Sri Fatmawati

• S.Si, M.Sc, Ph.D
• Professor (Associate) at Sepuluh Nopember Institute of Technology

Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7 beta,11 beta-dihydroxy-3, 15, 23-trioxo-5 alpha-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC(50) of 22.8 mu...

A series of lanostane-type triterpenoids, known as ganoderma acids were isolated from the fruiting body of Ganoderma lucidum. Some of these compounds were identified as active inhibitors of the in vitro human recombinant aldose reductase. To clarify the structural requirement for inhibition, some structure-activity relationships were determined. Ou...

α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl(3) extract of the fruiting body of G. lucidum was found t...

Among the indigenous knowledge possessed by Indonesians is their proficiency in utilizing medicinal plants. Madura Island, a constituent of East Java Province in Indonesia, stands out for its local wisdom associated with herbal ingredients. This indigenous knowledge pertaining to various medicinal substances can be explored through an ethnobotanica...

Gaharu bouya oil obtained from distillation of the woods from Gonystylus genus has attracted essential oil industry interest. However, the information about gaharu bouya essential oil profile is limited. The presence of Gonystylus species is also critically endangered on the IUCN Red List. Therefore, exploring the -omics profiles of Gonystylus banc...

COVID-19 has been a major global health concern for the past three years, and currently we are still experiencing coronavirus patients in the following years. The virus, known as SARS-CoV-2, shares a similar genomic identity with previous viruses such as SARS-CoV and MERS-CoV. To combat the pandemic, modern drugs discovery techniques such as in sil...

Stachytarpheta jamaicensis is one of the folk medicines used for the treatment of diabetes in Ambon, Indonesia, but there are limited studies on the bioactivities of its constituents. This study aims to assess the antioxidant and antidiabetic activities of four extracts of S. jamaicensis leaves extracted using several solvents. Bioassay guided frac...

Gonystylus bancanus wood or ramin wood has been generally known as a source of agarwood (gaharu) bouya, a kind of agarwood inferior type, or under the exported trading name of aetoxylon oil. The massive exploitation of ramin wood is causing this plant's extinction and putting it on Appendix II CITES and IUCN Red List of Threatened Species. To date,...

Objectives: An increase in gout prevalence has drawn attention among society and this situation drives the exploration of more favourable treatment using traditional medicinal plants which are rich in phenolic and flavonoid to avoid the side effects of modern medication. However, there are only few studies regarding the optimization of phytochemic...

SARS-CoV-2 caused a global pandemic in 2019 with mild flu-like clinical symptoms to severe symptoms that can cause death. Research to find the SARS-CoV-2 drug has been carried out through literature and in silico studies against SARS-CoV-2. Previous studies have reported the antiviral properties of some Indonesian herbs including Phyllantus niruri,...

This report describes the isolation and characterization of xanthones from Garcinia bancana Miq. and evaluates their antiplasmodial and anticancer activities. Macluraxanthone (1), isojacareubin (2), and gerontoxanthone C (3) were isolated from the stem bark of G. bancana Miq. for the first time. In silico molecular docking studies revealed the hydr...

In our continuation of exploring antidiabetic agents from Garcinia species, we found that the methanolic extract of G. macrantha A.C.Sm. exhibited considerable α-glucosidase inhibition of 58.20 ± 0.37% in sucrose substrate and 39.86 ± 2.07% in maltose substrate at 100 μg/mL. Phytochemical investigation on the extract revealed the presence of a new...

Malaria caused by Plasmodium parasites is a significant public health issue, particularly in tropical and subtropical regions. There is also resistance to chloroquine-based therapy, which highlights the need for novel therapeutic agents. Therefore, our project in exploring antiplasmodial agents from Garcinia Indonesia continues. This study evaluate...

Nicotiana tabacum (Solanaceae), also known as tobacco, is one of the most commercialized agricultural crops in the world. However, this plant is not commonly used either as a health treatment or in the discovery of drugs. This study aims to screen phytochemicals and antioxidant activity of N. tabacum leaf extract to find new biomarker compounds for...

