Souvik Kar

International Neuroscience Institute Hannover Germany

Abstract Background and objectives: The published data about mechanical thrombectomy (MT) in cancer patients is sparse. We present our institutional experience in this clinical scenario, and a meta-analysis. Methods: The baseline data, procedural data, clinical and radiological outcomes of MT were analyzed and compared among three groups of stroke...

Cerebral cavernous malformation (CCM) is a major cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms, including headaches, seizures, neurological deficits, and intracerebral hemorrhage. Its unpredictable clinical course and the current lack of therapies make the identification of...

Background The purpose of this study was to clarify whether the intrinsic depth of midbrain cavernous malformations (MCMs) influenced the surgical outcome. Methods The authors conducted a retrospective study of 76 consecutive patients who underwent microsurgical resection of a MCM. The vascular lesions were categorized into 4 distinct groups based...

Glioblastoma multiforme (GBM) is the most malignant brain tumor with patient mortality rate close to 100%, 5-yr survival rate of ∼5%, and a median survival of 14 mo. GBMs have notorious histomorphologic and molecular heterogeneities thus giving hope for development of future personalized therapies. We describe here a case of a 48-yr-old male patien...

Objective: The aim of this study was to analyze the differences between posterolateral and posteromedial approaches to pontine cavernous malformations (PCMs) in order to verify the hypothesis that a posterolateral approach is more favorable with regard to preservation of abducens and facial nerve function. Methods: The authors conducted a retrospe...

Small RNA sequencing by Illumina’s Next Generation technology has revolutionized the transcriptome analysis by facilitating massive parallel sequencing of RNA molecules at low cost. Illumina’s Next Generation RNA sequencing is ideal for profiling small RNA (microRNAs, snoRNAs, and piRNAs) libraries in the identification of novel biomarkers for bett...

This chapter provides an overview of medullary gliomas based on a retrospective study of 43 consecutive patients who underwent microsurgical tumor removal between 1996 and 2019. These tumors form a subgroup of intrinsic brainstem gliomas. The authors have analyzed the clinical and morphological features, patient selection, management strategies, su...

Cerebral cavernous malformations (CCMs) are low-flow vascular malformations in the brain associated with recurrent hemorrhage and seizures. The current treatment of CCMs relies solely on surgical intervention. Henceforth, alternative non-invasive therapies are urgently needed to help prevent subsequent hemorrhagic episodes. Long non-coding RNAs (ln...

An overview of brainstem gliomas in adult patients is provided in this chapter as well as results from a retrospective study conducted on 73 consecutive adult patients harboring intrinsic brainstem gliomas who underwent surgical treatment between 1996 and 2017. Presently, surgical treatment of brainstem gliomas is still not generally accepted and m...

BACKGROUND Due to the complex segmental organization of the brainstem, it is preferable to study midbrain cavernous malformations (MCMs) separately from pontine and medullary lesions. OBJECTIVE To evaluate clinical results after microsurgical removal of MCMs, assess predictors for outcome and introduce a topographical classification of MCMs. METH...

Cerebral cavernous malformations (CMs) have since long time been recognized as one of the most common vascular malformations of the central nervous system together with arteriovenous malformations, capillary telangiectasias, and venous angiomas. CMs were also described as occult vascular malformations because no abnormal vascularity is seen on angi...

Cerebral cavernous malformations (CCM) are vascular malformations associated with abnormally dilated blood vessels and leaky capillaries that often result in hemorrhages. Despite recent advances, precise understanding of the cellular and molecular mechanism leading to the pathogenesis of CCM remains elusive. Emerging evidence indicates that small n...

Anticancer target drugs (ATDs) specifically bind and inhibit molecular targets that play important roles in cancer development and progression, being deeply implicated in intracellular signaling pathways. To date, hundreds of different ATDs were approved for clinical use in the different countries. Compared to previous chemotherapy treatments, ATDs...

Cerebral cavernous malformations (CCM) are vascular malformations associated with abnormally dilated blood vessels and leaky capillaries that often result in hemorrhages. A precise understanding of the molecular mechanism leading to its pathogenesis is lacking. Emerging evidence indicates that small nucleolar RNAs (snoRNAs), belonging to the class...

Cerebral cavernous malformations (CCM) are vascular lesions associated with loss-of-function mutations in one of the three genes encoding KRIT1 (CCM1), CCM2, and PDCD10. Recent understanding of the molecular mechanisms that lead to CCM development is limited. The role of microRNAs (miRNAs) has been demonstrated in vascular pathologies resulting in...

Cerebral cavernous malformations (CCM) commonly known as cavernous hemangioma are associated with abnormally enlarged thin-walled blood vessels. As a result, these dilated capillaries are prone to leakage and result in hemorrhages. Clinically, such hemorrhages lead to severe headaches, focal neurological deficits, and epileptic seizures. CCM is cau...

Cerebral cavernous malformations (CCM) are common vascular malformation of the brain and are associated with abnormal angiogenesis. Although the exact etiology and the underlying molecular mechanism are still under investigation, recent advances in the identification of the mutations in three genes and their interactions with different signaling pa...