Sophia Sui

Sophia Sui
Deakin University · School of Medicine

PhD

About

39
Publications
4,404
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260
Citations
Citations since 2016
39 Research Items
260 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Introduction
Sophia Sui has been awarded an Executive Dean Health Research Fellowship, and currently works as a Postdoctoral Research Fellow at the IMPACT Institute, the School of Medicine, Deakin University. Sophia's current research focus on the project “skeletal muscle indicators and pathological pathways in cognitive frailty: opportunities for delaying dementia.”

Publications

Publications (39)
Article
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Background We aimed to compare prevalence estimates for sarcopenia in an Australian sample of older men and women by using different criteria. Methods Women (n = 323) and men (n = 342) aged 60-96 years from the Geelong Osteoporosis Study were included. Hand-grip strength (HGS) was measured by dynamometer (Jamar or Vernier) and appendicular lean mas...
Article
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We aimed to examine muscle strength, function and mass in relation to cognition in older men. This cross-sectional data-set included 292 men aged ≥60 yr. Handgrip strength (kg) was measured by dynamometry, gait speed by 4-metre walk (m/s) and appendicular lean mass (kg) by dual-energy x-ray absorptiometry. Cognition was assessed across four domains...
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Background: Low handgrip strength (HGS) is a measure of poor skeletal muscle performance and a marker of ill health and frailty. Muscle quality (MQ) is a measure of muscle strength relative to muscle mass. We aimed to develop normative data for HGS and MQ, report age-related prevalence of low HGS and MQ, and determine the relationship with age, an...
Article
Recommendations from the FNIH Sarcopenia Project are that appendicular lean mass (ALM, kg) adjusted for body mass index (BMI, kg/m²) be used for identifying low lean mass, with ALM/BMI cutpoints of < 0.789 m² for men and < 0.512 m² for women. We report normative ALM/BMI values for Australian adults, and compare the performance of cutpoints derived...
Article
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Background: Sarcopenic obesity refers to age-related loss of skeletal muscle mass and function, in the face of obesity. We aimed to examine the association of falls with sarcopenic obesity and its components, among elderly individuals in the population.Methods: Participants were 353 men and 245 women aged 65-98 yr of the Geelong Osteoporosis Study....
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Poor motor function or physical performance is a predictor of cognitive decline. Additionally, slow gait speed is associated with poor cognitive performance, with gait disturbances being a risk factor for dementia. Parallel declines in muscular and cognitive performance (resulting in cognitive frailty) might be driven primarily by muscle deteriorat...
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Purpose of Review Cognitive impairment is associated with obesity, sarcopenia, and osteoporosis. However, no critical appraisal of the literature on the relationship between musculoskeletal deficits and cognitive impairment, focusing on the epidemiological evidence and biological mechanisms, has been published to date. Herein, we critically evaluat...
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This paper finds that Pyongyang's nuclear issue is by no means China's "primary contradiction (top priority)" in its international relations. Chinese priority on the Korean peninsula is to keep stability and the status quo of a divided Korea rather than rush to find a resolution to the nuclear issue, which may result in a military imbalance on the...
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Accumulation of fat in the liver and skeletal muscle is associated with obesity and poor health outcomes. Liver steatosis is a characteristic of non-alcoholic fatty liver disease (NAFLD) and myosteatosis, of poor muscle quality in sarcopenia. In this study of 403 men (33–96 years), we investigated associations between the fatty liver index (FLI) an...
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We aimed to examine associations between skeletal muscle deficits and indices of poor health. Cut-points for skeletal muscle deficits were derived using data from the Geelong Osteoporosis Study and definitions from the revised European Consensus on Definition and Diagnosis and the Foundation for the National Institutes of Health. Participants (n =...
