Srecko Gajovic

Srecko Gajovic
University of Zagreb · Croatian Institute for Brain Reaserch

MD, PhD

About

109
Publications
15,845
Reads
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1,207
Citations
Additional affiliations
December 1988 - present
University of Zagreb School of Medicine
Position
  • Professor (Full)
Description
  • stem cells and biomaterials in brain repair after stroke, mouse model, in vivo imaging (MRI, BLI, FLI)

Publications

Publications (109)
Data
Open Access resource available for research purposes. The data collected in this dataset are narratives exploring public policies, attitudes, individual behaviors, and the collective experiences of the involved communities regarding vaccination during the COVID-19 pandemic. The narratives were written by the members of the interdisciplinary resear...
Article
By discussing the position of bio-conservatism and transhumanism, we question if the women menstrual cycle control would represent a new way toward a more responsive relation with one's own physical and mental health, a choice of freedom from undesired physiological conditions, a medicalization of a natural physiological event or an innovative carr...
Article
Full-text available
Due to the limited therapeutic options after ischemic stroke, gene therapy has emerged as a promising choice, especially with recent advances in viral vector delivery systems. Therefore, we aimed to provide the current state of the art of lentivirus (LV) and adeno-associated virus (AAV) mediated gene interventions in preclinical ischemic stroke mod...
Poster
Full-text available
INTRODUCTION: So far, due to large variability in outcomes following tMCAO-induced stroke in mice, single modality approaches have shown to be lacking in ability to differentiate between different experimental groups. Our goal was to construct a comprehensive mathematical model that encompasses various modalities in hopes that it would bring us a n...
Article
The COVID-19 pandemic represents a global challenge to be confronted by the biomedical community. This article aimed to explore how knowledgeable and competent researchers may contribute to fighting the pandemic, and to discuss the ethics and impact of this endeavor. Many medical researchers and in particular clinical practitioners are engaged in c...
Article
Full-text available
Wearing face masks is recommended as part of personal protective equipment and as a public health measure to prevent the spread of coronavirus disease 2019 (COVID-19) pandemic. Their use, however, is deeply connected to social and cultural practices and has acquired a variety of personal and social meanings. This article aims to identify the divers...
Article
Aim and objective: The overview of early embryo development was used to introduce the concept of embryo powers, representing the ability of an embryo to exert an action. Materials and methods: A theory-building approach was applied based on the sequence of events during early embryo development. Results: At the beginning of the development as a fer...
Article
Full-text available
The novelty of the COVID-19 pandemic is that it occurs in the globalized society enhanced by digital capabilities. Our aim was to analyze the psychological and emotional states of participants in different pandemic-related contexts including their digital and physical distancing behaviors. The online survey was applied during the ascending phase of...
Chapter
This chapter introduces the main theme of the book and describes the broad challenges that are encountered when navigating online knowledge landscapes in the digital world. The chapter emphasises the important contributions that the many different disciplines of the contributing authors make towards understanding this process of navigation. It prov...
Chapter
The availability of medical knowledge appears as a crucial element needed for the healthcare transition from medical paternalism towards person-centred care. Necessary expertise is provided by health professionals within the healthcare system; however, online resources represent the important complementary means to empower the individual and provid...
Data
The data collected in this dataset are narratives exploring public policies, attitudes, individual behaviors, and the collective experiences of the affected communities regarding face mask wearing at the onset of the COVID-19 pandemic. The narratives were written by the members of the interdisciplinary research network Navigating Knowledge Landscap...
Chapter
This chapter introduces the main theme of the book and describes the broad challenges that are encountered when navigating online knowledge landscapes in the digital world. The chapter emphasises the important contributions that the many different disciplines of the contributing authors make towards understanding this process of navigation. It prov...
Article
Full-text available
Together with its dominant immunological and bone remodeling involvement, RRO axis, comprising of receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG) signaling, is as well-implicated in CNS functioning and corresponding pathologies. The CNS aspects of RANKL/RANK/OPG (RRO) axis were systematically reviewed....
