Soumitra Ghosh

• Doctor of Medicine
• Professor at Institute of Post Graduate Medical Education and Research

RENAL DYSFUNCTION IN METABOLIC SYNDROME

Dengue is the foremost cause of arthropod-borne viral disease in the world. It is and commonly found in tropical and subtropical parts of the world. Dengue fever is caused by one of the four distinct serotypes (DENV 1–4) of single-stranded RNA Flavivirus genus and transmitted through Aedes mosquito. Infection caused by one serotype develops lifelon...

Scrub typhus is one of the endemic diseases leading to acute febrile illness in the topical countries. It can present with its various manifestations ranging from asymptomatic illness to serious multiorgan dysfunctions. The most common pathophysiology behind this multisystem manifestation is the systemic vasculitis due to exaggerated immune respons...

Cryptococcosis is the fungal infection caused by the yeast that belongs to the cryptococcus species which is divided into two broad categories, Cryptococcus neoformans and Cryptococcus gattii. Cryptococcosis is the opportunistic infection in the immunocompromised individual, particularly in HIV infected individual. In immunocompetent individuals, t...

Background Sudden upsurge in cases of COVID-19 Associated Mucormycosis (CAM) following the second wave of the COVID-19 pandemic was recorded in India. This study describes the clinical characteristics, management and outcomes of CAM cases, and factors associated with mortality. Methods Microbiologically confirmed CAM cases were enrolled from April...

Aim:To determine the efficacy of three disinfectants-2% Glutaraldehyde,0.2% Peracetic acid,70%Isopropyl alcohol with time(3 minutes and 7 minutes) on Staphylococcus Sp. and Candida Sp. on polyvinyl siloxane impression material. Settings and Design:This was an in vitro comparative study. Materials and Methods:A standard inoculum of 0.5 McFarlandwas...

Histoplasmosis is a systemic fungal disease caused by the dimorphic fungus Histoplasma capsulatum and is more common in immunocompromised patients. Histoplasmosis can present with a wide range of clinical manifestations from asymptomatic illness to severe organ dysfunctions and may need hospitalization. Histoplasmosis is a major opportunistic infec...

Background Increased occurrence of mucormycosis during the second wave of COVID-19 pandemic in early 2021 in India prompted us to undertake a multi-site case–control investigation. The objectives were to examine the monthly trend of COVID-19 Associated Mucormycosis (CAM) cases among in-patients and to identify factors associated with development of...

Scrub typhus is a mite borne zoonosis, caused by Orientia tsutsugamushi, a gram-negative intracellular organism. This infection usually presents in high prevalence in the rural areas of East Asia and Western pacific islands. It usually presents with fever, chill, myalgia, headache, skin rashes, having pathognomonic and skin lesion i.e. eschar in ~1...

INTRODUCTION: Myelitis is one of the rare complications in SLE. An absence of radiological correlate further compounds the challenges in diagnosis and subsequent therapeutics. CASE PRESENTATION: We herein report a case of SLE in young male who was initially admitted to our facility with features of Autoimmune hemolytic anemia, managed successfully...

Objectives This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalised COVID-19 adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC). Methods NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19...

Background: Increased occurrence of mucormycosis in India during the second wave of the COVID-19 pandemic in early 2021 in India subsequently prompted us to undertake a multi-site case-control investigation. The objectives were to examine the monthly trend of Covid-19 Associated Mucormycosis (CAM) cases among in-patients and to identify factors ass...

Background Severe Corona virus disease (COVID-19) is associated with high mortality. Although single centre intensive care units (ICU) have reported clinical characteristics and outcomes, no large scale multicentric study from India has been published. The present retrospective, multi-centre study was aimed to describe the predictors and outcomes o...

Background: There is more than twofold rise in prevalence of mucormycosis cases in India during the COVID-19 pandemic which needs to be evaluated. Aims: The study aimed to document the spectrum of cases of mucormycosis seen at our Institute during COVID-19 times. Methods: The study is a retrospective observational study carried out at our Inst...

