Srdjan Nikolovski

Loyola University Medical Center · Department of Pathology

Lymphoma patients are at increased risk of thromboembolic events but thromboprophylaxis in these patients is largely underused. We sought to develop and validate a simple model, based on individual clinical and laboratory patient characteristics that would designate lymphoma patients at risk for thromboembolic event. The study population included 1...

Venous thromboembolic events (VTE) are an underestimated health problem in patients with lymphoma. Many factors contribute to the pathogenesis of thromboembolism and the interplay between various mechanisms that provoke VTE is still poorly understood. The identification of parameters that are associated with an increased risk of VTE in lymphoma pat...

Aims: In the past two decades, there have been major improvements in the care of children with chronic kidney disease (CKD) that may have affected its morbidity and mortality rates. The epidemiology of the early stages of pediatric CKD with long term follow-up in countries with limited resources is often under-reported. The aim is to report epidemi...

Abstract Background and Aim: Functional voiding disorders (FVDs) are common problems in children. The effect of vibroacoustic therapy has not been examined in children with FVDs. The aim of this study was to investigate the efficacy of vibroacoustic therapy for treatment of FVDs in children. Methods: Seventy-eight children were included in this pro...

Introduction: Poor outcome is still a challenging concern in patients with out-of-hospital cardiac arrest (OHCA) world-wide and there are large differences between European countries regarding not only incidence rates, but survival rates as well. In 2014, Serbian Resuscitation Council initiated regular data collection on epidemiology of OHCA, acco...

Background: Kidney transplantation is one of the most effective therapies of choice for pediatric patients with end-stage renal disease (ESRD). Aim: Epidemiologic evaluation of pediatric kidney transplantation in Serbia and analysis of early indicators of kidney graft survival time. Materials and Methods: We analyzed data of pediatric kidney transp...

Background: Despite the improvements in treatment of patients with chronic kidney disease (CKD), the risk of progression and eventual mortality remains an issue of significant concern. Aim: The aim of this study is to analyze the basic parameters of overall survival (OS) of children with CKD, as well as factors with an impact on survival. Materials...

Introduction: Urinary tract infection (UTI) is one of the most common childhood diseases and causes of antibiotic prescriptions. Antibiotic treatment is usually initiated empirically, based on symptomatology, blood and urine analysis, knowing the potential pathogen distribution and sensitivity patterns in population. However, resistance patterns sh...

Introduction: Henoch Schӧnlein purpura (HSP), recently called IgA vasculitis is a systemic vasculitis characterized by deposits of immunoglobulin A in blood vessels. Renal impairment of these patients, IgA vasculitis nephritis (IgAVN), is the main determinant of prognosis. IgAVN is a relatively benign disease in children, whereas, long-term cohort...

Objective: This review will summarize overall aspects of defining various types of traumatic brain injury (TBI), as well as pathophysiologic mechanisms, symptomatology, immediate and neuroimaging evaluation, as well as management options in pediatric patients with mild TBI and concussion as its specific entity. Topic Review: TBI and concussion are...

Introduction: Urinary tract infection (UTI) is one of the most common childhood diseases and causes of antibiotic prescriptions. Antibiotic treatment is usually initiated empirically, based on symptomatology, blood and urine analysis, knowing the potential pathogen distribution and sensitivity patterns in population. However, resistance patterns sh...

Introduction: Henoch Schӧnlein purpura (HSP), recently called IgA vasculitis is a systemic vasculitis characterized by deposits of immunoglobulin A in blood vessels. Renal impairment of these patients, IgA vasculitis nephritis (IgAVN), is the main determinant of prognosis. IgAVN is a relatively benign disease in children, whereas, long-term cohort...

Introduction Heart diseases are the main cause of out-of-hospital cardiac arrest (OHCA) which is the leading cause of global mortality. Early positive on-scene and hospital admission outcomes are, therefore, significant factors with an influence on overall survival, in-hospital treatment success, as well as complete recovery and life quality prese...

Disastrous situations involving human population increase the risk of overwhelming first-responding services re-sources by the number of casualties and the severity of their injuries and other urgent medical conditions. In such cases, even non-medically educated individuals could be placed in a position to provide necessary medical attention even b...

Pharmacy institutions are one of the key elements in modern healthcare systems throughout the world. Pharmacies can be a part of the public healthcare system at primary, or secondary and tertiary levels. Also, pharmacies can be founded as a private institution, having the same roles and amount of responsibility compared to public ones. The aim of t...

