Sotiria Palioura

Sotiria Palioura
Bascom Palmer Eye Institute · Department of Ophthalmology

MD MSc PhD CEBT

About

65
Publications
25,103
Reads
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1,986
Citations
Citations since 2016
31 Research Items
1180 Citations
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2016201720182019202020212022050100150200
Introduction
Dr. Sotiria Palioura is a US-trained eye surgeon specializing in cornea transplantation, cataract surgery, refractive surgery, management of ocular surface tumors and inflammatory diseases. She completed her undergraduate, graduate and medical studies at Yale University. She was an ophthalmology resident at Harvard Medical School and a cornea and ocular surface disease fellow at the Bascom Palmer Eye Institute. She is certified both by the American and the European Boards of Ophthalmology.
Additional affiliations
October 2019 - present
Yale University
Position
  • Professor (Assistant)
Description
  • Involved in mentoring medical students and ophthalmology residents from the Department of Ophthalmology, Yale University School of Medicine, New Haven, Connectitut, USA. Yale medical students may elect to perform their international ophthalmology rotation with Dr. Palioura in Athens, Greece.
January 2017 - July 2020
Athens Vision Eye Institute
Position
  • Ophthalmologist
Description
  • Dr. Palioura's Clinical and Surgical Expertise includes: o Cataract surgery o Refractive surgery (LASIK, PRK) o Cornea transplantation o Collagen/Cornea crosslinking for keratoconus and corneal ectasias o Pterygium surgery o Surgical and medical management of ocular surface lesions (conjunctival squamous cell carcinoma, conjunctival melanoma, conjunctival lymphoma, primary acquired melanosis, conjunctival nevus, conjunctival papilloma) o Simple limbal epithelial transplantation
July 2015 - present
Bascom Palmer Eye Institute
Position
  • Professor (Assistant)
Description
  • Involved in clinical and surgical mentorship of ophthalmology residents from the Bascom Palmer Eye Institute (BPEI) at the University of Miami Miller School of Medicine. BPEI has been the #1 Eye Hospital in the United States since 2002 (https://health.usnews.com/best-hospitals/rankings/ophthalmology). Dr. Palioura spends about 1.5 months per year at BPEI and ophthalmology residents from BPEI may elect to perform their international ophthalmology rotation with Dr. Palioura in Athens, Greece.
Education
February 2019 - November 2019
Harvard University
Field of study
  • Principles and Practice of Clinical Research
August 2003 - June 2010
Yale University
Field of study
  • Molecular Biophysics and Biochemistry
August 2003 - June 2010
Yale University
Field of study
  • Medicine

