Sreeraj Vs

Sreeraj Vs
National Institute of Mental Health and Neuro Sciences | NIMHANS · Department of Psychiatry

MBBS, DPM, DNB (PSYCHIATRY), MNAMS FIPS
CLINICAL RESEARCH CENTRE FOR NEUROMODULATION IN PSYCHIATRY

About

121
Publications
17,820
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347
Citations
Additional affiliations
March 2018 - present
National Institute of Mental Health and Neuro Sciences
Position
  • Professor (Assistant)
March 2015 - March 2018
National Institute of Mental Health and Neuro Sciences
Position
  • Medical Doctor

Publications

Publications (121)
Article
Full-text available
Transcranial direct current stimulation (tDCS) is a promising adjuvant treatment for persistent auditory verbal hallucinations (AVH) in Schizophrenia (SZ). Nonetheless, there is considerable inter-patient variability in the treatment response of AVH to tDCS in SZ. Machine-learned models have the potential to predict clinical response to tDCS in SZ....
Article
Background and Purpose Emerging studies have shown that gut-derived endotoxins might play a role in intestinal and systemic inflammation. Although the significance of intestinal permeability in modulating the pathogenesis of Schizophrenia (SCZ) is recognized, not much data on the specific role of intestinal permeability biomarkers, viz., zonulin, l...
Article
Cognitive deficit is one of the core features of schizophrenia and is associated with poor functional outcomes. There is a lack of validated criteria to screen and monitor cognitive deficits in schizophrenia. This study aimed to evaluate the concurrent validity and sensitivity of MoCA (Montreal cognitive assessment) and DSST (digit symbol substitut...
Preprint
BACKGROUND Identifying biomarkers of response to Transcranial Magnetic Stimulation (TMS) in resistant depression is a priority for personalizing care. Clinical and neurobiological determinants of treatment response to TMS while promising, have limited scalability. Evaluating novel, technologically-driven, and potentially scalable biomarkers like di...
Article
Psychogenic vomiting (PV) refers to persistent or recurrent vomiting in the absence of any obvious organic cause and resulting from psychological mechanism. A diagnosis of PV is by made in the overall biopsychosocial context with emotional changes and psychological stressor often triggering the symptom production. Self-induced vomiting presents in...
Preprint
Background Family studies in obsessive-compulsive disorder (OCD) indicate higher rates of psychosis among their first-degree relatives (FDRs). However, the etiological and clinical relationships between the two disorders remain unclear. We compared the clinical characteristics & pharmacological treatment response in OCD patients with a family histo...
Article
Auditory Signal Detection (ASD) theory postulates that auditory verbal hallucinations (AVH) result from an aberrant association of meaningful connection to abstract noises. In this study, schizophrenia (SZ) patients with persistent AVH (N=17) and matched controls (N=25) performed an ASD task with concurrent functional near-infrared spectroscopy rec...
Chapter
Schizophrenia is a disabling psychiatric condition that can be treated by antipsychotic medications. The illness has a chronic course and requires long-term treatment for preventing the reemergence of symptoms. Long-acting injectable (LAI) antispychotics are an effective alternative mode of administration of antipsychotics. This chapter reviews the...
Conference Paper
Working memory and executive function deficits are the characteristic features of Mild Cognitive Impairment and mild Alzheimer’s Disease (mild AD). Studies exploring the alterations in working memory and executive functions show disrupted functional connectivity in Dorsolateral Pre Frontal Cortices (DLPFC) and Angular Gyrus (AG). Transcranial direc...
Preprint
Background: Neurocognitive deficits are considered an endophenotype for several psychiatric disorders, typically studied in unaffected first-degree relatives (FDRs). Environmental factors such as adverse childhood experiences (ACEs) may also affect neurocognition. This study examines the effect of ACEs on neurocognitive performance in FDRs of patie...
Article
Alcohol is known to have a neurotoxic effect on the brain of offspring of mothers consuming alcohol during pregnancy. Impact on the neurodevelopment in children who were exposed to alcohol specifically during the antenatal period without any clinically detectable features of fetal alcohol syndrome is less well studied. In this cross-sectional study...