INTRODUCTION Chronic kidney disease (CKD) mortality in children and adolescents is far more common comparing to the general population. The difference is even larger taking into consideration patients with end-stage renal disease (ESRD) only. RESEARCH AND FINDINGS We used data on 537 patients with CKD stage 2-5, treated in three different major te...

Although detected for the first time from a specimen collected on November 9, 2021 and although announced by the World Health Organization as a variant of concern for the first time on November 26, 2021, there is a possibility that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron (B.1.1.529) exists for a much longer...

Coronavirus disease-19 (COVID-19) has not been shown only as a story on its own. It initiated discussions on enormous amount of life areas, many of which have been more or less neglected. After initial stress mankind has suffered during the first several days after the initiation of the global COVID-19 pandemic, it seemed that many topics have reac...

With development of genomics, transcriptomics, metabolomics, proteomics, and lipidomics, new insights on etiology and pathogenesis have been acquired in investigating renal ischemia-reperfusion injury (IRI). Out of all mechanisms taking part in the course of developing kidney IRI, immunology play one of the most important roles. Therefore, the majo...

Objective: To analyze causes and consequences of filum terminale (FT) displacement in patients with tethered cord syndrome, as well as to evaluate best optimal diagnostic and treatment options. Topic Review: Tethered cord syndrome (TCS) is typically associated with a caudally shifted conus medullaris. FT malposition is also possible and, in most ca...

Urinary tract infection (UTI) is one of the most common childhood diseases and causes of antibiotic prescriptions. Antibiotic treatment is usually initiated empirically, based on symptomatology, blood and urine analysis, knowing the potential uropathogen distribution and sensitivity patterns in population. Prompt diagnosis and treatment are importa...

Fraud represents misleading and/or keeping individual or group of individuals in misleading state by conscious and planned incorrect or incomplete presentation of facts in order to achieve goal. By understanding behavior as an expression of human dynamics essence (connection between needs and tools by which they are satisfied, the way in which this...

In an era of increasing emphasis on autonomy doctors sometimes feel compelled to offer cardiopulmonary resuscitation (CPR), but do not always feel compelled to make a full effort. Doctors occasionally feel obliged to resuscitate hopelessly ill patients because their views on appropriate patient care conflict with the views of other doctors, the fam...

Introduction Although the global survival rate of patients after out-of-hospital cardiac arrest (OHCA) has increased in the previous years, there still remain significant multifactorial public health challenges with many important aspects influencing the overall survival rate of these patients. The objective of this article is to analyze basic epid...

The Aim: analysis of the influence of dispatcher assistance during cardiopulmonary resuscitation (CPR) of patients with out-of-hospital cardiac arrest (OHCA) in achieving return of spontaneous circulation (ROSC), better survival at the scene, survival to discharge, and 30-day survival. Materials and methods. This study includes epidemiological data...

Adult advanced life support guidelines 2021 provided by the European Resuscitation Council in its largest extent do not differ significantly from equivalent guidelines published six years ago. However, some important points were further emphasized, and some protocols show new additions and structural changes. According to the new guidelines, there...

Objective: To evaluate and summarize possible orbital signs in patients with hydrocephalus and their importance in management of those patients. Topic Review: Hydrocephalus can rarely cause orbital complications. Chronic increasing intracranial pressure (ICP) and severe enlargement of ventricular system could, however, lead to a prolapse of meninge...

Background: Wilms tumor (WT) is the most common renal cancer in children with exceptionally good survival rate. Aim: The objective of this study is to analyse the influence of clinical factors on overall (OAS) and relapse-free survival (RFS) in patients with WT. Methods: Study enrolled 48 WT patients aged 0-18 years, diagnosed and treated at the Un...

Background: Although the global survival rate of patients after out-of-hospital cardiac arrest (OHCA) increased in the last couple of decades, it still remains significant public health challenge with many important highly influencing aspects. Aim: To evaluate the influence of pre-hospitalization factors on survival-to-discharge of hospitalized OHC...

Objective: To summarize important aspects of intensive care unit (ICU) management of patients surviving cardiac arrest (CA). Topic Review: Post-CA syndrome consists of neurologic injury, myocardial dysfunction, systemic ischemia-reperfusion injury and multi-organ failure. Since CA as an event can lead to significant neuronal damage and impaired fun...

Background/Aim. Along with the great impact of 2019 coronavirus disease (COVID-19) on physical health, social functioning, and economy, this public health emergency has significant impact on mental health of people as well. The aim of this study was to assess the impact of outbreak-related information and public trust in the health system and preve...