Preprint
BACKGROUND The novelty of the COVID-19 pandemic is that it occurs in the globalized society enhanced by digital capabilities. OBJECTIVE To analyze the psychological and emotional states of participants in different pandemic-related situations together with their digital and physical distancing behaviors. METHODS The online survey was applied duri...
Article
Full-text available
Background: Online interactions within a closed WhatsApp group can influence the attitudes and behaviors of the users in relation to health issues. Objective: This study aimed to analyze the activity of the members of a WhatsApp group initiated to raise awareness of the possible health effects of 5G mobile networks and mobilize members to sign the...
Article
Background: Online interactions within a closed WhatsApp group can influence the attitudes and behaviors of the users in relation to health issues. Objective: This study aimed to analyze the activity of the members of a WhatsApp group initiated to raise awareness of the possible health effects of 5G mobile networks and mobilize members to sign the...
Article
Full-text available
The increased awareness of obstructive sleep apnoea’s (OSA) links to Alzheimer’s disease and major psychiatric disorders has recently directed an intensified search for their potential shared mechanisms. We hypothesised that neuroinflammation and the microglial TLR2-system may act as a core process at the intersection of their pathophysiology. More...
Preprint
Background: Online interactions within a closed WhatsApp group can influence the attitudes and behaviors of the users in relation to health issues. Objective: This study aimed to analyze the activity of the members of a WhatsApp group initiated to raise awareness of the possible health effects of 5G mobile networks and mobilize members to sign t...
Preprint
Full-text available
Background: The neurological mechanisms of the disease process of obstructive sleep apnea, the second most frequent sleep disorder, remain unclear whilst its links with several major neuropsychiatric disorders, such as depression, anxiety and even Alzheimers disorder, are increasingly recognised. A radical theory, that inflammation in the brain may...
Preprint
BACKGROUND The online interactions within closed WhatsApp groups can influence attitudes and behavior of the users in relation to health issues. OBJECTIVE To analyze members activity of a WhatsApp group initiated to raise awareness of the possible health effects of the 5G mobile networks and to mobilize members to sign a related petition. METHODS...
Article
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High salt (HS) dietary intake leads to impaired vascular endothelium-dependent responses to various physiological stimuli, some of which are mediated by arachidonic acid (AA) metabolites. Transgenic Tff3−/− gene knockout mice (Tff3−/−/C57BL/6N) have changes in lipid metabolism which may affect vascular function and outcomes of stroke. We aimed to s...
Article
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Magnetic resonance imaging (MRI) of superparamagnetic iron oxide-labeled cells can be used as a non-invasive technique to track stem cells after transplantation. The aim of this study was to (1) evaluate labeling efficiency of D-mannose-coated maghemite nanoparticles (D-mannose(γ-Fe 2 O 3 )) in neural stem cells (NSC) in comparison to the uncoated...
Article
Full-text available
The aim of this study was to apply multimodal in vivo imaging to assess the influence of altered innate immunity on brain repair after ischemic lesion. Tlr2-deficient mice were compared to wild type controls, as they lack Tlr2-mediated pro-inflammatory signaling triggered by postischemic necrosis. The ischemic lesion was induced by transient middle...
Article
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There has been a considerable volume of work which has sought to understand the way in which users of digital systems make sense of them and how they may (or may not) meet their needs, in areas such as health (Nettleton et al. 2005; Koh, et al., 2013; Record et al., 2018), political agency and civic engagement (Vromen et al., 2016) the emergence of...
Article
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Synchrotron radiation micro-computed tomography (SRµCT) based virtual histology, in combination with dedicated ex vivo staining protocols and/or phase contrast, is an emerging technology that makes use of three-dimensional images to provide novel insights into the structure of tissue samples at microscopic resolution with short acquisition times of...
Article
The rapid development and widespread applications of nanotechnology necessitates the design towards safe nanoparticles. Surface structure is among the most important physicochemical characteristics of metallic nanoparticles affecting their mode of action in certain biological or environmental compartments. This study aimed to investigate how differ...
