Srijita ChakrabartiAssam down town University · Department of Pharmacy
Srijita Chakrabarti
M.Pharm (Pharmaceutics); Ph.D.
About
31
Publications
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364
Citations
Introduction
Skills and Expertise
Additional affiliations
March 2020 - December 2023
December 2014 - December 2019
Education
September 2016 - September 2021
Publications
Publications (31)
Objective
Melatonin has been associated with accelerated tissue regeneration and grapeseed oil has abundant unsaturated fatty acids, particularly linoleic acid that makes it a strong antioxidant, having the potential to promote wound healing by enhancing the presence of free radicals at the wound site. The study is aimed to evaluate the potential o...
The fields of nanotechnology and nanomedicine have undergone a revolution. There has been a striking rise in authorized nanomedicines since 1980. Apart from functioning as therapeutic agents, they also act as carriers for delivering various active pharmaceuticals to target organs. The ultimate goal of nanomedicine has always been the generation of...
Human eyes, the most sensitive and vital organ of human body, comprise of various ocular barriers that makes it very challenging for the formulating scientist to develop and design ophthalmic dosage forms. There are several conventional ophthalmic dosage forms available in the market however; they possess some limitations such as rapid drainage, le...
The present study was carried out to formulate and evaluate Metformin
hydrochloride orodispersible tablets by direct compression method
using two superdisintegrants i.e., crospovidone and sodium
croscarmellose. The produced granules were assessed for some precompression factors such as, bulk density, tapped density,
compressibility (Carr's index),...
Different dermatological disorders have different effects on the lives of patients. Recently microsponge formulations have been used to treat several dermatological complications. Microsponges are basically tiny sponge like spherical particles with porous surface having valuable and attractive effect on topical delivery. The side effect of the used...
Burn injuries are most challenging to manage since it causes loss of the integrity of large portions of the skin leading to major disability or even death. Over the years, hydrogels are considered as a significant delivery system for wound treatment because of several advantages over other conventional formulations. We hypothesized that the bFGF-co...
The synthesized aerosolized biodegradable atropine loaded nanoparticle (ANP) and its influence on lung hyperresponsiveness, obstruction, and inflammation was investigated in adult Wistar rats. ANP was synthesized with biodegradable polymers-poly (lactic-co-glycolic acid) and poly ethylene glycol and characterized. Pharmacokinetics and biodistributi...
The objective of this present research work was to develop and optimize a liposomal gel containing a fourth generation fluoroquinolone antibiotic, besifloxacin hydrochloride (BSF−HCl), for ocular delivery using factorial design. The ocular delivery of BSF−HCl loaded liposomal gels may produce improve the ocular bioavailability with increased reside...
Health hazards of titanium dioxide nanoparticles (TiO2-NPs) have raised severe concerns because of the paucity of information regarding the toxic effects among the population. In the present research, the in vitro and in vivo cytotoxic potential of TiO2-NPs were evaluated using flow cytometric techniques. Further, in vitro and in vivo genotoxic end...
Drug delivery to the brain is one of the most challenging areas of research in the pharmaceutical field not only due to the blood–brain barrier (BBB) but also for the blood–cerebro-spinal fluid barrier. Being a delicate organ, the brain has a complex physiological structure and also a complicated mechanism of action. Tight junctions between the cer...
Using catalytic amount of Ag 2 CO 3 a simple, efficient and copper free green protocol has been developed to synthesize 1,4-disubstituted 1,2,3-triazoles regioselectively. Here, the cationic surfactant, cetylpyridinium chloride (CPyCl) in water provides a micellar media and accelerates the subsequent Ag(I)-catalysed azide-alkyne cycloaddition (AgAA...
Wound infections impose a remarkable clinical challenge that has a considerable influence on morbidity and mortality of patients, resulting in huge impact on economy. The unprecedented advancements in molecular biology have come up with new molecular and cellular targets that can be successfully applied to develop smarter therapeutics against diver...
In the recent years, growing concern about the potential toxicity of synthetic repellents has led to the development of environmentally safe non-toxic insect control methods. Present investigation explores the toxicological impacts of ethyl anthranilate-loaded mosquito repellent patch (EAMRP) on respiratory system following acute and sub-chronic in...
In the present investigation, the safety of novel combinational silver sulfadiazine-bFGF loaded hydrogel was assured by performing acute skin irritation, sensitization, acute dermal toxicity and eye irritation in compliance with the Organization for Economic Co-operation and Development guidelines. In the skin irritation study, placebo, test and po...
Gramine is a natural indole alkaloid that has been isolated from different raw plants occurring mainly in Avena sativa, etc. The study was aimed to investigate the possible in vitro antioxidant, in vitro mutagenic, in vitro antimutagenic, and in vivo genotoxic activity of gramine using ferric reducing ability of plasma (FRAP) assay, Metal chelating...
A simple, accurate and sensitive reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of ethyl 2-aminobenzoate (EAB) in a matrix type monolithic polymeric device and validated as per the International Conference on Harmonization guidelines. The analysis was performed isocratically on a ZORBAX...
Compromised stability of pharmaceutical formulations loaded with volatiles is a serious problem associated with devices designed to deliver volatile compounds. The present study has been focused to evaluate the stability potential of matrix-type polymeric patches composed of volatile ethyl anthranilate for prophylaxis against vector-borne diseases....
One-pot synthesis methods for development of hydrophilic imaging nanoprobes have advantages over multi-pot methods due to their simple procedures, less probability for degradation of efficiency, superior control over growth and morphology, cost effectiveness, improved scope for scale-up synthesis etc. Here, we present a novel one-pot facile synthes...
Paraquat(PQ) is one of the most widely used non-selective herbicides in the world, marketed globally under the brand name Gramoxone by Syngenta (Ahmed, A.A. 2009). Spraying PQ lets millions of farmers grow better crops more easily but it’s highly toxic nature affects human as well as animals through inhalation route (Kumar, Harish, et al. 2016). Th...
This investigation aims to isolate an Actinomycetes strain producing biosurfactant from unexplored region of industrial and coal mine areas. Actinomycetes are selected for this study as their novel chemistry was not exhausted and they have tremendous potential to produce bioactive secondary metabolites. The biosurfactant was characterized and furth...
Questions
Question (1)
I am preparing a formulation containing growth factors and silver sulfadiazine. I am estimating the release of growth factor using specific ELISA kit and the drug by HPLC method. Is there any problem if I follow the above method? As a genera trend, both growth factor and drug should be estimated simultaneously. However, this is not possible due the presence of growth factor which is degraded at RT. What should I do ? Please suggest.
