Souhil LebdaiUniversity of Angers | UA · Urology
Souhil Lebdai
Doctor of Medicine
About
148
Publications
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1,127
Citations
Citations since 2017
Publications
Publications (148)
Laparoscopic partial nephrectomy (LPN) after hyperselective embolization of tumor vessels (HETV) in a hybrid operating room (HOR) that combines traditional surgical equipment with advanced imaging technology, is a non-clamping surgical approach to treat localized kidney tumors that has shown promising short-term results. The aim of this study was t...
Laparoscopic partial nephrectomy (LPN) after hyperselective embolization of tumor vessels (HETV) in a hybrid operating room (HOR) that combines traditional surgical equipment with advanced imaging technology, is a non-clamping surgical approach to treat localized kidney tumors that have shown promising short-term results. The aim of this study was...
Backround:
Kidney is an essential regulator of arterial blood pressure (BP) via the renin-angiotensin system. The impact of kidney surgery on BP is unclear.
Objective:
To evaluate the consequences of kidney surgery for renal tumor on BP.
Design, setting and participants:
In a multicenter prospective study, we evaluated 200 patients who underwe...
Background:
Lithotripsy with holmium:yttrium-aluminum-garnet (Ho:YAG) laser is the current gold standard for treating stones of the upper urinary tract (UUT). The recently introduced thulium fiber laser (TFL) has the potential to be more efficient and as safe as Ho:YAG.
Objective:
To compare the performance and complications between Ho:YAG and T...
Background
Recently, Objective Structured Clinical Examinations (OSCE) became an official evaluation modality for 6-year medical students in France. Before, standard examination modalities were: written progressive clinical cases (PCC), written critical reading of scientific articles (CRA), and internship evaluation (IE). The aim of this study was...
Background:
Sarcopenia is defined as a loss of muscle mass and strength. Its effects on postoperative outcomes in oncology and geriatrics have already been shown. Approximately 40% of patients in end-stage renal failure are affected with sarcopenia. A recent study suggests that sarcopenia could predict surgical complications after renal transplant...
Résumé
Introduction
Une néphrectomie partielle devrait être réalisée pour une petite tumeur du rein localisée. En cas de doute, une biopsie peut conforter le diagnostic. L’objectif de cette étude était d’évaluer l’impact carcinologique d’un délai prolongé avant néphrectomie partielle.
Méthodes
Nous avons inclus dans la base de données prospective...
Although several studies have examined the relationship between organochlorine pesticides (OCPs) and prostate cancer (PCa) risk, no data are available concerning the association between OCPs concentrations in periprostatic adipose tissue (PPAT), which reflects cumulative exposure, and PCa aggressiveness. Moreover, no previous study has compared OCP...
Background
Pathologic nodal invasion at prostatectomy is frequently associated with persistently elevated prostate-specific antigen (PSA) and with increased risk of disease recurrence. Management strategies for these patients are poorly defined. We aimed to explore the long-term oncologic outcomes and patterns of disease progression.
Methods
We in...
Urinary tract infections, especially cystitis, are common infections; they are the second most prevalent cause of antibiotic prescriptions in community pharmacies. To reduce antimicrobial resistance, guidelines are revised regularly. This study aims to assess compliance between prescriptions collected in community pharmacies and French cystitis gui...
Script Concordance Testing (SCT) is a method for clinical reasoning assessment in the field of health-care training. Our aim was to assess SCT acceptability and utility with a survey and an institutional prospective evaluation of students’ scores.With a user’s online survey, we collected the opinions and satisfaction data of all graduate students a...
Introduction
Almost half of the patients have had recurrent nephrolithiasis despite undergoing effective treatment. Our objective is to determine the recurrence rate of lithiasis after endourological management of nephrolithiasis and identify the risk factors for these recurrences.
Methods
Data were gathered retrospectively from all patients who w...
Objectifs
Décrite pour la première fois en 1996, la néphrectomie laparoscopique pour reins polykystiques est maintenant couramment utilisée par plusieurs unités de transplantation. Cependant l’extraction de ces reins de haut volume est un défi qui n’a pas été résolu de manière adéquate. Nous avons expérimenté une technique de fragmentation manuelle...
Purpose
The 3D Navigo™ system is a magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS) fusion device for prostate targeted biopsies (TB). Our aim was to evaluate the clinically significant prostate cancer (CSC) detection rate of TB using the 3D Navigo™ system.