Aims: 1 Describe the epidemiology and determine risk factors for COVID-19 associated mucormycosis. 2 Elaborate the clinical spectrum of Rhino-Orbital-Cerebral Mucormycosis (ROCM), pattern of neuroaxis involvement and it's radiological correlates. Methods Observational study. Consecutive, confirmed cases of mucormycosis (N = 55) were included. A...

Adolescence is a challenging and dynamic period due to hormonal, physical, emotional, cognitive and social changes. Aggression in any form, if present or its manifestations is linked to various psychosocial maladjustments or mental disorders and is negatively associated with pro social behavior and adaptive social functioning, especially during ado...

Background Combination treatments, targeting multiple disease processes, benefit subjects with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, predicting treatment response and exacerbation risk remain challenging. Objective To identify genetic associations with AECOPD risk and response to combination therapy (flutic...

Background: There is overlap of symptoms in psychiatric disorders, especially in mental and behavioural disorders of childhood and adolescence. Half of all lifetime psychiatric disorders tend to arise by age 14 years and three fourths of them arise by age 24 years. Aim: To study the various types of mental and behavioural disorders of childhood...

p> Background : A realistic approach to the phonetic aspect in complete denture construction is most often subdued by various factors. The palatal rugae, an important landmark in speech orderliness, are frequently affected due to lack of proper texture on a complete denture. Establishing a correlation between customized palatal surfaces of complete...

Adolescence is a challenging and dynamic period due to hormonal, physical, emotional, cognitive and social changes. Aggression in any form, if present, or its manifestations is linked to various psychosocial maladjustments or mental disorders and are negatively associated with prosocial behavior and adaptive social functioning, especially during ad...

Transgender is an umbrella term for individuals whose gender identity or gender expression is different from their natal sex. In recent year's transgender people across class, culture, ethnicity, religion and other various demographics are receiving lot of public attention. Lot of research work has disclosed on structural oppression, social ostraci...

Current scientific information in Autoimmune rheumatic diseases ( AIRD ) revolutionised the outlook in dealing with the different diseases, Moving from the concept of NETosis through interferon based pathogenic modification gives a new horizon to have a deep insight into the rheumatological disorders. We have newer classification criterias of diffe...

Association of Takayasu arteritis (TA) and systemic lupus erythematosus (SLE) is rare in literature and the presence of TA, SLE, and antiphospholipid syndrome (APS) altogether is rarer. A 38-years-old female presented with the asymmetric pulses and blood pressure in upper and lower limbs was diagnosed as having TA by various imaging methods, there...

The use of ketogenic diets (KDs) for the management of type 2 diabetes mellitus (T2DM) and in weight-loss programs is long established, but high-quality data supporting them are limited and they remain controversial. In recent years there has been a trend towards individual, patient-centered medical nutrition therapy in which KD regimens have been...

Treatment of patients with the rare disease eosinophilic granulomatosis with polyangiitis (EGPA) with mepolizumab, a monoclonal antibody to interleukin-5 (IL-5) that reduces blood eosinophil counts, as an add-on therapy to glucocorticoid treatment, results in more accrued weeks in remission, reductions in glucocorticoid use and reductions in relaps...

Drug-induced bone disorders are a group of disorders characterized by osteomalacia or osteoporosis, with the common denominator being the iatrogenic nature of the disease. Drug-induced bone disorders are either due to the drug directly effecting the bone microarchitecture (osteoblastic or osteoclastic activity) or indirectly by interfering with Vit...

Introduction: Improved understanding of genetic effects on response to treatments with novel approaches for COPD with peripheral blood eosinophilia, such as mepolizumab (a humanized monoclonal antibody to IL-5), may improve treatment outcomes. We conducted a study to identify genetic variants associated with efficacy of mepolizumab COPD. Material...

Background: This study evaluated the real-world weight loss and glycemic outcomes of multidrug therapy (MDT) according to various combinations of metformin, sodium-glucose cotransporter -2 inhibitor (SGLT2i), glucagon-like peptide-1 receptor analogs (GLP1a), and orlistat in diabesity. Methods: Data retrospectively captured from medical records o...

