Srinivasa Rao Sirasanagandla

Srinivasa Rao Sirasanagandla
Sultan Qaboos University | SQU · Department of Human and Clinical Anatomy

PhD

About

119
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407
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Publications

Publications (119)
Article
17 Objectives: Physiological intracranial calcifications (PICs) are benign in nature and related to 18 aging. We aimed to study the frequency of physiological intracranial calcifications (PICs) in 19 pediatric population using computed tomography (CT). Methods: The brain CT scans of 20 consecutive patients (age range, 0-15 years) who had visited Su...
Article
COVID-19 lockdowns affected educational programs. Online learning has suddenly become the main form of medical education. However, attendance enhances a student's competency and professionalism. Rising student numbers and the COVID-19 pandemic make in-class learning challenging. This study investigates medical students' perceptions of a recently im...
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Bisphenol A (BPA) is a ubiquitous environmental toxin with deleterious endocrine-disrupting effects. It is widely used in producing epoxy resins, polycarbonate plastics, and polyvinyl chloride plastics. Human beings are regularly exposed to BPA through inhalation, ingestion, and topical absorption routes. The prevalence of BPA exposure has consider...
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Rheumatoid arthritis (RA) is an autoimmune disease, in which the inflammatory processes involve the skeletal system and there is marked destruction of the bones and the surrounding structures. In this review, we discuss the current concepts of osteoimmunology in RA, which represent the molecular crosstalk between the immune and skeletal systems, re...
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The incidence of metabolic syndrome and diabetes mellitus is increasing globally. A diet rich in carbohydrates increases the hyperglycemic state. While considering the lifestyle changes to combat life-threatening diseases, there is an effort to decrease the daily intake of carbohydrates. A low-carbohydrate diet also makes the body rely more on fat...
Preprint
Introduction Cervical ribs are the supernumerary ribs that usually arise from the seventh cervical vertebra. Ethnic and geographical variations in the prevalence of cervical ribs and elongated transverse processes have been reported. We aimed to study the prevalence of cervical ribs and elongated transverse processes in Omani subjects using compute...
Article
Objectives: A sound knowledge of the normal orbital dimensions is clinically essential for successful surgical outcomes. Racial, ethnic, and regional variations in the orbital dimensions have been reported. This study aimed to determine the orbital dimensions of Omani subjects who had been referred for computed tomography (CT) images at a tertiary...
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In this report, we present a case of a 51-year-old male patient with a left ventricular (LV) pseudoaneurysm and a ruptured lateral wall due to a previous myocardial infarction. This patient was referred to the Coronary Care Unit with a past history of acute coronary syndrome of two months. He presented with palpitations and acute pulmonary edema up...
Article
Bisphenol A (4,4′-isopropylidenediphenol) is an organic compound, commonly used in the plastic bottles, packaging containers, beverages and resin industry. The adverse effects of bisphenol A were studied in various systems of the body. Autophagy is a lysosomal degradation process meant for the regeneration of new cells. The role of bisphenol A on a...
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This is a case report of a 35-year-old man who was diagnosed with a bicuspid aortic valve associated with recurrent endocarditis complicated by an aortic root pseudoaneurysm. The pseudoaneurysm is a rare complication. In patients with infective endocarditis (IE), aortic root repair by bovine pericardial patch and subsequent graft infections are con...
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Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by increased intraocular pressure, which results in damage of the optic nerve and retinal ganglion cells, ultimately leading to visual field dysfunction. However, even with the use of intraocular pressure-lowering eye drops, the disease still progresses in some...
Article
All cells and intracellular components are remodeled and recycled in order to replace the old and damaged cells. Autophagy is a process by which damaged and unwanted cells are degraded in the lysosomes. There are three different types of autophagy, and these include macroautophagy, microautophagy and chaperonemediated autophagy. Autophagy has an ef...