The nutritional content of mushrooms depends on the type of substrate in the growing medium. Lignocellulose is one of the substrates used for fungal growth media. In this study, the effect of adding dried reeds (Imperata cylindrical (L.) Beauv) on Sengon (Paraserianthes falcataria (L.) Nielsen) sawdust-based media was investigated for wood ear mush...

As part of our project on exploring Indonesian medicinal plants for antidiabetic and anticancer agents, this study was conducted to investigate the total phenolic and flavonoid contents, and antioxidant, cytotoxic and antidiabetic properties of R. tomentosa leaf extracts. The antioxidant activity was tested using DPPH, ABTS, and FRAP methods. In vi...

Nicotiana tabacum (tobacco) is one of the most commercially farming products in the world. Indonesia is one of the top ten tobacco producing countries in the world since 1990’s. Based on literature studies, tobacco has the main secondary metabolites such as cembranoids and flavonoids. They have fine biological activities as antiviral, antimicrobial...

The oyster mushroom (Pleurotus ostreatus) is the most cultivated mushroom which its growth performance and nutritional composition depend on substrate types. Thus, this study investigated the effect of coconut coir on minerals and vitamins B contents in the oyster mushroom cultivation medium. The composition of coconut coir and Sengon’s sawdust as...

Moringa oleifera (Moringaceae) is an ornamental plant in tropical and subtropical areas. M. oleifera, known as kelor, is widely used in Indonesia as an edible plant and health supplement. In our research, the discovery of the bioactivity of various extracts, fractions, and isolated compound of M. oleifera leaves has been evaluated by antioxidant an...

This research aimed to determine the total antioxidant capacity of the ten fruits peel waste extract, namely palmyra palm (Borassus flabellifer), areca nut (Areca catechu), lanzones (Lansium parasiticum), plantain (Musa acuminata x balbisiana), kepok banana (Musa acuminata x balbisiana colla), peanuts (Arachis hypogaea L.), palm (Elaeis guineensis)...

Currently, no effective medication is available to treat diabetes despite this disease is a serious health problem. As part of our project to explore Indonesian medicinal plants for antidiabetic agents, this study aimed to investigate the total phenolic and flavonoid contents, antioxidant and antidiabetic properties of Melastoma malabathricum leave...

Seiring berkembangnya era globalisasi serta Perdagangan Masyarakat Ekonomi ASEAN, Kebutuhan akan produk halal semakin besar dan diminati. Halal menurut ketentuan syariat Islam adalah sesuatu yang baik, suci/bersih, dan tidak berbahaya. Sertifikat halal berfungsi sebagai salah satu alat bagi UMKM untuk meningkatkan nilai tambah produk yang dihasilka...

Fruit seed waste is part of the fruit that cannot be eaten, abundant and its use is still limited so that it is often considered garbage by the community. One effort to reduce waste is by utilising metabolism as secondary as fruit seed waste. This research determined the phytochemistry, total phenolic, total flavonoid and antioxidant of Dimocarpus...

Begonia medicinalis or known as benalu batu in Indonesia is a herbal plant that is locally used for traditional medicines. The secondary metabolites such as flavonoids, alkaloids, steroids, and terpenoids have been reported to be found in these plant extracts. The content of flavonoids can lead to anti-cancer abilities while heat-sensitive flavonoi...

This study aimed to isolate polyprenylated benzophenones from the rootbark of Garcinia celebica and assess their activities in vitro and in silico. The antioxidant activity was evaluated by the DPPH, ABTS, and FRAP methods. The cytotoxicity was evaluated against HeLa, MCF-7, A549, and B16 cancer cell lines. The antiplasmodial activity was performed...

Background: Calcium hydroxide is the gold standard medicament for root canal treatment. Enterococcus faecalis, the primary cause of intraradicular persistent endodontic infection, is often identified even after endodontic treatment. Thymoquinone, an active ingredient of Nigella sativa, has an antimicrobial effect on both gram-negative and positive...