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China's FTA strategy and its efforts in economic regionalism in the Pacific region are providing new impetus to deepening economic interdependence with its partners and domestic reform to sustain the country's economic growth. The FTAs in the Pacific region provide China and its economic partners with convenient access to their mutual markets, inve...
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China's vigorous involvement in the Pacific Island countries (PICs) is often surmised by scholars of international relations (Wesley-Smith 1; Pryke 2) to be primarily motivated by geopolitical calculations. This paper argues that China's increasing presence in the Pacific Islands indeed helps China create a "sphere of influence," but such geopoliti...
Article
Peripheral quantitative computed tomography (pQCT) assesses bone quantity and quality, complementary to current standard practice, and has potential to improve prediction of fracture risk. This study explored whether pQCT parameters were associated with prior fracture in men and found a number of parameters to be associated, particularly at the rad...
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Background Musculoskeletal conditions and physical frailty have overlapping constructs. We aimed to quantify individual contributions of musculoskeletal factors to frailty. Methods Participants included 347 men and 360 women aged ≥60 yr (median ages; 70.8 (66.1–78.6) and 71.0 (65.2–77.5), respectively) from the Geelong Osteoporosis Study. Frailty...
Article
Background Bone material strength index (BMSi) is measured in vivo using impact microindentation (IMI). However, the associations between BMSi and other bone measures are not clear. This study investigated whether bone parameters derived by peripheral quantitative computed tomography (pQCT) are associated with BMSi. Methods Participants were men (...
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Background Peripheral quantitative computed tomography (pQCT) can provide information complementary to dual x-ray absorptiometry (DXA), however, there is sparse normative data to enable meaningful clinical interpretation and comparison. This study aimed to develop age-stratified normative data for pQCT-derived bone parameters in Australian men. Me...
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Background Originally, sarcopenia meant 'poverty of flesh', but recent operational definitions have brought poor muscle function to the fore. None has considered psychological well-being. We compared muscle function components of the European Working Group on Sarcopenia in Older People Version 2 (EWGSOP2), the Foundation for the National Institutes...
Article
Background Originally, sarcopenia meant 'poverty of flesh', but recent operational definitions have brought poor muscle function to the fore. None has considered psychological well-being. We compared muscle function components of the European Working Group on Sarcopenia in Older People Version 2 (EWGSOP2), the Foundation for the National Institutes...
Article
Background : Sarcopenia-related declines appear to be adversely associated with cognition in the elderly. Poor muscle quality is a marker for sarcopenia, yet little research has examined the concurrence of poor muscle quality and poor cognition. The aim of this study was to investigate the association between muscle quality and cognitive function,...
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Stroke is a leading cause of death and disability and is responsible for a significant economic burden. Sarcopenia and cognitive dysfunction are common consequences of stroke, but there is less awareness of the concurrency of these conditions. In addition, few reviews are available to guide clinicians and researchers on how to approach sarcopenia a...
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We aimed to investigate cross-sectional associations between skeletal muscle density, a proxy measure for fatty infiltration into muscle, and cognition. Contributions from body fat mass, systemic inflammation and lifestyle were explored, as these factors have been identified in both muscle and cognitive deterioration. For 281 men (60–95year) from...
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Background: Prevalence estimates for sarcopenia vary depending on the ascertainment criteria and thresholds applied. We aimed to estimate the prevalence of sarcopenia using two international definitions but employing Australian population-specific cut-points. Methods: Participants (n = 665; 323 women) aged 60-96 years old were from the Geelong O...
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Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeletal muscle and neurocognition are poorly understood. We examined the cross-sectional relationship between lower limb muscle strength and global cognitive function. Participants were 127 women aged 51–87 years, from the Gee...
