Soraya Meftah

Soraya Meftah
University of Exeter | UoE · Medical School

BSc Biochemistry

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14
Publications
2,451
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184
Citations

Publications

Publications (14)
Article
Full-text available
Alzheimer's disease is connected to a number of other neurodegenerative conditions, known collectively as ‘tauopathies’, by the presence of aggregated tau protein in the brain. Neuroinflammation and oxidative stress in AD are associated with tau pathology and both the breakdown of axonal sheaths in white matter tracts and excess iron accumulation g...
Article
Full-text available
Background The choice and appropriate use of animal models in drug discovery for Alzheimer’s disease (AD) is pivotal to successful clinical translation of novel therapeutics, yet true alignment of research is challenging. Current models do not fully recapitulate the human disease, and even exhibit various degrees of regional pathological burden and...
Article
Full-text available
Narcolepsy type 1 is a disabling disorder with four primary symptoms: excessive-daytime-sleepiness, cataplexy, hypnagogic hallucinations and sleep paralysis. The three latter symptoms together with a short REM sleep latency have suggested impairment in REM sleep homeostatic regulation with an enhanced propensity for (i.e. tendency to enter) REM sle...
Article
Synaptic degeneration is currently the best correlate of cognitive decline in Alzheimer’s Disease. Tau pathology, one of the hallmarks of the disease, correlates well with synaptic degeneration and has been shown to abnormally mislocate to synapses in the disease. This process is thought to induce changes in the activity, number and structure of sy...
Article
Full-text available
Deceased. The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid-b and tau, which accumulate in the brain in Alzheimer's disease. Further, tau protein transference via the extracellular space, the compartment that is cleared by...
Preprint
Full-text available
Neurodegeneration driven by aberrant tau is a key feature of many dementias. Pathological stages of tauopathy are characterised by reduced synapse density and altered synapse function. Furthermore, changes in synaptic plasticity have been documented in the early stages of tauopathy suggesting that they may be a driver of later pathology. However, i...
Article
Objectif La symptomatologie de la narcolepsie suggère une dérégulation du sommeil paradoxal (SP). Chez les souris narcoleptiques délétées du gène hypocrétine (KO), la privation spécifique de SP par la méthode de la piscine a montré que la régulation homéostasique du SP est préservée. Toutefois, la latence d’apparition du 1er épisode de SP après pri...
Article
Objectif Certains symptômes de la narcolepsie comme la cataplexie ou la paralysie du sommeil sont considérés comme des états dissociés du SP, suggérant une dérégulation du SP. Vu et al. (2009) ont montré, chez 6 patients narcoleptiques, qu’il est plus difficile de priver de SP les patients que les témoins. Aucune étude de ce type n’a été réalisée c...

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