This study examined the synthesis of isoniazid-isatin hydrazone derivatives 5-7, followed by an investigation on the in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv, and molecular docking. A yield of 81 - 92 % of these compounds was achieved, with structural characterization by spectroscopic methods (FTIR, NMR, HRMS). The...

Momordica charantia is one of the herbaceous plants which widely distributed at tropical and subtropical regions. M. charantia, as known as pare, has been used as Indonesian traditional medicine for the treatment of bitter stomachic, laxative, and anthelmintic. This study aims to investigate the antioxidant activity of M. charantia leaves extracts...

Postpartum treatments have been used by local women in Indonesia for some time now. One commonly used postpartum treatment is the consumption of a traditional herbal medicine called PHM-1 during the first 40 days after childbirth. In addition, a second medicine known as PHM-2 is taken for days 41-80. However, sufficient scientific evidence about th...

Heterocyclic nitrogen compounds are privileged structures with many applications in the pharmaceutical and nutraceutical industries since they possess wide bioactivities. Trisindolines are heterocyclic nitrogen compounds consisting of an isatin core bearing two indole moieties. Trisindolines have been synthesized by reacting isatins with indoles us...

The Yamaguchi reaction is widely and generally applied to synthesize esters and lactones. It involves 2,4,6-trichlorobenzoyl chloride as the Yamaguchi reagent, 4-dimethylaminopyridine, and triethylamine. Pyrazinamide is a crucial first-line drug for tuberculosis treatment, therefore their analogues are interesting in organic synthesis. In general,...

One of the most lethal and frequent infectious diseases worldwide is tuberculosis. Multi and extensively tuberculosis drug-resistant constitutes a serious problem and emphasizes the need for novel anti-tubercular agents. Accordingly, various pyrazine-2-carboxamides were synthesized and evaluated as potential anti-tuberculosis agents. The synthesis...

Cassia alata or locally known as Ketepeng Cina (Indonesia) and Gelenggang (Malaysia) has been used as a traditional medicine to treat various diseases, especially skin diseases. In addition, C. alata has been reported to have potential anti allergic, anti inflammatory, antioxidant, anticancer, antidiabetic, and antifungal. Metabolite compounds that...

Sonneratia, a genus of mangroves from family Lythraceae, is reported for number of high biological activity including antimicrobial. Sonneratia ovata Backer is one of the species which traditionally used by Indonesian people for the treatment of some diseases. In this research, the investigation about biological activity of S. ovata Backer as anti-...

Over the past few decades, complementary medicine therapy using medicinal plants have been developed in healthcare. Phytochemical studies about medicinal plants have been conducted to verify their potency as medicinal remedies in modern therapeutics. Dipterocarpus littoralis commonly known as Meranti Jawa in Indonesia is traditionally used to treat...

The radical scavenging assays of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulphonic (ABTS) acid for various extracts and fractions of Garcinia lasoar Pam stem bark had been examined. The methanol extract showed high total phenolic (272.98 mg GAE (gallic acid equivalent)/100 g) and total flavonoid (223...

Gout is a common disease affected most of the people due to the elevation of uric acid in the blood. Flavonoid and phenolic compounds are reported to exert the anti-gout activity of medicinal plants. Hence, this study aimed at optimizing the extraction conditions of phenolic and flavonoid compounds as well as the anti-gout (xanthine oxidase inhibit...

Garcinia husor is one of the folk medicines in Maluku-Indonesia. This species has been used for the treatmet of Malaria disease. The phytochemical contents and antiplasmodial activity not reported yet. In this study we evaluated the quantitative phytochemicals, in vitro and in vivo antiplasmodial activity of stem bark ethyl acetate extract. In vitr...

Ganoderma lucidum is one of the many mushrooms utilized by the people as a medicine for cancer, asthma, diabetes and hearth disease. The purpose of this experiment is to determine the antioxidant activity of the extracts from G. lucidum using different solvents. The simplicial powder of G. lucidum are subjected to maceration using water, methanol,...

Many plants of the family of Araceae possess significant benefit as medicinal plants. Anthurium hookerii is herbaceous genus of the family of Araceae. A. hookerii leaves were extracted with five dissimilarity solvents (methanol, water, ethyl acetate, n-hexane, and dichloromethane). The extracts were evaluated for their phytochemical, total phenolic...

