Stalin Dhas

• Ph.D.,
• Assistant Professor (Research) at Sathyabama Institute of Science and Technology

The emergence of multidrug-resistant fungi Candida auris is a worldwide health crisis connected with high rates of mortality. There is a critical need to find novel and unique antifungal compounds for treating infections of multidrug-resistant fungi such as C. auris. This study aimed to illustrate that biosynthetic gene clusters in native bacterial...

Novel antifungal drugs are urgently needed to treat candidiasis caused by the emerging fungal multidrug-resistant pathogen Candida auris. In this study, the most cost-effective drug repurposing technology was adopted to identify an appropriate option among the 1615 clinically approved drugs with anti-C. auris activity. High-throughput virtual scree...

Agricultural productivity is serious concern for all the developing countries to meet the emerging needs of the human population. There is requirement of green compounds to achieve the productive agriculture and worldwide an average of 35% of crop yield is lost due to preharvest pest. Today, the commonly produced chemical pesticides in agriculture...

Aquatic pathogens contribute to the most severe economic loss in fishes. Nanoparticles are being developed as potent antimicrobial agents against various pathogens. The bacteria Aeromonas caviae is one of the most common aquatic pathogens that infects the majority of economically important fishes causing significant losses to the aquaculture indust...

Abstract Recent advancements in the field of nanotechnology have enabled targeted delivery of drug agents in vivo with minimal side effects. The use of nanoparticles for bio˗imaging has revolutionized the field of nanomedicine by enabling non-invasive targeting and selective delivery of active drug moieties in vivo. Various inorganic nanomaterials...

Aquatic pathogens contribute the most severe economic loss in fishes. Nanoparticles are being developed as potent antimicrobial agents against various pathogens. This study involved the synthesis and characterization of a novel chitosan‐selenium nanoflower employing multiple spectroscopic and microscopic approach. The UV‐vis spectra obtained at 265...

The current challenges in cancer treatment using conventional therapies have made the emergence of nanotechnology with more advancements. The exponential growth of nanoscience has drawn to develop nanomaterials (NMs) with therapeutic activities. NMs have enormous potential in cancer treatment by altering the drug toxicity profile. Nanoparticles (NP...

Enterocytozoon hepatopanaei parasite (EHP) is identified as an emerging pathogenic microsporidium parasite in shrimp culture industry. Though the etiology, disease pattern and sustainability of shrimp are well known, significantly less research has been carried out about the disease transmission and symptoms of infected aquatic animals. The present...

Plant gums are bio-organic substances that are derived from the barks of trees. They are biodegradable and non-adverse complex polysaccharides that have been gaining usage in recent years due to a number of advantages they contribute to various applications. In this study, gum was collected from Moringa oleifera and Azadirachta indica trees, then d...

Discharge of nanomaterials into the environment contributes to a diverse group of pollutants. In the present study, the toxicity of selenium nanoparticles (SeNPs) on the marine diatom Chaetoceros gracilis was studied in the laboratory by conducting 96-h toxicity experiments. The SeNPs were synthesized by reducing sodium selenite using L-cysteine an...

In recent years, Nanotechnology has attained extraordinary attention as the needs of this modern lifestyle is inclining day by day. The application of nanoparticles has extended its wings in various fields. Researchers across the globe are still exploring the applications of NPs, especially metallic NPs. Among the metallic NPs, silver NPs have spec...

The presence and longevity of nanomaterials in the ecosystem, as well as their properties, account for environmental toxicity. When nanomaterials in terrestrial and aquatic systems are exposed to the prevailing environmental conditions, they undergo various transformations such as dissociation, dissolution, and aggregation, which affects the food c...

Biosynthesis of silver nanoparticles (AgNPs) has been performed using various sources including plants and fungi. Sargassum swartzii is an alga that has a vast spectrum of biological activities and is predominantly found on the Indian coasts. In this study, AgNPs was biosynthesized using S. swartzii and evaluated for its antibacterial potency again...

Biosynthesis of silver nanoparticles (AgNPs) has been performed using various sources including plants and fungi. Sargassum swartzii is an alga that has a vast spectrum of biological activities and is predominantly found on the Indian coasts. In this study, AgNPs was biosynthesized usingS.swartzii and evaluated for its antibacterial potency against...

Objective Development of antimicrobial materials using nano approach and several industries like aquaculture greatly depend on novel biogenic materials. Biogenic techniques to develop nanomaterials with potent antimicrobial activity have been explored recently. The present study demonstrates the green synthesis of AgNPs using butter fruit (Persea a...

Biosurfactants (BSs) are surface-active agents that are produced by various microorganisms and capable of reducing the surface and interfacial tension between different fluid phases. The importance of BS in the field of biomedical has been well-known due to its antimicrobial, antibiofilm (ABF), and antiadhesive (AAD) properties against various path...

Pectin is a polymer commonly found in the fruit peels. Pectin-mediated gold nanoparticles (AuNPs) were fabricated and characterized by spectroscopic and microscopic analysis. The transmission electron microscopy revealed the presence of polymorphic and polydisperse nanoparticles in the size range of 4-18 nm. Cytotoxicity studies using 3-(4,5-dimeth...

Latex, a milky substance found in a variety of plants which is a natural source of biologically active compounds. In this study, Latex was collected from raw Carica papaya and was characterized using UV–Vis, FTIR and GC–MS analyses. Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized, coated with C. papaya latex (PL-Sp) and charac...

Water pollution is one of the most threatening problem globally as the freshwater reserves were contaminated with dye and other toxic effluents released from the industries. This study utilizes nanoparticles along with the waste substance to enhance the removal efficiency of crystal violet dye. Peels of orange are generally discarded and considered...

