Sorin Rugina

Sorin Rugina
Ovidius University of Constanţa · Faculty of Medicine -Doctoral School

Professor
Professor of Infectious Disease and Epidemiology,Ovidius University of Constanta,Faculty of Medicine - Doctoral School

About

241
Publications
13,459
Reads
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2,125
Citations
Additional affiliations
May 2001 - present
Universitatea Ovidius Constanţa
Position
  • Research Director
Description
  • This Research Group work in HIV/AIDS,Hepatitis,Antimicrobials,and other fiels of Infectious Diseases researches.
September 1995 - January 2015
Ovidius University of Constnta
Position
  • Rector

Publications

Publications (241)
Article
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Infective endocarditis represents a rare complication among patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); it is often a nosocomial infection and the symptomatology can be masked by respiratory failure symptoms from SARS-CoV-2 bronchopneumonia. Management of patients with severe forms of SARS-COV-2 infection wh...
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Emery–Dreifuss muscular dystrophy (EDMD) is a rare genetic disease that affects the musculoskeletal system, including the heart, causing rhythm disorders and cardiomyopathy, sometimes requiring an implantable cardioverter-defibrillator (ICD) or heart transplantation due to severe heart damage. The case described herein concerns a 16-year-old girl,...
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The pathophysiology of accelerated atherosclerosis in people living with Human Immunofediciency virus (HIV) is complex. Coronary artery disease (CAD) has become an important cause of mortality in these patients. They often have atypical symptoms, leading to frequently missed diagnoses. We report a case of a 51-year-old male undergoing antiretrovira...
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Introduction: Thrombocytopenia is common in SARS-COV-2 infection, and about a quarter of cases have moderate thrombocytopenia. Severe thrombocytopenia is less common and is associated with severe forms of COVID-19. The pathogenesis of this thrombocytopenia appears to be complex, the immune mechanism being incriminated. Immune thrombocytopenic purp...
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Infections with carbapenem-resistant Enterobacteriaceae are emerging as an important challenge in healthcare settings. Currently, carbapenem-resistant Klebsiella pneumoniae (CRKP) are the species of CRE most commonly encountered in hospitals. CRKP is resistant to almost all available antimicrobial agents, and infections with CRKP have been associat...
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Climate change creates new challenges for preventing and protecting human health against different diseases that could appear and propagate. The Aedes albopictus mosquito species is an important vector for different diseases like dengue fever or zika. Although this species is not “indigenous” in Europe, its presence is noticed in many countries on...
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Healthcare associated infections in pediatric patients are a major public health problem due to the fact that this category has a high infectious risk due to the body's high susceptibility to these infections. This study aims to highlight that good reporting and management of these cases are essential in combating HAI by intensifying prevention mea...
Article
The healthcare associated infections (HAI) represent a significant problem for the public heath and it has a big impact on the following plans: epidemiological, clinical and economical. Also, a major importance represents the activity of monitoring and controling the infections along with a corect reporting of the cases. The authors conducted a ret...
Article
Healthcare-associated infections (HAI) represent infections that happened during after hospitalization, the symptoms starting at least 48 hours after admission, being present during hospitalization or after discharge. A common category of HAI are surgical infections that have a major clinical and financial impact. The aim of this study is the analy...
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The healthcare associated infections are the infections in the newborn confirmed by bacteriological cultures (blood culture, culture of cerebrospinal fluid, urine); positive anamnestic-clinical data after 72 hours of life, associated with ICU hospitalization and invasive procedures (intubation, mechanical ventilation, umbilical and peripheral vein...
Article
It has been estimated that the human gut contains about 1,000 species of bacteria and 100 times more genes than are found in the human genome. Over 2 Kg - as weight. It is the human microbiom that form a true “forgotten organ” of our body. Due to the abuse of antibiotics, the Clostridium difficile infection became one of the top nosocomial infectio...
Article
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Under conditions of increased consumption of antibiotics, pseudomembranous colitis has become a common condition in Romanian hospitals. Severe forms of the disease are becoming more common, recurrences are numerous, and metronidazole and vancomycin therapy has failed to prevent these recurrences. The study aims to identify the characteristics of pa...
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This paper shows the results of a retrospective observational analytical study that has enrolled 166 HIV positive patients diagnosed with a neurological complication between June 2012 and June 2020, in Clinical Infectious Diseases Hospital of Constanta. 119 patients (71,69%) were diagnosed with one of the three neurological complications: HIV assoc...