Purpose: No studies have investigated genetic effects on quality of life (QoL) measurements like improvements in the St George's Respiratory Questionnaire (SGRQ) scores for chronic obstructive pulmonary disease treatments with fluticasone propionate/salmeterol (FSC). Therefore, in addition to testing genetic effects on change from baseline in trou...

Vascular complications in forms of venous and arterial thrombi are common scenario in antiphospholipid syndrome with raised titer of antibodies. Here we describe an 18 years old female who was admitted with right parotid swelling due to external carotid artery thrombi within gland parenchyma in antiphospholipid syndrome, with past history of right...

Case Report: A 65-years-old female patient presented with high-grade (~104°F) fever for 3 months before admission, associated with bilateral multiple small and large joint pain and swelling. Although there was a history of macular rash over body during peak of fever, there was no rash at time of presentation. The patient had bilateral axillary lymp...

Abstract : Paranormal phenomena refer to perception without mediation of the known sensory, or to movement without participation directly or indirectly of known motor process and have a direct bearing in the mind-brain relations. They are not very uncommon both in the developed and the developing world. Though often viewed as controversial its exis...

Abstract : To our mind, always it comes what is guilt exactly. The definition that appears in books is too superficial and literary. But this emotion plays a great role in every one’s life. A lot of psychological problems occur which may not be pathological but it disturbs the life of an individual. So when this guilt within us remains and is not r...

Context: Determination of horizontal condylar guidance (HCG) by various clinical and radiographic methods was performed by several investigators. If a correlation between HCG values using lateral radiographic tracing and protrusive interocclusal records can be established, the necessity of performing elaborate recording procedures can be eliminated...

Superior vena cava (SVC) syndrome occurs because of SVC obstruction by mediastinal mass, with features of venous stasis and Pancoast syndrome manifested by tumour of the lung apex with features of invasion to adjacent bones, soft tissues and the nervous system. Small cell carcinoma lung is commonly found to cause SVC syndrome, Pancoast is a rare as...

Leptospirosis is a disease caused by leptospira a spirochete which involves multiple organs. Towering high transaminase levels in the severe form of the disease is unheard of till date. Thus we are going to present the story of a 32 year male, with initial SGPT level of 3520 U/lit who came up with the diagnosis of leptospirosis and recovered due to...

Aims: This study aims to find the effect of change in different salivary factors before and after complete denture insertion and to measure the maxillary denture retention in different arch forms. Materials and methods: Thirty completely edentulous individuals (10 each of square, tapered, and ovoid arch form of maxilla) belonging to the age grou...

Background The efficacy of inhaled corticosteroids (ICS) for chronic obstructive pulmonary disease (COPD) varies between patients, which may be partially due to genetic differences. A single-nucleotide polymorphism, rs37972, in the glucocorticoid-induced transcript 1 gene (GLCCI1) has been associated with variations in response (forced expiratory v...

Skin Involvement is seen nearly 76 per cent of Systemic lupus erythematosus (SLE) patients, but bullous lesion however accounting for less than one per cent of cutaneous manifestation of lupus erythematosus. A 21-year-old female presented with fever, polyarthalgia and vesicobullous skin lesion and acute renal failure. Clinico-pathological evaluatio...

Background and objectives Treatment with mepolizumab, a humanized monoclonal antibody to interleukin-5, reduces the rate of asthma exacerbations and the requirement for systemic glucocorticoids while maintaining asthma control. Treatment decisions are guided by predictors of response, including blood eosinophil thresholds in patients with frequent...

Baclofen is a gamma-aminobutyric acid type B receptor agonist used as an anti-craving agent for treatment of alcohol dependence. It has gained popularity in the recent times because it is well tolerated even in patients with hepatic impairments. Herein we are summarizing the latest literature about baclofen induced hypomania and are reporting a cas...

