
Sowjanya PulipatiVignan Pharmacy College · Department of Biotechnology
Sowjanya Pulipati
Doctor of Philosophy (Biotechnology)
About
53
Publications
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Introduction
Skills and Expertise
Additional affiliations
July 2006 - present
July 2006 - present
Education
November 2002 - April 2005
Publications
Publications (53)
Artificial intelligence (AI) is playing an increasingly critical role in advancing green organic chemistry by optimizing chemical processes to minimize environmental impact. From predicting reaction outcomes to designing eco-friendly synthetic pathways, AI tools are contributing to sustainable chemical research. This review explores the application...
In this work, a series of new indolyl-triazole compounds (IT1-8) were synthesized, characterized and evaluated for their in vitro antimicrobial activities. The synthesis involved reactions of indole acetic acid and hydrazine, followed by cyclization with various reagents, yielding triazole compounds elucidated by TLC, IR, NMR, and mass spectral dat...
Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP from other GLP-1RAs as it is currently the only one available in both subcutaneous and oral formulations effective in enhancing glycemic control and promoting weight loss. However, as time has passed, certain safety concerns have emerged regarding their use. Oral semaglutide is prescribed...
Dostarlimab sometimes referred to as TSR-042 or JNJ record for the treatment of solid tumors. It selectively targets the programmed cell death protein 1 (PD the class of monoclonal antibodies known as immune checkpoint inhibitors. By suppressing T immune system from targeting healthy cells, the PD however, frequently use this technique to avoid imm...
This research looked into how well Aloe vera juice works as an antioxidant in the production of selenium nanoparticles. A UV-visible spectrophotometer, Transmission electron microscopy and the ABTS and DPPH tests were used to do the testing. The UV-Vis spectrum of aloe vera extract at 350 nm shows that it contains round and hollow particles with si...
Preclinical testing hepatoprotective potential of hydroalcoholic leaf extract of Calycopteris floribunda against liver damage caused by atorvastatin and clopidogrel. Atorvastatin and clopidogrel were delivered intraperitoneally for 14 days at 80mg/kg and 20mg/kg respectively, while leaf extract was given orally for the same period at 200mg/kg and 4...
Seven semicarbazone derivatives incorporating either substituted furan or thiophene were synthesized by reacting phenylurea with
semicarbazide and various heteroaryl aldehydes. The newly synthesized compounds were characterized using IR, NMR, mass spectrometry
and elemental analysis. Additionally, their antibacterial and anti-tubercular activities...
The World Health Organization (WHO) has officially categorized COVID-19 as a global pandemic, leading to a significant crisis in global public health. Vitamin D is emerging as a crucial micronutrient under investigation for its potential to prevent and mitigate the impact of COVID-19. Observational studies have revealed an inverse relationship betw...
Background and Objective: The tiny, fragrant shrub Artemisia nilagirica (Clarke) is a member of the Asteraceae family. This plant's leaves and flowering top have been used in traditional medicine as an antimalarial, nerve tonic, and anticancer drug, and there is evidence of anti-leishmanial efficacy. Material and Methods: The plant specimen was obt...
There is a rapidly expanding discipline dedicated to the creation of non-biodegradable nanoparticles for use in nanomedicine and nanotechnology. The purpose of this study is to create and test the efficacy of colloidal silver nanoparticles as an antibacterial and antifungal agent. Standard chemical reduction techniques have been used to prepare the...
The WHO classified COVID-19 a global pandemic, and its emergence has caused a disaster in global public health. Vitamin D is one of the main micronutrients being researched for its potential to have a preventive effect against the COVID-19 condition. Serum 25-hydroxyvitamin D (25(OH)D) concentrations and the risk or severity of coronavirus disease...
Background and Introduction: The prevalence of hyperglycemic diseases known collectively as diabetes has reached epidemic proportions in the current century. Diabetics are particularly vulnerable to infections, which can have devastating health consequences. The purpose of this research was to examine the effects of an aqueous extract of Cyperus ro...
In several cultures, black cumin, also known as Nigella sativa, has long been used medicinally. Recent research has revealed that this plant has potent anti-inflammatory and antioxidant qualities, making it a possible treatment for several medical conditions. Additionally, because of its capacity to detoxify the liver and protect it from harm, Nige...
Fermented foods are known as probiotics which contain healthy live bacteria. These foods undergone fermentation process during which bacteria converts the starches and sugars in that food into lactic acid and acetic acid. These foods have high nutritional values, easy to prepare and are economical. The bacteriocins produced by lactic acid bacteria...
We identified twenty-two new sacubitril derivatives (5a-v) as lead compounds for various biologically active targets. These compounds were synthesized by reacting an intermediate compound (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(amino)-2-methylpentanoic acid ethyl ester hydrochloride with respective carboxylic acid (RCOOH). The molecular structures of a...