Article
Full-text available
Nutraceutical agents and food supplements are commonly used as treatment adjuncts in neuropsychiatric disorders. Curcumin, a bioactive agent obtained from the rhizome of Curcuma longa, with its antioxidant and anti-inflammatory properties, has gained much research attention in the last few decades. In this narrative review, we intend to summarize t...
Article
Full-text available
Non-invasive brain stimulation techniques such as conventional transcranial direct current stimulation (tDCS) and high definition tDCS (HD-tDCS) are increasingly being used as add-on treatment options in schizophrenia and obsessive-compulsive disorder (OCD). This is reporting of the use of a novel accelerated, symptom-specific, add-on tDCS (combini...
Article
Full-text available
Dengue is an arboviral infection endemic in tropical countries. Neurological sequelae to dengue infection are not uncommon, and psychiatric manifestations are increasingly reported. This narrative review aims to present the varied manifestations, postulated mechanisms, and the available treatment options for psychiatric morbidity associated with de...
Article
Background Minor physical anomalies (MPA) are markers of impaired neurodevelopment during the prenatal stage. Assessing MPA across psychiatric disorders may help understand their shared nature. In addition, MPA in family members would indicate a shared liability and endophenotype potential. We examined familial aggregation of MPA and their role as...
Article
Pyrexia of unknown origin (PUO) broadly includes any febrile illness lasting ≥ 3 weeks with a temperature > 38.3°C (100.9°F) on at least 2 occasions in the absence of a known immunocompromised state and an uncertain diagnosis after a thorough assessment including history taking, physical examination, and appropriate investigations. PUO can be due t...
Article
Objectives Electric field modeling utilizes structural brain magnetic resonance images (MRI) to model the electric field induced by non-invasive transcranial direct current stimulation (tDCS) in a given individual. Electric field modeling is being integrated with clinical outcomes to improve understanding of inter-individual variability in tDCS eff...
Article
Full-text available
Objective: The Accelerator program for Discovery in Brain disorders using Stem cells (ADBS) is a longitudinal study on five cohorts of patients with major psychiatric disorders from genetically high-risk families, their unaffected first-degree relatives, and healthy subjects. We describe the ADBS protocols for acquisition, quality assurance (QA),...
Article
The risk of neutropenia decreases significantly after the first year of clozapine initiation, and indefinite hematological monitoring is increasingly questioned. Despite comparable risks of neutropenia, the guidelines for antithyroid drugs – carbimazole and propylthiouracil do not recommend routine hematological monitoring. Assuming a similar patho...
Article
Full-text available
The population of older adults in India was 8.6% of 1.2 billion, which translates to 103.8 million as per the 2011 census.1 The steady decadal growth in the older-adult population poses several challenges for geriatric mental healthcare services. The National Mental Health Survey (NMHS, 2016)2 reported that the lifetime prevalence of mental morbidi...
Article
Full-text available
Background: Obsessive-compulsive disorder (OCD) is a heterogeneous illness, and emerging evidence suggests that different symptom dimensions may have distinct underlying neurobiological mechanisms. We aimed to look for familial patterns in the occurrence of these symptom dimensions in a sample of families with at least two individuals affected with...
Article
A history of psychiatric illnesses in family members of those diagnosed to have an illness has been of significant interest both in research and in clinical practice. Almost all of the major psychiatric illnesses have a familial component to them, perhaps influenced by genetics and a shared environment or their combination. Systematic attempts have...
Article
HD-tDCS (High-definition transcranial direct current stimulation) is a novel non-invasive brain stimulation (NIBS) technique based on the principle that when weak intensity electric currents are targeted on specific areas of the scalp, they cause underlying cortical stimulation. HD-tDCS shares its technical methodology with conventional tDCS (monta...
Article
Introduction : Transcranial Direct Current Stimulation (tDCS) has been beneficial for treating auditory verbal hallucinations (AVH) in schizophrenia (SZ). Aberrant auditory signal detection (ASD) is one of the pathogenetic mechanisms for AVH. We investigated the correlates of ASD with AVH and the impact of single-session tDCS on ASD in SZ patients....
