Sophie Antoine-Jonville

Sophie Antoine-Jonville
Université d´Avignon et des Pays du Vaucluse | UAPV · Département Sciences et Techniques des Activités Physiques et Sportives

About

78
Publications
16,549
Reads
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1,136
Citations
Additional affiliations
February 2011 - August 2011
University of Toronto
September 2003 - present
Université des Antilles et de la Guyane
September 2003 - present
Université des Antilles et de la Guyane
Position
  • Professor (Assistant)
Education
October 1999 - August 2002
Université de Poitiers
Field of study
  • Exercise physiology - Sports Sciences

Publications

Publications (78)
Article
Full-text available
Purpose Sickle cell trait is characterized by the presence of both normal and abnormal haemoglobin in red blood cells. The rate of exertional collapse is increased in athletes and military recruits who carry the trait, particularly in stressful environmental conditions. The aim of the present study was to investigate microvascular function and its...
Article
Aim The study investigated changes in microvascular perfusion during post-exercise recovery in those with type 2 diabetes, with or without peripheral neuropathy, as well as in healthy controls and those with obesity. Methods Skin blood perfusion was assessed in each group using laser doppler flowmetry and laser speckle contrast imaging before and...
Article
Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): European Commission, Region Guadeloupe Background. Sickle cell trait (SCT) is an inherited red blood cell condition without medical consequence in most cases. However, its strong association with increased risk of exercise-induced sudden death (i...
Article
Inflammation and oxidative stress play a key role in the pathophysiology of sickle cell disease (SCD). However, the potential influence of different sickle genotypes, or hydroxyurea (HU) treatment on these factors remains poorly documented. The present study compared several plasma markers of inflammation and oxidative stress, as well as microvascu...
Article
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Physical activity during pregnancy has many health benefits. However, the physical activity level is insufficient throughout pregnancy and women report perceived barriers to physical activity. This study assessed the impact of a counseling intervention offered in addition to routine pregnancy care on physical activity patterns, perceived barriers,...
Article
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Chronic hemolysis, enhanced oxidative stress and decreased nitric oxide (NO) bioavailability promote vasculopathy in sickle cell anemia (SCA). Oxidative stress and NO are known to modulate eryptosis in healthy red blood cells (RBCs), however their role in SCA eryptosis and their impact on the genesis of RBC-derived microparticles (RBC-MPs) remains...
Preprint
Full-text available
Background: Pregnant women declare perceived barriers to physical activity. Although physical activity is not often dispensed, effective counseling by health professionals is recommended. Health professionals training has been proposed as a target to improve physical activity effective counseling. The objective was to evaluate the physical activity...
Article
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Background and objective Warm exposure places high demands on thermoregulation mechanisms, which depend on the effectiveness of the microvascular function. The associations between the microcirculation and metabolism in warm environments have received little attention. The purpose of this study was to explore skin blood flow (SkBF) in response to f...
Article
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Blood viscosity is an important determinant of local flow characteristics, which exhibits shear thinning behavior: it decreases exponentially with increasing shear rates. Both hematocrit and plasma viscosity influence blood viscosity. The shear thinning property of blood is mainly attributed to red blood cell (RBC) rheological properties. RBC aggre...
Article
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Objective: Hot environments are associated with impaired glucose metabolism at rest in healthy humans. The purpose of this study was to explore the contribution of key glucoregulatory hormones and biomarkers to this altered glucose tolerance. Methods: The effects of ambient temperature on glucose tolerance and its determinants were assessed with a...
Article
Objectives: To investigate the associations between several sickle cell disease genetic modifiers (beta-globin haplotypes, alpha-thalassemia, and glucose-6-phosphate dehydrogenase deficiency) and the level of oxidative stress and to evaluate the association between oxidative stress and the rates of vaso-occlusive events. Study design: Steady-sta...
Article
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The objective is to present the case of a 21-yr-old athlete observed with non-physiological immediate postprandial insulin response (1162 pmol/l; normal glucose excursion: 6.6 mmol/l), in a warm environment. No suspicion or evidence of any underlying pathology was found in this well-trained Afro-Caribbean male runner. He never reported any hypoglyc...