Publications

Publications (65)
Article
Full-text available
Purpose: To describe the case of a monocular patient with ocular mucous membrane pemphigoid (MMP) and open angle glaucoma refractory to medical treatment, who was successfully managed with ab interno goniotomy at the time of cataract surgery. Methods: A 63-year-old woman with a history of severe MMP presented with exacerbation of the disease in...
Article
Introduction Management of ocular surface squamous neoplasia (OSSN) has been a matter of debate among ocular oncologists. While surgical excision with tissue biopsy has been the gold standard, topical chemotherapy with agents such as interferon-α2b, 5-fluorouracil, and mitomycin C, as well as less invasive diagnostic modalities, are becoming increa...
Article
Full-text available
Purpose: To estimate the net cost effect associated with the real-world practice of repeated use of designated single-use medical devices (SUDs) versus their proper single use in cataract surgery in Greece. Design: A cost-benefit analysis model was constructed in the form of a decision tree. Methods: A digital expert panel was assembled in ord...
Article
Purpose: To report a case of a culture-negative deep fungal corneal infection that was diagnosed after histopathology of an anterior segment optical coherence tomography-guided endothelial biopsy. Methods: A 22-year-old woman with history of contact lens wear and concomitant topical steroid use presented with a mid-stromal corneal infiltrate tha...
Article
Abstract Purpose: To compare the endothelial cell density (ECD) and quality of corneal grafts from young donors who sustained airbag deployment in motor vehicle accidents (MVA) or gunshot wounds (GSW) to the head with grafts from donors of similar age who died of other causes. Methods: This is a retrospective comparative series of 65 corneal...
Article
Purpose: To describe a case of paraneoplastic pemphigus (PNP) presenting as spontaneous bilateral corneal perforations in a patient with follicular dendritic cell sarcoma. Methods: Retrospective chart review Results: A 73-year-old Greek woman with a history of follicular dendritic cell sarcoma (FDCS) presented with bilateral corneal perforations an...
Article
Full-text available
Purpose: To present the molecular mechanisms involved in the pathogenesis of conjunctival melanoma (CM) and review the existing literature on targeted molecular inhibitors as well as immune checkpoint inhibitors for the management of locally advanced and metastatic disease. Methods: A comprehensive review of the literature was performed using th...
Article
Full-text available
PurposeWe report a case of intraocular invasion of ocular surface squamous neoplasia (OSSN) through a cataract surgery wound that manifested as an anterior chamber membrane, and perform a review of the literature.Methods An 87-year-old woman with history of an incompletely excised OSSN 10 days prior presented with decreased vision due to an anterio...
Article
Purpose: To report 2 cases of herpes simplex virus (HSV) stromal keratitis with epithelial ulceration that were managed using optical coherence tomography-generated pachymetric and corneal epithelial thickness maps. Methods: Two patients with a history of HSV keratitis with nonhealing epithelial defects were referred to the Athens Vision Eye Ins...
Article
Full-text available
Objective To assess the impact of a 5 min interactive online survey on raising awareness about cornea donation and willingness to become a donor. Methods An interactive online questionnaire was used to collect information regarding awareness, perceptions and attitudes towards cornea donation and to educate the participants about the process and va...
Article
Full-text available
Purpose: To report a case of Polyarteritis Nodosa (PAN) presenting as bilateral episcleritis and interstitial keratitis along with erythema nodosum and atrial fibrillation and to review the ophthalmic literature on PAN with anterior segment findings. Observations: A 35-year old man presented with a two-month history of bilateral episcleritis, sk...
Article
Full-text available
Background: To report a case of bilateral benign reactive lymphoid hyperplasia (BRLH) of the conjunctiva treated with oral doxycycline and perform review of the literature evaluating the presentation, treatment and risk of transformation to lymphoma. Case presentation: A case report is described and review of the literature from January 1975 to...
Article
Conjunctivochalasis (CCH) is a bilateral conjunctival condition characterized by loose, redundant conjunctival folds, typically in the inferior bulbar conjunctiva. It is a common cause of ocular irritation, especially in older age. For asymptomatic CCH, no treatment is necessary. For treatment of symptomatic CCH, however, a variety of medical and s...
Article
Full-text available
Mucous membrane pemphigoid (MMP) is a systemic cicatrizing autoimmune disease that primarily affects orificial mucous membranes, such as the conjunctiva, the nasal cavity, the oropharynx, and the genitalia. Ocular involvement occurs in about 70% of all MMP cases. Ocular MMP (OcMMP) also encompasses the conditions linear immunoglobulin A disease, mu...
Article
Full-text available
Purpose To describe a patient with late post-operative endophthalmitis and clear cornea tunnel infection caused by Candida parapsilosis that was masquerading as chronic anterior uveitis. Observations A 62-year old woman with history of uncomplicated cataract surgery 7 months prior and chronic postoperative anterior uveitis, presented with an endot...
Article
Full-text available
Congenital cataracts are the primary cause of treatable childhood blind- ness worldwide, affecting about four infants per 10,000 live births. Current surgical techniques have helped thousands of patients, but the limitations of these techniques led Lin et al. to report an alternative approach that they claim leads to a regenerated lens with refract...
Article