Methods
Patients who underwent TB with the 3D Navigo™ system in our cente...
Purpose: Almost half of the patients have had recurrent nephrolithiasis despite undergoing effective treatment. Our objective is to determine the recurrence rate of lithiasis after endourological management of nephrolithiasis and identify the risk factors for these recurrences.
Methods: Data were gathered retrospectively from all patients who were...
Hypothesis:
Partial Nephrectomy is oncological safe in patients with pT3a RCC.
Purpose:
To compare the oncological and functional outcomes of patients with pT3a RCC scheduled for PN and RN.
Materials and methods:
We retrospectively reviewed patients with pT3a N0 M0 RCC who underwent partial or radical nephrectomy from 2005 to 2016. Perioperati...
Purpose:
Vascular targeted photodynamic therapy (VTP) is a nonsurgical tumor ablation approach used to treat early-stage prostate cancer and may also be effective for upper tract urothelial cancer (UTUC) based on preclinical data. Toward increasing response rates to VTP, we evaluated its efficacy in combination with concurrent PD-1 inhibitor/OX40...
Résumé
Objectif
L’objectif du Comité des Troubles Mictionnels de l’Homme (CTMH) de l’Association Française d’Urologie (AFU) était de mettre à jour les recommandations françaises parues en 2012 et celles de l’EAU parues en 2019 concernant la prise en charge chirurgicale et interventionnelle de l’obstruction sous-vésicale (OSV) liée à une hyperplasi...
Introduction:
New surgical techniques for the treatment of benign prostatic obstruction (BPO) have emerged in recent years. We sought to give an overview on each of these technologies.
Material:
A comprehensive review of the literature between 2013 and 2020 was carried out by a panel of national experts already practicing these interventions. Al...
Objectifs
La prise en charge chirurgicale par néphrectomie partielle d’une tumeur du rein localisée peut-être retardée en raison des comorbidités du patient ou encore de problèmes d’accès au bloc opératoire. L’objectif de cette étude était d’évaluer l’impact carcinologique d’un délai prolongé avant néphrectomie partielle.
Méthodes
Nous avons inclu...
Objectifs
Il est décrit que près d’un patient sur deux récidive une migration lithiasique après un premier épisode de colique néphrétique. L’objectif de cette étude était de déterminer le taux de récidive lithiasique après la prise en charge urologique d’un calcul urinaire et d’identifier des facteurs de risque de récidive.
Méthodes
Nous avons réa...
Objectifs
Rapporter les résultats à 1 an du traitement mini-invasif de l’hyperplasie bénigne de prostate (HBP) par thermothérapie convective à la vapeur d’eau (système REZUM).
Méthodes
Cette technique a été proposée dans 2 centres français aux patients ayant une HBP symptomatique ou compliquée, en alternative à un traitement chirurgical ablatif cl...
Objectives:
To determine whether immersive virtual patient simulation (IVPS) on the MedicActiv platform is influential in improving student academic performance in module validation tests.
Design:
In this prospective randomized controlled study a comparison was made between IVPS training combined with regular faculty courses versus courses alone...
Purpose
To report the results of convective radiofrequency (RF) water vapor thermal therapy in men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) with one-year follow-up evaluation.
Material and method
The study was conducted in 2 French hospitals, for men with moderate to severe LUTS secondary to BPH,...
Résumé
Introduction
La néphrectomie partielle (NP) après embolisation des vaisseaux tumoraux en salle hybride (NPESH) combine l’embolisation des vaisseaux tumoraux et l’énucléation de la tumeur sous coelioscopie dans un même temps opératoire. L’objectif de cette étude était d’évaluer l’impact de l’utilisation d’une salle hybride sur la prise en ch...
Vascular-targeted photodynamic therapy (VTP) using padeliporfin is currently assessed as a low-risk prostate cancer (LRPCa) treatment. The aim of this study was to assess erectile function outcomes of VTP for LRPCa treatment. We prospectively included all patients treated with VTP for LRPCa. The primary endpoint was the post-treatment International...
Objectifs
Le système 3D Navigo™ permet la réalisation de biopsies de prostate ciblées (BPC) par fusion d’images échographie-IRM. L’objectif de cette étude était d’évaluer le taux de détection du cancer de prostate (CaP) cliniquement significatif (CSC) par BPC utilisant le système 3D Navigo™.