Article
Objectives: The aim of this study was (1) to investigate the associations between several sickle cell disease genetic modifiers (beta-haplotypes, alpha-thalassemia and glucose-6-phosphate-deshydrogenase (G6PD) deficiency) and the level of oxidative stress and (2) to evaluate the association between oxidative stress and the rates of vaso-occlusive (...
Article
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We evaluated anthropometric characteristics and physical fitness in 556 Melanesian adolescents from rural and urban New Caledonia to build health education programs focused on physical activity. In 2013, body weight, height, skinfold thickness, lean body mass (LBM), percentage fat body mass (%FBM), physical fitness (power, agility, speed, maximal a...
Article
The aim of the present study was to test the effects of hydroxyurea (HU) therapy on clinical, hematological and hemorheological parameters in adult patients with sickle cell anemia (SCA). Hematological and hemorheological parameters were measured in 28 SCA patients before HU therapy (i.e., baseline) and at 6, 12 and 24 months of treatment. RBC defo...
Article
Full-text available
Understanding the regulation of human food intake in response to an acute exercise session is of importance for interventions with athletes and soldiers, as well as overweight individuals. However, the influence of hot and cold environments on this crucial function for the regulation of body mass and motor performance has not been summarized. The p...
Article
The present study investigated cerebral and muscle hemoglobin oxygen saturation (tissue oxygen index, TOI) in children with sickle cell anemia (SS), sickle cell hemoglobin C disease (SC) and healthy children (AA). TOI was measured by near-infrared spectroscopy (NIRS) and spectral analysis of the TOI variability was used to assess flowmotion and vas...
Article
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The present study investigated cerebral and muscle hemoglobin oxygen saturation (tissue oxygen index, TOI) in children with sickle cell anemia (SS), sickle cell hemoglobin C disease (SC) and healthy children (AA). TOI was measured by near-infrared spectroscopy (NIRS) and spectral analysis of the TOI variability was used to assess flowmotion and vas...
Article
Full-text available
Oxidative stress and haemolysis-associated nitric oxide (NO) depletion plays a crucial role in the development of vasculopathy in sickle cell anaemia (SS). However it remains unknown whether oxidative stress and haemolysis levels influence vascular function in patients with sickle haemoglobin C disease (SC). In this context microvascular response t...
Article
Full-text available
It is unclear whether vascular function, in micro- and macrocirculation, is affected similarly in children with sickle cell anaemia (SS) and children with sickle haemoglobin C (SC) disease. Therefore, we compared micro and macrovascular functions in healthy (AA) children, children with SS and SC disease. Moreover, given that physical activity is kn...
Article
p class="Pa7"> Objective: Thrifty genotypes may predis­pose to type 2 diabetes and body fat (%BF) excess through a differentiated relationship between physical activity and body fat. We explored this hypothesis in Asian Indians, a population thought to be thrifty. Methods: Three hundred and nine Guade­loupian adolescents responded to the modi­fiabl...
Article
A high demand on thermoregulatory processes may challenge homeostasis, particularly regarding glucose regulation. This has been understudied, although it might concern millions of humans. The objective of this project was to examine the isolated and combined effects of experimental short-term mild heat exposure and metabolic level on glycoregulatio...
Article
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Background : Strategies for physical education (PE) classes in tropical climate are nee- ded to optimize health outcomes. We hypothesized that ergonomic strategies using free hydration during PE would positively impact the physical activity and well-being of chil- dren. Methods : Forty-eight 13- to 15-year-old students participated in two randomize...
Article
For physical activity promotion to be effective from a public health view, adequate communication between the different actors is required. In this perspective, we propose to explicit the bioenergetic notions used to quantify and qualify intensity of physical activities, physical activity and sedentary behaviors, and lifestyles. Public health recom...
Article
Autonomic nervous system (ANS) activity has been suggested to modulate the clinical severity of sickle cell anemia (SCA) by increasing the risk for vaso-occlusive events. Regular physical activity (PA) is known to improve ANS activity and health status in several cardiovascular and metabolic diseases. Whether regular PA improves the health status o...