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In order to control and end the AIDS epidemic, we all need to hit the 0-0-0 target. That means 0 HIV infections, 0 mortality caused by AIDS and 0 discrimination. We performed a retrospective observational analytical study on 166 HIV positive patients with a neurological complication, diagnosed between June 2012 and June 2020, in Clinical Infectious...
Article
Anemia is frequent in HIV infected patients, but its multi­fac­torial origin complicates the differential diagnosis and, as a consequence, the proper treatment. Moreover, the etiology of anemia in HIV infection often remains unclear. In recent years, research was conducted in order to clarify the mechanisms that lead to HIV-associated anemia. Direc...
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Chronic kidney disease is an important comorbidity of HIV infection causing real problems in the evolution and medical healthcare of HIV-positive patients. In recent years, a significant number of HIV-positive patients develop renal dysfunction, several mechanisms being incriminated: direct effect of the virus, toxic effect secondary to of antiretr...
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One of the most common manifestations in HIV infected patients are hematological. Few studies on these manifestations have been conducted in Romania and worldwide. Anemia and infections occur frequently among people living with HIV and reflect the immune suppression of the host. Besides, the etiology of anemia in HIV infection often remains unclear...
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From the onset of the first case until now, HIV infection is one of the most studied pathologies in the medical field, due to the incompletely known action of the virus per se, as well as the comorbidities associated with it. Currently, a field of interest in research is occupied by cardiovascular comorbidities, being more and more frequent at PLWH...
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The infection with Clostridium difficile (CDI), which appeared at epidemic level, after acquiring the germ of some fluoroquinolone resistance genes, initially considered nosocomial infection and adverse effect post-antibiotic therapy, is affecting more and more people without risk factors and extending into the community. This paper proposes an ana...
Article
Background: Doravirine is a novel, non-nucleoside reverse transcriptase inhibitor that has shown non-inferior efficacy to ritonavir-boosted darunavir, with a superior lipid profile, in adults with HIV who were treatment naive at week 48 in the phase 3 DRIVE-FORWARD trial. Here we present the 96-week data for the study. Methods: This randomised,...
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Clostridium difficile infection (CDI) associates in the spectrum of comorbidities, more and more often, chronic toxic metabolic or viral hepatic diseases. Patients with chronic hepatic diseases have more severe episodes of CDI with poorer prognosis than episodes of CDI that have occurred in patients with other comorbidities. The measures of prophyl...
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Clostridium difficile is a microorganism - a Gram-positive anaerobic bacterium that has developed and hyperspecialized the ability to form spores. Outside the host, Clostridium difficile germinates spores which are resistant to unfavorable environment and for an extremely long time period. Clostridium difficile infection frequently occurs on a back...
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Clostridium difficile infection (CDI) in Galati county is an very important public health problem, the number of cases per 100 outpatients being in the first 5, nationally. The percentage of community-associated infection in this county is higher than the national and european ones. We performed a prospective observational study on 720 patients adm...
Article
Background: The safety and efficacy of doravirine were compared with that of efavirenz as initial treatment of adults living with HIV-1 infection (NCT01632345). Methods: A Phase 2b double-blind trial with participants stratified by screening HIV-1 RNA (≤ or >100 000 copies/ml) and randomized 1:1:1:1:1 to receive once-daily doravirine (25, 50, 10...
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The current HAART has modified natural history of HIV infection and it has practically turned the disease into a manageable chronic condition. Even though the benefits of HAART use are overwhelmingly greater than possible metabolic syndrome and cardiovascular disease risks, close management of those patients is called for, especially due to the fac...
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Enterotoxins produced by Clostridium difficile cause a series of biochemical and immunological manifestations in the cascade leading to alteration of the enterocitus cytoskeleton, intestinal inflammation and diarrhea that can greatly impair the patient’s biological status. The genome of the Clostridium difficile bacterium shows a series of evolutio...
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The intestinal transit disorders are polymorphic clinical manifestations requiring complex differential diagnosis and a multidisciplinary medical team. A major challenge for the clinician is the differentiation of patients with organic suffering versus functional disorder. Anemia is the most common extra-digestive manifestation of intestinal inflam...
