Sreekumaran Edakkot

Sreekumaran Edakkot
University of Calicut · Department of Life Sciences

Doctor of Philosophy

About

24
Publications
7,594
Reads
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174
Citations
Citations since 2017
4 Research Items
103 Citations
2017201820192020202120222023051015202530
2017201820192020202120222023051015202530
2017201820192020202120222023051015202530
2017201820192020202120222023051015202530
Additional affiliations
January 2001 - July 2002
University of Nebraska Medical Center
Position
  • PostDoc Position

Publications

Publications (24)
Article
Full-text available
Glutamate is one of the most abundant excitatory neurotransmitters of brain, plays an important role in learning and memory. Monosodium glutamate (MSG) is a sodium salt of L-glutamate, a well-known fl avor enhancer. Because of its capacity to increase the palatability, nowadays it is most widely used in all households and fast foods. The present st...
Article
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Vitamins B complex and homocysteine has been given much attention as preventive factors against cognitive decline and dementia. Hyper homocysteinaemia has been suggested as a cause or mechanism in the development of Alzheimer’s disease and other forms of dementia. The present study is designed to know the role of vitamin B complex and homocysteine...
Article
Full-text available
Introduction: Different studies have shown the role of micro and macronutrients on cognitive function. Macronutrients have been involved in many metabolic activities of the body including oxidation and reduction reactions in the central nervous system. This involvement of macronutrients in the activities of central nervous system indicates its role...
Article
Full-text available
The present study was undertaken to investigate the neuroprotective effect of Vitex negundo on cognitive impairment induced by scopolamine, a muscarinic antagonist, in Wistar albino rats. Memory impairment was induced by administration of scopolamine intraperitoneally. Aqueous extract of Vitex negundo was fed to the rats at a dosage of 1000 mg per...
Article
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The present study was to evaluate the anti-dementic effect of Moringa oleifera on scopolamine induced male Wistar albino rats. Animals were grouped into normal control, scopolamine control, moringa control, moringa + scopolamine, donepezil control, donepezil + scopolamine. Dementia was induced in rats by administration of scopolamine (1 mg/kg intra...
Article
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Malondialdehyde (MDA) is an end product of lipid peroxidation, involved in several enzymatic and non enzymatic reactions. The present study compares the level of malondialdehyde on self generated alcoholic product Dasamoolarishta with the lab grade ethanol treated healthy rats. In this study, 18 Wistar albino male rats of the same age, littermates...
Article
Full-text available
Disturbances in Calcium (Ca2+) and phosphorus metabolism were observed in uncomplicated type 1 Diabetes Mellitus and type 2 Diabetes Mellitus patients. Hormones like PTH, calcitonin etc are involved in it. There is a growing body of evidence that sensory neuropathy in diabetes is associated with abnormal calcium signaling in dorsal root ganglion ne...
Article
Full-text available
The objective of this study is to determine whether people with diabetes have an increased risk of cognitive impairment and cognitive decline. The subjects under study were classified into three groups: test, control and general. In the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) ten-word list, a person's ability to recall is...
Article
Full-text available
To detect the effect of dementia related problems on a person's cognitive functions, especially memory and the occurrence of depression like symptoms by using Mini Mental State Examination (MMSE) and Geriatric Depression Scale (GDS). The subjects were divided into three, one as general group who are non-diabetic, second as control group who are dia...
Article
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The anti-diabetic effect of aqueous extract of the leaves of Calycopteris floribunda (Combretaceae) was investigated in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight). The test group received single dose of the extract (500 mg/kg body weight) da...
Article
Full-text available
The anti-diabetic effect of aqueous extract of the leaves of Calycopteris floribunda (Combretaceae) was investigated in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight). The test group received single dose of the extract (500 mg/kg body weight) da...
Article
Full-text available
Stress has negative effect on health and type 2 diabetes patients may be at an increased risk. Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense mechanisms can increase lipid peroxidation and insulin resistance. The objective of the present study was to demonstrate the efficacy of yogic practice in geriatri...
Article
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Introduction: Aromatherapy is categorized as a form of complementary and alternative medicine (CAM), and has been steadily gaining popularity in today's society. Aromatherapy is considered by many to promote comfort, well-being and invigorating. However there appears to be insufficient supporting evidence to validate physiological changes that may...
Chapter
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The vertebrate retina is a well-characterized central nervous system (CNS) structure, consisting of seven major cell types, which in adult are arranged in a stereotypical laminar organization. These cell types are born in an evolutionarily conserved temporal sequence: the majority of retinal ganglion cells (RGCs), horizontal cells, amacrine cells,...
Article
The membrane properties of cells help integrate extrinsic information relayed through growth factors, chemokines, extracellular matrix, gap junctions and neurotransmitters towards modulating cell-intrinsic properties, which in turn determine whether cells remain quiescent, proliferate, differentiate, establish contact with other cells or remove the...
Article
Aluminum chloride (AlCl(3); 4 mg/kg) was injected into the cerebrospinal fluid of adult rats as a one time dose. Rapid Golgi stained sections of hippocampus were examined for detailed histology of neurons in CA1, CA2, and CA3 areas. The axonal length and number of dendritic branches were seen reduced 30 days later in aluminum (Al)-injected group wh...
Article
Full-text available
A single injection of aluminium chloride (4 mg/kg) into the cerebrospinal fluid of adult rats resulted in significant loss of spatial memory 30 days later tested through T-maze scores, when compared to vehicle-injected controls. A single treatment with Desferrioxamine (10 mg/kg) injected sub-cutaneously one day after the administration of aluminium...
Article
Full-text available
Impairment in T-maze performance of adult rats caused by aluminium (Al3+) and the reversal of it by betaine, a methyl donor, was studied. Besides, conformational change in the secondary structure of β-amyloid peptide (Aβ) brought about by the addition of Al3+ in vitro, was also studied using CD-spectroscopy. The organismal study proved that betaine...
Article
Full-text available
Aluminium (Al3+)induces conformational change in the synthetic β-amyloid peptide 1-40 (Aβ1-40) from α-helix to β-pleated sheet. Boron in the form of B(OH)3 reverses the effect of Al3+ on Aβ, restoring the α-helical conformation. As Aβ1-40 is not intrinsically toxic until it forms fibrillar aggregates and as the formation of secreted amyloid precurs...

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