Article
Current evidence suggests that intrauterine bisphenol A (BPA) exposure increases the risk of developing cardiovascular diseases in later stages of life. The beneficial effect of resveratrol (Rsv) on developmental programming of atherosclerosis lesions formation in offspring is seldom reported. Hence, we sought to study the effect of maternal Rsv in...
Article
Bisphenol A (BPA) is an industrial ubiquitous compound, frequently used to produce synthetic polymers and epoxy resins. BPA is a well-recognized endocrine disruptor and xenoestrogen compound. Evidence from epidemiological and experimental studies suggests that perinatal BPA exposure (gestation and/or lactation) increases the risk of developing vari...
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Background: Peroneus tertius muscle (PTM) is a muscle of the anterior compartment of the leg. It is a highly variable muscle with a prevalence rate ranging from 42%-100% in different populations worldwide. We sought to explore the frequency of PTM and its existing variants, based on surface anatomical evaluation of the foot, in Omani subjects. Me...
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The atlas (C1) is known to present congenital anomalies in its anterior and posterior arches. The reported incidence of C1 anomalies is varied among the ethnic groups. We sought to determine the prevalence and various existing variations of C1 arch congenital anomalies in Omani subjects. This study was carried out by reviewing the cervical spine co...
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Ethnic diversity is associated with variability in the prevalence rates of fabella. We aimed to evaluate the prevalence and the radiological features of fabella in Omani patients. This is a retrospective analysis of hospital electronic database of patients referred for radiological investigations (radiographs and magnetic resonance imaging) of the...
Article
Sesamoid bones show considerable variations in their occurrence among various ethnicities. This study aims to evaluate the prevalence and distribution patterns of the sesamoid bones of the hands among Omani patients who were referred for radiological investigations. The influence of gender and different age groups on the occurrence of sesamoid bone...
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Objectives: The prevalence and appearance of sesamoid bones in the foot vary considerably among different populations and ethnic groups. We sought to evaluate the prevalence and distribution patterns of foot sesamoid bones among Omani patients referred for radiological investigation. Methods: We conducted a retrospective study among patients who...
Article
Knowledge of variant course and branching pattern of the facial artery gains importance in the surgeries of upper neck and face. The authors report a unilateral anomalous course and a redundant loop of right facial artery as seen in an adult male cadaver. The right facial artery had its origin from the external carotid artery. It pierced through th...
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Objectives: We sought to evaluate the proportion of ossification of the posterior longitudinal ligament (OPLL) of the cervical spine and associated factors among Omani patients. Methods: We reviewed the cervical spine computed tomography (CT) scans of all patients referred to the Radiology Department, Sultan Qaboos University Hospital, from 2011...
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Cleft hand is a group of hand deformities in which the central digits of the hand are congenitally absent. The soft tissue variations of cleft hand are rarely described. Hence, we report the anatomic variants of a unilateral atypical cleft hand with the absence of all of the phalanges of the middle finger. The 2nd and 3rd lumbricals showed a variat...
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Preaxial polydactyly is a common congenital anomaly of the hand. In this anomaly, an additional digit is seen along the preaxial border of the thumb. Several possible types of preaxial polydactyly have been observed and categorized into several types based on the level of duplications. In the present case, we report an unusual type of polydactyly i...
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Background The current strategies to prevent and treat menopausal osteoporosis are hormone replacement therapy (HRT). However, the long-term use of hormone replacement therapy is limited due to its side-effects. Alternately, use of phytoestrogens has been implicated. Trigonella foenum graecum (TFG) seeds are rich in phytoestrogen and known traditio...
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Anatomical variations involving the flexor digitorum longus (FDL) and flexor hallucis longus (FHL) tendons are clinically important because of their significant role in reconstructive surgeries of tibialis posterior tendon insufficiencies and Achilles tendinopathies. Harvesting of grafts from these complex variations of FDL and FHL are surgically c...