Purpose: To report 2 cases with late postoperative Candida albicans interface keratitis and endophthalmitis after Descemet stripping automated endothelial keratoplasty (DSAEK) with corneal grafts originating from a single donor with a history of presumed pulmonary candidiasis. Methods: Two patients underwent uncomplicated DSAEK by 2 corneal surg...
Article
Purpose: Stenotrophomonas maltophilia, an uncommon cause of infectious keratitis, is difficult to treat because of its resistance to multiple antibiotics. The purpose of this study is to describe the clinical features, antibiotic susceptibility profile, and outcomes of S. maltophilia keratitis. Methods: A retrospective review of records from 198...
Article
Objective To assess the ability of novice clinicians to use a commercially available high-resolution anterior segment optical coherence tomography (HR-OCT) device to diagnose various lesions of the ocular surface and cornea. Methods Cross-sectional study. Twenty-six black-and-white HR-OCT images were projected, and clinicians were asked to determi...
Article
Introduction: Cornea clarity is essential for optimal vision at any age. In childhood, loss of corneal transparency may also lead to amblyopia. Thus, proper management of the conditions that lead to corneal scarring and neovascularization in children is of utmost importance. Areas covered: Herein, we review the pathophysiology of the main causes of...
Article
Introduction: Topical chemotherapy has gained popularity among clinicians for the treatment of ocular surface squamous neoplasia (OSSN) . The principal topical chemotherapy agents used in the management of OSSN are interferon-α2b, 5-fluorouracil, and mitomycin C. High-resolution optical coherence tomography (HR-OCT) is a non-invasive technique that...
Article
Purpose: To evaluate the feasibility of Descemet stripping endothelial keratoplasty using grafts preloaded by an eye bank in a commercially available insertion device. Methods: In this retrospective case series, a series of 35 eyes in 34 consecutive patients who underwent Descemet stripping endothelial keratoplasty for Fuchs endothelial dystroph...
Article
Full-text available
Regeneration of the corneal surface after an epithelial insult involves division, migration, and maturation of a specialized group of stem cells located in the limbus. Several insults, both intrinsic and extrinsic, can precipitate destruction of the delicate microenvironment of these cells, resulting in limbal stem cell deficiency (LSCD). In such c...
Article
Full-text available
Bacterial keratitis can lead to severe visual impairment from corneal ulceration, subsequent scarring, and possible perforation. The mainstay of treatment is topical antibiotics, whereas the use of adjunctive topical corticosteroid drops remains a matter of debate. Herein, we review the rationale for and against the use of topical corticosteroids a...
Article
Our purpose is to comprehensively review the state of the art with regard to Stevens- Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to improving the management of associated ocular surface complications. SJS and TEN are two ends of a spectrum of immune-mediated disease, characterized in the acute phase by a...
Article
Full-text available
The intent of this review is to comprehensively appraise the state of the art with regard to Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to the ocular surface complications and their management. SJS and TEN represent two ends of a spectrum of immune-mediated, dermatobullous disease, characterized i...
Article
Purpose: To report a case of wavelike interface opacities in a patient who underwent Descemet-stripping automated endothelial keratoplasty (DSAEK) and was managed conservatively over the course of 7 years. Methods: A 65-year-old woman underwent DSAEK for pseudophakic bullous keratopathy. Textural wavelike opacities were noted in the graft-host i...
Chapter
The cornea is an avascular tissue in the anterior portion of the globe that consists of six layers, including the epithelium, basement membrane, Bowman’s layer, stroma, Descemet’s membrane, and endothelium. The cornea measures approximately 400 μm in thickness centrally and features an intrinsic convex outward curvature, which provides light refrac...
Article
A 10-year-old boy presented to a cornea subspecialty clinic with a 6-month history of intermittent redness, swelling, and itching of the right eye. He had seasonal allergies but was otherwise healthy. He had not been wearing his contact lenses since the episodes started. The patient’s symptoms persisted despite previous treatment regimens with topi...
Chapter
The intraocular (crystalline) lens is a biconvex structure that serves to refract the incident light in conjunction with the cornea. The crystalline lens is comprised of the lens capsule (which completely surrounds the lens anteriorly and posteriorly), the lens epithelium, and lens fibers (which includes the cortex). Cataracts consist of opacificat...
Article
Implantation of a keratoprosthesis device is indicated for the visual rehabilitation of patients with corneal blindness in whom a standard corneal allograft would likely fail. The Boston keratoprosthesis type I device is a collar button-shaped device, composed of polymethyl methacrylate and titanium, whereas the type II device has an additional ant...
Article
Full-text available
Ocular surface squamous neoplasia (OSSN) encompasses a range of corneal and conjunctival lesions from intraepithelial dysplasia to invasive squamous cell carcinoma. The mainstay of treatment for OSSN has traditionally been surgical excision with wide margins and cryotherapy. Increasing evidence on the efficacy and safety of medical therapy and the...
Article
A 68-year-old man came to the emergency department with a 4-day history of abrupt-onset fever, maculopapular skin rash, bilateral eyelid pain, redness, and discharge. His medical history was significant for ulcerative colitis, which was treated with mesalamine and azathioprine. He experienced an ulcerative colitis flare 2 months prior to presentati...
Article