Acquired immunodeficiency syndrome is caused by a retrovirus human immunodeficiency virus (HIV). Resistance to antiviral drugs is alarming in antiretroviral therapy and medical management of HIV-infected patients. Thus, identifying novel antiviral drugs is critical and medicinal plants are an excellent source for such discoveries. The current study...
Controlled-release systems also offer a sustained-release profile but, in contrast to sustained-release forms, controlled-release systems are designed to lead to predictably constant plasma concentrations, independently of the biological environment of the application site. This means that they are actually controlling the drug concentration in the...
Background: The current study assesses the anthelmintic impact of root extracts of MANSOA ALLIACEAE on Pheretima posthuma compiled by molecular docking analysis of phytocompounds steemed from the plant with the -Tubulin (PDB ID: 1SA0). Methods: In this study, P. tomentosa root was subjected to extraction using methanol and water. In vitro, anthelm...
Since plants are used as therapeutic agents, the present study is designed to evaluate the phytochemical profile and antimicrobial activities of flower of Tecoma stans (L.) ethanolic extract (TSEE) against selective Gram-positive, Gram-negative bacteria in-vitro. Tecoma stans is a flowering perennial shrub belongs to the family Bignoniaceae. The en...
Cancer is a serious concern at present. Development of affective and side effects lacking anticancer therapy is the trending research direction in healthcare. Bioactive phytochemicals are preferred as they pretend differentially on cancer cells only without altering normal cells. The present study is aimed to isolate, characterize and to evaluate a...
Antimicrobial drug resistance is one of the major threats due to the wide usage of broad-spectrum antimicrobial drugs in the general population. The present study was undertaken to investigate the antibacterial potential of Alternanthera philoxeroides methanolic extract (APME) against multidrug-resistant UTI pathogens. The preliminary phytochemical...
Aim: The present study was designed to evaluate the antibacterial activity of Mentha piperita (L) leaf extract against clinical isolates of urinary tract infections. Introduction: M. piperita L. (Peppermint) is a strongly scented herb belonging to family Lamiaceae. The plant is stimulant, aromatic and used for headache, vomiting and allaying nausea...
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Fermentation is a process which involves slow decomposition of organic substances, induced by enzymes or microorganisms that basically convert carbohydrates into organic acids. Fermented foods and beverages have a diversity of traditions and cultural preferences based on the geographical areas from which they have originated. Fermented fruits and v...
Pharmacy students should be given opportunity to learn and practice interpersonal communication skills. Pharmacists are the medication experts
and are the healthcare professionals the public can have easy and direct access to resolve their concerns. Clinical pharmacists work directly
with doctors, health professionals and patients to ensure that th...
Since plants are used as therapeutic agents, the present study is designed to evaluate the phytochemical profile and antimicrobial activities of flower of Tecoma stans (L.) ethanolic extract (TSEE) against selective Gram positive, Gram negative bacteria in-vitro. The dried flowers were extracted by cold maceration process using ethanol. Presence of...
Free radicals or reactive oxygen species are involved in various pharmacological conditions. As synthetic antioxidants possess numerous adverse health effects, the medicinal plants possessing antioxidant components can be used to prevent harmful effects of reactive oxygen species. In the present study leaves of Amaranthus tricolor Linn were used to...
Introduction: Clinical pharmacists work directly with doctors, health professionals and patients to ensure that the medications prescribed for patients contribute to the best possible health outcomes. Therefore, pharmacy students should be given opportunities to learn and practice interpersonal communication skills. Objectives: This observes opinio...
As part of pharmacological-phytochemical integrated studies on medicinal plants from Indian flora, costunolide (1) and dehydrocostus lactone (2), were isolated as major phytochemicals from Saussurea lappa, a plant traditionally used in different Asian systems of medicine. A series of 1,4-disubstituted-1,2,3-triazoles conjugates were synthesized thr...
Dental caries is one of the most prevalent diseases in humans. Endogenous oral bacterial species play a major role in the initiation and progression of the dental caries. Effective prevention of dental caries can be achieved by mechanical plaque removal or chemical agents. All parts of plant have been used as a crude drug for the treatment of tumor...
Since plants are used as therapeutic agents, the present study is designed to evaluate the antimicrobial activities of ethanolic extract of fresh stems of Pongamia pinnata Linn against selective Gram positive, Gram negative bacteria and fungi strains in-vitro. The Pongamia pinnata ethanolic extract (PPEE) was prepared by cold maceration. The prelim...
Nutraceuticals are regarded as bioactive food products that provide health as-well-as medical benefits such as
prevention and treatment of diseases. The need of herbal medicine is increasing day-by-day. With the modernized,
competitive and stressful conditions, all types of diseases are having a field day. Allopathic cure is available for most
of t...
The aim of the present study was to investigate antimicrobial efficacy of leaves of Alternanthera philoxeroides against various Gram positive, Gram negative bacteria and fungi in in-vitro. Susceptibility of Gram positive (Staphylococcus aureus, Bacillus subtilis, Bacillus megaterium, Enterococcus faecalis, Streptococcus mutans), Gram negative (Esch...