Article
Citation: Pasco, J.A.; Stuart, A.L.; Sui, S.X.; Holloway-Kew, K.L.; Hyde, N.K.; Tembo, M.C.; Rufus-Membere, P.; Kotowicz, M.A.; Williams, L.J. Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women.
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Sarcopenia is the loss of skeletal muscle mass and function with advancing age. It involves both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and reduced neurological drive. Cognitive decline refers to diminished or impaired mental and/or intellectual functioning. Contracting skeletal muscle is a major source...
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Dementia comprises a wide range of progressive and acquired neurocognitive disorders. Obesity, defined as excessive body fat tissue, is a common health issue worldwide and a risk factor for dementia. The adverse effects of obesity on the brain and the central nervous system have been the subject of considerable research. The aim of this review is t...
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Frailty, a clinical syndrome characterized by multisystem dysregulation, has been associated with high levels of oxidative stress. We investigated the association between serum total antioxidant capacity (TAC) and frailty in older men. This cross-sectional study included 581 men (age 60–90 years) enrolled in the Geelong Osteoporosis Study. Frailty...
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Over the post–Cold War era, China and Russia have been committed to creating a strategic partnership in an attempt to contain the US hegemony and bring the world a new international order. As a part of this partnership and their efforts in achieving the above goals, these two states have increasingly intensified their military cooperation over the...
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Few studies have investigated the prevalence of frailty in the Australian general population. This study determined the prevalence of frailty in a population-based sample of older adults and examined the relationship between frailty and comorbid conditions. Men (n = 347) and women (n = 360) aged ≥ 60 year from the Geelong Osteoporosis Study (GOS) w...
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Obesity is characterised by excessive body fat and is associated with several detrimental health conditions, including cardiovascular disease and diabetes. There is some evidence that people who are obese have structural and functional brain alterations and cognitive deficits. It may be that these neurophysiological and behavioural consequences are...
Article
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Background: Frailty is characterised by age-related declines in physical, psychological and social functioning. Features of frailty overlap with risk factors for fragility fractures. The aim of this study was to investigate the association between the fracture risk assessment tool (FRAX®) and frailty. Methods: In cross-sectional analysis, frailt...
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Background: The extent of muscle deterioration associated with ageing or disease can be quantified by comparison with appropriate reference data. The objective of this study is to present normative data for lower-limb muscle strength and quality for 573 males and 923 females aged 20-97 yr participating in the Geelong Osteoporosis Study in southeas...
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Background: What happens in the early-elderly ‘pretiree’ period potentially influences the divergent paths of healthy or unhealthy ageing. In this cross-sectional study, we aimed to profile musculoskeletal health and lifestyle behaviours for men and women in their late-fifties and sixties.Methods: For 482 participants from the Geelong Osteoporosis...
Chapter
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本书以“‘印太战略’构想与澳大利亚”为主题,全方位展示了澳大利亚、新西兰和太平洋岛国2017~2018年政治、经济、社会和对外关系等方面的最新动态。全书分为总报告,澳达比亚、新西兰、太平洋岛国国别区域篇,专题篇,大事记等几个部分。2017~2018年度,大洋洲政治、经济和外交形势发展基本保持稳定;“印度洋-太平洋”成为分析和决策的关注焦点,说明了区域认同的社会建构性质以及这些愿景可能被赋予的不同目的。
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本书以“变局中的大洋洲对外关系”为主题,全方位展示了澳大利亚、新西兰和太平洋岛国2018~2019年政治、经济、社会和对外关系等方面的最新动态。
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Book abstract: 本书以“全球治理框架下的大洋洲区域合作”为主题,全方位展示了澳大利亚、新西兰和太平洋岛国2016~2017年政治、社会、经济和对外关系等方面的最新动态。书中剖析了美国特朗普政府的亚太战略转变对大洋洲地区的影响,如中澳关系、美新关系;在全球治理框架下,澳大利亚的太平洋地区合作政策面临新的挑战,大平洋岛国在区域合作中谋求独立和更多的话语权。
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本书不仅包含大洋洲区域各国家和地区层面一年来的新情况、新发展以及面临的各种问题与挑战,也涵盖了该区域与外部世界的多层次、全方位交流问题,特别是投资、援助、贸易、气候变化等。既深入分析了区域内重点国家的政治、经济、外交等各方面的情况,也重点关注包括中国在内的各种外部力量如何参与该地区事务、塑造与该区域国家的双边或多边关系,特别分析了中国企业在该地区投资面临的各种风险,并提出了相关建议。

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