Méthodes
Nous avons prospectivement inclus tous les pati...
Objectifs
Les cas cliniques progressifs sont des outils pédagogiques imparfaits. L’utilisation d’un simulateur numérique permet d’intégrer aux cas cliniques : un interrogatoire, l’examen clinique, la consultation du dossier médical, et l’intégration d’un feedback et références pédagogiques. L’objectif de cette étude était d’évaluer l’apport de la p...
Objectifs
La néphrectomie partielle après embolisation des vaisseaux tumoraux en salle hybride (NPESH) combine l’embolisation des vaisseaux tumoraux et l’énucléation de la tumeur sous cœlioscopie dans un même temps opératoire. L’objectif de cette étude était d’évaluer l’impact de l’utilisation de la NPESH sur la prise en charge des patients traités...
Objectives:
During ureteroscopy for urolithiasis, postoperative ureteral drainage with double J stent is frequently used. It may reduce acute postoperative pain and late ureteral stenosis. Double J stent can have negative impact on life quality. After uncomplicated intervention, double J stent is not mandatory. Objective of our study was to evalua...
Background:
Evaluating the efficacy of focal therapy for prostate cancer is limited by current approaches and may be improved with biological imaging techniques.
Objective:
We assessed whether positron emission tomography/computed tomography with gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA PET/CT) can be used to predict rela...
Résumé
Introduction
Actuellement, environ 50 % des cancers de la prostate nouvellement diagnostiqués sont localisés à la glande prostatique et de faible risque selon la classification de d’Amico. Les thérapies focales, dont l’objectif est le traitement de la seule lésion index du cancer, apparaissent comme une nouvelle alternative en cours d’évalu...
Vascular-targeted photodynamic therapy (VTP) induces rapid destruction of targeted tissues and is a promising therapy for prostate cancer. However, the resulting immune response, which may play an important role in either potentiating or blunting the effects of VTP, is still incompletely understood. Myeloid cells such as myeloid-derived suppressor...
Purpose:
Ejaculatory dysfunction is the most common side effect related to surgical treatment of benign prostatic obstruction (BPO). Nowadays, modified surgical techniques and non-ablative techniques have emerged with the aim of preserving antegrade ejaculation. Our objective was to conduce a systematic review of the literature regarding efficacy...
Abstract Background Lower urinary tract symptoms related to benign prostatic obstruction (BPO) are frequent in men aged > 50 years. Based on the use of innovative medical devices, a number of transurethral ablative techniques have recently been developed for the surgical treatment of BPO. In recent years, GreenLight photoselective vaporization of t...
Objectifs
La néphrectomie partielle cœlioscopique (NPC) après embolisation sélective des vaisseaux tumoraux est une nouvelle approche de la chirurgie partielle rénale. L’objectif de cette étude était de mesurer l’évolution de la fonction rénale à la suite d’une NPC après embolisation sélective.
Méthodes
Nous avons recueilli prospectivement dans la...
Objectifs
La photothérapie dynamique au wst11 (PTD) est une thérapie focale en cours d’évaluation dans le traitement des cancers de prostate de faible risque. La dysfonction érectile (DE) est l’une des principales complications après traitements radicaux des cancers de prostate. L’objectif de notre étude est d’évaluer la fonction érectile avant et...
Objectifs
L’organisation des soins en onco-urologie est variable d’un centre à l’autre. Nous rapportons notre expérience de prise en charge des cancers du rein métastatique dans un service universitaire d’urologie.
Méthodes
Nous avons inclus dans cette étude tous les patients traités pour un cancer du rein métastatique de février 2016 à avril 2018...
Objectifs
La découverte de calculs dans un rein chez un patient en état de mort encéphalique est rare. Elle ne contre-indique pas le prélèvement, ni la greffe. La stratégie à adopter pour le traitement de ces calculs n’est pas codifiée. Faut-il les traiter avant ou après la transplantation ? Quelques équipes ont proposé un traitement par urétérosco...
Objectifs
Les cellules myéloïdes infiltrant les tumeurs (tim) forment un microenvironnement protumoral pouvant induire des résistances aux thérapies focales. Le récepteur au csf1 (csf1r) favorise le recrutement tumoral des tim.
