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Sophie Anne Millar

Sophie Anne Millar
European Federation of Pharmaceutical Industries and Associations (EFPIA)

PhD

About

24
Publications
37,173
Reads
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726
Citations
Citations since 2016
21 Research Items
725 Citations
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2016201720182019202020212022050100150200
Introduction
I completed my PhD in Medicine at the University of Nottingham where I studied osteocalcin and cannabis based medicines. I am now working in EU Health Policy and Communications based in Brussels.
Additional affiliations
May 2015 - September 2015
University College Dublin
Position
  • Research Assistant
Description
  • Assessing total habitual beverage consumption in Irish adolescents
Education
September 2011 - May 2015
University College Dublin
Field of study
  • Human Nutrition

Publications

Publications (24)
Article
Full-text available
Cannabidiol (CBD) has substantial therapeutic potential, but its development as an effective drug by the pharmaceutical industry is hindered by intrinsic characteristics such as low bioavailability, low water solubility, and variable pharmacokinetic profiles. Importantly, lack of patentability of the drug substance also limits the likelihood of an...
Article
Full-text available
IntroductionWhile the beneficial effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on cardiovascular and renal outcomes are recognized, their direct effects on endothelial function remain unclear. We, therefore, undertook a systematic review to evaluate the current literature in this area. Methods Electronic databases (PubMed, EMBASE, a...
Article
Full-text available
Osteocalcin (OCN) is a bone-derived protein that is detected within human calcified vascular tissue. Calcification is particularly prevalent in chronic kidney disease (CKD) patients but the role of OCN in calcification, whether active or passive, has not been elucidated. Part 1: The relationship between OCN, CKD and vascular calcification was asses...
Article
Full-text available
The past few decades have been characterised by political endeavours to maximise internet access throughout the European Union, in particular through the development of the digital single market. However, it is being increasingly recognised that the internet, in spite of all its benefits, can also have significant negative effects on individuals an...
Article
Full-text available
Recent research suggests that the future combat against antimicrobial resistance (AMR) may involve probiotic-based approaches. Their use in our microbial ecosystems, including humans, animals and the healthcare environment, may provide a novel approach which deserves exploration
Article
Full-text available
Life expectancy has been projected to continue to rise in industrialised countries, including in Europe, mostly due to increases in people reaching the age of 65 years and older. What if life expectancy in Europe rose further and reached 150 years? This publication approaches the concept of increased life expectancy in terms of increased adult life...
Article
Full-text available
Some human observational studies have suggested an anti‐inflammatory role of osteocalcin (OCN). An inflammatory protocol using interferon‐γ and tumor necrosis factor‐α (10 ng/ml) was employed to examine the acute (24 hr) and chronic (144 hr) effects of uncarboxylated OCN (ucOCN) in commercial, primary, subcultured human aortic endothelial cells (HA...
Article
Full-text available
Bone-derived factors that demonstrate extra-skeletal functions, also termed osteokines, are fast becoming a highly interesting and focused area of cross-disciplinary endocrine research. Osteocalcin (OCN), fibroblast growth factor-23 (FGF23) and lipocalin-2 (LCN-2), produced in bone, comprise an important endocrine system that is finely tuned with o...
Article
Full-text available
Aims: Cannabidiol is a cannabis-derived medicinal product with potential application in a wide-variety of contexts, however its effective dose in different disease states remains unclear. This review aimed to investigate what doses have been applied in clinical populations, in order to understand the active range of cannabidiol in a variety of med...
Article
Full-text available
The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothelial cells (HAECs) and smooth muscle cells (HASMCs) were treated with ucOCN (0.1-50 ng/ml) and change...
Article
Full-text available
Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient. The aim of this review was to collate published data in this area. Methods: A systematic search of PubMed and EMBASE (including MEDLINE...
Article
Full-text available
The euphoric feeling described after running is, at least in part, due to increased circulating endocannabinoids (eCBs). eCBs are lipid signaling molecules involved in reward, appetite, mood, memory and neuroprotection. The aim of this study was to investigate whether activities other than running can increase circulating eCBs. Nine healthy female...
Article
Full-text available
The euphoric feeling described after running is, at least in part, due to increased circulating endocannabinoids. Endocannabinoids are lipid signalling molecules involved in reward, appetite, mood, memory and neuroprotection. The aim of this study was to investigate whether activities other than running can increase circulating endocannabinoids. 9...
Article
Full-text available
The endocannabinoid system (ECS) is involved in many physiological processes including fertility, pain and energy regulation. The aim of this systematic review was to examine the contribution of single nucleotide polymorphisms (SNPs) of the ECS to adiposity and glucose metabolism. Database searches returned 734 articles, of which 65 were included c...
Article
Full-text available
9-Tetrahydrocannabinol (THC) has complex effects on the cardiovascular system. We aimed to systematically review studies of THC and haemodynamic alterations. PubMed, Medline, and EMBASE were searched for relevant studies. Changes in blood pressure (BP), heart rate (HR), and blood flow (BF) were analysed using the Cochrane Review Manager Software. T...
Article
Full-text available
Background Osteocalcin (OC) is an intriguing hormone, concomitantly being the most abundant non-collagenous peptide found in the mineralized matrix of bone, and expanding the endocrine function of the skeleton with far-reaching extra-osseous effects. A new line of enquiry between OC and vascular calcification has emerged in response to observations...
Poster
Full-text available
Abstract: Cardiovascular disease is the number one killer worldwide. Osteocalcin (OCN) is an intriguing, unique hormone having established roles throughout the body emigrating beyond its origin of the bone extra cellular matrix. A new line of enquiry between OCN and vascular calcification has emerged in response to observations that the mechanism o...
Article
Full-text available
Despite cannabidiol (CBD) having numerous cardiovascular effects in vitro, its haemodynamic effects in vivo are unclear. Nonetheless, the clinical use of CBD (Epidiolex) is becoming more widespread. The aim of this systematic review was to establish whether CBD is associated with changes in haemodynamics in vivo. Twenty-five studies that assessed t...
Article
Objective: No up-to-date data on the dietary intake of Irish adolescents are available. The aim of the present pilot study was to obtain and compare cross-sectional information on habitual adolescent beverage consumption between four distinct post-primary schools in the Republic of Ireland, in 2014-2015. Design: A cross-sectional observation stu...
Article
Full-text available
Background: Water-loss dehydration (hypertonic, hyperosmotic, or intracellular dehydration) is due to insufficient fluid intake and is distinct from hypovolemia due to excess fluid losses. Water-loss dehydration is associated with poor health outcomes such as disability and mortality in older people. Urine specific gravity (USG), urine color, and...
Conference Paper
Full-text available
Recent attention from health organisations has highlighted the consumption of sugar sweetened beverages among adolescents, and their impact on health(1,2). Within Ireland, there is a lack of current beverage consumption data among this age group, the most recent data on this cohort being from the National Teens’ Food Survey (NTFS) 2005-2006(3). The...

Questions

Questions (5)
Question
Hi,
I'm looking for a negative control for osteocalcin expression (ELISA, PCR) - but seems to be very widely expressed...
Does anyone know or have tried a tissue or cell line that could be used as a negative control?
Thank you!
Sophie
Question
Ideally with a detection range between 0-100 ng/mL
For use with cell culture with human cell lines
Question
Easy/difficult to transfect?
Any recommendations for companies and products?
Thank you in advance!
Question
Either for WB, IF or ELISA for expression studies
Likewise any recommendations on a good antagonist/inhibitor would be much appreciated...or siRNA?
Thank you

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Projects

Projects (2)
Project
Involving cell culture, wire myography, imaging and protein expression experiments.