Soumen Choudhury

Soumen Choudhury
Duvasu Mathura University · Department of Veterinary Pharmacology and Toxicology

MVSc., PhD (Pharmacology)

About

89
Publications
11,742
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
568
Citations
Introduction
We are working on the mechanistic aspects of vascular dysfunctions in sepsis using different functional and molecular techniques. We are also working on role of different receptors and ion channel in regulating myogenic response of myometrium and uterine artery. Our laboratory s equiped with facilities of isometric tension measurement (wire myograph and organ bath), blood pressure measurement, RT-qPCR, Western blot, immunohistochemistry etc.
Additional affiliations
October 2011 - present
Duvasu Mathura University
Position
  • undergraduate and post graduate teaching
January 2011 - present
Indian Veterinary Research Institute
Education
September 2009 - December 2014
September 2005 - September 2007
Duvasu Mathura University
Field of study
  • MVSc
September 2000 - September 2005
Central Agricultural University
Field of study
  • BVSc & AH

Publications

Publications (89)
Article
Full-text available
This study was conducted to evaluate the effect of inorganic and nano copper (nanoCu) supplementation on superoxide dismutase (SOD) and catalase (CAT) gene expression, antioxidant status, and immune response in growing Sahiwal heifers. Twenty-four Sahiwal heifers were allocated at random into four groups of six heifers in each groups and fed for 12...
Preprint
This study was conducted to evaluate the effect of inorganic and nano copper (Cu) supplementation on superoxide dismutase (SOD) and catalase (CAT) gene expression, antioxidant status and immune response in growing Sahiwal heifers. Twenty four Sahiwal heifers were allocated at random into four groups of six heifers in each groups and fed for 120 day...
Article
Full-text available
Inhibition of Notch signaling in macrophages is known to reduce inflammation, however, its role in regulating vascular hyporeactivity in sepsis is unknown. Thus we aimed to evaluate the effect of sepsis on vascular Notch signaling. Polymicrobial sepsis was induced by caecal ligation and puncture (CLP) in mice. mRNA expressions of Notch receptors (N...
Article
Full-text available
This study unravels the differential involvement of calcium signaling pathway(s) in PGF2α-induced contractions in myometrium of nonpregnant (NP) and pregnant buffaloes. Compared to the myometrium of pregnant animals, myometrium of NP buffaloes was more sensitive to PGF2α as manifested by changes in mean integral tension (MIT) and tonicity. In the p...
Article
Full-text available
Atopic dermatitis (AD) is one of the most common skin diseases of dogs. Defects in the skin barrier and overproduction of inflammatory cytokines may be the pathogenesis of canine AD. Therefore, the present study was aimed to quantify the gene expression of certain skin barrier proteins and inflammatory cytokines in dogs with AD. Eleven dogs with AD...
Article
Full-text available
Background and Aim: Selection and dissemination of plasmid-encoded extended-spectrum β-lactamase (ESBL) among Enterobacteriaceae confers resistance to beta-lactam antibiotics. The purpose of this study was to determine the prevalence and molecular characteristics of ESBL-producing organisms isolated from dairy cattle with a uterine infection. Mate...
Chapter
Globally, coffee is consumed as a functional beverage due to its nutraceutical value and positive physiological effects. Coffee is an important source of several nutritious and therapeutic phytoconstituents including lipids, carbohydrates, minerals, vitamins, and nitrogenous compounds, along with bioactive compounds like cafestol and kahweol diterp...
Article
Aim Cell-based therapy has emerged as promising strategy for chronic and impaired wounds treatment. Current research is focused on developing biomaterial systems that act as a niche for mesenchymal stem cells (MSCs) to promote wound healing through paracrine molecular cascading. This study was aimed to evaluate the wound healing potential of Velgra...
Article
Full-text available
Hexavalent chromium, a well-known environmental toxicant, adversely affects female reproduction and results in abnormal implantation, fetal resorption, and reduction in litter size. Uterine myogenic activity is under control of number of receptors and ion channels, and it regulates fetal-implantation and feto-maternal communication. Despite several...