Article
Full-text available
Журналы, не относящиеся к категории «ведущих», сталкиваются с проблемами обеспечения поступле- ний лучших статей, влияния на рост и развитие науки на локальном и международном уровнях и индек- сирования в престижных библиографических базах данных. Существуют финансовые и нефинансовые факторы, которые затрудняют выполнение надлежа- щих редакционных...
Article
Safe and successful bioapplications of metallic nanoparticles depend on their physicochemical characteristics, in particular their surface properties. This study aimed to investigate how different surface functionalization of silver nanoparticles (AgNP) affect their interaction with mammalian liver cells with regard to cytotoxicity, genotoxicity an...
Article
Full-text available
Background Sleep apnea is a chronic, widely underdiagnosed condition characterized by disruption of sleep architecture and intermittent hypoxia due to short cessations of breathing. It is a major independent risk factor for myocardial infarction, congestive heart failure and stroke as well as one of the rare modifiable risk factors for Alzheimer’s...
Data
Comprehensive collection of computer codes written in VHSIC Hardware Description Language (VHDL) for the programming of various parameters of the hypoxic chamber regulators. (ZIP)
Article
Full-text available
Monodisperse, superparamagnetic oleic acid-stabilized Fe3O4 nanoparticles of different sizes were prepared by thermal decomposition of Fe(III) oleate. The particles were subsequently coated by silica shells of different thicknesses (yielding Fe3O4&SiO2) using a water-in-oil (w/o) reverse microemulsion technique and/or were decorated with amino grou...
Article
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The Sarajevo Declaration is aimed at upgrading standards of editing and publishing scholarly journals across Balkan and Mediterranean countries. Journal editors from regional and other non-mainstream science countries are encouraged to familiarize themselves with the statements and amend their instructions accordingly.
Article
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Abstract The First Mediterranean Seminar on Science Writing, Editing & Publishing (SWEP 2016) was held in Sarajevo, Bosnia & Herzegovina from 2nd to 3rd December 2016. It was organized by Academy of Medical Sciences of Bosnia and Herzegovina, running concurrent sessions as part of its Annual Meeting titled “ “Days of AMNuBiH - Theory and Practice i...
Article
To analyse events following transplantation of stem cells in the brain robust tools for tracing stem cells are required. Here we took advantage of the mouse strain B6.Cg-Tg(Thy1-YFP)16Jrs/J (Thy1 YFP-16), where yellow fluorescent protein (YFP) is under control of the promoter of Thy1 gene. This allows visualising whole neurons, i.e. their cell body...
Article
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We have synthesized and characterized a self-assembling tripeptide hydrogelator Ac-l-Phe-l-Phe-l-Ala-NH2. A series of experiments showed that the hydrogel material could serve as a stabile and biocompatible physical support as it improves the survival of HEK293T cells in vitro, thus being a promising biomaterial for use in tissue engineering applic...
Article
Occlusion of cerebral arteries leads to ischemic stroke accompanied by subsequent brain edema. Bradykinin (BK) is involved in the formation of cerebral edema, and natriuretic peptides (NPs) potentially have beneficial effects on brain edema formation via a still unknown mechanism. The aim of this study was clarifying the mechanisms of action of NPs...
Article
Full-text available
Background: Cell tracking is a powerful tool to understand cellular migration, dynamics, homing and function of stem cell transplants. Nanoparticles represent possible stem cell tracers, but they differ in cellular uptake and side effects. Their properties can be modified by coating with different biocompatible polymers. To test if a coating polym...
Poster
The increasing interest and exponentially growing applications of metallic nanoparticles necessitate research on their bioavailability and effects on living tissues. Understanding of effect of the characteristics of nanoparticles on their distribution, cellular uptake and response is still imperative. This study aimed to explore the toxicity and up...
Article
Full-text available
Today patients are confronted with an increase in complexity of health-related information, including that on medical procedures, data interpretation, and multifaceted therapeutic strategies. At the same time, there is a justified need to simplify information in order to enable patients to make decisions about themselves (1). The patient is indeed...
