Sophie Pils

Sophie Pils
University of Vienna | UniWien · Medizinische Universität Wien

About

84
Publications
12,991
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,097
Citations
Citations since 2017
39 Research Items
890 Citations
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150

Publications

Publications (84)
Article
Full-text available
Background There is limited data on human papillomaviruses (HPV) prevalence in transpeople due to low acceptance rate of screening methods. HPV tests from self-collected urine are gender-neutral, have a high acceptance, and have a comparable accuracy in females to clinician-collected samples. The aim of this study was to evaluate both the HPV preva...
Article
Full-text available
Background: Over the last decades, there has been a substantial increase in the incidence of higher-order multiple gestations. Twin pregnancies are associated with an increased risk of gestational diabetes mellitus (GDM). The literature on GDM rates in triplet pregnancies is scarce. Methods: A retrospective cohort study was performed to assess t...
Article
Full-text available
Importance In addition to treatment efficacy, evaluation of adverse effects and quality of life assessments have become increasingly relevant in oncology. Objective To evaluate the association of watching Disney movies during chemotherapy with emotional and social functioning and fatigue status. Design, Setting, and Participants This randomized c...
Article
Full-text available
PurposeTo evaluate HPV and p16ink4a status as prognostic factors in patients with invasive vulvar cancer.Methods Retrospective analysis of disease-free (DFS) and disease-specific survival (DSS) of patients with invasive vulvar cancer at a single tertiary care center. Histology, HPV and p16ink4a status were evaluated in the context of a global multi...
Conference Paper
Introduction/Background Women with treatment of HSIL of the cervix have an increased risk for subsequent HPV related diseases. Developed for primary prevention, the HPV vaccines have demonstrated disease reduction in females and males after treatment of HPV related disease. We investigated the influence of HPV vaccination before or after conization...
Conference Paper
Introduction/Background Beside treatment efficacy, evaluation of side effects and quality of life (QoL) assessments have become more and more relevant in oncology. In this study, the influence of Disney movies during chemotherapy on emotional and social functioning as well as fatigue status was evaluated. Methodology 50 patients with gynecologic c...
Article
Full-text available
Purpose Vasa praevia is a rare condition with high foetal mortality if not detected prenatally. There is limited evidence available to determine the ideal timing of delivery and management recommendations. The aim of this study was to critically review our experience with vasa praevia, with a focus on diagnosis and management. Methods In a retrosp...
Article
Full-text available
To evaluate routine laboratory parameters in women with and without placental abruption (PA) and in controls, 417 women were included in this retrospective cohort study in a tertiary-care center. 118 women with PA (Group A: 54 without vaginal bleeding and Group B: 64 with bleeding), 130 women without either PA or vaginal bleeding throughout their p...
Article
In this case report, we present a case of false positive CA 19-9 and CA 125 levels in a patient with suspected endometriotic cysts. The patient is a 34-year-old nulliparous woman with heavy black tea consumption and elevated CA 19-9 and CA 125 levels. After discontinuation of black tea intake and careful exploration of other possible factors, CA 19...
Article
Full-text available
Purpose To evaluate whether anti-Mullerian hormone, basal follicle-stimulating hormone, luteinizing hormone, estradiol, and female age would predict future outcomes in women with idiopathic recurrent miscarriage. Methods One hundred and sixteen women with idiopathic recurrent miscarriage were retrospectively included. Luteal support with or withou...
Article
Full-text available
Purpose: To review our experience in ultrasound fetal weight estimation in our large population of triplet pregnancies. Methods: Ninety-seven triplet pregnancies were retrospectively included between January 2003 and January 2017. Sonographic fetal weight estimation using Hadlock's and Schild's formulas was compared to actual birth weight in a t...
Conference Paper
Fragestellung: In den letzten beiden Jahrzehnten kam es zu einer Zunahme der Inzidenz von Vulvakarzinomen, wobei Humane Papilloma Virus (HPV) Infektionen eine zentrale Rolle spielen. Der Einfluss der HPV-Infektion auf das Rezidiv-freie Intervall sowie das Gesamtüberleben bei Patientinnen mit Vulvakarzinom wurde evaluiert. Material und Methodik: Im...
Article
Full-text available
Human extravillous trophoblast (EVT) invasion of the pregnant uterus constitutes a pivotal event for the establishment of the maternal-fetal interface. Compromised EVT function manifesting in inadequate arterial remodeling is associated with the severe pregnancy disorder early-onset preeclampsia (eoPE). Recent studies suggest that EVTs invade the e...