Article
Full-text available
We investigated the effect of erythropoietin (EPO) posttreatment on survival time and vascular functions in a mouse model of sepsis. Sepsis was induced by cecal ligation and puncture. After 20 + 2 hours of sepsis, thoracic aorta was isolated for assessing its reactivity to norepinephrine (NE) and acetylcholine (ACh). We also measured the tissue nit...
Article
Full-text available
We investigated the effect of erythropoietin on sepsis-induced haematological changes in mice. Sepsis was induced by caecal ligation and puncture. In this study, blood was collected after 20 ± 2 hr of surgery from Sham operated (SO), Sham operated (SO)+EPO, sepsis (CLP) and CLP+EPO. Clinical scoring was done. Septic animal showed bloated appearance...
Article
Full-text available
The present study was designed to assess the cardio-protective role of oleic acid in myocardial injury (MI) induced by intra-peritoneal injection of isoprenaline (ISO) in rats for 2 consecutive days. Oleic acid (OA) was administered orally (@ 5 mg/kg b.wt and 10 mg/kg b.wt) for 21 days before inducing MI. Pre-exposure to OA at higher dose significa...
Article
Full-text available
Present study was undertaken to unravel the endothelium-dependent and endothelium-independent relaxant pathways in uterine artery of non-pregnant buffaloes. Isometric tension of arterial rings was recorded using data acquisition system based polyphysiograph. Acetylcholine (ACh) produced endothelium-dependent vasorelaxation by releasing nitric oxide...
Article
The proliferation of Demodex mites is mainly controlled by host immunity; however, the precised mechanism of host-mite interplay and host immune response in the cutaneous microenvironment of dogs with generalized demodicosis (GD) are not yet established. In the present study, we envisaged the alterations in the expression of toll-like receptors (TL...
Article
Full-text available
Present experiment was conducted to examine whether the supplementation of different organic sources of Cr (Chromium) would improve the performance of heat-stressed calves. Twenty-four female Hariana calves were divided into four treatments (six calves per treatment): (1) calves fed on basal diet (0 mg Cr/kg DM); (2) calves fed on basal diet supple...
Article
Ethnopharmacological relevance: Synthetic antiviral drugs have several limitations including high cost. Thus research on antiviral property of medicinal plants is continuously gaining importance. Polyalthia longifolia possesses several medicinal properties and has been used in traditional ayurvedic medicine for treatment of dermatological ailments...
Article
Overproliferation of Demodex mites in dogs with compromised immunity attributed to the development of canine demodecosis. Whether clinical signs of canine demodecosis are triggered by genetically-mediated specific immunodeficiency in dogs or the Demodex mites induce lesions in hair follicles and result in compromised immunity is yet to be fully expl...
Article
The study was conducted to evaluate the effect of ethion in biological rhythmicity in cage system rearing. Twenty-four poultry birds were divided into four groups (n = 6) and were administered with ethion i.e. group I (control), group II (2.5 mg/kg body weight), group III (5.0 mg/kg body weight) and group IV (7.5 mg/kg body weight) via per os route...
Article
Background: Mercury is an established environmental toxicant reported to cause reproductive disorders in women, however, its direct action on myometrial activity is yet to be understood. Earlier we have reported the underlying mechanism of mercury-induced myometrial contractions following in vitro exposure; however, no such information on the effe...
Article
Background: The pathogenesis of canine atopic dermatitis (AD) is complex. Dysregulation of the cutaneous immune system is considered an important regulator of the allergic response. Exploration of association of interleukin-17 (IL-17), IL-31, IgE and leukogram attributes with canine AD could provide novel insights into its immunopathology. Hypoth...
Article
Present study was conducted to evaluate the rhythm of hepatological health in indigenous chicks on exposure of ethion following two fortnight intervals. In present study 24 birds were divided randomly and equally into four groups (n = 6) i.e. group I, II, III and IV. Group I served as control, group II, III and IV were administered with ethion at 2...
