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Introduction
Additional affiliations
January 2008 - December 2015
Position
- Research Assistant
Publications
Publications (61)
Question
Dyspnoea persisting despite treatments of underlying causes requires symptomatic approaches. Medical hypnosis could provide relief without the untoward effects of pharmacological approaches. We addressed this question through experimentally induced dyspnoea in healthy humans (inspiratory threshold loading –excessive inspiratory effort– and...
Background
Dyspnea conveys an upsetting or distressing experience of breathing awareness. It heavily weighs on chronic respiratory disease patients, particularly when it persists despite maximal treatment of causative abnormalities. The physical, psychological and social impacts of persistent dyspnea are ill-appreciated by others. This invisibility...
Question
Human PHOX2B mutations result in life-threatening sleep-related hypoventilation (congenital central hypoventilation syndrome, CCHS). Most patients retain ventilatory activity when awake through a respiratory-related cortical network. We hypothesised that this need to mobilise cortical resources to breathe would lead to breathing-cognition...
Background
Dyspnea is a frightening and debilitating experience. It attracts less attention than pain (‘dyspnea invisibility’), possibly because of its non-universal nature. We tested the impact of self-induced experimental dyspnea on medical residents.
Materials and Methods
During a teaching session following the principles of experiential learni...
Background
More than a symptom, dyspnoea is an existential experience shaping the lives of those afflicted, particularly when its persistence despite maximal pathophysiological treatments makes it pervasive. It is, however, insufficiently appreciated by concerned people themselves, family members, healthcare professionals and the public (dyspnoea i...
To our knowledge, this is the first study exploring the interferences between inspiratory loading and cognition in healthy subjects with the concomitant use of neuropsychological tests and electroencephalographic recordings. Inspiratory loading was associated with dyspnea, respiratory-related changes in brain activation, and a pattern of deteriorat...
Question addressed:
In contrast with pain, dyspnoea is not visible to the general public who lack the corresponding experiential baggage. We tested the hypotheses that the generalised use of face masks to fight SARS-CoV2 dissemination could change this and sensitise people to respiratory health.
Methods:
General population polling (1012-person p...
Background
Chronic Obstructive Pulmonary Disease (COPD) is one of the top 10 causes of death worldwide, representing a major public health problem. Researchers have been looking for new technologies and methods for patient monitoring with the intention of an early identification of acute exacerbation events. Many of these works have been focusing i...
The objective of this study was to test the capacity of vibrotactile stimulation transmitted to the wrist bones by a vibrating wristband to awaken healthy individuals and patients requiring home mechanical ventilation during sleep. Healthy subjects (n = 20) and patients with central hypoventilation (CH) (Congenital Central Hypoventilation syndrome...
Background
Poor sleep is common in intensive care unit (ICU) patients, where environmental factors contribute to reduce and fragment sleep. The objective of this study was to evaluate the impact of earplugs and eye mask on sleep architecture in ICU patients.
Methods
A single-center randomized controlled trial of 64 ICU patients was conducted from...
Les interventions basées sur la pleine conscience (MBI: Mindfulness Based Interventions) ont récemment fait leur apparition en médecine occidentale. L’efficacité de ces programmes a été démontrée en ce qui concerne la régulation émotionnelle et le déploiement des ressources cognitives, notamment de l’attention. Malgré l’intérêt potentiel des MBI su...
Table of contents:
PHYSICIANS ABSTRACTSO1 Impact of tracheal cuff shape on microaspiration of gastric contents in intubated critically ill patients: a multicenter randomized controlled study (BEST CUFF)Emmanuelle Jaillette, Christophe Girault, Guillaume Brunin, Farid Zerimech, Arnaud Chiche, Céline Broucqsault-Dedrie, Cyril Fayolle, Franck Minacor...
Objectif
Analyse descriptive entre les patients narcoleptiques diagnostiques avant et apres 18 ans.
Methodes
Les donnees ont ete extraites du programme national de recherche multicentrique francaise sur la narcolepsie (PHRC AOM07-138, etude NarcoBANK) et 23 patients pediatriques du centre de Lyon ont ete ajoutes a cette base de donnees. Les caracte...
Objectif
Le syndrome de Kleine-Levin (KLS) est caractérisé par des épisodes récurrents d’hypersomnie avec troubles cognitifs et comportementaux chez l’adolescent. Sa cause est inconnue. Comme plus de 10 familles multiplex ont été rapportées dans le monde, nous avons comparé les cas familiaux et sporadiques.
Méthodes
Les cas familiaux ont été ident...
Sleep is deeply altered in mechanically ventilated ICU patients. The mechanisms responsible for altered sleep include the presence of an endotracheal tube, patientventilator asynchronies, caregiving activities, environmental noise and light, and severity of illness.
Since sleep deprivation is a risk factor for neurologic and physical complications,...
Objective:
To compare the benefits and risks of lithium therapy vs abstention/other treatments in Kleine-Levin syndrome (KLS).
Methods:
In a KLS cohort followed in a single center, 130 patients regularly took lithium carbonate (median dose 1,000 mg/day; n = 71; 40 children), valproate (n = 5), contraceptive pill (n = 5), or no treatment (n = 49)...