Article
Celiac trunk is the first ventral branch of the abdominal aorta. It usually terminates by giving three branches; the common hepatic artery, the left gastric artery and the splenic artery. We report a rare variation of the branching pattern of the celiac trunk. The Celiac trunk divided into two branches; left gastric artery and splenicogastroduodena...
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Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by calcification of different entheseal sites including the anterior longitudinal ligament of the spine. There is no documented information about DISH in Oman. This study determined the prevalence of DISH and associated factors among elderly subjects in a national tertiary care referr...
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Osteochondromas develop as cartilaginous nodules in the periosteum of bones. They are the commonest benign tumors of the skeleton, generally observed in the long bones. Rarely, they are also found in the axial skeleton, flat bones of skull and facial bones. During a regular dissection, we came across a solitary osteochondroma in posterior surface o...
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p> Background: Congenital fusion of atlas to the basiocciput is defined as atlanto-occipital assimilation/occipitalization of atlas. Case report: During the norma basalis demonstration session of skull, we have noticed an assimilation/occipitalization of atlas vertebra. Atlas fusion may be complete or partial; assimilation of atlas is associated w...
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Background: Metformin is the common first-line medication for treating type 2 diabetes. Besides its anti-hyperglycemic property, various studies have isolatedly shown its effectiveness in reducing body weight and ameliorated components of metabolic syndrome. However, it has not been evidently shown weather metformin is effective as a dual treatment...
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Shape and position of the stomach can vary greatly with or without any physiological disturbances. However some of its rare shapes may result in the formation of volvulus or may increase the risk of gastric ulcer. Variant shapes of the stomach may be of congenital occurrence or are acquired later on in life. We report here an atypical form of hourg...
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It is quite common to see abnormal peritoneal folds in the abdominal cavity. Some of them might compress or strangulate the viscera and others might determine the direction of the flow of peritoneal fluid, pus or blood. Many unusual clinically important peritoneal folds such as Ladd's band, cysto-gastro-colic fold, omento-cystic fold, and cysto-col...
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Ectopic thyroid is considered as one of the developmental anomalies of the thyroid gland. It is usually found in the midline, along the line of descent of thyroid diverticulum. Ectopic thyroid is very rarely found in the lateral part of the neck. During the routine dissection classes for undergraduate medical students, we came across the presence o...
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Brachial plexus frequently presents variations of its cords and branches. We saw concurrent variations of lateral pectoral, median and musculocutaneous nerves. There were two lateral pectoral nerves. Median nerve was formed by the union of 3 roots; two lateral roots and one medial root. Medial root arose from the ulnar nerve. Musculocutaneous nerve...
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Anomalies of anterior arch of atlas vertebra are seldom reported in the literature. Presence of inferior accessory ossicle is one of the reported anomalies of the anterior arch of atlas. In the present case, we report a rare case of unusual morphology of the atlas vertebra. It was observed in one of the bones macerated locally for the teaching purp...
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Introduction: Meckel’s diverticulum or ileal diverticulum is one of the common congenital anomalies of the digestive system. It may not cause any problems in many, but may form serious life threatening complications in a few. Materials and Methods: We conducted a histo-morphological study of a giant Meckel’s diverticulum found during cadaveric diss...
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Occurrence of vascular variations in the upper limb is not uncommon and is well described in the medical literature. However, occurrence of superficial ulnar artery associated with unusual origin of the common interosseous and ulnar recurrent arteries is seldom reported in the literature. In the present case, we report the anomalous origin of commo...
Article
El conocimiento de las variaciones en los alrededores de la fosa cubital es útil para cirujanos ortopédicos, cirujanos plásticos y médicos en general. Observamos las variaciones arteriales y musculares en y alrededor de la fosa cubital. La arteria braquial terminó 2 pulgadas por encima de la base de la fosa cubital. Las arterias radiales y cubitale...