Article
Full-text available
The present experiment was conducted to examine whether the supplementation of different organic Cr sources would improve the performance of heat-stressed calves. Twenty-four female Hariana calves were divided into four treatments (six calves per treatment): (1) calves fed on basal diet (0 mg Cr/kg DM); (2) calves fed on basal diet supplemented wit...
Chapter
Majority of the plants used in traditional system of medicine are rich in polyphenols and flavonoids which not only regulate the growth of plants but also are rich source of phytochemicals employed in human and animal health. Polyphenols and flavonoids have been advocated as nutraceuticals in human medicine to treat certain modern lifestyle disease...
Article
Full-text available
Apparently healthy, eight parturient Sahiwal cows were enrolled and blood samples were collected five times: at enrolment −14, −7, 0 (day of parturition), +7, and +14 days of parturition. Another eight healthy non-pregnant Sahiwal cows in mid-lactation (>90 days of lactation) have served as standard base value control. The transition Sahiwal cows w...
Article
Full-text available
Adverse effects of mercury on female reproduction are reported; however, its effect on myogenic activity of uterus and mechanism thereof is obscure. Present study was undertaken to unravel the mechanistic pathways of mercuric chloride (HgCl2)-induced myometrial contraction in rats. Isometric tension in myometrial strips of rats following in vitro e...
Article
Aim: Role of TRPV4 channel in regulation of endothelial function in the carotid artery in deoxycorticosterone acetate (DOCA) model of hypertension in rat was studied. Methods: 8–10 weeks old albino Wistar rats divided into three groups namely Control, UNX and hypertensive animals. Vascular smooth muscle response was studied in isolated carotid arte...
Article
Full-text available
The present study was designed to assess the deleterious effects of bovine tropical theileriosis on the cardiovascular system and the consequent myocardial involvement in young calves. Myocardial effects in parasitic diseases are often neglected. Hemolytic anemia, associated secondary hypoxia, and vasculitis are cardinal features of bovine theileri...
Article
Background: Endocannabinoids level are reported to increase in sepsis, however, the role of vascular cannabinoid receptor-1 (CB1R) in sepsis-induced vascular hyporeactivity is yet to be unravelled. Methods: Polymicrobial sepsis was induced by caecal ligation and puncture in mice. Isometric tension in isolated aortic rings during early (6 h) and...
Article
Widespread incidence of Demodex mites throughout the mammalian class and occasional serious and fatal outcomes in dogs, warrant an insight into the host-parasite interface especially. Therefore, the present study was aimed to unravel the interplay between innate immune response and canine demodicosis. The dogs diagnosed to have natural clinical dem...
Article
Present study was undertaken to characterize the voltage gated potassium channel (Kv 1.1) in bull spermatozoa using sixty four ejaculates collected from four Hariana bulls. Functional characterization was undertaken using a selective blocker of Kv channel, 4-Aminopyridine (4-AP) while molecular presence of Kv on bull spermatozoa by immunoblotting a...
Chapter
Sepsis is the systemic inflammatory response syndrome that occurs during infection and is exacerbated by the inappropriate immune response encountered by the affected individual. Despite extensive research, sepsis in humans is one of the biggest challenges for clinicians. The high mortality rate in sepsis is primarily due to hypoperfusion-induced m...
Article
Full-text available
Present study was undertaken to study the effect of 28-days exposure of female adult rats to cadmium (Cd) in drinking water @ 3, 10 and 30 parts per million (ppm) on myometrial responsiveness to different spasmogens and unravel the possible mechanism of alterations in myometrial activity. Cadmium and Ca(2+) levels in blood and uterus were measured...
Article
Full-text available
The present study was undertaken to evaluate modulatory effect of Eucalyptus robusta leaves crude extract and cefixime on oxidative stress induced after experimentally-induced endometritis in female wistar rats. Isolates obtained from clinical cases of endometritis and maintained in laboratory by subculturing the isolates were inoculated as 1 x 10...