The aim of the present study was to optimize media components to increase the production of biosurfactant (Bs) by Streptomyces youssoufiensis SNSAA03 employing response surface methodology (RSM) and artificial neural network (ANN). The RSM showed the following as the optimal condition for the production of Bs: glucose 15 g L–1, casein 0.3 g L–1, Na...

Hydroxyapatite (HAP) have been widely used as bone implants for its biocompatibility, and bioactivity. Other approaches like scaffold development, drug delivery and nanomaterials preparation are explored recently. Herein, hydroxyapatite incorporated with 5-nitroisatin (HAP-5 N) were prepared and tested for its anticancer potential. The prepared HAP...

Kappaphycus alvarezii, a macroalgae which produces a strong and rigid gel like substance called κ-carrageenan. The development of ice-ice disease in the K.alvarezii seaweed has considerable consequences for the carrageenan business. Effect of ice-ice diseases on carrageenan quality in relation to healthy K. alvarezii was examined completely by diff...

Sulfated polysaccharides (SP) from seaweeds exhibit numerous biological activities and are less toxic than conventional antiviral drugs. However, little is known about their mode of action. This study aims at extracting the polysaccharides from brown seaweed Sargassum ilicifolium and then evaluating its antiviral activity against fish Betanodavirus...

In the last few decades, there has been major technology advancement in solid-state fermentation (SSF) process. This chapter discusses about current progress in SSF and usage of agroindustrial waste or residues (AIW) as substrate for the production of biologically active metabolite. The modeling in SSF and types of bioreactor (BR) used in the SSF p...

s White spot syndrome virus (WSSV) is the pathogen agent of a white spot disease causing significant mortalities in shrimp, crab and other crustaceans. In this study, the protective efficacy of a DNA construct encoding WSSV viral protein 28 (VP28) gene encapsulated with chitosan/Tripolyphosphate (CS/TPP) nanoparticles was examined in marine water c...

Marine algae Sargassum wightii Greville ex J.Agardh and Valonopsis pachynema (G. Martens) Borgesen were collected from the coastal area of Tuticorin, Tamil Nadu and subjected to cold striping extraction and phytochemical analysis. The preliminary phytochemical analysis identified cardiac glycosides, phenolic compounds, and carbohydrates in both the...

Biosynthesis of gold nanoparticles has been carried out with various sources like bacteria, plants and algae. Seaweeds have high nutritional and medicinal properties. Sargassum plagiophyllum is seaweed that has excellent antioxidant activity. This study aims at evaluating the antimicrobial activity of biosynthesize. d gold nanoparticles from the ex...

Silver is a potent antimicrobial agent and it has been used in metallic and metallic salts form for antimicrobial applications, since the emergence of antibiotics the utilization of silver has declined. Antimicrobial agents have a major role in water treatment, chemical industries, food preservation, aquaculture ponds, agricultural productivity and...

Abstract In the present study, a new cell line from the vertebra of mosquitofish Gambusia affinis was successfully established and characterized. The cell line is named as bone Gambusia affinis (BGA) and subcultured for more than 55 passages in Leibovitz's/L15 medium supplemented with 15% FBS at 28°C. The cell line has a modal chromosome number of...

Quercetin is well known for its effective inhibition of cancer cell proliferation by inducing the apoptosis. In the present study, quercetin isolated from Allium cepa were loaded on a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA) microspheres and its apoptotic potential in Michigan Cancer Foundation (MCF-7) cell was investigated. PLGA...

Development of biologically inspired synthesis of nanoparticles is important by using natural sources like biological systems. In this study, a rapid and eco-friendly method for synthesis of gold nanoparticles (GNPs) by Sargassum polycystum is reported. The synthesized GNPs using marine alga on reduction of chloroauric acid (HAuCl4) were characteri...

In the present study, gold nanoparticles (AuNPs) were synthesized using leaf extract of Syzygium jambolanum and capping agent has been explored. The synthesized AuNPs have been characterized using UV-visible spectroscopy (UV-vis), fourier transform infrared spectroscopy (FTIR), high resolution transmission electron microscopy (HRTEM) and atomic for...

Development of novel antidiabetic agents using various organic compounds and biomolecules has been in practice for a long time. Recently, nanomaterials are also being used in antidiabetic studies for their unique properties such as small size, biocompatibility and ability to penetrate cell membrane for carrying drugs. Herein, in vivo antidiabetic a...

Exploitation of advancements in antimicrobial agent synthesis assisted by nanomaterials has received considerable attention in the recent years. Based on this, an eco-friendly approach for the synthesis of silver chloride nanoparticles (AgClNPs) using aqueous extract of Sargassum plagiophyllum is emphasized. UV-vis spectroscopy, Fourier transform i...

Materials with enhanced physical and biological properties have been used for biomedical applications and can be developed by functionalizing them using various components. Hydroxyapatite (HAP), among other available synthetic material, serves as one of the best tools in orthopaedics and ceramic coatings. The porous structure of HAP helps in bone c...

Development of reliable method for the green synthesis of gold nanoparticles (AuNPs) using medicinally valued Adhatoda vasica Nees has been studied here. The color change and the Surface Plasmon Resonance (SPR) confirmed the formation of AuNPs. The biosynthesized AuNPs were characterized using UV-visible Spectroscopy (UV-vis), Fourier Transform Inf...

A simple biological method for the synthesis of gold nanoparticles (AuNPs) using Cassia auriculata aqueous leaf extract has been carried out in the present study. The reduction of auric chloride led to the formation of AuNPs within 10 min at room temperature (28°C), suggesting a higher reaction rate than chemical methods involved in the synthesis....