Sophie Locke

Sophie Locke
Universitätsklinikum Carl Gustav Carus Dresden · Bereich Nephrologie

MD candidate

About

8
Publications
1,064
Reads
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53
Citations
Additional affiliations
October 2019 - present
Universitätsklinikum Carl Gustav Carus Dresden
Position
  • Student
Description
  • MD candidate
Education
September 2014 - November 2021
Technische Universität Dresden
Field of study
  • Human medicine

Publications

Publications (8)
Article
Currently, we are experiencing a true pandemic of a communicable disease by the virus SARS-CoV-2 holding the whole world firmly in its grasp. Amazingly and unfortunately, this virus uses a metabolic and endocrine pathway via ACE2 to enter our cells causing damage and disease. Our international research training programme funded by the German Resear...
Article
Kidney transplantation has become a lifesaver for patients worldwide. The major organ sources are brain dead donors (BDD). Accumulating evidence suggests that brain death contributes to an impairment of renal function and to nephron loss by acute tubular necrosis (ATN). Together with the surgical procedure, this inevitably results in acute kidney i...
Article
Full-text available
Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma membrane rupture of cells in a specific section of a nephron, referred to as acute tubular necrosis (ATN). Whereas the involvement of necroptosis is well characterized, genetic evidence supporting the contribution of ferroptosis is lacking. Here, we demonstrate that...
Article
Full-text available
Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as acute kidney injury, myocardial infarction, and stroke, all of which are triggered by glutathion...
Article
Full-text available
Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to acute kidney injury (AKI), but the role of pyroptosis is unclear. Pyroptosis is mediated by the pore-forming protein gasdermin D (GSDMD). Here, we report a specific pattern of GSDMD-protein expression in the peritubular compartment of mice that underwent bi...
Preprint
Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis contribute to acute kidney injury (AKI), but the role of pyroptosis is unclear. Pyroptosis is mediated by the pore-forming protein gasdermin D (GSDMD). Here, we report a specific pattern of GSDMD-protein expression in the peritubular compartment of mice that underwent bil...
Article
Diabetic nephropathy is the most common condition that requires a chronic renal replacement therapy, such as haemodialysis, peritoneal dialysis, kidney transplantation or simultaneous kidney-pancreas transplantation. Chronic kidney disease progression, that is the loss of nephrons which causes the continuous decline of the eGFR, underlies the patho...
Article
Full-text available
The cytosolic protein rubicon (RUBCN) has been implicated in the removal of necrotic debris and autoimmunity. However, the role of RUBCN in models of acute kidney injury (AKI), a condition that typically involves necrotic kidney tubules, was not investigated. Here, we demonstrate that RUBCN-deficient mice are hypersensitive to renal damage induced...

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