Soraya Salas Silva

• Professor
• Professor (Assistant) at Hanyang University

Purpose: Over the past decade, interest in exosomes as therapeutics has surged. In particular, stem-cell-derived exosomes may be more effective as a treatment for liver disease than the stem cells themselves. We have previously developed human chemically derived hepatic progenitors (hCdHs) from human hepatocytes. hCdHs can differentiate into hepat...

Backgrounds/aims: Liver organoids have emerged as a powerful tool for studying liver biology and disease and for developing new therapies and regenerative medicine approaches. For organoid culture, Matrigel, a type of extracellular matrix, is the most commonly used material. However, Matrigel cannot be used for clinical applications due to the pre...

Alcohol-induced pancreas damage remains as one of the main risk factors for pancreatitis development. This disorder is poorly understood, particularly the effect of acetaldehyde, the primary alcohol metabolite, in the endocrine pancreas. Hepatocyte growth factor (HGF) is a protective protein in many tissues, displaying antioxidant, anti-apoptotic,...

Abstract Aim: Cholestasis remains a partially characterized disease. Evidence has been gained that it is a systemic disease that begins in the liver but significantly impacts other organs and systems such as the kidney, heart, and intestine, among others. One of the primary damage mechanisms is the generation of reactive oxygen species (ROS), which...

Hepatocyte growth factor (HGF) has been proved to protect the liver against α-naphthylisothiocyanate (ANIT)-induced cholestasis by acting as an antioxidant agent and redirecting toxic biliary solutes towards blood for urinary excretion. However, this may represent an additional potential risk for kidney integrity, which is already compromised by th...

Introduction and Objectives he prevalence of cholestasis has been increasing in recent years; The excretion of bile acids via basolateral has been demonstrated to prevent the excessive accumulation in the hepatocyte, and the liver-intestine axis has been seen affected by enterohepatic circulation deregulation. The epithelial permeability loss cause...

Hepatocellular carcinoma (HCC) accounts for 85% of primary liver cancer, the third most com-mon cause of cancer-related deaths worldwide. Its incidence has been increasing in both men and women. In Western countries, high-calorie diets, mainly rich in carbohydrates such as fructose, represent a significant concern due to their repercussions on the...

The mechanism of damage of the biliary epithelium remains partially unexplored. However, recently many works have offered new evidence regarding the cholangiocytes' damage process, which is the main target in a broad spectrum of pathologies ranging from acute cholestasis, cholangiopathies to cholangiocarcinoma. This is encouraging since some works...

Background Type 2 Diabetes (T2D) is characterized by deregulation in carbohydrate and lipid metabolism, with a very high mortality rate. Glucose Transporter type 4 (GLUT4) plays a crucial role in T2D and represents a therapeutic target of interest. Tillandsia usneoides (T. usneoides) is a plant used as a remedy for diabetes. T. usneoides decreased...

Simple Summary It is well known that non-alcoholic fatty liver disease is an important risk factor in the development of hepatocellular carcinoma, but the implication of cholesterol in this subject remains unclear, especially in western countries where its consumption is particularly elevated. This work provides evidence of a cholesterol-related tr...

Introduction and objectives It is well-known that signaling mediated by the hepatocyte growth factor (HGF) and its receptor c-Met in the liver is involved in the control of cellular redox status and oxidative stress, particularly through its ability to induce hepatoprotective gene expression by activating survival pathways in hepatocytes. It has be...

Background and aim: Hepatocellular carcinoma (HCC) is the fourth cause of cancer-related death and its incidence has been increasing in both men and women. One of the main concerns has been the consumption of hypercaloric diets mainly rich in carbohydrates such as fructose. High fructose diet is related to the development of Non-Alcoholic Fatty Liv...

Introduction and objective: Non-alcoholic fatty liver disease remains as one of the main liver disorders worldwide. It is widely accepted that is the kind of lipid, rather than the amount deposited in the cells that determines cell damage. Cholesterol and saturated free fatty acids are deleterious lipids when accumulated but, in contrast, there ar...

Cholestasis is a clinical syndrome common to a large number of hepatopathies, in which either bile production or its transit through the biliary tract is impaired due to functional or obstructive causes; the consequent intracellular retention of toxic biliary constituents generates parenchyma damage, largely via oxidative stress-mediated mechanisms...

Background and aim: Hepatocellular carcinoma (HCC) comprises between 75% - 85% of reported cases of primary liver cancer and is the fourth cause of cancer-related death in men mostly. The consumption of hypercaloric diets mainly rich in carbohydrates such as fructose has increased in recent years. High fructose diet is related to the development of...

Background and aim: Hepatocellular carcinoma (HCC) comprises between 75% - 85% of reported cases of primary liver cancer and is the fourth cause of cancer-related death in men mostly. The consumption of hypercaloric diets mainly rich in carbohydrates such as fructose has increased in recent years. High fructose diet is related to the development of...

Among hepatic diseases, cholestatic ductopenic cholangiopathies are poorly studied, and they are rarely given the importance they deserve, especially considering their high incidence in clinical practice. Although cholestatic ductopenic cholangiopathies have different etiologies and pathogenesis, all have the same target (the cholangiocyte) and sim...

Nowadays, reactive oxygen species-mediated cellular signaling is a growing field. The evidence of the requirement of these species in cellular processes such as proliferation, differentiation, apoptosis and even, survival, is leaving clear that reactive oxygen species are not just noxious entities, not anymore. As it happens in many biological syst...