Context: Many authors have conducted studies that determine horizontal condylar guidance (HCG) using various methods, articulator systems, and recording materials. However, there is a dearth of literature on variability existing in HCG in individuals with different skeletal relationships. This study is an attempt to verify whether such a difference...

Reveal of Wilson’s disease with viral hepatitis is reported earlier in the literature as a rare association. Here we have reported a case of late onset Wilson’s disease diagnosed after hepatitis E infection in a 45 years old male who had no manifestation of liver disease before the infection and rapid deterioration thereafter.

Background: Inhaled corticosteroids (ICSs) are considered the most effective anti-inflammatory therapy for asthma control and management; however, there is substantial treatment response variability. Objective: We sought to identify genetic markers of ICS response by conducting the largest pharmacogenetic investigation to date in 2672 ICS-treate...

Context: This study evaluated the efficacy of denture adhesive, cleanser, chlorhexidine, and brushing against Candida albicans biofilm developed on an acrylic surface and predicted the most effective, simple, and inexpensive way to maintain denture health, thereby preventing denture stomatitis. Aims: To find the best possible method for maintain...

Asenapine is a sublingually absorbed newer second-generation antipsychotic that is approved for the treatment of schizophrenia and bipolar disorder in patients, with a lower extrapyramidal adverse effect potential. We report an adolescent boy having schizophrenia who developed an acute dystonic reaction after 4 days when the dose of asenapine was i...

Background Treatment with long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) for chronic obstructive pulmonary disease (COPD) is standard, but response varies. We investigated genetic association with treatment response to umeclidinium (UMEC, a LAMA), vilanterol (VI, a LABA), and combination therapy. Methods Data from 1...

Statement of problem: No cost-effective method of ascertaining bone density from 2-dimensional radiographic images is currently available for dental implants before surgery. Purpose: The purpose of this in vivo study was to use digital panoramic radiology and dental computed tomography (CT) to evaluate the bone density of specific points in the...

Background:Previous work has identified prevalence rate for psychiatric disorders in individual with epilepsy and its correlation. However studies from this part of country are quite a few, and no systematic attempt has earlier been made to study prevalence, nature of psychopathology ,and any correlation of duration of psychiatric illness with dura...

Background: Major depressive disorder is widely prevalent in post myocardial infarction (MI) period. Various studies have reported a significant relationship between these two major disease states. Aim: To examine depression after MI and its socio-demographic variation. Methods: The study was a follow up study on patients of acute MI (n=50) atten...

Aim: This study includes a comparative evaluation of the various surface treatments of the intaglio surface of crowns in combination with various luting agents for maximal retention. Materials and Methods: Totally, 150 dies of a standard complete crown preparation were fabricated. Wax pattern with a loop on the occlusal surface was prepared on each...

Background: There is a dearth of research on the correlation between emotional quotient (EQ) and intelligence quotient (IQ), and specifically among medical students and interns. So, we in our study aim to find out the correlation between these two variants of intelligence, and their relation to academic performance among medical interns as well as...

Background: Depressive symptoms are very usual in patients experiencing a history of myocardial infarction (MI). An individual who has developed depression after an episode of MI becomes non compliant with the treatment of cardiology. Aim: To test the impact of post MI depression on drug adherence of cardiological medicines. Settings and design:...

Background: Major depressive disorder is very usual in patients experiencing a history of myocardial infarction (MI). Raising level of Troponin I could be a tool to predict the severity of post myocardial infarction depressive disorder. Aims: The purpose of this work was to test the relationships between levels of Troponin I and severity of post MI...

Pharmacokinetic variability in drug exposure is a concern for all compounds in development including those for the treatment of asthma and other respiratory disorders. Substantial variability in the oral clearance of GSK2190915, a 5-lipoxygenase-activating protein inhibitor that attenuates the production of leukotriene B4 and cysteinyl leukotrienes...

