Sophie L. Russell

Coventry University | CU · Centre for Health and Lifesciences

Background: Hypertrophic cardiomyopathy (HCM) is a global heart disease with great variability in disease severity, which can lead to significant impairment of exercise capacity. In healthy populations, oxygen consumption is related to cardiac output and arteriovenous oxygen difference. We sought to determine the relationship between hemodynamics (...

Purpose This study evaluated the relationship between HRV and echocardiography indices of cardiac function. Methods Healthy individuals ( N = 30) aged 33 ± 10 years old, underwent short‐term resting HRV assessment and transthoracic echocardiography with speckle tracking analysis. Time domain ‐ (i.e. R‐R interval, root mean square of successive RR...

Background and Aims Arterial function (specifically arterial stiffness) is an important cardiovascular risk factor. Pulse wave velocity (PWV) and augmentation index (Alx $x$) are established indicators of arterial function. The present study aimed to evaluate the repeatability and reproducibility of PWV and Alx $x$ in healthy individuals. Methods...

Background Coronavirus disease 2019 (COVID‐19) was declared a global pandemic in 2019. It remains uncertain to what extent COVID‐19 effects the heart in heathy individuals. To evaluate the effect of the COVID‐19 on cardiac structure and function in middle‐aged and older individuals. Methods A single‐centre prospective observational study enroled a...

Background COVID-19 is associated with a cytokine storm leading to a pro-inflammatory response. Little is known about the miRNA expression profile associated with inflammatory signalling pathways i.e. high vascular endothelin growth factor (VEGF) and/ or creatine kinase (CK) in people with a history of COVID-19. Purpose To identify the signalling...

Heat stress induced damage to the gastrointestinal barrier can induce local and systemic inflammatory reactions implicated in heat-stroke. Gastrointestinal barrier damage has been shown to be greater in older relative to young adults following hyperthermia. However, comparisons between young and older adults have been limited to brief exposures (3...

Purpose Prolonged work in the heat increases the risk of acute kidney injury (AKI) in young men. Whether aging and age-associated chronic disease may exacerbate the risk of AKI remains unclear. Methods We evaluated plasma neutrophil gelatinase-associated lipocalin (NGAL) and serum kidney injury molecule-1 (KIM1) before and after 180 min of moderat...

Purpose: Arterial stiffness is an important cardiovascular risk factor. Pulse wave velocity (PWV) and augmentation index (Alx) are established indicators of arterial stiffness. The present study aimed to evaluate the repeatability and reproducibility of PWV and Alx in healthy individuals. Methods: Forty healthy participants (age 33±11 years, 17 fe...

Introduction Coronavirus disease 2019 (COVID-19) may lead to impaired cardiovascular function in middle-age and older adults. The aim of the present study was to evaluate the effect of COVID-19 on arterial stiffness in previously healthy women and men. Methods Eighty-four healthy individuals with history of COVID-19 (mean age: 60±7 years, 55% wome...

Introduction Coronavirus disease (COVID-19) was declared a global pandemic in 2019. It remains uncertain to what extent COVID-19 effects the cardiovascular system. The aim of the present study was to evaluate the effect of COVID-19 on cardiac structure and function in middle-aged and older people. Methods A single centre, prospective, observationa...

Background The clinical manifestation of COVID-19 is associated with infection and inflammation of the lungs, but there is evidence to suggest that COVID-19 may also affect the structure and function of the cardiovascular system. At present, it is not fully understood to what extent COVID-19 impacts cardiovascular function in the short- and long-te...

Background and Aims Single‐use electrocardiography (ECG) leads have been developed to reduce healthcare‐associated infection. This study compared the validity and reliability of short‐term heart rate variability (HRV) obtained from single‐use disposable ECG leads. Methods Thirty healthy subjects (33 ± 10 years; 9 females) underwent 5‐min resting H...

Background Pulse wave velocity (PWV), a measure of arterial stiffness and function, is an important cardiovascular risk factor. However, there is limited evidence reporting the association between arterial stiffness and cardiac function. Aim Evaluate the relationship between PWV and echocardiography measures of cardiac function. Methods Forty hea...

Background The evaluation of heart rate variability (HRV) has become increasingly common, as a simple, non-invasive measure that is sensitive to physiological changes and can help to structure exercise training programmes, adaptation, and recovery. Novel single-use electrocardiography (ECG) leads have been developed to monitor HRV in clinical and r...

Objective Heart rate variability (HRV) is a measure of cardiac autonomic function. This study evaluated the relationship between HRV and echocardiography derived measures of cardiac function. Methods Thirty healthy participants (age 33±10 years) underwent five-minute HRV measurement and echocardiography at rest. HRV variables included: R-R average...

Background The impact and management of sub-clinical hypoxia during hemodialysis is a significant medical challenge. As key determinants of O2 availability and delivery, proposed mechanisms contributing to hypoxia include ischemia, alkalemia and pulmonary leukocyte sequestration. However, no study has comprehensively investigated and compared these...

A large body of research supports the use of exercise to improve symptoms, quality of life, and physical function in patients with chronic heart failure. Previous reviews have focused on reporting outcomes of exercise interventions such as cardiorespi-ratory fitness. However, none have critically examined exercise prescription. The aim of this revi...