Sreeja C Nair

• Amrita Vishwa Vidyapeetham

Aim: To investigate the efficacy of exosome-like nanovesicles from citrus lemon (EXO-CLs) in combating oxidative stress associated with Alzheimer's disease. Materials & methods: EXO-CLs were isolated through differential ultracentrifugation, characterized for particle size and evaluated for antioxidant activity. Results: EXO-CLs exhibited a mean si...

Aim: To review the state of the art aspects and contemporary innovative drug delivery strategies, for the treatment of vitreoretinal diseases, their mechanism of action through ocular routes and their future perspectives. Materials & methods: Scientific databases such as PubMed, Science Direct, Google scholar were used to obtain 156 papers for revi...

Blood brain barrier is considered as the physiological barrier that restricts the entry of molecules into the central nervous system. The drug delivery mechanisms across blood brain barrier becomes important in case of infectious diseases like meningitis. It is the inflammation occurring in meninges due to infection with wide varieties of microbes....

The threat posed by COVID 19 outbreak, which is considered to be a global pandemic, is immeasurably affecting all the communities worldwide. COVID-19 is a zoonotic disease, which can affect birds, humans and, other animals. The emergence of this pandemic has been creating a tragic situation worldwide by affecting more people through human-human tra...

The emerging Coronavirus Disease-19 (COVID-19) pandemic has had a global impact on all important aspects of our society. As it is known, SARS-Cov-2 can withstand up to 72 h in adverse environmental conditions, which can aid its rapid spread. Woefully, an efficacious and approbated vaccine for the SARS-CoV-2 virus remains unavailable, which makes th...

Pharmaceutical research has developed various new types of innovative forms of drug delivery. Advancement in current drug delivery methods has led to the development of numerous new revolutionary technologies that support safe and efficient formulations over existing ones. Novasome technology is one of the latest liposome developments that have ove...

It’s been nearly 100 y of effort to study the organization and role of the blood brain-barrier and still, we strive to find better techniques to overcome this barrier to deliver the drugs to the brain effectively with reduced systemic side effects. The advances in nanotechnology have given newer horizons in achieving this goal since the nano-scaled...

Objective: To formulate and characterize Lorazepam loaded buccal patches using mucoadhesive, biodegradable, natural polymers-pectin (hydrophilic) and collagen (lipophilic) for treating epileptic seizures. Methods: Lorazepam loaded buccal patches were prepared by solvent casting method and were subjected to various Physico-chemical evaluation parame...

Objective: To formulate and characterize midazolam loaded niosomal transdermal patches for overcoming the frequent dosing and lower bioavailability complications associated with conventional therapy. Methods: The loaded niosomal transdermal patches were prepared by thin film hydration method. The preliminary evaluation and characterization studies...

The vesicular drug delivery systems are promising approaches to overthrown the problems of drugs having lesser bioavailability and rapid elimination from the body. The four type of lipid based drug delivery systems are: solid-lipid particulate system, emulsion based system, solid lipid tablet and vesicular system. Cryptosomes, a novel emerging vesi...

Nano discs recently evolved as a novel tool for studying the membrane associated proteins and serve as an effective drug delivery system. Nano discs constitute disc shaped nano particles and can be defined as a membrane system which is synthetic in nature and aids in the study of membrane proteins. It is mainly made of phospholipid bilayer and the...

A novel drug delivery system is the one that ensures optimum dose at the right time, at the right location. Porphysomes are among those drug delivery systems. Porphysomes are a means of vesicular drug delivery systems. They are liposome-like structures composed completely of porphyrin lipid. The porphysomes encapsulates the active medicament in ves...

In the present investigation, the effect of timolol maleate loaded ocuserts was studied as an alternative for conventional anti-glaucoma formulation. Ocuserts were prepared using natural polymer sodium alginate and ethyl cellulose. Physico-chemical properties along with drug entrapment efficiency (94-98%), content uniformity (93.1% ± 0.264-98.00% ±...

Background A novel drug delivery system for treating acute epileptic condition. Objective To develop an intranasal mucoadhesive formulation of Lamotrigine (LTG) loaded insitu gel, for the treatment of epilepsy to avoid possible side effects and first pass metabolism associated with conventional treatment. Methods Lamotrigine was loaded into diffe...

The study aims to develop enzymosomes as an emerging novel drug delivery system for site-specific action. Enzymosomes utilises the specific nature of an enzyme, which is binding to a specific substrate at a controlled rate and catalysing product production step. An enzyme is encapsulated by coupling covalently to the surface of liposomes/lipid vesi...

Objectives : The present study was aimed to overcome the problems associated with the drug such as bioavailability, to reduce the dosage regimen, half life and to determine the appropriateness of niosomal formulation as a drug carrier.Methods: The niosomal suspension was prepared by thin film technique, by varying ratios of span 60 and cholesterol...

Objectives: The objective behind the study is to develop a mucoadhesive rectal hydrogel from carbamazepine (CBZ) – rice bran wax (RBW) microspheres for the purpose of controlled release for the treatment of epilepsy. Methods: The study was conducted to formulate controlled release rectal hydrogel loaded with CBZ – RBW microspheres in two different...