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Background: Doravirine is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) with a pharmacokinetic profile supporting once-daily dosing, and potent in-vitro activity against the most common NNRTI-resistant HIV-1 variants. We compared doravirine with ritonavir-boosted darunavir, when both were given with two nucleoside reverse transcri...
Article
Obiective. Identificarea prevalenţei rezistenţei dobândite la INRT (inhibitorii non-nucleozidici de reverstranscriptază) şi al profilelor de rezistenţă la un lot de pacienţi cu multiple scheme de terapie antiretrovirală din Constanţa şi evaluarea opţiunilor terapeutice remanente. Material şi metode. Studiu retrospectiv ce a inclus 144 pacienţi sero...
Article
Studiul nostru a inclus 505 de copii spitalizaţi în Spitalul Clinic de Boli Infecţioase Constanţa în 2011-2012 cu gastroenterită cu rotavirus. Am analizat fişele medicale ale pacienţilor şi am extras datele demografice, temperatura, frecvenţa vărsăturilor şi a scaunelor diareice. Am împărţit grupul de cazuri în 4 grupe: asocierea cu infecţii respir...
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Objective. To determine the prevalence of acquired drug resistance (ADR) and of resistance patterns in treatment-experienced HIV infected patients from Constanta in order to establish the best therapeutic options in NRTI class. Material and methods. A retrospective study which included 144 treatment-experienced HIV patients with confirmed viral fai...
Article
Our study included 505 children hospitalized in the Clinical Hospital of Infectious Diseases Constanta in 2011-2012 with gastroenteritis with rotavirus. We analyzed the medical records of the patients and extracted demographic data, temperature, and frequency of vomiting and diarrheic stools. We divided the group of cases into 4 groups associated w...
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Background: Gastroenteritis with rotavirus is the leading cause of severe diarrhea among infants and young children. The aim of the study was to evaluate the clinical aspects of the rotavirus gastroenteritis comparatively with non-rotavirus disease. Material and methods: We conducted an observational, retrospective study, that included children hos...
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Background: The infection with rotavirus is a frecquent cause of accute diarrheal disease in infants and young children anywhere in the world. Objective: The aim of this study was to evaluate the clinical characteristics and the severity of nosocomial gastroenteritis with rotavirus. Material and methods: We conducted a descriptive, observational,...
Article
The presence of hemichorea–ballism in patients with cerebral toxoplasmosis is not common. Some studies have reported them as the second most frequent movement disorder after Parkinsonism (1). We present the case of a 28 years old woman with relapse of toxoplasmosis manifested as hemiballismus of the right limbs. Despite the medical treatment, the m...
Article
Apariţia tulburărilor de mişcare de tip hemicoree-hemibalism la pacienţii diagnosticaţi cu toxoplasmoză cerebrală, este una neobişnuită. Unele studii raportează frecvenţa acestor tulburări de mişcare pe locul doi, după parkinsonism (1). Vom prezenta cazul unei paciente în vârstă de 28 de ani, cu toxoplasmoză recidivantă, manifestată clinic sub form...
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ABSTRACT Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by reactivation of the John Cunningham (JC) polyoma virus. It occurs in patients with severe cellular immunodeficiency such as HIV infection, being one of the AIDS-defining illnesses. The prognosis of this disease was rese...
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Toxic megacolon is a life-threatening disease and is one of the most serious complications of : In the last two years, three Caucasian female patients have been diagnosed with toxic megacolon and treated in the Clinical Infectious Diseases Hospital, Constanta. All patients had been hospitalized for non-related conditions. The first patient was in c...
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The objectives of the study were to determine the efficacy of pegylated interferon alfa 2 b (PegINF) and ribavirin (RBV) treatment in co-infected HIV / HCV patients, to identify predictive factors associated with sustained viral response (SVR) in these patients. Out of the 956 HIV infected patients, 38 were HCVAb (4%) positive, 14 of which had unde...
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Toxic megacolon can be a form of severe clinical course of the infection with Clostridium difficile (ICD), life-threatening, requiring a particular course of treatment. Infection with Clostridium difficile in the Galati Infectious Disease Hospital presents rising number of cases, namely 172 cases in 2014, 271 cases in 2015 and 301 cases in 2016 wit...
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Hepatitis C virus (HCV) infection affects approximately 180 million people worldwide, which accounts for roughly 2% - 3% of the world’s population. Complications arising from chronic HCV infection include the development of cirrhosis, end stage liver disease, and hepatocellular carcinoma (HCV). Objective: The study analyses management of anemia wit...
