Sreejith Raveendran

Sreejith Raveendran
Teesside University · School of Health and Life Sciences

Ph.D.
Looking for potential PhD students who are interested to work in Novel Cancer Therapeutics & AI based Cancer diagnostics

About

28
Publications
3,722
Reads
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737
Citations
Additional affiliations
February 2022 - present
Teesside University
Position
  • Assistant Professor / Lecturer in Biotechnology
Description
  • Currently working as Lecturer in Biotechnology: Research and teaching interests inlcude Bionanotechnology, Biomedical Science, Immunology, Cancer theragnostics, 3D bioprinting.
November 2019 - January 2022
Indian Institute of Technology Delhi
Position
  • Project Coordinator - India-Japan Project
Description
  • Project Coordinator for Collaborative education and research program between Indian Institute of Delhi and Toyo university, Japan
October 2017 - October 2019
University of Brighton
Position
  • Marie Sklodowska Curie Actions Individual Fellow
Description
  • Combinatorial targeted drug development for glioblastoma

Publications

Publications (28)
Article
Multi-Modal Targeting Strategy for Breast Cancer In article number 2000145 by Sreejith Raveendran, D. Sakthi Kumar and co-workers, a multi-modal targeting strategy for breast cancer using combinatorial nanodrug complex is studied and ultra-structural visualization of subcellular targeting and multiple parallel damage caused to breast cancer cells a...
Article
Ultrastructural visualization of targeted nanoparticles against its interactions with subcellular organelles through electron microscopy and its 3D rendering is always challenging. Mechanistic and conformational understandings of specific subcellular connections of novel smart nanocarriers with various intrinsic receptors of breast cancer cells are...
Article
Full-text available
Despite of aggressive surgical resections and combinatorial chemoradiations, certain highly malignant populations of tumor cells resurrect and metastasize. Mixed-grade of cancer cells refuses to standard-of-care therapies by developing intrinsic chemoresistance and subsequently ends-up in tumor relapse. Macroautophagy is a membrane trafficking proc...
Article
Full-text available
Morusin, a water-insoluble prenylated flavonoid is known for its numerous medicinal properties. It manifests its anticancer potential by suppression of genes involved in tumor progression. However, poor solubility of the drug results in low bioavailability and rapid degradation thus hindering its clinical utilization. In order to overcome this, we...
Article
Cellulosic materials have been of tremendous importance to mankind since its discovery due to its superior properties and its abundance in nature. Recently, an increase in demand for alternate green materials has rekindled the interest for cellulosic materials. Here bacterial cellulose has been functionalized with sulfate groups through acetosulfat...
Article
Bioinert gold nanoparticles of various shapes and functionalities are widely accepted as contrast agents (CAs) for several modalities of imaging, viz., electron microscopy, computerized tomography (CT), X-ray and photoacoustic (PA) imaging. However, testing of novel compact-imaging probes for ocular diagnostic imaging is always challenging. Here, u...
Article
Full-text available
Biodegradable polymers are popularly being used in an increasing number of fields in the past few decades. The popularity and favorability of these materials are due to their remarkable properties, enabling a wide range of applications and market requirements to be met. Polymer biodegradable systems are a promising arena of research for targeted an...
Article
Gold nanocages (AuNcgs) are well-studied, hollow, metallic nanostructures that have fascinated researchers in the fields of nanotechnology, materials science, photoelectronics, biotechnology, and medical science for the last decade. However, the time-consuming synthesis of AuNcgs has limited their widespread use in materials science and nano-biotec...
Article
Heat Shock Protein 90 (Hsp90) has been extensively explored as a potential drug target for cancer therapies. 17- N-allylamino- 17-demethoxygeldanamycin (17AAG) was the first Hsp90 inhibitor to enter clinical trials for cancer therapy. However, native drug is being shown to have considerable anticancer efficacy against pancreatic cancer when used in...
Article
Full-text available
Extensive cancer research in the past few decades has identified the existence of a rare subpopulation of stem cells in the grove of cancer cells. These cells are known as the cancer stem cells marked by the presence of surface biomarkers, multi-drug resistance pumps and deregulated self-renewal pathways (SRPs). They have a crucial role in provokin...