Background An important step toward understanding the biological mechanisms underlying a complex disease is a refined understanding of its clinical heterogeneity. Relating clinical and molecular differences may allow us to define more specific subtypes of patients that respond differently to therapeutic interventions. Results We developed a novel...

AIM : It was thought previously that morbidity and mortality are directly related to both Systolic and Diastolic blood pressure . However evidences from different studies suggest that systolic hypertension deserves more importance especially due to its profound effect on cardiovascular disease progression. Isolated systolic hypertension (ISH) has n...

This study is conducted to assess the performance of teachers in private higher educational institutions in West Bengal. The objective of the study is to analyze the classroom behavior of faculties in private higher educational institutions in West Bengal. Through this research paper factors are identified that affects teaching effectiveness of fac...

Dental impressions, contaminated with saliva, blood, plaque, are potential source of infection. All impressions should be disinfected after their removal from mouth to prevent cross contamination. Different methods have been tried to disinfect the commonly used irreversible hydrocolloid impression material, but they have been shown to influence the...

Tramadol is a widely used medication by physicians and is held to be a safe analgesic. It has been claimed to be helpful in the elderly and hepatic and renally compromised subjects. We would like to report a case of delirium in a middle-aged female with acute pain abdomen on tramadol while being treated in the surgical unit. The patient developed a...

So far, the discussion on climate change in India has largely remained confined to two aspects of the problem: the international talks process and its inequities, and the potentially destructive impact of changes in earth’s natural cycles caused by global warming. Attempting to go beyond the constraints of this discussion, this book explores the in...

Increasing life expectancy, age-related reduction in adaptability and progressive severe mandibular resorption, all add to the difficulty in achieving prosthetic success. The conventional mandibular denture is usually less retentive than the maxillary one and successful treatment involves the development of lingual retention for the mandibular dent...

Graves' disease is a unique conglomeration of cardiovascular, neurological, ophthalmological, and other systemic manifestations. In this study we have tried to explore the psychiatric dimensions of this disease. This study attempted to explore clinical features, types, and treatment outcome of psychiatric disturbances in Graves disease. This is a p...

This case report describes a 22 year old boy presenting with a history of wearing female garments for sexual arousal. He was treated successfully with the help of behaviour therapy.

Background: Although recurrent manic episodes is rare, but in our clinical practice we have found that recurrent mania is much more common. And it was our observation that those who come with recurrent mania are more asthenic or ectomorphic body built whereas bipolar patients are more of pyknic or endomorphic in their body built. Bipolar group and/...

To evaluate the extent of posterosuperior bony overhang required to be removed for proper exposure of the incudo-stapedial complex during stapes surgery. Whether an assessment can be made out about the extent of the posterosuperior bony overhang clinically or not. A prospective study. One hundred patients of Stapedial Otosclerosis were included in...

A study was undertaken amog 80 non-diabetic patients of acute myocardial infarction (AMI) admitted within 24 hours of the onset of pain, to investigate the prevalence and significance of microalbuminuria (MA) as a predictor of in-hospital mortality, and also to correlate it with other well-established prognostic markers. Spot urinary albumin-to-cre...

Oncogenous osteomalacia is a rare paraneoplastic renal phosphaturic condition, often associated with highly vascular benign mesenchymal tumors. We report a case of a 48-year-old male who presented with debilitating osteomalacia unresponsive to standard therapy. Two years later, sinonasal hemangiopericytoma was diagnosed; the patient underwent compl...

To identify the predictors of severe outcomes in patients with haemotoxic viper bite certain independent variables were recorded like age, sex, ethnicity, bite sites, duration of prehospital period, prehospital treatment, onset of systemic bleeding, local oedema, ecchymoses, blister, hematocrit, platelet count, whole blood clotting time, serum elec...

We studied 89 non-diabetic patients of acute ischaemic stroke, confirmed by imaging, admitted within 24 hours of onset, to investigate the prevalence and significance of micro-albuminuria (MA) as a predictor of in-hospital mortality. Two control groups consisted of 70 patients with non-stroke chronic neurological diseases and 60 age- and sex- match...