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The HIV epidemic in Constanta describes a unique pattern in the world. It has outbreak in 1986, in the pediatric population and it is of a monoclonal aspect, being determined by the F1 subtype. The evolution of the epidemic has known different stages in time: it spreads to the adult population, the transmission pathway becomes predominantly sexual...
Article
Background HCV direct-acting antivirals (DAAs) have made treatment easier for both patients and healthcare practitioners, but have also brought new challenges in terms of patient management and monitoring prior to, during, and after treatment. Methods To sum up and unify the clinical experience of Romanian DAA prescribing physicians, we have organi...
Article
Objective. Highlighting seborrheic dermatitis prevalence in HIV patients and evaluating clinico-therapeutical correlations. Material and methods. Between 1.10.2011 – 31.12.2014 we performed a prospective study on a group of 121 HIV-positive patients hospitalized in the HIV Adults Department in the Infectious Diseases Hospital, Constanta, to determi...
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Cancers have been recognized as a major health problem in patients with HIV. The first cases reported, before the existence of the virus was proven, involved patients with immunosuppression and a history of illness characterized by fever, weight loss and/or lymphadenopathy lasting weeks of months. As the population grows older, a consequence of bet...
Conference Paper
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Abstract Background The theme chosen is representative of current progress, expressing general public health services in Romania, especially regarding HIV-AIDS healthcare insurance, the specific elements of management epidemiological HIV AIDS impact on the environment The main objective - We have proposed organizing an existing case law database,...
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Introduction. Context of the research in Constanta County: Constanta is a tourist town with special profile (port, airport), petrochemical industry and Midia Năvodari textile industry - Integrata Cloth factory, agriculture (“IAS” - state farms, “CAP” - agricultural production cooperatives) , mining industry – Altan Tepae, in the psycho-sociologic...
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Conferinta de Boli Infectioase Craiova, 7 – 9 MAI 2015 Volum rezumate CLINICAL AND EPIDEMIOLOGICAL ASPECTS OF INFLUENZA AND SERIOUS RESPIRATORY INFECTIONS DURING 2014-2015 SEASON IN CONSTANTA Roxana-Carmen Cernat1, Irina-Magdalena Dumitru1,2, Raluca Elena Slujitoru1, Elena Dumea1,2, Andra Elena Petcu1, Carmen Ilie-Serban1, Eugenia Muja1, Aura Gherg...
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The objective of the study was to determine the association of host human leukocyte antigen (HLA) class II genotype DRB1 alleles with the response to interferon therapy, viral loads and extent of liver fibrosis in a group of Romanian patients diagnosed with chronic hepatitis C, with different clinical outcomes. Class II HLA genes, particularly the...
Article
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In the past years there have been numerous discoveries regarding treatment of patients with HIV. If at first the doctors watched as patients live longer, now we want these patients to live better with regimens potent, safe, individualized and without side effects. HAART has revolutionized “the world HIV” and caused a significant reduction in mortal...
Article
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We analyzed a total of 412 adult patients diagnosed with toxoplasmosis in the Clinical Infectious Diseases Hospital Constanta between 01Jan 2010 - 01 Jan 2015. Of these patients, 82.03% were from urban area, 74% female, majority aged 30-48 years. 3.15% were diagnosed with HIV infection (13 patients), in four of these patients, toxoplasmosis was the...
Conference Paper
Full-text available
Introduction: Influenza and severe acute respiratory infections are an important public health issue due to the unpredictability in what concerns the circulation of the influenza viral types and because of the receptive human mass characteristics. Objectives: assessing the circulation of the viral types during the 2014-2015 flu season in Constanta...
Conference Paper
Introducere: Gripa si infectiile respiratorii severe (SARI) reprezinta o problema importanta de sanatate publica datorita impredictibilitatii circulatiei tipurilor virale gripale si a caracteristicilor masei populationale receptive. Obiective: Evaluarea circulatiei tipurilor/subtipurilor gripale in sezonul 2014-2015 in Constanta si determinarea for...
Article
Objectives. To describe particular aspects of dermatoses in HIV-positive patients and assess clinical and therapeutical correlations. Material and methods. A systematic review was performed of the medical literature, totaling 49 works, to evaluate information on the following dermatological diseases: syphilis malignant, pruritic papular eruption of...