The present work is aimed at exploring the phytochemical analysis and antibacterial activity of methanol leaf extract of Alternanthera philoxeroides (Mart.) Griseb. Many plants have been used medicinally because of their antimicrobial traits, which are due to compounds synthesized in the secondary metabolism of the plant. The plant material was ext...
Urinary tract infections (UTI) are the most common form of bacterial infections, affecting people throughout their lifespan. The present study was designed to evaluate the antibacterial activity of Amaranthus tricolor leaf extract and its phytoconstituents against clinical isolates of urinary tract infections. In the present study, the leaf extract...
Alternanthera philoxeroides, commonly known as alligator weed, is an emergent aquatic plant belongs to the family Amaranthaceae. Alternanthera philoxeroides is an ornamental plant found throughout India. The methanolic extract of whole plant was evaluated for antinociceptive and antihyperglycemic activities. In present investigation the detailed Ph...
UV rays extends down to the earth's atmosphere from sunlight assist our body to synthesize Vitamin D which strengthens our bones and teeth. Commercially UV radiation has various uses like sterilization and disinfection. But excessive unprotected exposure to sunlight may lead to sun burns and other skin complications. The present study was designed...
Medicinal plants are important in the traditional medicine and as well as modern pharmaceutical drugs. In traditional system of medicine various plant parts like leaves, flowers, stems, fruits, seeds, barks and even whole plants are used for the treatment. Traditionally the leaves, seeds, roots and entire plant of Amaranthus viridis Linn is used in...
The present study is designed to determine the tannin content and evaluation of antibacterial activity of Crossandra infundibuliformis (Acanthaceae) flower extracts against pathogens associated with urinary tract infections. The Urinary Tract Infections represent one of the most common diseases occurring from the neonate to the geriatric age groups...
The present study is designed to determine the tannin content and evaluate antibacterial activity of crude extracts of Amaranths tricolor (L) leaf against few pathogens. The leaf powder was extracted by successive solvent extraction using petroleum ether, chloroform, ethyl acetate and methanol. The extracts were analyzed for presence of phytoconsti...
Medicinal plants are important in the traditional medicine and as well as modern pharmaceutical drugs. In traditional system of medicine various plant parts like leaves, flowers, stems, fruits, seeds, barks and even whole plants are used for the treatment. Traditionally the leaves, seeds, roots and entire plant of Amaranthus viridis Linn is used in...
Spathodea campanulata belongs to the family Bignoneaceae, commonly known as the Fountain tree, African tulip tree, Flame-of-the forest. The leaves possess analgesic and anti-inflammatory activities. The ethanolic extract of leaf and flower shows antimicrobial properties. The roots peel contains iridoid glucoside and phenolic derivatives p-hydroxy-b...
The aim of the present study was to evaluate the qualitative analysis of phytochemicals and antimicrobial activity of chloroform, acetone, methanol and aqueous extracts of Spathodea campanulata. The antimicrobial activity of different extracts of S. campanulata was tested against the Gram-positive and Gram-negative bacterial strains and fungi by ag...
The aim of the present study is to evaluate the flower extracts of Crossandra infundibuliformis (L)Nees, (Acanthaceae) for its phytochemical constituents and antimicrobial properties. The flowers of C.infundibuliformis were extracted with chloroform, acetone, methanol and water by cold maceration. The extracts were used to evaluate the presence of...
The objective of the present work was to evaluate the invitro anthelmintic potency of n-Hexane Extract (nHE), Acetone Extract (AE), Ethanol Extract (EE), Methanol Extract (ME) and Aqueous Extract (AqE) of flowers of Ixora coccinea Linn. using Indian earthworm (Pheretima posthuma). 25ml of the formulation containing 25mg/ ml and 50mg/ml of all the e...
Eradication of pathogenic bacterial infection is the most effective means of curing several diseases and preventing recurrent episodes. The main objective of this study was to evaluate the comparative antibacterial activity of Ixora coccinea L. plants with red, orange, pink and white flowers against tested bacteria Escherichia coli, Staphylococcus...
The aim of present work is to screen out the antibacterial properties of flowers. Since plants are used as therapeutic agents, the present study is designed to evaluate the phytochemical profile and antibacterial activities of fresh and dry flower extracts of Caesalpinia pulcherrima L. against selective Gram positive & Gram negative strains invitro...
A. Abstract: The aim of the present study was to evaluate the phytochemical profile and antibacterial activitity of flower extracts of Ixora coccinea Linn. The studies on the antibacterial activity of n-hexane extract (nHE), benzene extract (BE), diethyl ether extract (DEE), acetone extract (AE), ethanol extract (EE), methanol extract (ME) and aque...
Eradication of pathogenic bacterial infection is the most effective means of curing several diseases and preventing recurrent episodes. The main objective of this study was to evaluate the comparative antibacterial activity of Ixora coccinea L. plants with red, orange, pink and white flowers against tested bacteria Escherichia coli, Staphylococcus...