Objective: The objective behind our study is that a mucoadhesive rectal hydrogel chitosan sodium alginate carbamazepine (CBZ) microspheres for the purpose of controlled release for the treatment of epilepsy to avoid the possible side effects. Methods: The study was conducted to formulate controlled release chitosan sodium alginate CBZ microspheres...

Site-specific drug delivery plays important role in the delivery drug the targeted site for orally and parentral routes of administration. Microspheres constitute an important part of this particulate drug delivery system by virtue of their small size and efficient carrier characteristics. Magnetic microsphere has been alternatively traditional met...

Epilepsy, a serious neurological abnormality which exhibit neuronal misfiring and send out of incorrect signals as its major characters which ultimately lead to seizures. The etiological factors of seizures vary widely ranging from Hypoxia to brain tissues, infection or injury to brain tissues and also certain inborn defects, stress, consumption of...

Vesicular drug delivery system has overtaken the pre existing drugs by improving therapeutic efficacy and by sustaining and controlling action. Liposomes, herosomes, sphingosomes, ethosomes, cubosomes, pharmacasomes, niosomes, transferosomes are the newly developed vesicular drug delivery system. This article mainly deals with the sphingosomal drug...

Ocular route of drug delivery is one of the most challenging arena faced by the pharmaceutical scientist, it is because of the complex anatomy, physiology of eye which makes the delivery of drug so complex. The challenge to the formulator is to circumvent the protective barriers of the eye without causing permanent tissue damage. Novel delivery sys...

The finger nails or ungues are hard covering which form the horny zone of the epidermis. They overlie the dorsal aspect of the distal phalanges. Nail diseases are distinct from diseases of the skin. Although nails are a skin appendage, they have their own signs and symptoms which may relate to other medical conditions. The nail disease has clinical...

Conventional ocular preparation like eye drop, solutions or suspensions often result in poor bioavailability and patient compliance. Timolol maleate is a beta adrenoceptor blocker widely used in treatment of glaucoma in the form of eye drop. The study aimed in preparing Timolol Maleate ocular inserts (ocuserts) enhancing ocular bioavailability and...

This paper introduces a novel type of injectable temperature-sensitive chitosan polymer based in situ gel for the local delivery of Satranidazole into the infected periodontal pocket. The thermo gelling polymer, chitosan with different concentrations has been used for formulation of in situ gel of Satranidazole with 10 % propylene glycol as plastic...

The delivery of effective level of therapeutically active compound influences the effectiveness any herbal medication. When a dministered orally or topically, severe limitations occur in the bioavailability of th e same. Compared to the conventional phyto molecules or botanical extracts, planterosomes, which are newly, introduced herbal formulation...

Ufasomes are unsaturated fatty acid vesicles . They are the suspensions of fatty acids and their ionized species (soap) which are arra nged as closed lipid bilayer . The molecular arrangement in ufasome is that the hydrocarbon ta ils are oriented toward s inferior of the membrane and carbonyl groups are in contact with water. The stabi lity of form...

The human nose has the potential to be an alternative route for the systemic delivery of a wide range of therapeutic agents. The richly supplied vascular nature of the nasal mucosa and its high drug permeation makes it a potential route for the administration of many drugs including proteins, peptides and vaccines. Nasal route is most suitable for...

An objective of periodontal treatment is to suppress or eliminate sub gingival periodontal pathogens. Local delivery devices for periodontitis are designed to deliver the drug locally into periodontal pocket. Satranidazole is a 5-nitroimidazole derivative active against gram negative anaerobic periodontal infections. For site specific one time cont...

Objective: The objective behind the study was to develop a bio erodible mucoadhesive buccal patch containing Cefixime trihydrate as a therapeutic agent for the treatment of bacterial infections and their evaluation. Methods: Cefixime trihydrate buccal patches were prepared by solvent casting method. Results: The formulated patches were subjected to...

The present study was aimed to develop a mucoadhesive in-situ gel of Carvedilol for improved bioavailability by circumventing the hepatic first pass metabolism and patient compliance. Carvedilol was incorporated into the blends of thermoreversible polymer pluronic F 188(PF 188) and bioadhesive polymer Carbopol 940 in the form of in-situ gel by cold...

Objective: The goal in using a local nonsurgical controlled intrapocket device for the delivery of an antimicrobial agent is the achievement and maintenance of therapeutic drug concentration for the desired period of time. Methods: The study was conducted to fabricate a bio erodible delivery system for Satranidazole, dispersed in two different poly...

Periodontal pockets act as a natural reservoir filled with gingival crevicular fluid for the controlled release delivery of antimicrobials directly. This article reflects the present status of nonsurgical controlled local intrapocket delivery of antimicrobials in the treatment of periodontitis. These sites have specialty in terms of anatomy, permea...

Periodontal diseases have been considered as" infections" in which microorganisms initiate and maintain the destructive inflammatory response. However, the nature of the periodontal disease resulting from dental plaque appears to depend to a large extent on the interaction among the bacterial agent, the environment, and the response of the host's d...

The main objective of the present study was to conduct an in depth study of the advances made in the therapy with music and the developments made in its applications in the health care, using primarily resources of published material in the internet. The current study was mainly aimed at understanding music therapy from the perspective of its appli...