Article
Precise control of the placement and patterning of graphene on various substrates has tremendous impact in many fields, such as nanoscale electronics, multifunctional optoelectronic devices, and molecular sensing. A one-step facile technique involving N2-plasma promotes surface modification and enhances the surface wettability of the substrate. The...
Article
Full-text available
Abstract 1. Poultry processing generates a large quantity of feather waste. Feathers are a rich source of keratin and could be used as a feather meal in the feed industry if the keratin is degraded using suitable microorganisms. 2. In this study, keratin-degrading microorganisms were isolated from a poultry farm. The predominant organisms were iden...
Article
The rising consciousness about the benefits of environment friendly and biodegradable materials demand a substitute for the prevailing non-degradable and toxic materials. Towards this aspect bacterial cellulose (BC) has numerous potential applications owing to their vital properties like high biocompatibility, biodegradability, and ecofriendly natu...
Article
Extremophiles are the group of organisms that are far overlooked for exploring novel biomaterials in the field of material science and bionanotechnology. Extremophilic bacterial-sulfated exopolysaccharide, mauran (MR), is employed for the bioreduction and passivation of gold nanoparticles (AuNps) to enhance the biocompatibility of AuNps and used fo...
Article
Microbial exopolysaccharides (EPSs) are highly heterogeneous polymers produced by fungi and bacteria that have garnered considerable attention and have remarkable potential in various fields, including biomedical research. The necessity of biocompatible materials to coat and stabilize nanoparticles is highly recommended for successful application o...
Article
The nanocrystals, so-called quantum dots (QDs), are undisputedly excellent fluorescent markers for imaging and clinical diagnostics. However, their toxicity is always a perturbing issue and remains as the major hindrance for biocompatible imaging and other biomedical applications. Here, we have demonstrated the extraction and application of an extr...
Article
Mauran (MR), a highly polyanionic sulfated exopolysaccharide was extracted from moderately halophilic bacterium; Halomonas maura and characterized using X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy. Purified MR was evaluated for antioxidant defense mechanisms under in vitro conditions using L929, mouse fibroblast cel...
Article
Controlled and targeted drug delivery is an essential criterion in cancer therapy to reduce the side effects caused by non-specific drug release and toxicity. Targeted chemotherapy, sustained drug release and optical imaging have been achieved using a multifunctional nanocarrier constructed from poly (D, l-lactide-co-glycolide) nanoparticles (PLGA...
Article
Highly conductive biocompatible graphene is synthesized using ecofriendly reduction of graphene oxide (GO). Two strains of non-pathogenic extremophilic bacteria are used for reducing GO under both aerobic and anaerobic conditions. Degree of reduction and quality of bacterially reduced graphene oxide (BRGO) are monitored using UV–vis spectroscopy, X...
Article
Extremophilic bacterial polysaccharide based biocompatible nanofibers were produced for the first time via electrospinning technique. Mauran (MR), an extremophilic sulfated exopolysaccharide was extracted from moderately halophilic bacterium, Halomonas maura and characterized for the application of nanofiber synthesis. Thin-uniform MR nanofibers we...
Article
Unlabelled: Sulfated polysaccharides are complex polysaccharide molecules with excellent physico-chemical properties and bioactivities. On the basis of origin, they are classified as plant, animal, microbial and chemically synthesized sulfated polysaccharides. They have been widely applied in the fields of material and biological sciences. Biocomp...
Article
Full-text available
Cancer stands as a leading cause of mortality worldwide and diagnostics of cancer still faces drawbacks. Optical imaging of cancer would allow early diagnosis, evaluation of disease progression and therapy efficiency. To that aim, we have developed highly biocompatible PEG functionalized cadmium chalcogenide based three differently luminescent quan...

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Projects

Project (1)
Archived project
Cancer Nanotechnology and Combination Therapies for cancers. Nanoformulation of drugs using biocompatible nanoparticles and targeting