Sorousheh Samizadeh

Facial volumetric restoration, augmentation, and contouring with injectable products such as hyaluronic acid dermal fillers are exceedingly popular procedures in the minimally invasive and non-surgical era. These agents are traditionally used to merely fill lines and wrinkles, however, with the evolution of products and enhanced knowledge, these ag...

Methods: MSCs were harvested from young, adult and ovarectomized animals and transfected with CXCR4; these cells were administered intravenously in ovarectomized rats. Micro CT and mechanical testing was completed after 12 weeks. Results: rats injected with young CXCR4 transfected cells had significantly higher BMD compared to placebo injected r...

Large bone defects and nonunions are serious complications that are caused by extensive trauma or tumour. As traditional therapies fail to repair these critical-sized defects, tissue engineering scaffolds can be used to regenerate the damaged tissue. Highly porous titanium scaffolds, produced by selective laser sintering with mechanical properties...

Objectives: Cellular movement and relocalisation are important for many physiologic properties. Local mesenchymal stem cells (MSCs) from injured tissues and circulating MSCs aid in fracture healing. Cytokines and chemokines such as Stromal cell-derived factor 1(SDF-1) and its receptor chemokine receptor type 4 (CXCR4) play important roles in maint...

This study investigated the osteoconductive properties of a porous hydroxyapatite (HA) scaffold manufactured using a novel technique similar to the bread-making process, alone and in combination with an alginate polysaccharide fiber gel (HA/APFG putty) and autologous bone marrow aspirate (BMA). The hypothesis was that the HA/APFG putty would be as...

Synthetic calcium phosphate (CaP) based biomaterials have been widely investigated as osteoconductive and osteoinductive materials in the repair and regeneration of bone due in part, to their excellent biocompatibility, safety, unlimited availability and cost effectiveness. TCP, hydroxyapatite and a combination of both are amongst the very first an...

The clinical demand for effective dermal substitutes continues as current commercially available products present limitations. However, there are no definitive in vitro methods to predict in vivo outcomes such as integration, cellularization and contraction, which may help the development of new dermal scaffolds. This study aimed to develop a multi...

The commercially available collagen-based dermal reconstruction scaffolds Integra® (I) and Matriderm® (MD) are not widely used in major trauma because of variable integration and equivocal outcomes. Smart Matrix (SM) is a new fibrin based scaffold which shows rapid integration and vascularisation in vivo. The aim of this study was to create a novel...

The effect of increasing strut porosity on the osteoinductivity of porous calcium phosphate (CaP) and silicate-substituted calcium phosphate (SiCaP) bone substitute materials was investigated in an ovine ectopic model. One to two millimeter-sized granules or block implants with strut porosities of 10, 20, or 30% were inserted into the left and righ...

The osteoinductivity of silicate-substituted calcium phosphate and stoichiometric calcium phosphate was investigated with use of ectopic implantation. Implants with a macroporosity of 80% and a strut porosity of 30% were inserted into sites located in the left and right paraspinal muscles of six female sheep. After twelve weeks in vivo, a longitudi...

A large number of bone substitute materials are available; for which some authors claim osteoconductivity and some osteoinductivity. In order to rank these materials an in vivo analysis was carried out. These materials were chosen based on their availability and claimed mode of action. Silicon substituted Hydroxyapatite (SiHA), Hydroxyapatite (HA),...

Introduction: Incorporation of Silicon into the HA structure enhances the bioactivity of Hydroxyapatite (HA). Silicon substituted calcium phosphate (SiCaP/SiHA) has been introduced as an osteoconductive material for bone formation. However, the osseoinductive capacity of this biomaterial has not been assessed. A previous study by Hing et al shows t...