Conference Paper
Fragestellung: Human Papillomavirus (HPV) wird vorwiegend per Sexualkontakt übertragen und ist ursächlich für eine Vielzahl von Krebserkrankungen. Achtsamkeit, Wissen und der Wille präventive Maßnahmen zu setzen, sind essentiell für die Reduktion der Inzidenzrate der HPV Infektionen und deren assoziierten Krankheiten. Material und Methodik: 113 Pat...
Conference Paper
Fragestellung: In den letzten beiden Jahrzehnten kam es zu einer Zunahme der Inzidenz von Vulvakarzinomen, wobei Humane Papilloma Virus (HPV) Infektionen eine zentrale Rolle spielen. Der Einfluss der HPV-Infektion auf das Rezidiv-freie Intervall sowie das Gesamtüberleben bei Patientinnen mit Vulvakarzinom wurde evaluiert. Material und Methodik: Im...
Article
Objective: To evaluate the rate of live birth and the duration of survival after termination of pregnancy without feticide. Methods: We conducted a retrospective analysis of 241 terminations of pregnancy without feticide for fetal anomalies or genetic abnormalities between 20 0/7 and 24 0/7 weeks of gestation at a single tertiary care referral c...
Article
Full-text available
We correlated Anti-Mullerian hormone (AMH) levels and other parameters for ovarian reserve to the gestational age at the time of pregnancy loss in women with idiopathic recurrent miscarriage. In a retrospective study, 79 patients had suffered a total of 266 miscarriages. When comparing women with an “unembryonic” to those with an “embryonic” most r...
Article
Full-text available
N-glycosylation plays a fundamental role in many biological processes. Human diamine oxidase (hDAO), required for hista-mine catabolism, has multiple N-glycosylation sites, but their roles, for example in DAO secretion, are unclear. We recently reported that the N-glycosylation sites Asn168, Asn538, and Asn745 in recombinant hDAO (rhDAO) carry comp...
Article
Full-text available
Background Intrauterine hematomas are a common pregnancy complication. The literature lacks studies about outcomes based on hematoma localization. Thus, we aimed to compare pregnancies complicated by an intraplacental hematoma to cases with a retroplacental hematoma and to a control group. Methods In a retrospective case-control study, 32 women wi...
Article
Background: Even if vulvar cancer is not common, over one hundred women are affected in Austria per year. There is strong evidence that basaloid and warty variants are associated with types of human papillomavirus (HPV). Methods: The aim of this study is to analyze the types of HPV in vulvar cancer in Austria. This cross-sectional period-prevale...
Article
Full-text available
Purpose: To review our experience with a screening program that included sequential cervical length measurements in our large population of triplet pregnancies. Methods: Seventy-eight triplet pregnancies were retrospectively included. Cervical length measurements were performed by transvaginal ultrasound in 2-week intervals from week 16 + 0 onwa...
Article
Study question: Do extravillous trophoblasts (EVTs) invade non-arterial decidual vessels in healthy and pathological pregnancies? Summary answer: Our results reveal that trophoblast invasion of venous and lymphatic vessels is a frequent event during the first trimester of pregnancy and is compromised in? recurrent spontaneous abortion (RSA). In...
Article
Full-text available
Background: The immunogenicity profile of the 9-valent HPV (9vHPV) vaccine was evaluated across five phase III clinical studies conducted in girls and boys 9-15 years of age and young women 16-26 years of age. The effect of baseline characteristics of subjects on vaccine-induced HPV antibody responses was assessed. Methods: Immunogenicity data f...
Article
Etiologic factors for recurrent miscarriage (RM) include autoimmune diseases, the most frequently antiphospholipid syndrome and thyroiditis. Some women who suffer from RM might also have an altered immune system. We aimed to evaluate possible associations between anti-Thyroid and anti-phospholipid antibodies in women with RM. In a retrospective cas...
Article
Since 2006, three vaccines against infections and disease caused by human papillomavirus (HPV) became available in Europe—in 2006 a quadrivalent HPV 6/11/16/18 vaccine, in 2007 a bivalent HPV 16/18 vaccine and in 2015 a nonavalent HPV 6/11/16/18/31/33/45/52/58 vaccine. HPV 16 and 18 are the most oncogenic HPV strains, causing about 70% of cervical...
Article
Objectives: Diamine oxidase (DAO) is essential for extracellular degradation of histamine. For decades activity assays with inherent limitations were used to quantify the relative amounts of DAO. No reference DAO standard is available. Absolute DAO amounts cannot be determined. Controversy exists, whether DAO is circulating or not in non-pregnant...
Article
Full-text available
Aims/hypothesisA history of gastric bypass surgery can influence the results of the OGTT recommended during pregnancy. Therefore, we compared OGTT glucose kinetics and pregnancy outcome between pregnant gastric bypass patients and BMI-matched, lean and obese controls. Methods Medical records were used to collect data on glucose measurements during...
