava L. (Myrtaceae) yielded a new benzophenone glycoside, Guajaphenone A (2)
together with two known compounds, Garcimangosone D (1) and Guaijaverin (3).
Their structures were elucidated by analysis of spectroscopic data including 1D and 2D
NMR and electrospray ionis...
Background: The absorption of ciprofloxacin is reported to be impaired by polyvalent cations such as magnesium, calcium and iron which can form complexes with the drug. Biochemical analysis of unripe plantain showed that it contains high concentrations of such polyvalent cations, amino acids, vitamins and carbohydrates.
Aim: This study was aimed at...
The anti-fungal activity of the leaves of African mistletoe plant used in traditional and folkloric medicine was studied using standard procedures. The methanolic extracts of mistletoe leaves harvested from three different host trees {Kola acuminata, Irvingia gabonensis and Persea americana} were tested against clinical isolates of some common path...
Bidimensional NMR analysis may be a useful tool to resolve the structure of chemical compounds also in mixture. This letter would demonstrate how these techniques could be applied e.g. to the reported case on identification of benzophenone glycoside from Psidium guajava. A tentative structure for the secondary component, not yet described, was poss...
Carbamazepine is a drug of choice for the treatment of partial and tonic-clonic seizures. Its innovator brand, and other generic products are utilized interchangeably in many countries as an anticonvulsant, and for the treatment of peripheral neuralgia. These products are expected to be chemically and bio-pharmaceutically identical in order to achi...
Quality assurance and control of pharmaceutical products is very important for achieving a therapeutically active and standard product. This can be achieved by monitoring some parameters that are specified in the monograph of the drug or product . This study was aimed at evaluating the pharmaceutical profile of different brands of diazepam availabl...
Recently, multisource psychotropic medications have become the mainstay of clinical management of psychotic and neurological disorders resulting in decreased treatment costs. The World Health Organization (WHO), however, had estimated that 30 % of the medicines in circulation in low- and middle-income countries, like Nigeria, are substandard and co...
The need to constantly evaluate the quality of multisource drugs to ascertain their pharmaceutical equivalence and interchangeability cannot be overemphasized. Fluoxetine, a selective serotonin reuptake inhibitor antidepressant, is one of the commonly utilized multisource psychotropic agents in many parts of the globe, with an equally great potenti...
Fluconazole is an antifungal agent commonly used for several fungal infections bedeviling many developing countries across Africa. Quality assurance of multi-source pharmaceutical products ensures that the manufacturing processes of the products comply with required specifications thereby assuring product efficacy when used interchangeably. This st...
In recent times, generic brands of psychotropic medications have flooded the Nigerian market, thus, decreasing the cost of managing mental health disorders. However, the World Health Organization (WHO) had estimated that 30 % of the medicines in circulation in low- and middle-income countries, like Nigeria, are substandard and counterfeit. Poor qua...
This study investigated the phytochemical constitution and the analgesic/anti-inflammatory effects of the methanol leaf extracts of Alafia barteri (MeAB) using standard procedures. The analgesic/anti-inflammatory effects were compared with that of common NSAIDs. The preliminary phytochemical screening of the methanol leaf extract of Alafia barteri...
Pregabalin, a neuropsychotropic agent, is a drug of choice for the treatment of epilepsy and neuropathic pain. Several brands are available in the Nigerian drug market which raises the challenge of determining the products that could be interchanged with the innovator brand or with other generics. Therefore, the current study was carried out to eva...
Herbal therapies are commonly used to treat or manage various diseases including diabetes mellitus. Pentaclethra macrophylla Benth (Fabaceae) has been a popular remedy for various diseases such as antitumor, antimicrobial, purgative, analgesic, antiseptic, antipyretic and anti-inflammatory and a major ingredient in the recipes of Eastern Nigeria (I...
Esomeprazole is a highly marketed anti-ulcer drug across Nigeria other sub-Saharan regions. The pharmaceutical quality of the various generics of esomeprazole sold in these regions becomes of utmost importance in ensuring that optimal therapeutic benefits were obtained after administering any of the available brands in clinical practice.
This study...
Present study was aimed at the bio-synthesis and characterization of silver nanoparticles (AgNPs) using bacterial cell free lysate of Bacillus specie isolated from iron-rust contaminated soil sample from the Niger Delta region of Nigeria. This method was cost effective, eco-friendly and an alternative to chemical synthesis which is hazardous and re...
Azithromycin an antibiotic drug has a half-life of 50-60 hours and a bioavailability of 37-42 %, it undergoes appreciable first pass metabolism, has very poor aqueous solubility with an expected poor skin permeability. The aim of present work was to evaluate the effect of permeability enhancers: Tween 80, Tween 20, Sodium lauryl sulphate, propylene...
Methanol extracts of the leaf, stem and root barks of Chrysophyllum albidum were analyzed for their total polyphenol contents, flavonoids concentration and in vitro antioxidant activity using ultraviolet (UV) spectrophotometric analysis of the gallic acid equivalent (GAE), quercetin equivalent (QE), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) reductio...