Article
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Background: The acute relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake (FI) has not been defined. Objective: To determine acute relationships between RER, modified by exercise and a glucose load, and FI and net energy balance (NEB) in physically active normal-weight boys and men. Methods: In a...
Article
Human red blood cells (RBC) express an active and functional endothelial-like nitric oxide (NO) synthase (RBC-NOS). We report studies on RBC-NOS activity in sickle cell anemia (SCA), a genetic disease characterized by decreased RBC deformability and vascular dysfunction. Total RBC-NOS content was not significantly different in SCA patients compared...
Article
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Aims The clinical syndrome of heart failure includes exercise limitation that is not directly linked to measures of cardiac function. Quadriceps fatigability may be an important component of this and this may arise from peripheral or central factors. Methods and results We studied 10 men with CHF and 10 healthy age-matched controls. Compared with...
Article
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The aim was to compare the relationship between body composition and body size in two subgroups with different metabolic risk. Body-mass index z-scores (BMIZ), bicipital, tricipital, subscapular and iliac thicknesses were determined in 178 India-originating Guadeloupian (IOG) adolescents and 481 controls of other origins. Various equations were tes...
Article
L’école contribue à la construction des habitudes alimentaires des enfants. En Guadeloupe, malgré une progression des prévalences du surpoids infantile : 18 % (étude Calbas, ORSaG 2005), 22,9 % (étude Podium, AGRUM 2010) et du diabète : 7,3 à 8,1 % (INVS, 2007–09), la collation de 10 heures subsiste. Visant un retour à l’équilibre de l’apport énerg...
Article
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The use of nutritional supplements among exercisers in gyms has been never investigated in the Middle East. The aim of the current study was to assess the prevalence intake of nutritional supplements and the potential influencing factors among people exercising in gyms in Beirut city. In this cross-sectional study, 512 exercisers, aged between 20 a...
Article
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The authors investigated the anthropometric and physiological characteristics of young Guadeloupian competitive swimmers in relation to swimming performance and compared the abilities of these children with those of the young white swimmers reported in the literature. All 2004 competitive swimmers between 10 and 14 y old (126 children, 61 boys and...
Article
The oxygen uptake efficiency slope (OUES) is a promising submaximal index of exercise capacity, but its relationships to other indices characterizing physical fitness and ventilatory efficiency have not been widely investigated in heart failure. Sixty-three male patients with stable chronic heart failure performed a symptom-limited maximal exercise...
Article
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A reliable submaximal test for assessing cardiorespiratory function would be of interest in clinical practice. Baba et al. (1996) proposed the oxygen uptake efficiency slope (OUES) derived from the relation between oxygen uptake ( and minute ventilation during incremental exercise. We evaluated the validity of OUES by comparing maximal oxygen uptak...
Article
The Tropical climate imposes a high level of physiological stress, which could modify the target heart rate in training load prescription, as the recommendations are often determined by maximal oxygen uptake testing in temperature-neutral laboratories. To test this hypothesis, 7 high-level cyclists performed two randomised maximal tests in neutral...
Article
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The aim was to examine the relationship between physical activity pattern and dietary profile. Although some clustering of the variables related to these major determinants of cardiovascular risk has been demonstrated, they have not been extensively studied together. PARTICIPANTS, DESIGN, AND SETTING: Two hundred two female university students from...
Chapter
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Maximal oxygen uptake (VO2max) measured during a standardized incremental maximal exercise test is the most widely used parameter for assessing aerobic fitness. However, patients with poor motivation, cardiorespiratory disease (chronic heart failure (CHF) or chronic obstructive pulmonary disease) and children are often unable to achieve maximal exe...
Article
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The present study aimed at comparing the anthropometric profile of Asian Indian adolescents from Guadeloupe with that of their island counterparts. A total of 720 voluntary 11- to 17-year-old students participated: 180 Asian Indians and 540 age- and sex-matched students of other origin. Weight and height were measured to calculate the BMI. Waist an...
