Spoorthy Babu

Spoorthy Babu
VIT University | VIT · Centre for Bioseparation Technology

PhD Scholar, MS in Biotechnology

About

21
Publications
9,113
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104
Citations
Introduction
Phytomedicine enthusiast currently working at the Centre for Bioseparation Technology, VIT, Vellore, India. The research focus is on Diabetes, Natural product extraction and research interest lies in diabetes cancer Biology and molecular mechanism of human diseases. The current project is Natural Products and Diabetes.

Publications

Publications (21)
Article
Plant polyphenols have recently gained attention in nutraceutical and pharmaceutical industries due to their various therapeutic potentials. However, the polyphenols are prone to oxidation, unstable towards heat, light, pH and their unpleasant taste also limits their application. The usage of encapsulated polyphenols can alleviate these drawbacks a...
Article
Ethnopharmacological relevance Aloe vera (L.) Burm.f. is an ancient medicinal plant that belongs to the family Asphodelaceae. It has a rich source of bioactive constituents such as carbohydrates, polyphenols, peptides, sterols and tannins, etc. Aloe vera has multiple biological activities such as anti-inflammatory, antioxidant and antidiabetic acti...
Article
Ethnopharmacological relevance Aloe barbadensis Miller, commonly known as Aloe vera has been used since time immemorial for treatment of various diseases such as cancer, inflammatory disorders, diabetes, wound healing etc. Aim Diabetes mellitus is a complex disorder and understanding the molecular mechanisms involved is a key to identify different...
Article
Ethno-pharmacological relevance The genus Aloe has a long history of usage in medicine. Aloe barbadensis Miller, commonly known as Aloe vera, is said to possess anti-diabetic, anti-inflammatory, anti-cancer, anti-microbial, immunomodulation, wound healing properties. Aim of the study In diabetes mellitus, loss in intestinal permeability is observe...
Article
Full-text available
The therapeutic and pharmacological properties of plant bioactive constituents still continue to be the subject of many researches. Species of the Aloe genus have a history in folklore medicine and they have gained more attention over the years due to their various medicinal properties. Phytochemical studies have revealed that the Aloe species cont...
Book
Objective: To evaluate Aloe vera (Aloe barbadensis Miller) gel extract for in vitro antioxidant activity and in vivo antioxidant & anti-inflammatory activities. Methodology: In vitro antioxidant activity of Aloe vera gel extract was evaluated by ABTS, DPPH, hydrogen peroxide and metal chelating activity and anti-inflammatory activity by inhibitio...
Chapter
Full-text available
Objective: To evaluate Aloe vera (Aloe barbadensis Miller) gel extract for in vitro antioxidant activity and in vivo antioxidant & anti-inflammatory activities. Methodology: In vitro antioxidant activity of Aloe vera gel extract was evaluated by ABTS, DPPH, hydrogen peroxide and metal chelating activity and anti-inflammatory activity by inhibitio...
Article
Full-text available
A series of spiro-[indoline-3,3′-pyrrolizin/pyrrolidin]-2-ones, 4, 5 and 6 were synthesized in a sequential manner from Cu–TEMPO catalyzed dehydrogenation of alkylated ketones, 1 followed by 1,3-dipolar cycloaddition of azomethine ylides via decarboxylative condensation of isatin, 2 and L-proline/sarcosine, 3 in high regioselectivities and yields....
Chapter
Vegetables are known to possess various health benefits besides being beneficial to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. Most of common vegetables are consumed after being cooked. Zingiberofficinale (Ginger) and Colocasiaesculenta (Taro) are edible tubers which are predomin...
Book
Murraya koenigii (Curry leaves), Moringa oleifera (Drumstick leaves) and Allium fistulosum (Spring Onion) are leafy vegetables which are used for their nutritional properties. These are used as dietary source and for its iron bioavailability. These are culinary vegetables which are available throughout the year and are cost-effective. An attempt wa...
Book
Vegetables are known to possess various health benefits besides being beneficial to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. Most of common vegetables are consumed after being cooked. Zingiberofficinale (Ginger) and Colocasiaesculenta (Taro) are edible tubers which are predomin...
Book
Vegetables are known to possess various health benefits besides being beneficial to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. Most of common vegetables are consumed after being cooked. Zingiberofficinale (Ginger) and Colocasiaesculenta (Taro) are edible tubers which are predomin...
Article
Full-text available
Aloe vera (Aloe barbadensis Miller) is a perennial succulent plant belonging to the Aloeaceae family and has been used for many centuries for its medicinal properties. Among the Aloe vera plant parts, gel is being widely studied for their biological properties. However, epidermis and flowers are neglected and are not probed for their importance. In...
Article
Full-text available
Objective: To evaluate the anti-inflammatory potential of peptide/polypeptide fraction of Aloe vera through in vitro and in vivo studies. Methods: The peptide/polypeptide fraction from Aloe vera was obtained through trichloroacetic acid precipitation. The anti-inflammatory property of the peptide/polypeptide fraction was tested by protein denaturat...
Article
Full-text available
In this article we report the effect of silver nanoparticles which were synthesize from Ficus Benjamina leaves (Green Synthesis) which was administered to normal body cells (HEK293) and cervical cancer cells (HeLa) in vitro to evaluate its possible apoptotic (anti-cancer) potentials. Silver nanoparticles are obtained from its precursor; silver nitr...
Article
Full-text available
Macrophage migration inhibitory factor (MIF) is a pluripotent cytokine which plays roles in inflammation, immune responses and cancer development. It assists macrophages in carrying out functions like phagocytosis, adherence and motility. Of late, MIF is implicated in almost all stages of neoplasia and expression is a feature of most types of cance...

Questions

Questions (3)
Question
I have a plant sample which is more in carbohydrate content(around 200 mg/g) and protein content is around 2.5 mg/g according to bradford assay. I did 30% TCA precipitation. the protein content increased to 5mg/g but carbohydrate is still present around 10mg/g. Even though, carbohydrate has drastically reduced, but when I compare it with protein after TCA precipitation, carbohydrate is more.I want to know if TCA is able to precipitate some amount of carbohydrates
Question
I am working on crude plant extract powder. I want to know what molecular weight of peptides/proteins get extracted using different % of TCA. I am planning to use 10 to 50% TCA. Are there any chances that other biomolecules of plants may get precipitated during TCA
Question
Should I use only PNPG , buffer and incubate for 30 mins and check the OD at 410 nm to plot the standard glucosidase curve?
How do i dissolve PNPG, because even after heating and filtering, its forming crystals

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Projects

Projects (2)
Project
To understand mechanism of alleviation of diabetes through natural products
Archived project