The aim of this study was to evaluate antioxidant and antibacterial activities of Ischaemum indicum leaves extracts based on different polarity solvents: water, methanol, ethyl acetate, dichloromethane, and n-hexane. The antioxidant activity was evaluated using ABTS and DPPH methods, while the antibacterial activity was determined by broth dilution...

Chromolaena odorata L. (Asteraceae) is one of the tropical plants which is widely used as traditional medicines for diabetes and soft tissue wounds treatment in some regions in East Indonesia. The present study was aimed at determining the bioactive compounds of C. odorata leaves. The methanol and ethyl acetate extracts of C. odorata leaves have th...

p class="Katakunci"> Muntingia calabura ( Muntingiaceae ) merupakan Jamaican cherry yang dikenal di Indonesia sebagai Kersen atau Talok. Metabolit sekunder sebagai konstituen kimia telah diisolasi dari daun, batang dan akar M. calabura . Flavonoid merupakan konstituen utama penyusun metabolit sekunder dari tanaman ini. Kelompok flavonoid telah dila...

Different solvent extracts of Anthurium plowmanii leaves were assayed for antioxidant and antibacterial activities. Methanol extract had the highest inhibition of DPPH and ABTS scavenging activities among extracts. Concentrations of methanol extract required for 50% inhibition of DPPH radical scavenging effect were recorded as 231,59 μg/mL. The IC5...

Indonesian traditional herbal medicine for post partum contains many plants such as Kunyit (Curcuma longa), meniran (Phyllanthus urinaria), akar manis (Glycyrrhiza glabra), lempuyang (Zingiber zerumbet), temulawak (Curcuma zanthorrhiza), jungrahap (Baeckea frutescens L.), bangle (Zingiber montanum), binahong (Anredera cordifolia), asem (Tamarindus...

Artocarpus champeden, commonly known as cempedak in Indonesia, belongs to the Moraceae family. In folk medicine, A. champeden is used to treat various diseases such as diabetic, malaria and cancer. This curing ability indicates the active component content in the plant as antioxidant, antidiabetic, antimalarial or anticancer. The present study was...

Public health is one of the main problems for the people of Indonesia. One of the causes of health problems is pathogenic bacteria from the environment that easily enter the body and multiply to produce various diseases and infections. Plants extracts are one of the most important natural resources and alternative in the treatment effort as well as...

Six new compounds including four new xanthones, cylindroxanthones D-G (1-4), and two new biphenyls, cylindrobiphenyls A and B (5 and 6), were isolated from the stems of Garcinia cylindrocarpa together with 28 known compounds (7-34). The structures of the new compounds were established on the basis of extensive 1D and 2D NMR and HRESIMS spectroscopi...

DDT (4,4-Dichlorodiphenyltrichloroethane) is one of the persistent organic pollutants that was extensively used in the 1940s as insecticide to control malaria. Even though DDT was banned since 1970, DDT and its metabolites are still present ubiquitously in the environment and have negative effects on human health. In this study, the ability of brow...

Sonneratia ovata Backer is a mangrove plant as well as folk medicine from Aru Islands, Maluku-Indonesia which is traditionally used for treatment of many diseases. The present research has been purposed at antioxidant activity from stem bark of S. ovata. The methanol extract showed the highest in vitro antioxidant activity with IC50 values of 4.73...

DDT (4,4-Dichlorodiphenyltrichloroethane) is one of the persistent organic pollutants that was extensively used in the 1940s as insecticide to control malaria. Even though DDT was banned since 1970, DDT and its metabolites are still present ubiquitously in the environment and have negative effects on human health. In this study, the ability of brow...

The higher consumption of fruit, herbs, spices, and vegetables is well known and practical strategy to cure human cancers owing to their presence of bioactive compounds. Among these, Nigella sativa is a promising source of bioactive compounds including thymoquinone, monoterpenes, p-cymene and α-piene etc. Thymoquinone has been found effective to in...