Article
Obesity is the source of many health problems in Guadeloupe. The aim of this study was to describe the relationships between daily energy intake and expenditure, and weight status. Three consecutive daily recalls for activities and food intake were used to assess energy expenditure and energy intake in 20- to 60-year-old Guadeloupian men and women....
Article
Full-text available
Aerobic performance is dependent on both cardio-respiratory and peripheral factors with hemodynamic parameters playing a major role. However, whether blood rheology might affect aerobic performance through an effect on hemodynamic factors is not known. The aim of the present study was to assess the relationships between hemodynamic, hemorheological...
Article
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To compare the levels of leisure-time physical activity (LTPA) of Guadeloupeans originating and not originating from India. Two hundred and sixty of 10-18-year-old Guadeloupeans originating from India (Asian Indians) matched on sex and age with 520 Guadeloupeans not originating from India (Controls) participated in the present study. The participan...
Article
We assessed the ability of the oxygen uptake efficiency slope, whether calculated on 100 and 80% of maximal exercise test duration (OUES(100) and OUES(80)), to identify the change in cardiorespiratory capacities in response to hypoxia in subjects with a broad range of V(O2 peak). Four maximal exercise tests were performed in trained (T) and untrain...
Article
The status of ethnic minority has been reported to be associated with a tendency toward sedentary behavior. The Guadeloupean population is composed of Afro-Caribbeans and an Asian Indian minority. This study examined the association of ethnicity and physical activity on the island. Energy expenditures (EE), energy intakes (EI), and macronutrient in...
Article
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This study investigated the cardioventilatory responses during heavy exercise in sickle cell trait carriers (SCTc) and subjects with normal hemoglobin (control group). Eight SCTc and six control subjects repeated three incremental exercise tests (Iet) separated by 10-min recoveries. Cardioventilatory parameters were analyzed at rest and during the...
Article
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This study investigated 1) whether ventilatory and lactic thresholds (VT and LT, respectively) are different in sickle cell trait carriers (SCTc) and subjects with normal hemoglobin (control group), and 2) whether the first LT and VT and the second LT and VT are respectively coincident in the two populations. Seven SCTc and 8 control subjects perfo...
Article
Whole body exercise is followed by a depression of the diaphragm motor evoked potential (MEP). It is unknown whether the change is due to diaphragm activity or whole body exercise. To test the hypothesis that exercise-induced MEP depression was related to diaphragm activity, we performed two experiments. The first examined the effect of whole body...
Article
Full-text available
The tropical climate imposes a high level of physiological stress during exercise. As a result of this stress, adaptations may be induced and could benefit athletes upon return to a neutral climate. To test this hypothesis, climate effects on swimming performance were assessed in 16 swimmers: 6 trained for 8 days in a tropical climate, 6 trained fo...
Article
Reduced diaphragm contractility occurs in some healthy subjects when they exercise to exhaustion. This indicates low frequency fatigue, which may contribute to task failure. We hypothesised that patients with congestive heart failure (CHF) might be especially vulnerable to the development of low frequency diaphragm fatigue after exhaustive exercise...
Article
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Interchangeability between fast Fourier transform (FFT) and autoregressive (AR) analysis was assessed on series of 256 R-R intervals recorded in 56 seated subjects and in 15 men performing an orthostatic test. Low- (LF) and high-frequency (HF) components were calculated and expressed both in absolute (square milliseconds) and normalized units (NU)....
Article
The costal and crural parts of the diaphragm differ in their embryological development and physiological function. It is not known if this is reflected in differences in their motor cortical representation. We compared the response of the costal and crural diaphragms using varying intensities of transcranial magnetic stimulation of the motor cortex...
Article
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The present investigation was intended to assess the consequences of an inspiratory load on the diaphragm central component of fatigue during exercise. We recorded the motor potential evoked (MEP) by transcranial magnetic stimulation of the motor cortex in 10 subjects. The diaphragm and rectus femoris were studied before and 10, 20, and 40 min afte...