Article
Syndromes of schizophrenia, bipolar disorder, obsessive-compulsive disorder, substance use disorders, and Alzheimer's dementia are highly heritable. About 10-20% of subjects have another affected first-degree relative (FDR), and thus represent a ‘greater’ genetic susceptibility. We screened 3583 families to identify 481 families with multiple affec...
Poster
Semantic dementia (SD) is a variant of primary progressive aphasia (PPA) which is characterised by impaired confrontation naming, single word comprehension and object recognition with preserved fluency and syntax. Similar to many other neurodegenerative dementias, there is currently no effective treatment for semantic dementia. Neuromodulatory inte...
Article
Neurocognitive cognitive deficits including working memory (WM) impairment is a key component of schizophrenia (SCZ). Though a prefrontal cortex (PFC) abnormality is recognised to contribute to WM impairment, the exact nature of its neurobiological basis in SCZ is not well established. Functional near infra-red spectroscopy (fNIRS) is an emerging l...
Article
Background Facial emotion recognition (FER) deficit is documented in many psychiatric disorders, including bipolar disorder (BD). However, its role as a risk-marker in BD is not well researched. In the present study, we investigated the role of FER and the corresponding prefrontal neurohemodynamic changes (PNHC) with functional near infra-red spect...
Article
Full-text available
Objective Adverse childhood experiences are linked to the development of a number of psychiatric illnesses in adulthood. Our study examined the pattern of adverse childhood experiences and their relation to the age of onset of major psychiatric conditions in individuals from families that had ⩾2 first-degree relatives with major psychiatric conditi...
Article
Full-text available
Psychiatric disorders have always been seen as character disturbances and hence have always bore higher stigma than many other physical illnesses. In most of the cases the stigma is seen as negative stereotype arising out of poor awareness about the condition. In that case the stigma should reduce with the increase in the awareness about the condit...
Preprint
Full-text available
Objective: The Accelerator Program for Discovery in Brain Disorders using Stem Cells (ADBS) is a longitudinal study focused on collecting and analysing clinical, neuropsychological, neurophysiological, and multimodal neuroimaging data from five cohorts of patients with major psychiatric disorders from genetically high-risk families, their unaffecte...
Article
Dengue is a tropical arboviral infection associated with inducing mania in a few cases. Flaviviridae (including Dengue virus)with itsepigenetic influences throughhistone deacetylase (HDAC) may lead to symptom manifestations. Valproate and quetiapine have HDAC inhibitory property and may have pathophysiologically relevant effects in curtailing these...
Article
Full-text available
Background Auditory verbal hallucinations (AH), one of the hallmark symptoms, are present in 60–80% of schizophrenia (SZ) patients. 25% of patients suffering from AH in schizophrenia fail to respond to any psychotropic medication. Non-invasive brain stimulation techniques like transcranial direct current stimulation (tDCS), with cathodal electrode...
Article
The utility of non-invasive brain stimulation techniques to alleviate resistant delusions in schizophrenia is an under-researched area. In this study, we report the effectiveness of alpha transcranial alternating current stimulation (tACS) targeting the medial prefrontal cortex in ameliorating persistent delusions. Twelve Schizophrenia patients (N=...
Article
Full-text available
Transcranial direct current stimulation (tDCS) is a type of non-invasive brain stimulation technique that is explored as an add-on treatment for the alleviation of symptoms across the diverse symptom domains in neuropsychiatric disorders. In psychiatry, data is emerging on the effects of tDCS as an add-on treatment in schizophrenia as well as obses...
Chapter
Full-text available
Neuromodulatory techniques are gaining increasing interest toward application in understanding the pathogenesis as well as therapeutics of several neuropsychiatric disorders. Several factors modulate the effect of these techniques on brain function. Given the significant influence of gender on brain structure and function, it is important to evalua...
Preprint
Full-text available
We aimed to characterize potential transdiagnostic neurocognitive endophenotypes in a large cohort of multiplex families affected with two or more individuals having a major psychiatric illness(MPI) i.e., schizophrenia(SCZ), bipolar disorder(BPAD), substance use disorders(SUD) and obsessive-compulsive disorder(OCD). We recruited 640 individuals tha...