Article
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GAP43 is a protein involved in neurite outgrowth during development and axon regeneration reflecting its presynaptic localization in developing neurons. Recently, it has been demonstrated that GAP43 is a ligand of CASP3 involved in receptor endocytosis and is also localized post-synaptically. In this study, by using a transgenic mouse strain carryi...
Article
In this review article articular cartilage structure and organization is explained, followed by brief discussion on articular cartilage focal lesion development and subsequent endogenous regeneration, which mainly relies on presence of intrinsic healing capacity. In case of full thickness focal chondral defects intrinsic healing ability is insuffic...
Article
Full-text available
The nucleolar protein 2 gene encodes a protein specific for the nucleolus. It is assumed that it plays a role in the synthesis of ribosomes and regulation of the cell cycle. Due to its link to cell proliferation, higher expression of Nop2 indicates a worse tumor prognosis. In this work we used Nop2(gt1gaj) gene trap mouse strain. While lethality of...
Article
Today's researchers are faced with a change from curiosity-driven to mandate-driven research. These two approaches are well combined within scientific networks (Actions) supported by the European Cooperation in Science and Technology (COST) program. The functioning of COST Actions, although directed only to networking, has a substantial impact on E...
Article
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract, believed to originate from the interstitial cells of Cajal or their stem cell-like precursors. Recent studies incidentally found the expression in interstitial cells of Cajal of the signal-transducing adaptor molecule-2 (STAM2), which is an endoso...
Article
Full-text available
Sustainable solutions and political regulation require public discussions, engagement, and dialogue at the interfaces between science and society. The communication and medialization of innovative knowledge is a key aspect for societal engagement, but also a major source of distortion. Knowledge about bio-objects, generated from biomedical and biot...
Article
Toll-like receptor 2 (TLR2) is involved in innate immunity in the brain and in the cascade of events after ischemic stroke. The aim of this study was to get an insight into the expression of genes related to TLR2 signaling pathway and associated with inflammation and apoptosis in the later stages of brain response after ischemic injury. Middle cere...
Article
Full-text available
Reviewing the past and the present status of personalized medicine, the hope and promise from several years ago was critically compared to what is really achieved to tailor the drug treatment according to the patient's individuality. The basis for consideration is what we know about the variant of the disease the patient is suffering from, and abou...
Article
STAM2 is a tyrosine-phosphorylated protein suggested to be involved in cargo selection during endocytic pathway, regulation of exocytosis and intracellular signaling. Gene trap method was used to create via insertional mutagenesis a mutant mouse line with integration of promoterless βgeo (lacZ-neomycin phosphotransferase fusion) gene in the second...
Article
Stem cells -based therapy is one of the most promising therapeutic approaches for amyotrophic lateral sclerosis (ALS), which is a fatal neurodegenerative disease without cure. This paper reviews the most intriguing pre-clinical and clinical studies and reports the current status of knowledge regarding ALS pathogenesis, confronting it with stem cell...
Article
Full-text available
The transplantation of neural stem cells (NSCs) is a challenging therapeutic strategy for the treatment of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). To provide insight into the potential of the intravenous delivery of NSCs, we evaluated the delivery of NSCs marked with green fluorescent protein to the central nervous s...
Article
Full-text available
Besides its well-known role in cervical carcinoma, HPV is also suggested to be involved in lung cancer development. A number of authors have been investigating the presence of HPV in histological materials. We used routine bronchial aspirates from 84 patients with lung carcinoma for DNA extraction and then performed polymerase chain reaction for hi...
Article
Common pathological features of neurodegenerative diseases are progressive dysfunction and neuronal death. In amyotrophic lateral sclerosis (ALS), motor neurons are selectively affected, leading to death because of paralysis. The main therapeutic goal in neurodegenerative diseases is to diminish neural dysfunction and to replace non-functional cell...
Article
There are only a few systematic reports about DNA extraction from routine diagnostic cytological specimens. An inevitable drawback of such techniques is increased spending of time and funds required for obligatory DNA purification. To implement a simple protocol for human DNA isolation from cytological specimens related to lung cancer, bronchial as...