The aim of this study was to isolate and evaluate the antimicrobial constituent of the leaves of Pterocarpus santalinoides DC (Fabaceae) growing in the tropical rain forest region of Nigeria, Sub Saharan Africa. The powdered leaf materials were defatted with n-hexane and extracted in a soxhlet extractor with 90.0 % methanol. The methanol extract wa...
Cola nitida has been found to be an abundant source of natural antioxidants and also a great therapeutic agent for the prevention and management of free radical-mediated diseases. This study was aimed at evaluating and comparing the phytochemical and in vitro antioxidant activity of different parts of Cola nitida. Total phenolic and flavonoid
conte...
ABSTRACT
The aim of this study was to carry out a spectrophotometric and other pharmaceutical quality evaluation of different brands of azithromycin dihydrate tablets and capsules from Nigerian markets and to predict their bioequivalence using in vitro dissolution tests. The evaluation was done by carrying out tests such as weight uniformity, friab...
INTRODUCTION Generally, pharmaceutical dosage forms, such as tablets, with same drug content may not give the same therapeutic response as the differences of formulation additives in the tablets, physical form of the drug and variation in manufacturing process might give rise to variation in the observed dissolution profile and therapeutic effect i...
In recent time, various phytosynthetic methods have been employed for the fabrication of silver nanoparticles; these unique metal nanoparticles are used in several applications which include pharmaceuticals and material engineering. The current research reports a rapid and simple synthetic partway for silver nanoparticles (AgNPs) using root bark aq...
The study was aimed at the pharmaco-chemical analysis and toxicological evaluation of three edible clay (ulo) samples from parts of southern Nigeria. The elemental constituents of the samples were determined by Atomic Absorption Spectroscopy (AAS) while the moisture and ash contents were determined using standard procedures. The acute toxicity assa...
Objective: Mimosa pigra roots are used in traditional medicine in the treatment of fever, headaches and cold. This study investigated the ethanol extract of the root of Mimosa pigra for its analgesic and anti-inflammatory activities in albino rats. Methods: The analgesic activity was evaluated by radiant heat tail flick method while the anti-inflam...
Sterile water for injection used in pharmaceutical and clinical practices
are expected to comply with standard specifications. The purpose of
this study was to conduct physicochemical and microbiological
assessment of commercially available sterile water for injection found
in Nigeria market. The physicochemical tests were carried out
following sta...
Mimosa pigra is used in traditional medicine to lower blood glucose in diabetic patients. The objective of this study was to evaluate the anti-hyperglycaemic activity of the ethanol root extract of Mimosa pigra in albino rats. The rats were divided into five groups, each containing five rats. Group1served as the normal control (non-diabetic), group...
The aim of this study was to determine and compare the amount of cefixime trihydrate present in different brands of the drug formulation using spectrophotometric method. Six (6) commercially available brands of cefixime sold in Nigerian pharmacies were analyzed using an already developed and validated simple ultraviolet spectroscopic method. The dr...
The aim of the present study was to evaluate and compare the relative contributions of different polyphenols to the antioxidants activities of different parts of the plant Terminalia glaucescens. Preliminary phytochemical screening of the crude extracts and solvent fractions of the root, stem and leaves of the plant was carried out using standard p...
The use of herbal medicines in the treatment of pain and inflammation has increased significantly in recent years as herbal drugs have become the most accessible form of healthcare to majority of the population in most developing nations. This study was therefore aimed at the investigation and evaluation of the analgesic and anti inflammatory effec...
The antibacterial-assay-guided evaluation of the leaf extracts of African mistletoe specie, Loranthus micranthus was carried out using standard procedures. The methanol extract (CMFM) of the leaves harvested from Persea americana (host-tree) was tested against some standard bacteria using the agar-well diffusion method. The phytochemical and bioass...
The present study was aimed at evaluating the wound healing effect of some solvent fractions of the leaves of Chromolaena odorata herb growing in the tropical rainforest region of Southern Nigeria using albino rats. The excision model used was adopted from standard procedures. Phytochemical constituents present in the pulverized crude extract and s...
The use of herbal medicines in the treatment of pain and inflammation has increased significantly in recent years as herbal drugs have become the most accessible form of healthcare to majority of the population in
most developing nations. This study was therefore aimed at the investigation and evaluation of the analgesic and anti inflammatory effec...
The anti-fungal activity of the leaves of African mistletoe plant used in traditional
and folkloric medicine was studied using standard procedures. The methanolic
extracts of mistletoe leaves harvested from three different host trees {Kola
acuminata, Irvingia gabonensis and Persea americana} were tested against
clinical isolates of some common path...
Background: Studies have shown an increase in the usage of generic drug products from multiple sources. These generic drugs are expected to satisfy similar established standards as the original or innovator brands.
Aim: To assess the standards and interchangeability of six common brands of paracetamol (acetaminophen) tablet generics marketed in Nig...
A comparative study of the phytochemical and anti-microbial properties of leaves of Loranthus micranthus harvested from six host trees, namely, Irvingia gabonensis, Pentaclethra macrophylla, Kola acuminata, Baphia nitida, Persea americana and Azadirachta indica, was carried out using standard methods. The result showed marked variations in phytoche...