Le but de cette étude était de démontrer que l’ajout d’un inhibiteur du csf1r améliorait l’efficacité de la photothérapie...
Objectifs
L’étude de phase III pcm301 avait comparé la photothérapie dynamique au wst11 (ptd) et la surveillance active dans le traitement du cancer de la prostate de bas-risque et avait démontré une réduction significative du taux de thérapies radicales (tr) à 2 ans.
L’objectif était d’évaluer les taux d’incontinence urinaire (iu) et de dysfonctio...
Purpose:
To evaluate long-term use, efficacy and tolerability of transcutaneous tibial nerve stimulation (TTNS) in the treatment of refractory overactive bladder (OAB).
Methods:
We performed a prospective observational study and included all patients treated in a single center for OAB persisting after first-line anticholinergic treatment, with ≥...
Introduction:
and objectives: vascular-targeted photodynamic therapy with TOOKAD® (VTP) is a new therapeutic option for localized prostate cancer (PCa) management. The objectives are to assess the feasibility of radical prostatectomy (RP) after VTP and describe functional and oncological outcomes.
Material and methods:
we retrospectively include...
Background and objective:
To assess the medium-term tumor control in patients with localized prostate cancer (PCa) treated with vascular-targeted photodynamic (VTP) therapy with TOOKAD Soluble WST11 (VTP) and to assess the medium-term tolerability of the treatment.
Design, setting, participants, and intervention:
During the clinical phase II stu...
BACKGROUND:
Genetic and nutritional factors have been linked to the risk of aggressive prostate cancer (PCa). The fatty acid (FA) composition of peri-prostatic adipose tissue (PPAT), which reflects the past FA intake, is potentially involved in PCa progression. We analysed the FA composition of PPAT, in correlation with the ethno-geographical origi...
Purpose:
WST11 vascular targeted photodynamic therapy (VTP) is a local ablation approach relying upon rapid, free radical-mediated destruction of tumor vasculature. A phase III trial showed that VTP significantly reduced disease progression when compared to active surveillance in patients with low-risk prostate cancer (PCa). The aim of this study...
We report the case of a 23-year-old woman treated by mesalazine for ulcerative colitis and who subsequently presented recurrent renal colic due to mesalazine urinary stones. This is the second case described in the literature.Mesalazine stones are soft, friable and have an orange-beige color. They are not visible on non-contrast computed tomography...
Objectifs
La thérapie focale par thérapie photodynamique vasculaire ciblée avec TOOKAD® soluble (VTP) est l’une des nouvelles alternatives à faible morbidité pour traiter le cancer localisé de la prostate. L’objectif de notre étude était d’évaluer la faisabilité d’une prostatectomie radicale (PR) en cas d’échec ou de récidive après VPT et décrire d...
Objectifs
La photo-vaporisation sélective de la prostate (PVP) par le laser Greenlight™ est une option dans le traitement chirurgical de l’hypertrophie bénigne de la prostate (HBP). L’essai randomisé Goliath a montré une non-infériorité de cette option par rapport à la RTUP à 2 ans. Cependant, certains patients nécessitent un retraitement chirurgic...
Background:
Previous studies have suggested a link between metabolic syndrome (MetS) and prostate cancer (PCa). In the present study, we aimed to assess the association between MetS and markers of PCa aggressiveness on radical prostatectomy (RP).
Methods:
All patients consecutively treated for PCa by RP in 6 academic institutions between August...
Recommended options for low-risk prostate cancer treatment are active surveillance, radical treatments or watchful waiting. Focal therapies are currently assessed for low risk prostate cancer treatment. Focal therapies can be performed in research protocols. Oncologic results of these focal treatments are encouraging and show excellent tolerance wi...
Patients and methods:
We included prospectively 60 patients over 75 years, with an indwelling catheter for acute or chronic retention, who were candidates to endoscopic surgery for BPH. Patients underwent the Brief Geriatric Assessment (BGA) and the Comprehensive Geriatric Assessment (CGA) in order to classify them into 3 groups: "vigorous", "vuln...
Las estenosis ureteroileales tienen una incidencia del 2-12%. En la mayoría de los casos, se sitúan en la unión ureteroileal izquierda y se producen con más frecuencia después de la radioterapia o de una cirugía complicada con una fístula anastomótica. Suelen ser poco sintomáticas y su diagnóstico se sospecha ante la aparición de insuficiencia rena...