Article
Variaciones en el patrón de ramificación de la arteria ilíaca interna son ocasionalmente encontradas en las disecciones cadavéricas y las cirugías. Algunas de las variaciones son de importancia quirúrgica y clínica e ignorarlas podría derivar en alarmantes sangrados durante las prácticas quirúrgicas. Evaluamos las variantes en el patrón de la arter...
Article
Los pliegues peritoneales anómalos alrededor de la vesícula biliar son muy raros y pocos fueron reportados en el pasado. La presencia de tales pliegues peritoneales son probablemente debidos a la extensión del mesenterio ventral que forma el omento menor. En el caso presente, reportamos un pliegue peritoneal anómalo suspendiendo la vesícula biliar...
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La disección cuidadosa del tercio posterior de la parte superficial de la glándula salival submandibular es uno de los pasos quirúrgicos esenciales en la extirpación endoscópica glandular, evitando daños en la arteria facial. Un buen conocimiento de la poco común relación entre la arteria facial y la glándula salival submandibular es de vital impor...
Article
Background: Flexor carpi radialis (FCR) is frequently used in reconstruction procedures involving the hand and wrist regions. Despite having tremendous clinical significance, very few studies have been conducted on the heterogeneity of the FCR. Its surgical importance in grafting techniques and tendon transfers prompted us to study the morphometry...
Article
The present study was aimed to investigate hepatoprotective activity of Zincovit drop on the CCl4 induced hepatotoxicity in Wistar rats. Hepatotoxicity was induced by administering CCl4 (1 ml/kg body weight; 1:1 CCl4 and olive oil). Zincovit drop at three different doses (25, 50 and 100 mg/kg/day, orally) were administered to the respective group o...
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Arterial supply for the derivatives of foregut in the abdomen is provided by the branches of the celiac trunk. Celiac trunk is the first ventral branch of abdominal aorta and usually branches into splenic, common hepatic and left gastric arteries. Variations in the branching pattern of celiac trunk are common but in most of the people, they remain...
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The testis is the organ upon which the survival of the human species depends. Abnormalities of testicular vessels may lead to loss of gametogenesis and hormone production. Reported here is a case of bilateral variations of the testicular vessels observed in a male cadaver during the first year MBBS dissection classes. The right testicular vein bifu...
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Variations of dorsal and volar digital cutaneous branches of ulnar nerve are of tremendous clinical importance for successful regional nerve blocks, skin flaps, carpal tunnel release and placement of electrodes for electrophysiological studies. With the aforementioned clinical implications it is worth to report the variations of cutaneous branches...
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A thorough knowledge of possible variations of pelvic vasculature is very useful for surgeons, gynaecologists, radiologists, urologists and orthopaedic surgeons. We report multiple vascular variations in the left half of the pelvis of an adult male cadaver. Iliolumbar artery arose from the main trunk of the internal iliac artery. Posterior division...
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Background: Annular pancreas is an unusual and not often reported congenital anomaly of the pancreas. Thus, it is rarely suspected when the patient is asymptomatic. However, the condition may be occasionally associated with other clinical complications of the abdomen. Case Presentation: We report here a case of partial or incomplete annular pancrea...
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Thymus is a bilobed organ usually situated in the superior mediastinum. Thymus is normally active until puberty and as age advances it undergoes considerable fibro-fatty degeneration and is replaced by fatty tissue. We found a persistent thymus in an adult male cadaver aged 70 years approximately. It apparently looked healthy. Hence the objective o...
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Knowledge of variations of the vessels closely related to the pancreas adds greatly to the success of pancreatic surgery. Splenic vein is one of the vessels that are closely related to the pancreas. Its variations might not only change the haemodynamics in the vein but also cause unexpected bleeding during pancreatic surgery. During our dissection...
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Though anomalies of the superior belly of the omohyoid have been described in medical literature, absence of superior belly of omohyoid is rarely reported. Herein, we report a rare case of unilateral absence of muscular part of superior belly of omohyoid. During laboratory dissections for medical undergraduate students, unusual morphology of the su...