Article
Full-text available
Objective: To evaluate anti-Mullerian hormone, basal follicle stimulating hormone, luteinizing hormone, estradiol, and female age in women with recurrent miscarriage and to compare women with explained and idiopathic recurrent miscarriage. Design: Retrospective cohort study. Setting: University hospital, tertiary care center. Patients: Women...
Data
Dataset. Data of patients suffering from recurrent miscarriage. (XLSX) (XLSX)
Article
Full-text available
Objectives: The overall safety profile of the 9-valent human papillomavirus (9vHPV) vaccine was evaluated across 7 Phase III studies, conducted in males and females (nonpregnant at entry), 9 to 26 years of age. Methods: Vaccination was administered as a 3-dose regimen at day 1, and months 2 and 6. More than 15 000 subjects received ≥1 dose of 9v...
Article
Purpose: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world. Current treatment options provide relief from symptoms rather than stop disease progress. Results from various preclinical experiments suggest a causal benefit of acetylic salicylic acid (ASA) in the treatment of COPD. Hence, this study set ou...
Article
Full-text available
Purpose: Velamentous umbilical cord insertion (VCI) is associated with adverse pregnancy outcomes. Literature lacks data on Doppler. We aimed to evaluate obstetric outcomes and results of uterine and umbilical artery Doppler flowmetry associated with VCI. Materials and methods: In a retrospective case-control study, 108 singleton pregnancies wit...
Article
Full-text available
Background: There are few valid predictors for preterm delivery after cerclage. Experience with a screening program that included four sequential cervical length measurements in singleton pregnancies after cerclage is reviewed. Methods: In this retrospective cohort study, 88 singleton pregnancies after cerclage were included. Cervical length (CL...
Article
Fragestellung: In den letzten beiden Jahrzehnten kam es zu einer Zunahme der Inzidenz von Vulvakarzinomen bei jüngeren Frauen. Dieser Anstieg ist durch HPV Infektionen bedingt. Wir präsentieren die österreichischen Daten eines internationalen Kooperationsprojektes, bei welchem die typenspezifische HPV Prävalenz in invasiven Vulvakarzinomen bestimmt...
Article
Full-text available
The upcoming year 2016 will be marked by two significant events: the ninevalent HPV vaccine will be available in Europe and The Netherlands will be the first country to implement primary HPV screening for the precursors of cervical cancer. Europe has a substantial burden of HPV-related disease. More than 44,000 new cases of HPV-related anogenital...
Article
Full-text available
Background: Medical staff's influence on patient outcomes has become a subject of interest. We evaluated experienced midwives and compared their performance concerning perineal lacerations (PL). Methods: In a retrospective cohort study, 1937 women with singleton pregnancies who had delivered spontaneously with a cephalic presentation by experien...
Article
Full-text available
An investigational monovalent HPV 16 virus like particle (VLP) vaccine has been shown to prevent persistent infection and cervical disease related to HPV 16 and was the proof of concept (2002). Designed to prevent the bulk of invasive cervical cancer, a quadrivalent (HPV 6/11/16/18) and bivalent (HPV 16/18) vaccine have been available since 2006 an...
Article
The MPO system plays an important role in the control of infections and the deletion of malignant cells. Nevertheless, alternations in the MPO system can lead to DNA damage and carcinogenesis. Polymorphisms in the MPO Gene have been associated with an increased expression of MPO and a higher risk for development of cancer. This study evaluates the...
Article
Objective To determine the optimal serum β- hCG cut- off level to predict MTX treatment success in tubal ectopic pregnancy (EP). Study design Data of 240 women, who presented between 2003 and 2011 at the Department of Gynecology and Obstetrics, Medical University of Vienna, with tubal EP and who received MTX as primary treatment, were retrieved fr...
Article
Objective To review our experience with a screening programme that included four sequential cervical length (CL) measurements from 16 to 22 weeks of gestation. Design Historical cohort study. Setting Tertiary-care centre in a university hospital. Population There were 312 singleton pregnancies in 321 women with a previous large loop excision of the...
Article
Full-text available
Background The vaccinations against human papilloma virus (HPV) are highly effective in preventing persistent infection. The level of knowledge about HPV and the consequences of an infection with this virus are low in the general population and in patients who suffer from HPV-associated diseases. We aimed to compare the level of knowledge about HPV...
Article
Objective To evaluate whether the maximum degree of placental invasion (placenta accreta, increta or percreta) can be predicted with ultrasound imaging, using criteria developed in our department. Methods This was a retrospective study of all 232 patients at risk for placental invasion who were part of a routine screening program for placental inva...
