
Srija RoyIndian Institute of Chemical Biology | IICB · Cancer Biology and Inflammatory Disorder Division (IICB)
Srija Roy
Master of Science
PhD Scholar
About
3
Publications
1,939
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32
Citations
Introduction
I am interested in studying the intricate signaling mechanisms responsible for tumorigenesis and chemotherapeutic drug resistance.
Additional affiliations
Education
April 2018 - June 2020
April 2013 - June 2016
Publications
Publications (3)
Recently, an article titled "Non-cell-autonomous cancer progression from chromosomal instability" was published in Nature, Aug 2023. In this study, Li et. al. elaborated a dependency of immune cells enrichment in the tumour microenvironment (TME) on chromo-somal instability (CIN) in cancer cells [1]. This insightful research sheds light on the pote...
Over the course of three decades of study, the deubiquitinase Herpesvirus associated Ubiquitin-Specific Protease/Ubiquitin-Specific Protease 7 (HAUSP/USP7) has gradually come to be recognized as a crucially important molecule in cellular physiology. The fact that USP7 is overexpressed in a number of cancers, including breast, prostate, colorectal,...
Questions
Question (1)
I have used this BIorad Powerpac Basic for 4 years now, before which it was used for another 5-6 years. Generally we addressed the E1 error by compensating with fresh buffer and/or filling the buffer upto the required level, and the powerpac would be back on track. 50V of constant voltage gave me 25-30mA. Only this time, I used fresh buffer and checked the level but the powerpac was running on low current (50V gave me 11mA; constant current of 30mA gave me 200V). Later the powerpac kept showing E1 no matter what voltage I set. Whereas another powerpac with the same gel setup ran with sufficient current.
Please suggest me any means that I can address this issue. Is my powerpac broken or is there an issue with power supply? Can it be repaired?