During the clinical part of my medical school education, I spent several days working as an assistant in hospitals located in a multiethnic environment in the Balkans. Numerous war-like civil conflicts were reflected in the constant tension and dangerous situations. Those specific situations resulted in increased stress and fear during work in the...

n addition to their rarity, skull vascular lesions, as challenging topic in pediatric neurosurgery, require special attention. Our case correlates in great extent to the complexity of making the correct diagnosis, which is not the case with symptomatology. The majority of patients with skull base lesions often present with significant functional de...

Neurometabolic changes in the acute phase after cerebral concussion Legend: K+- potassium Ca++ - calcium ATP - adenosine-triphosphate AP - action potential

Timeframe for metabolic events after traumatic brain injury Legend: K+- potassium Ca++ - calcium 2DG - 2-deoxy-D-glucose CBF - cerebral blood flow

Neurometabolic cascade of cerebral concussion Legend: K+- potassium Ca++ - calcium Na+ - sodium EC - extracellular IC - intracellular ATP - adenosine-triphosphate AP - action potential Glu - glutamate ROS - reactive oxygen species BBB - blood-brain barrier

Objective: Review of existing literature data describing pleural effusion as a rare complication in ventriculo-peritoneal shunt (VPS) as a method of cerebrospinal fluid (CSF) derivation. Topic Review: CSF shunting is one of the main treatment options in children with hydrocephalus. VPS, as well as other CSF shunting procedures, however, often lead...

Review of existing literature data describing pleural effusion as a rare complication in ventriculo-peritoneal shunt (VPS) as a method of cerebrospinal fluid (CSF) derivation.

Review of findings published so far in literature regarding anterior sacral meningocele.

Analysis of the occurrence of spinal dysraphism in children and the frequency of associated complications that require involvement of multidisciplinary medical teams in treatment of children with this anomaly.

Introduction: Congenital prepubic sinus as a very rare congenital anomaly with variety of morphologic and pathologic presentations is usually presented in children younger than five years of age. One of mostly accepted theory of its development describes it as a type of urethral duplication. Material: We report the process of diagnosis and successf...

In 82 cases thrombosis had been identified after CVL placement. Those patients required placement of new CVL. CVL dysfunction occurred in 14% in the prior month. Intraluminal tissue plasminogen activator (tPA) was the preferred treatment for a suspected clot, which was followed by CVL removal, and systemic tPA. In conclusion, surgical methods for C...

This is the method for successful surgical creation of RC-AVFs in children with a recipient vein diameter less than 2mm, and recipient artery diameter less than 1.2mm which proved that microsurgery is currently the best method for RC-AVF creation in children.

This study showed successful creation of RC-AVFs in children with a recipient vein diameter less than 2mm, and recipient artery diameter less than 1.2mm which proved that microsurgery is curently the best method for RC-AVF creation in children.

Nephrectomy via dorsal lumbotomy has been proved to be very good option in patients with CKD. Low rate of postoperative complications and especially good postoperative recovery are the main advantages of this nephrectomy approach. Still, there are certain drawbacks, as risk for injury of certain neural elements and these key points require an exper...

The majority of hypospadias failures can be salvaged with one surgical procedure. Our new surgical technique for urethroplasty proved to be an excellent procedure of choice in repairing failed hypospadias surgery because of very low postoperative complications incidence.

to assess the rates of response and overall survival, as well as examining the side effect profile. Methods: Data from 2012 to 2016 were collected retrospectively from pharmacy records for all lymphoma patients treated with thalido-mide. The majority of these patients were multiply relapsed. Patients were all started on 50 mg daily, with dose escal...

Introduction: Skull fractures in neonatal period are uncommon and can be manifested through variety of clinical and radiological signs. Often, they are associated with cephalhematoma with no or mild neurological symptoms. It is well known that impressive skull fractures require surgical intervention. In most other cases, only conservative treatment...

Introduction There are few prediction tools for estimating the risk of thrombosis but they are based on studies performed on hospitalized medical patients without cancer or on hospitalized neutropenic cancer patients without special consideration to lymphoma patients. Aim Aim of our study was to determine incidence of thromboembolic (TE) events in...

Background: An increased risk for thromboembolism in cancer patients has been observed in patients with solid tumors, whereas little data exist on malignant lymphoma. Aim: Determination of incidence of thromboembolic events (TE) in patients with non Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL) and chronic lymphocytic leukemia (CLL) who were treate...

Introduction: An increased risk for thromboembolism in cancer patients has been observed in patients with solid tumours, whereas little data exist on malignant lymphoma. Aim: Determination of incidence of thromboembolic events (TE) in patients with non Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL) and chronic lymphocytic leukemia (CLL). Material an...