Article
To review our experience with a screening programme that included four sequential cervical length (CL) measurements from 16 to 22( ) weeks of gestation. Historical cohort study. Tertiary-care centre in a university hospital. There were 312 singleton pregnancies in 321 women with a previous large loop excision of the transformation zone (LLETZ), and...
Article
Background: Transporter associated with antigen processing (TAP) is responsible for peptide loading onto class I major histocompatibility complex (MHC-I) molecules. TAP seems to facilitate the detection of HPV by MHC-I molecules and contributes to successful eradication of HPV. TAP polymorphisms could have an important impact on the course of HPV...
Article
Objective To review our experience with a screening programme that included four sequential cervical length (CL) measurements from 16 to 22 weeks of gestation. Design Historical cohort study. Setting Tertiary-care centre in a university hospital. Population There were 312 singleton pregnancies in 321 women with a previous large loop excision of the...
Article
Purpose: The extent of conization seems to influence the risk of preterm birth. The aim of this study was to compare the cone volume after surgical resection with large loop excision of the transformation zone (LLETZ) and cold knife conization (CKC). Methods: The present retrospective multi-center study comprises 804 consecutive women, who under...
Article
Abstract We evaluated dehydroepiandrosterone-sulfate (DHEA-S) levels in premature ovarian failure (POF) patients with and without Hashimoto's thyroiditis, and the impact of DHEA supplementation on thyroid autoantibodies. In a retrospective case series, we included 67 women with spontaneous POF who received estrogen/gestagen replacement with or with...
Article
Full-text available
Background Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), a coregulator of the estrogen receptors (ERs) alpha and beta, is a potential proto-oncogene in hormone dependent gynecological malignancies. To better understand the role of PELP1 in epithelial ovarian cancer (EOC), the protein expression and prognostic significance of PELP1 w...
Article
In epithelial ovarian cancer (EOC), literature on the prognostic value of B-cell lymphoma 2 (Bcl-2) is limited and inconsistent. Little is known about the expression patterns and the prognostic value of prosurvival proteins of the Bcl-2-associated athanogene (BAG) family proteins interacting with Bcl-2. The major aim of this study was to further de...
Article
Full-text available
Background Dexmedetomidine is an α-2-receptor agonist which might be used as an additive to local anaesthetics for various regional anaesthetic techniques. We therefore designed this prospective, double-blinded, controlled volunteer study to investigate the effects of dexmedetomidine as an adjuvant to ropivacaine on peripheral nerve block.Methods U...
Article
Fragestellung: Proline- Glutamic acid- and leucine-rich protein (PELP) 1, ist ein bekannter Mediator der Wirkungen der Ostrogen-Rezeptoren und ein potentielles Proto-Onkogen in hormonabhangigen Malignomen. Wir haben die Expressionsmuster und die prognostische Bedeutung von PEPL1 gemeinsam mit den Ostrogen Rezeptoren alpha und beta in Frauen mit Ova...
Article
In pregnant women, circulating alloantibodies, triggered by exposure to paternal HLA antigens, are frequently detectable. The finding of lower alloantibody levels in women who experience spontaneous abortion (miscarriage) has led to the speculation that antipaternal antibodies could favor maintenance of pregnancy, whereas their lack poses a risk of...
Article
Fragestellung: Das klinische Bild von vulvären intraepithelialen Neoplaisen (VIN) als direkten Vorstufen von Vulvakarzinomen ist vielfältig und unspezifisch. Trotz chirurgischer Therapie kann es zu invasiven Vulvakarzinomen kommen. Bis heute gibt es keinen aussagekräftigen Marker, der uns eine Voraussage ermöglicht welche VIN mit höherem Risiko zur...
Article
Fragestellung: Morbus Paget der Vulva ist eine sehr seltene, neoplastische Erkrankung. Chirurgisches Management ist das übliche therapeutische Vorgehen, das jedoch von hohen Rezidivraten gekennzeichnet ist. Ziel unserer Arbeit war eine Zusammenfassung der an unserer Klinik betreuten Patientinnen zu erstellen. Methodik: In einer retrospektive Datena...
Article
Cervical biopsy often causes discomfort and pain. To compare local anesthesia (1% lidocaine) with forced coughing as pain relief, we quantified the actual pain experienced during cervical punch biopsies. For a prospective trial conducted at the Medical University of Vienna, 68 women undergoing cervical punch biopsies for assessment of abnormal cerv...
Article
Fragestellung: Cervical biopsy often causes discomfort and pain. We quantified the actual pain experienced during cervical punch biopsies either under local anesthesia with 1% lidocaine or with forced coughing. Methodik: Sixty-eight consecutive women undergoing cervical punch biopsies for assessment of abnormal cervical smears were randomized in t...