Sreekumaran Nair

Sreekumaran Nair
Jawaharlal Institute of Postgraduate Medical Education & Research | JIPMER · Department of Biometrics

PhD Professor of Biostatistics

About

204
Publications
79,874
Reads
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3,986
Citations
Introduction
Professor and Head of Biostatistics and Head the Biostatistics Masters and Doctoral program at Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), an Institute of National Importance, Ministry of Health and Family Welfare, Government of India. Direct the JIPMER Research Leadership mentoring Programme-JRLMP
Additional affiliations
August 2006 - March 2017
Manipal Academy of Higher Education
Position
  • Professor
Description
  • Lead Masters and Doctoral programme in Biostatistics
October 1993 - July 2006
Kasturba Medical College, Manipal
Position
  • Professor
July 1987 - May 1993
Indian Istitute of Technology Delhi
Position
  • PhD
Description
  • PhD Scholar
Education
July 1987 - May 1992
Indian Institute of Technology Delhi
Field of study
  • Stochastic Processess
August 1982 - May 1984
University of Kerala
Field of study
  • Statistics

Publications

Publications (204)
Article
Background Portal hypertension is secondary to either cirrhotic or non-cirrhotic causes, and complicating pregnancy poses a challenge to the treating team. A systematic review was performed to determine maternal and perinatal outcomes in women with portal hypertension. Outcomes were compared among those with cirrhotic (CPH) with non-cirrhotic porta...
Article
Full-text available
Aim: To perform network meta-analysis for a head-to-head comparison of various interventions used in COVID - 19 on mortality, clinical recovery, time to clinical improvement and the occurrence of serious adverse events. Methods: Systematic search was performed using online databases with suitable MeSH terms including coronavirus, COVID-19, Rando...
Article
Background Multivariate meta-analysis is used when multiple correlated outcomes are reported in a systematic review. This study explored the application of multivariate meta-analysis in such a context. The objectives of the present study were to compare the summary findings and decisions between univariate and bivariate meta-analyses, as well as to...
Article
Introduction: One of the stringent assumptions about covariates in the Cox hazard and Logistic regression modelling is that they should be independent. Incorporating correlated covariates as such into the model might distort the precision of the estimates due to multicollinearity. One way to deal with multicollinearity is by using Principal Compone...
Article
Objective Epilepsy is one of the most prevalent neurological conditions and carbamazepine is a commonly used anti-seizure drug (ASD), especially in developing nations. There are reports of carbamazepine causing atrioventricular conduction defects and autonomic dysfunctions and its implication in Sudden Unexpected Death in Epilepsy (SUDEP) is contro...
Article
Background: Neonatal pneumonia remains a significant contributor to infant mortality in India and responsible for increased prevalence of infant deaths globally. Objective: To identify risk factors associated with neonatal pneumonia and its mortality in India. Study design: A systematic review was conducted including both analytic study design...
Article
Background: Evidence-based practice (EBP) endeavors to integrate the best available evidence with clinical expertise and patient preference to enhance clinical outcomes. For nurses to effectively demonstrate EBP, the concepts of EBP should be systematically incorporated into the nursing curriculum, with nurse educators playing a pivotal role in ex...
Preprint
Full-text available
Background The increasing incidence of breast cancer necessitates the need to explore alternate screening strategies that circumvent the setbacks of conventional techniques specially among population that report earlier age at diagnosis. Serum autoantibodies is one such potential area of interest. However, their ubiquitous presence across cancer ty...
Article
Background In clinical setting, to answer a research question, very often more than one outcome variables are used which are statistically correlated. Univariate analysis approach, which is commonly used in such context, violates the assumption of independence for correlated variables, while multivariate approach could give more robust and precise...
Article
Full-text available
Background Neonatal pneumonia is one of the leading factors contributing to neonatal mortality. The objective of this review was to identify the barriers associated with case management of neonatal pneumonia in India by conducting a scoping review. Methods Nine databases (PubMed, ProQuest, Ovid Medline, CINAHL, Web of Science, EMBASE, IndMED, SCOP...
Article
Full-text available
Context: Anemia is a public health problem that can lead to growth, cognitive, and motor impairments. Objective: To collate evidence on interventions for addressing childhood and adolescent anemia. Methods: In this overview of systematic reviews, we included Cochrane as well as non-Cochrane systematic reviews (SRs) irrespective of language and publ...
Article
Full-text available
Objective This study was conducted to assess the incidence of sudden cardiac death (SCD) in post myocardial infarction patients and to determine the predictive value of various risk markers in identifying cardiac mortality and SCD. Methods Left ventricular function, arrhythmias on Holter and microvolt T wave alternans (MTWA) were assessed in patie...
Article
Full-text available
Objective To explore stressors and support system for families with a neonate admitted with a systemic infection. Design Qualitative study using in-depth interviews (IDIs), based on principles of grounded theory. Setting A busy level III neonatal unit of a tertiary care teaching hospital in coastal Karnataka, India, between May 2018 and January 2...
Article