Article
Full-text available
Present study unravels the existence and functional involvement of store-operated calcium channels in myometrium of non-pregnant buffaloes. Uteri along with ovaries were collected from nondescript adult cyclic buffaloes immediately after their slaughter from the local abattoir. Under a resting tension of 2 gm, effect of CaCl2 in the absence and pre...
Article
Full-text available
Background: Hydrogen sulphide (H2S), a member of the gasotransmitters family, is known to play patho-physiological role in different body systems including during pregnancy. But its involvement in myometrial spontaneity and associated signalling pathways in uterus in non-pregnant animals is yet to be studied. Present study describes the effect of L...
Article
Ethnopharmacological relevance: Bacterial endometritis is one of the major causes of reproductive disorders including infertility in farm animals. Antibiotics are generally used for treatment of such disorders but now a days residues of antibiotics are of great public health concern, therefore, phytoremediation is being considered as an alternativ...
Article
Full-text available
The present study was conducted to examine differential expression pattern of HSP genes and adaptability in Indian goat breeds of semiarid region. The study was conducted in five animals from each breed viz. Barbari, Sirohi, and Jhakrana during winter, thermo-neutral and summer seasons. The respiratory rate (RR) and rectal temperature (RT) of the g...
Article
This study unravels the differential involvement of calcium signaling pathway(s) in PGF2α-induced contractions in myometrium of non-pregnant and pregnant buffaloes. Compared to the myometrium of pregnant animals, myometrium of non-pregnant buffaloes was more sensitive to PGF2α-induced contractile effect as manifested by the changes in mean integral...
Article
In this paper, store-operated calcium channels (SOCC) have been pPharmacologically characterization of in myometrium of non-pregnant buffaloes (Bubalus bubalis).
Article
Full-text available
Background and Objective: Saraca indica and Eucalyptus citriodora have been used in traditional medicine against variety of health disorders. Present study was undertaken with the objective of evaluating the in vitro antifungal activity of methanolic extracts of leaves of Saraca indica L. (SI) and Eucalyptus citriodora (EC) individually and both in...
Article
Lead produced dose-dependent contractile effect on buffalo myometrium and it was more marked on tonicity and amplitude while almost negligible on phasic contractions and frequency. In the presence of Ca²⁺-free Ringer Locke solution (RLS) and nifedipine, lead-induced uterotonic effect was significantly attenuated with decrease in Emax thus, suggesti...
Article
Lead produced dose-dependent contractile effect on buffalo myometrium and it was more marked on tonicity and amplitude while almost negligible on phasic contractions and frequency. In the presence of Ca2+-free Ringer Locke solution (RLS) and nifedipine, lead-induced uterotonic effect was significantly attenuated with decrease in Emax thus, suggesti...
Article
Full-text available
Present study was undertaken to study the effect of 28 days exposure of female adult rats to Cd in drinking 2 water @ 3, 10 and 30 parts per million (ppm) on myometrial responsiveness to different spasmogens and unravel the possible mechanism of alterations in myometrial activity. Cadmium and Ca2+ 3 levels in blood and uterus were measured 4 by ato...
Article
Full-text available
Arsenic is a groundwater pollutant and can cause various cardiovascular disorders in the exposed population. The aim of the present study was to assess whether subchronic arsenic exposure through drinking water can induce vascular dysfunction associated with alteration in plasma electrolytes and lipid profile. Rats were exposed to arsenic as 25, 50...
Article
Present study unravels the involvement of different calcium signaling pathways in oxytocin-induced contractions in myometrium of non-pregnant and pregnant buffaloes during early and mid-pregnancy stages. Uteri of pregnant animals were more sensitive than of non-pregnant buffaloes. Phasic contractions and frequency of contraction significantly incre...