Chapter
Diagnosis, evaluating symptom changes, and prognosis in schizophrenia are primarily based on complete history, structured interviews, and rating scales. Biomarkers are objectively measured indicators of normal biological or pathological processes which might indicate the presence and severity of an illness. Though the evidence for its clinical util...
Article
Measurement based care (MBC) implies the utilization of structured objective scales/batteries in the assessment and monitoring of an illness. Patients with schizophrenia with heterogeneous presentation would potentially benefit better through MBC. Time constraints and additional work burden are frequently cited as barriers in implementing objective...
Article
Full-text available
Identification of biomarkers in mental illnesses is an important step toward developing reliable diagnostic tests, identifying people at risk, predicting the course and prognosis of illnesses, and developing an etiopathophysiologically valid psychiatric classification system. Event‐related potentials (ERP) are voltage fluctuations in the electroenc...
Preprint
Full-text available
The Accelerator program for discovery in brain disorders using stem cells (ADBS) is an ongoing longitudinal study investigating the neurobiological aspects of five psychiatric disorders. This article explores the frequency of manifestations of different psychiatric symptoms and syndromes in the participants and their relatives from this multiplex f...
Article
Background: Differential susceptibility model hypothesizes that a genotype need not be unfavorable all the time as postulated in stress-diathesis model but can be beneficial in a supportive context. Single-nucleotide polymorphism (SNP) (rs18000795) within the promoter region of interleukin-6 (IL-6) gene was earlier noted to have a differential sus...
Article
Transcranial direct current stimulation (tDCS), a non-invasive, neuromodulatory technique, is being increasingly applied to several psychiatric disorders. In this study, we describe the side-effect profile of repeated tDCS sessions (N = 2005) that were administered to 171 patients (156 adults and 15 adolescents) with different psychiatric disorders...
Article
Background: Differential susceptibility model hypothesizes that a genotype need not be unfavorable all the time as postulated in stress-diathesis model but can be beneficial in a supportive context. Single-nucleotide polymorphism (SNP) (rs18000795) within the promoter region of interleukin-6 (IL-6) gene was earlier noted to have a differential susc...
Preprint
Full-text available
Objective Adverse Childhood Experiences (ACEs) are linked to the development of a number of psychiatric illnesses in adulthood. Our study examined the pattern of ACEs and their relation to the age of onset (AAO) of major psychiatric conditions in individuals from families that had ≥ 2 first degree relatives with major psychiatric conditions (multip...
Article
Full-text available
Benign Joint Hypermobility Syndrome (BJHS) is thought to be an inherited connective tissue disorder with an autosomal dominant pattern, clinically characterized by hypermobility and pain in multiple joints in the absence of systemic rheumatologic disorder. There is no consensus on whether this as an independent disorder or a milder variant of well‐...
Article
Obsessive-compulsive disorder (OCD)with comorbid bipolar affective disorder (BPAD)is often faced with a therapeutic challenge. Pharmacological treatment strategy engaged towards alleviating symptoms in OCD has the propensity to precipitate a manic switch in patients with comorbid BPAD. Advanced non-invasive brain stimulation techniques like high de...
Article
Full-text available
Objectives: Dental illness and psychiatric illness are among the most prevalent health prob-lems all over the world. Evidence suggests that people with mental illness are more vulnerable to dental neglect and poor oral health. Health care professions including dentists are not immune to social prejudices and share the general public’s attitude attr...
Article
Full-text available
Transcranial direct current stimulation (tDCS) is a novel brain stimulation technique which has kindled hope in alleviating motor, language as well as cognitive deficits in neuronal injury. Current case report describes application of tDCS in two phases using two different protocols in a patient with hypoxic injury. In the first phase anodal stimul...
Article
Full-text available
Atypical antipsychotics are known to be associated with electroencephalogram abnormalities. Olanzapine can lower seizure threshold and induce epileptiform discharges. However in patients on Olanzapine for the treatment of a primary psychiatric disorder, clinical seizure is a rare occurrence. We report the case of a 23-year-old female with mild ment...