Objective:
To evaluate bleeding risk in patients on anticoagulation for mechanical cardiac valve operated for benign prostatic obstruction (BPO).
Material and method:
Fifty-eight patients operated between 1998 and 2014, in seven French departments of Urology were included. Forty-five patients were operated by conventional surgery (transurethral...
Purpose:
To evaluate perioperative cost related to surgical treatments of benign prostatic obstruction (BPO): photoselective vaporization of the prostate (pvp), holmium/thullium laser enucleation (HoLEP/ThuLEP), transurethral resection of the prostate (TURP) and open prostatectomy (OP).
Material and methods:
We retrospectively collected data fro...
Purpose:
To assess the mid-term oncological outcomes of vascular-targeted photodynamic therapy with padeliporfin for low-risk prostate cancer treatment.
Material and methods:
We prospectively assessed all patients treated with vascular-targeted photodynamic therapy for low-risk prostate cancer in our center. Patients were followed every 6 months...
Objectifs
Les propriétés hémostatiques de la photo-vaporisation prostatique (PVP) par laser GreenLight® en font une technique de choix pour les patient traités par antiaggrégant plaquettaire (AAP) ou traitement anticoagulant (TAC). L’objectif de cette étude était d’évaluer les résultats de la PVP en fonction de la prise d’un AAP ou d’un TAC.
Métho...
Objectifs
Des facteurs génétiques et nutritionnels ont été associés à l’agressivité du cancer de la prostate (CaP). Le tissu adipeux, dont la composition en acides gras (AG) reflète l’apport nutritionnel, est potentiellement impliqué dans la progression du CaP. L’objectif est d’analyser la composition en AG du tissu adipeux péri-prostatique (TAPP),...
Background:
The management of metastatic renal cell carcinoma (mRCC) has been transformed by the use of targeted therapies, ablative therapies and improved surgical techniques. The objective of this study was to identify therapeutic strategies that resulted in complete remission (CR) and to assess survival of patients in CR.
Methods:
In a prospe...
Purpose:
To present a systematic review of the different therapeutic sequences in metastatic castration-resistant prostate cancer (mCRPC).
Methods:
Evidence acquisition on therapeutic sequences in mCRPC was performed by a MEDLINE search using combination of the following key words: "prostate cancer," "metastatic," "castration resistant," "enzalu...
Objectifs
La rémission complète (RC) est l’objectif recherché dans la prise en charge des cancers. Ces dernières années, la prise en charge du cancer du rein métastatique a été transformée par l’utilisation des thérapies ciblées, des thérapies ablatives et l’amélioration des techniques chirurgicales. L’objectif de cette étude a été d’identifier les...
Introduction:
The medicoeconomic issues of drug management of benign prostatic hyperplasia (BPH) are essential due to the aging population and the increasing number of therapeutic options. It is thus essential to assess the cost-effectiveness in order to define the most appropriate therapeutic strategies economically. The objective of this work wa...
Objective:
The aim of the study was to evaluate renal function and to identify factors associated with renal function deterioration after retrograde intrarenal surgery (RIRS) for kidney stones.
Materials and Methods:
We retrospectively analyzed patients with renal stones treated by RIRS between January 2010 and June 2013 at a single institute. We...
A 49-year-old woman was treated for right kidney stones using flexible ureteroscopy and laser lithotripsy. She was readmitted 2 weeks after the treatment with complaints of walking difficulties. On neurologic examination, it was found that she had a bilateral proprioceptive dysfunction. Spinal MRI revealed an intramedullary lesion at the T10-T11 le...
To review current knowledge on clinical outcomes and peri-operative complications of prostatic arterial embolization (PAE) in patients treated for lower urinary tract symptoms (LUTS) related to benign prostatic obstruction (BPO).
A systematic review of the literature published from January 2008 to January 2015 was performed on PubMed/MEDLINE.
Fifty...
Rare and severe complications of benign prostatic hyperplasia (BPH) surgery are poorly documented in the literature. Our purpose was to make an inventory of severe and unexpected complications of BPH faced by urologists of the French Association of Urology (AFU).
A declarative 13-question survey was sent by e-mail 2 months before the 108th French C...