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Currently, numerous invasive procedures are preferred in cephalic vein (CV) and axillary vein (AV) than other veins in the neck. Anatomical variations of these veins in the axilla and delto-pectoral region may result in failure and postoperative complications of the procedures. A thorough knowledge of possible variations of AV and CV may immensely...
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Peroneus tertius (PT) is frequently used as a free muscle flap to treat the soft tissue defects and osteomyelitis, in the lower limb as it is functionally insignificant while balancing the foot during walking. The morphology of the PT is highly variable. In the present case we report a rare case of unusual morphology of the PT in a formalin embalme...
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Imaging technology with its advancement in the field of urology is the boon for the patients who require minimally invasive approaches for various kidney disorders. These approaches require a precise knowledge of the normal and variant anatomy of vessels at the hilum of the kidney. During routine dissections, a variation in the branching pattern of...
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During our dissection classes, we observed a lobulated spleen with multiple hila and fissures. The spleen presented 4 hila and 5 deep fissures. The hila were seen on the visceral surface. The fissures extended into the substance of the spleen from superior border, inferior border and the visceral surface. Because of these fissures, the spleen appea...
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Knowledge of development and various possible positions of the appendix is important in understanding the pathophysiology of appendicitis. In the present case, we report on a lateral pouch type of appendix in a formalin-embalmed male cadaver. The appendix was found to be situated in a space between the caecum and the lateral abdominal wall. A short...
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Double gallbladder is one of the rare congenital anomalies of the gallbladder. Failure to detect an accessory gallbladder hampers diagnosis and treatment of cholecystitis, which might result in recurrent attacks of cholecystitis. In addition, presence of peritoneal folds extending from the stomach and duodenum to the gallbladder is very rare. Here...
Article
Objective: The present study was intended to assess the effect of environmental enrichment on the diabetes as well as combined actions of diabetes and stress on the neurons of the motor cortex of rat brain. Background: Untreated diabetes mellitus causes severe insults to the neurons of the central nervous system. Treatment with environmental enr...
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Variations in the origin of arteries in the abdomen are very common. With the invention of new operative techniques within the abdomen cavity, the anatomy of abdominal vessels has assumed a great deal of clinical importance. We report here a rare case of formation of an "arterial glomerulus" at the hilum of the right kidney by the branches of right...
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Petroleum ether fraction of Cissus quadrangularis (PECQ) impact on the development of osteopenia in type 1 diabetic rat model has been evaluated. Diabetic rats were treated orally with two doses of PECQ. Another group of diabetic rats were treated with subcutaneous injection of synthetic human insulin. The cortical and trabecular bone thickness and...
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Ansa cervicalis (AC) frequently shows its variations in the formation and distribution pattern. However, variation in its looping pattern associated with abnormal topographic disposition is relatively rare. Knowledge on the possible deviations in the looping pattern is clinically important, to avoid iatrogenic injuries in surgical procedures. We re...
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The occurrence of the lesser occipital nerve (LON) at an anomalous location in the “carefree part” within the posterior triangle has been seldom reported in the literature. We are reporting a rare case of location of the LON in the “carefree part” of the posterior triangle, in a 55- year-old formalin embalmed male cadaver. LON, after emerging from...
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The lumbar part of the diaphragm arises from the lumbar vertebrae by right and left crura. The duplication of crura of the diaphragm is rarely reported in the past. During regular dissection classes to the medical students, we came across a case of duplicated right crus of the diaphragm. The right crus of the diaphragm was duplicated completely and...
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Delayed fetal skeletal ossification is one of the known complications of maternal diabetes. The present study was designed to evaluate the protective role of petroleum ether extract of Cissus quadrangularis (PECQ) on diabetes-induced delayed fetal skeletal ossification. Female Wistar rats were rendered diabetic with streptozotocin (STZ, 40 mg/kg, i...