Article
Modulation of myometrial spontaneity by lead acetate trihydrate (Pb) and its regulatory pathways were studied in estrogenized rats. Isometric tension in myometrial strips under a resting tension of 1 g was measured using data acquisition system-based physiograph and Lab Chart Pro v7.3.7 software. Lead produced a dose-dependent inhibitory effect on...
Article
The present study aimed to investigate the association of cholinesterase activity with trypanosomosis in buffaloes. Thirty-three clinical cases of trypanosomosis in water buffaloes, found positive for trypomastigotes of T. evansi on blood smear examination, were divided into two groups based on clinical manifestations. Twenty diseased buffaloes rev...
Article
Background: The aim of the present study was to observe the concomitant activation of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) pathways by TRPV4 channel agonist GSK1016790A in the rat pulmonary artery and explore the mechanism by which NO synthase inhibition attenuates EDHF-mediated relaxation in endothelium-intact r...
Article
Lung is one of the vital organs which is affected during the sequential development of multi-organ dysfunction in sepsis. The purpose of the present study was to examine whether combined treatment with atorvastatin and imipenem could attenuate sepsis-induced lung injury in mice. Sepsis was induced by caecal ligation and puncture. Lung injury was as...
Article
We investigated the effect of erythropoietin (EPO) posttreatment on survival time and vascular functions in a mouse model of sepsis. Sepsis was induced by cecal ligation and puncture. After 20 ± 2 hours of sepsis, thoracic aorta was isolated for assessing its reactivity to norepinephrine (NE) and acetylcholine (ACh). We also measured the tissue nit...
Article
Full-text available
We have recently reported that pre-treatment, but not the post-treatment with atorvastatin showed survival benefit and improved hemodynamic functions in cecal ligation and puncture (CLP) model of sepsis in mice. Here we examined whether combined treatment with atorvastatin and imipenem after onset of sepsis can prolong survival and improve vascular...
Article
Full-text available
This study was undertaken to elucidate the adverse effect of lead on female reproductive system following in vivo exposure in rats. Animals of Group II, III and IV received lead acetate in drinking water (30, 100 and 300 ppm, respectively) for 28 days whereas Group I served as control. Lead levels in digested blood and bone samples were measured us...
Article
Full-text available
Objectives: This study was undertaken to elucidate the adverse effect of lead on female reproductive system following in vivo exposure in rats. Materials and Methods: Animals of Group II, III and IV received lead acetate in drinking water (30, 100 and 300 ppm, respectively) for 28 days whereas Group I served as control. Lead levels in digested bloo...
Article
Full-text available
The aim of the present study was to characterize TRPV4 channels in pregnant and nonpregnant mouse uterus and examine their functional role in spontaneous and agonist-induced contractions. We used RT-PCR, Western blot and immunohistochemistry experiments to demonstrate the presence of TRPV4 mRNA and protein, respectively in both pregnant and nonpreg...
Article
The present study was undertaken to evaluate the effect of alcoholic extract of Dalbergia sissoo leaf extract (DSE) on isoproterenol (ISP)-induced myocardial injury in rats. Evaluation of three doses (30, 100 and 300 mg/kg of body weight) of DSE was done in ISP-treated rats. ISP was used at 85 mg/kg body weight by subcutaneous route for two subsequ...
Article
Full-text available
Present study was undertaken to characterize the presence of histamine H1R using molecular biology tools and unravel the influx and release mechanism(s) involved in calcium signaling cascades in histamine-induced myometrial contraction in buffaloes. Presence of H1R mRNA transcript and immunoreactive membrane protein in buffalo myometrium was confir...
Article
Full-text available
Impaired cardiac β-adrenoceptor signaling is an important cause of sepsis-induced myocardial depression in man and experimental animals. We examined the effect of atorvastatin pretreatment on myocardial β1-adrenoceptor (β1-AR) expressions and post-receptor signaling in a mouse model of sepsis (CLP; caecal ligation and puncture). After 20±2 h of sur...