Objective:
In Kleine-Levin syndrome (KLS), episodes of hypersomnia, cognitive, and behavioral disturbances alternate with asymptomatic periods. Because 50% of patients report decreased academic performances, we evaluated their cognitive status during asymptomatic periods, determinants of deficits, and changes during follow-up.
Settings:
KLS nati...
To evaluate the frequency, severity, and associations of symptoms of attention-deficit/hyperactivity disorder (ADHD) in children with narcolepsy with and without cataplexy.
Cross-sectional survey.
Four French national reference centers for narcolepsy.
One hundred eight consecutively referred children aged younger than 18 y with narcolepsy, with (Nw...
Objectif
Le syndrome de Kleine-Levin (KLS) est une maladie du sujet jeune constituée par des épisodes répétés d’une à plusieurs semaines avec une hypersomnie récurrente et des troubles cognitivo-comportementaux, alternant avec des périodes sans symptômes. La maladie est considérée comme bénigne. Nous voulons évaluer les troubles cognitifs en périod...
Type 1 narcolepsy, a disorder caused by a lack of hypocretin (orexin), is so strongly associated with human leukocyte antigen (HLA) class II HLA-DQA1(∗)01:02-DQB1(∗)06:02 (DQ0602) that very few non-DQ0602 cases have been reported. A known triggering factor for narcolepsy is pandemic 2009 influenza H1N1, suggesting autoimmunity triggered by upper-ai...
Objective
Kleine-Levin syndrome is a rare disease characterized by recurrent episodes of hypersomnia with behavioral and cognitive disturbances. We aimed at describing the diagnosis procedure, risk factors, and severe forms.Methods
In consecutive patients referred for suspected Kleine-Levin syndrome, we detailed differential diagnoses, and atypical...
Aims: To evaluate the health-related quality of life (HRQL) and its correlates in children and adolescents with narcolepsy. Methods: We compared the clinical characteristics of control subjects and patients with primary narcolepsy from data collected at the National Reference Centers for Narcolepsy. Results: The cohort included 69 control subjects...
Aims:
To evaluate the health-related quality of life (HRQL) and its correlates in children and adolescents with narcolepsy.
Methods:
We compared the clinical characteristics of control subjects and patients with primary narcolepsy from data collected at the National Reference Centers for Narcolepsy.
Results:
The cohort included 69 control subj...
Kleine-Levin syndrome is characterized by relapsing-remitting episodes of severe hypersomnia, cognitive impairment, apathy, derealization and behavioural disturbances. Between episodes, patients have normal sleep, mood and behaviour. Functional imaging studies performed in small series of patients with Kleine-Levin syndrome with visual or semi-quan...
Objectives: We aimed to evaluate depressive feelings and their correlations in children and adolescents with narcolepsy collected in national reference centers for narcolepsy. Methods: We compared clinical and sleep characteristics of patients with and without depressive symptoms evaluated on the Children's Depression Inventory (CDI). Results: Our...
An increased incidence of narcolepsy in children was detected in Scandinavian countries where pandemic H1N1 influenza ASO3-adjuvanted vaccine was used. A campaign of vaccination against pandemic H1N1 influenza was implemented in France using both ASO3-adjuvanted and non-adjuvanted vaccines. As part of a study considering all-type narcolepsy, we inv...
Aims:
To evaluate the impact of obesity on clinical and sleep characteristics in a population of narcoleptic children.
Methods:
Data from the children diagnosed with idiopathic narcolepsy in the National Reference Centers for Narcolepsy were collected between 2008 and 2011. Clinical and electrophysiological characteristics were compared between...
The benefit/risk ratio of modafinil was recently re-evaluated by the European Medicines Agency and was shown to be negative for idiopathic hypersomnia (IH) because of insufficient data.
To evaluate the benefit/risk ratio of modafinil in idiopathic hypersomnia (with and without long sleep time) vs. narcolepsy/cataplexy.
The benefit (Epworth sleepine...
Narcolepsy and Parkinson's disease (PD) are associated with hallucinations, excessive daytime sleepiness, REM sleep behavior disorder (RBD), as well as complete (narcolepsy with cataplexy) vs. partial (PD, narcolepsy without cataplexy) hypocretin-1 deficiency.
To compare the hallucinations associated with narcolepsy to those of PD.
One hundred pati...
Our purpose of this study was to investigate whether clinical rapid eye movement sleep behavior disorder (RBD) is indicative of more widespread degenerative changes in Parkinson's disease (PD), using a longitudinal cohort. In 2005 and 2007, we prospectively collected clinical and treatment characteristics of 61 consecutive patients with PD. The pre...
Camptocormia (a flexion of the trunk that only appears when standing or walking) affects a minority of patients with Parkinson's disease (PD). As it responds poorly to levodopa and is associated with reduced midbrain and pons volume, it may result from non-dopaminergic, brainstem lesions. As several sleep abnormalities in PD also result from non-do...
To document unusual, nonviolent behaviors during REM sleep behavior disorder (RBD) and evaluate their frequency in Parkinson disease (PD).
Most behaviors previously described during RBD mimic attacks, suggesting they proceed from archaic defense generators in the brainstem. Feeding, drinking, sexual behaviors, urination, and defecation have not bee...