Objectives: To systematically review the maternal and fetal outcomes in pregnant women who underwent percutaneous balloon mitral valvuloplasty (PBMV) during pregnancy. Methods: A search was conducted on Medline and Embase databases to identify studies published between 2000 and 2018 that reported on maternal and fetal outcomes following PBMV perfor...
Article
Diffusion tensor imaging (DTI) appears as a sensitive method to study Parkinson’s disease (PD) pathophysiology and severity. Fractional anisotropy (FA) value is one of the scalar derivatives of DTI used to find out anisotropy within a voxel in a tissue and used for determining white matter integrity in aging and neurodegenerative diseases. We studi...
Preprint
Full-text available
Background: Diffusion tensor imaging (DTI) appears as a sensitive method to study Parkinsons disease (PD) pathophysiology and severity. Fractional anisotropy (FA) value is one of the scalar derivatives of DTI used to find out anisotropy within a voxel in a tissue and used for determining white matter integrity in aging and neurodegenerative disease...
Preprint
BACKGROUND Diffusion tensor imaging (DTI) appears as a sensitive method to study Parkinsons disease (PD) pathophysiology and severity. Fractional anisotropy (FA) value is one of the scalar derivatives of DTI used to find out anisotropy within a voxel in a tissue and used for determining white matter integrity in aging and neurodegenerative diseases...
Article
Full-text available
Objectives: To evaluate the effects of atomoxetine on complex attention and other neurocognitive domains in idiopathic Parkinson's disease (PD). Methods: Interventional trials reporting changes in complex attention and other neurocognitive functions (Diagnostic and Statistical Manual of Mental Disorders-5) following administration of atomoxetine...
Article
Introduction: External Cephalic Version (ECV) reduces breech presentation at term and thus contribute to the reduction of cesarean section. This study was done to determine the factors associated with the successful ECV in women with breech presentation after 36 weeks’ gestation and also to develop and validate a clinical score which could be utili...
Article
Background: Rice fortification with vitamins and minerals has the potential to increase the nutrition in rice-consuming countries where micronutrient deficiencies exist. Globally, 490 million metric tonnes of rice are consumed annually. It is the dominant staple food crop of around three billion people. Objectives: To determine the benefits and...
Article
Full-text available
Background: Vitamin A deficiency is a significant public health problem in many low- and middle-income countries, especially affecting young children, women of reproductive age, and pregnant women. Fortification of staple foods with vitamin A has been used to increase vitamin A consumption among these groups. Objectives: To assess the effects of...
Article
Full-text available
Background: The incidence of neonatal sepsis in India is the highest in the world. Evidence regarding its risk factors can guide clinical practice and prevention strategies. Objective: To review, assess and synthesize the available literature from India on the risk factors of sepsis among neonates. Methodology: A systematic review was conducte...
Data
Completed PRISMA checklist for the study. (DOC)
Data
Protocol of the systematic review. (DOCX)
Data
Results from studies not included in meta-analysis. (DOCX)
Data
Definitions and diagnostic criteria in included studies. (DOCX)
Data
Risk factor profile of the included studies. (DOCX)
Data
Quality assessment of included studies. (DOCX)
Data
Forest plots illustrating subgroup analysis. (DOCX)
Data
Funnel plots illustrating publication bias assessment. (DOCX)
Article
Background: Congenital bleeding disorders can cause obstetric haemorrhage during pregnancy, labour and following delivery. Desmopressin acetate (DDAVP) is found to be an effective drug which can reduce the risk of haemorrhage and can also stop bleeding in certain congenital bleeding disorders. Its use in pregnancy has been controversial. Hence ben...
Article
Full-text available
Toothbrushes play an essential role in personal oral hygiene by effective plaque removal.However, they get heavily contaminated by bacteria, viruses, yeasts, and fungi which may originate from the oral cavity after every use as well as from the environment where they are stored. This systematic review was conducted to identify various decontaminati...
Article
Full-text available
Introduction: Fractional Anisotropy (FA) values are considered as a solid concrete index for determining white matter integrity in ageing and neurodegenerative diseases. FA is more comparable and reliable parameter than individual diffusivity parameters. A b-value and Time of Echo (TE) significantly affect the reproducibility and accuracy of Diffus...
Article
Background: Community-based health insurance (CBHI) has been one of the options of health financing in India for a large number of population from the informal sector constituting about 90% of the total population. The objective of this study was to find out what are the factors which have influenced the beneficiaries to enroll in the schemes and a...
Article
Aims: To evaluate the effect of metformin on various parameters of exercise capacity [oxygen consumption (VO2), peak oxygen consumption (VO2peak), heart rate (HR), exercise test duration, respiratory exchange ratio (RER), rating of perceived exertion (RPE), lactate and ventilatory anaerobic threshold (VAT)]. Methods: Studies reporting change in...
Article
The ⁵⁹ Co( n , 2 n ) ⁵⁸ Co reaction cross sections relative to the cross sections of the ¹¹⁵ In( n , n ′) 115m In reaction have been measured at the effective neutron energies of 11.98 and 15.75 MeV by using activation and off-line γ -ray spectrometric technique. Neutron beam used in the present experiment was generated from the ⁷ Li( p , n ) ⁷ Be...
Article
Background: This study reviewed the completeness of reporting in Indian qualitative public health research (QPHR) studies using the 'Consolidated Criteria for Reporting Qualitative Research' (COREQ) checklist. Methods: Search results from five electronic databases were screened by two independent reviewers. We included English-language, primary...