Purpose: To evaluate the use of the Boston keratoprosthesis type I implantation in patients with mucous membrane pemphigoid (MMP). Methods: Retrospective review of 8 eyes of 8 patients with severe ocular surface disease and corneal blindness as a result of MMP who underwent Boston keratoprosthesis type I implantation at the Massachusetts Eye and...
Article
Superselective delivery of chemotherapy through the ophthalmic artery, i.e. ophthalmic artery chemosurgery, has been used for the treatment of advanced intraocular retinoblastoma. Herein, we evaluate the efficacy of ophthalmic artery chemosurgery for retinoblastoma associated with >50% retinal detachment. Retrospective review of 37 eyes of 34 retin...
Article
Purpose: To report a case of corneal hydrops in a patient with keratoglobus that was managed with endothelial keratoplasty to achieve corneal stability and prevent a limbus-to-limbus tear in Descemet membrane. Methods: A 30-year-old man with keratoglobus presented with corneal hydrops in his left eye resulting from a central vertical tear in Des...
Article
Full-text available
Ophthalmic artery chemosurgery (OAC) for retinoblastoma was introduced by us 5 years ago for advanced intraocular retinoblastoma. Because the success was higher than with existing alternatives and systemic side effects limited we have now treated less advanced intraocular retinoblastoma (Reese-Ellsworth (RE) I-III and International Classification R...
Article
In Archaea selenocysteine (Sec) is synthesized in three steps. First seryl-tRNA synthetase acylates tRNA(Sec) with serine to generate Ser-tRNA(Sec). Then phosphoseryl-tRNA(Sec) kinase (PSTK) forms Sep-tRNA(Sec) , which is converted to Sec-tRNA(Sec) by Sep-tRNA:Sec-tRNA synthase (SepSecS) in the presence of selenophosphate produced by selenophosphat...
Article
The essential methanogen enzyme Sep-tRNA:Cys-tRNA synthase (SepCysS) converts O-phosphoseryl-tRNA(Cys) (Sep-tRNA(Cys)) into Cys-tRNA(Cys) in the presence of a sulfur donor. Likewise, Sep-tRNA:Sec-tRNA synthase converts O-phosphoseryl-tRNA(Sec) (Sep-tRNA(Sec)) to selenocysteinyl-tRNA(Sec) (Sec-tRNA(Sec)) using a selenium donor. While the Sep moiety...
Article
Full-text available
Selenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of selenocysteine formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRN...
Article
Full-text available
Selenocysteine and pyrrolysine, known as the 21st and 22nd amino acids, are directly inserted into growing polypeptides during translation. Selenocysteine is synthesized via a tRNA-dependent pathway and decodes UGA (opal) codons. The incorporation of selenocysteine requires the concerted action of specific RNA and protein elements. In contrast, pyr...
Article
Full-text available
Making Selenocysteine In humans, selenocysteine is the only amino acid that lacks its own transfer RNA (tRNA) synthetase and is synthesized on its cognate tRNA. The process involves mischarging of tRNA sec with serine, phosphorylation of the serine, and then conversion of the phosphoserine into selenocysteine by the enzyme SepSecS using selenophosp...
Article
Full-text available
The micronutrient selenium is found in proteins as selenocysteine (Sec), the 21st amino acid cotranslationally inserted in response to a UGA codon. In vitro studies in archaea and mouse showed that Sec-tRNA(Sec) formation is a 3-step process starting with serylation of tRNA(Sec) by seryl-tRNA synthetase (SerRS), phosphorylation of serine to form ph...
Article
Selenocysteine (Sec) is the 21st genetically encoded amino acid found in organisms from all three domains of life. Sec biosynthesis is unique in that it always proceeds from an aminoacyl-tRNA precursor. Even though Sec biosynthesis in bacteria was established almost two decades ago, only recently the pathway was elucidated in archaea and eukaryotes...
Article
Full-text available
A high level of accuracy during protein synthesis is considered essential for life. Aminoacyl-tRNA synthetases (aaRSs) translate the genetic code by ensuring the correct pairing of amino acids with their cognate tRNAs. Because some aaRSs also produce misacylated aminoacyl-tRNA (aa-tRNA) in vivo, we addressed the question of protein quality within t...
Article
Full-text available
The micronutrient selenium is present in proteins as selenocysteine (Sec). In eukaryotes and archaea, Sec is formed in a tRNA-dependent conversion of O-phosphoserine (Sep) by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS). Here, we present the crystal structure of Methanococcus maripaludis SepSecS complexed with PLP at 2.5 Å resolution...
Article
Full-text available
At the time of its discovery four decades ago, the genetic code was viewed as the result of a "frozen accident." Our current knowledge of the translation process and of the detailed structure of its components highlights the roles of RNA structure (in mRNA and tRNA), RNA modification (in tRNA), and aminoacyl-tRNA synthetase diversity in the evoluti...
Article
Full-text available
The trace element selenium is found in proteins as selenocysteine (Sec), the 21st amino acid to participate in ribosome-mediated translation. The substrate for ribosomal protein synthesis is selenocysteinyl-tRNASec. Its biosynthesis from seryl-tRNASec has been established for bacteria, but the mechanism of conversion from Ser-tRNASec remained unres...
Article
Several methanogenic archaea lack cysteinyl-transfer RNA (tRNA) synthetase (CysRS), the essential enzyme that provides Cys-tRNA(Cys) for translation in most organisms. Partial purification of the corresponding activity from Methanocaldococcus jannaschii indicated that tRNA(Cys) becomes acylated with O-phosphoserine (Sep) but not with cysteine. Furt...
Article
Full-text available
The methanogenic archaea Methanocaldococcus jannaschii and Methanothermobacter thermautotrophicus contain a dual-specificity prolyl-tRNA synthetase (ProCysRS) that accurately forms both prolyl-tRNA (Pro-tRNA) and cysteinyl-tRNA (Cys-tRNA) suitable for in vivo translation. This intriguing enzyme may even perform its dual role in organisms that posse...

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