Antioxidant and antibacterial activities of Ananas comosus peel extracts (n-hexane, dichloromethane, ethyl acetate, methanol and aqueous) had been evaluated. The antioxidant activity had been evaluated by using DPPH (2,2-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azinobis-3-ethylbenzothiazole-6-sulfonic acid) methods, while antibacterial activity ha...

Chromolaena odorata L. (Asteraceae), recognized as Siam weed, is one of the most widely used tropical plants for traditional medicine such as diarrhea, diabetes and soft tissue wounds. The previous study reported that the isolation of Chromolaena odorata L. obtained flavonoid compounds. 2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) i...

Antioxidant activities of Syzygium polyanthum Wight leaves extracts (methanol, ethyl acetate, dichloromethane, and hexane) were evaluated by using DPPH (2,2-diphenyl-2-picrylhydrazyl hydrate) and ABTS (2,2’-azinobis (3-ethylbenzothiazole-6-sulfonic acid) methods. The methanol extract showed the highest antioxidant activity of DPPH assay among extra...

Moringa oleifera have been evaluated for its antioxidant activity. M. oleifera leaves were extracted with methanol, ethyl acetate, dichloromethane and n-hexane. The antioxidant activity of extracts were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay and an improved 2,2’-azino-bis-[3-ethylbenzothiazoline sul...

New Prenylated stilbene derivatives, 3-hydroxy-4-prenyl-5-methoxy-stilbene acid (1) and 5,4'-dihydroxy-3-methoxy-2-prenyl-stilbene (2) had been isolated from methanol extract of Cajanus cajan (L.) Millsp. (Pigeon pea), a member of family fabaceae. The aim of this present work was to evaluate its in vitro antioxidant activity using 2,2-diphenyl-1-pi...

New Prenylated stilbene derivatives, 3-hydroxy-4-prenyl-5-methoxy-stilbene acid (1) and 5,4'-dihydroxy-3-methoxy-2-prenyl-stilbene (2) had been isolated from methanol extract of Cajanus cajan (L.) Millsp. (Pigeon pea), a member of family fabaceae. The aim of this present work was to evaluate its in vitro antioxidant activity using 2,2-diphenyl-1-pi...

Moringa oleifera have been evaluated for its antioxidant activity. M. oleifera leaves were extracted with methanol, ethyl acetate, dichloromethane and n-hexane. The antioxidant activity of extracts were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay and an improved 2,2’-azino-bis-[3-ethylbenzothiazoline sul...

Kajian kimiawi tumbuhan dari sejumlah spesies Garcinia, yang dikenal tumbuhan keluaga Manggis sudah dilakukan sejak awal tahun 2002 sampai saat ini, telah dihasilkan sejumlah senyawa golongan fenolat seperti, turunan santon terprenilasi, biflavonoida dan aril-kumarin. Dari kebergaman senyawa-senyawa tersebut telah pula dilakukan pengujian terhadap...

Three new xanthones, cylindroxanthones A-C (1-3), were isolated from the stem bark of Garcinia cylindrocarpa. The structures were established on the basis of spectroscopic analysis. The molecular structure of 1 was unequivocally confirmed by single-crystal X-ray diffraction analysis. These three xanthones were evaluated regarding their cytotoxicity...

We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 µg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. W...

Abstract— New Prenylated stilbene derivatives, 3-hydroxy-4-prenyl-5-methoxystilbene acid (1) and 5,4'-dihydroxy-3-methoxy-2-prenyl-stilbene (2) have been isolated from methanol extract of Cajanus cajan (L.) Millsp. (Kacang kayu), a member of family fabaceae. The aim of this present work was to evaluate its in vitro antioxidant activity using 2,2-di...

CHCl(3) extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ga...

The human aldose reductase inhibitory effects of the methanol extracts of 17 medicinal and edible mushrooms were examined. Ganoderma lucidum showed the highest aldose reductase inhibitory activity compared with the other mushrooms. The effect of an ethanol extract of G. lucidum on the galactitol level in the eye lens was studied in a galactosemic r...