Technical Report
Full-text available
The document gives the information on contextualising the evidence from the review for South Asia and in particular to Nepal. The most common programmes implemented in South Asian countries are Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA) followed by cash transfer programmes. These programmes are proven to be effective for imple...
Article
Full-text available
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the efficacy and safety of pertussis vaccination in pregnancy for preventing whooping cough in early infancy.
Article
Full-text available
Introduction India accounts for more neonatal deaths than any other country. There is a lack of consolidated evidence from India regarding the determining factors of pneumonia in neonates. This systematic review is aimed to consolidate and appraise the evidence on risk factors and determinants of pneumonia among neonates in India. Methods and anal...
Chapter
This chapter provides a brief overview of the commonly used popular statistical packages for thesis or research project data analysis and report preparation.
Article
Full-text available
Background: Neonatal systemic infections and their consequent impairments give rise to long-lasting health, economic and social effects on the neonate, the family and the nation. Considering the dearth of consolidated economic evidence in this important area, this systematic review aims to critically appraise and consolidate the evidence on econom...
Article
Full-text available
Background: Depression is one of the more common mental health conditions found among people suffering from chronic diseases. Its presence in patients with type 2 diabetes could hinder the adherence to and effectiveness of treatment. Most studies on depression among patients with diabetes are hospital-based suggesting the need for a community-based...
Research
Full-text available
How to Cite: Nair, S.N., Darak, S., Parchure, R., Parsekar, S.S., Darak, T., Nelson, H., Bevilacqua, V., Vijayamma, R., and Menon, S. (2017). Effectiveness of Behaviour Change Communication interventions in improving the delivery of health messages for ante-natal care in limited literacy settings: Implications of evidence for South Asia. London: E...
Research
Full-text available
How to cite: Nair, N S., Darak, S., Parsekar, S.S., Parchure, R., Darak, T., Nelson, H., Vijayamma, R., and Menon, S. (2017). Effectiveness of Behaviour Change Communication interventions in improving the delivery of health messages for ante-natal care in limited literacy settings: An evidence summary. London: EPPI-Centre, Social Science Research U...
Article
Full-text available
Introduction: Fifty-three percent of Indian under-5 deaths occur during the neonatal age group. Recognizing that there is a lack of illustrated district-level data on neonatal mortality in India, we mapped this to visually highlight districts where neonatal health issues require the most attention. Methods: District-level estimates of 596 Indian...
Poster
Full-text available
Objective To systematically review the completeness of reporting in published, qualitative public health research (QPHR) studies in India. Design An electronic search was conducted in PubMed, Ovid MEDLINE, Web of Science, SCOPUS, and GoPubMed to identify English language primary QPHR studies from India, published between January 1, 1997, and June 3...
Article
Full-text available
Introduction India contributes to the highest number of neonatal deaths globally. It also has the greatest number of pneumonia-related neonatal deaths in the developing world. We aim to systematically review the evidence for the factors associated with mortality due to neonatal pneumonia in the Indian context, to address the lack of consolidated ev...
Article
Full-text available
Introduction India contributes to the highest neonatal deaths globally. Case management is said to be the cornerstone of pneumonia control. Much of the published evidence focuses on children aged 1 to 59 months. This scoping review, thus, aims to identify the treatment options for and barriers to case management of neonatal pneumonia in India. Met...
Article
Full-text available
Introduction India accounted for more neonatal deaths (estimated at 696 000) than any other country, as of 2015. Of these , most neonatal deaths due to infections can be attributed to pneumonia which accounts for 16% of all neonatal mortalities (2010). Despite simple, inexpensive case management strategies being available, pneumonia continues to ca...
Article
The objective of this study was to find out the perceptions of beneficiaries in comparison to non-beneficiaries of a community-based health insurance scheme. Both quantitative and qualitative methods were used to carry out this study; a cross-sectional household survey on 1,639 households was carried out, where the respondents were required to rate...
Technical Report
Full-text available
The data in this laboratory document are specific to the design of a particular experiment performed to measure the reaction cross section of $^{59}Co(n,2n)^{58}Co$ reaction relative to the cross section of $^{115}In(n, n')^{115m}In$. The interpolation to find the efficiencies of characteristic gammas ($ 0.336241 $ and $ 0.810759 $ MeV) in our part...
Chapter
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To investigate the evidence for the efficacy of physical fitness training in the rehabilitation of spinal cord injury when compared to no training or usual care. © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Technical Report
Full-text available
In this report, we present a logbook documentation including the quantitative steps for covariance analysis of efficiency calibration of HPGe detector using the standard sources namely 152Eu, 133Ba, and 60Co. We exercise with linear parametric functions $\ln \varepsilon =\Sigma^{m}_{k=1}p_{k}(\ln E)^{k-1}$ for different values of k to fit the full-...