Sónia N. Pedro

Sónia N. Pedro
University of Aveiro | UA · Division of Biochemistry

MSc Clinical Biochemistry

About

13
Publications
2,420
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206
Citations
Introduction
Sónia N. Pedro is currently a biochemistry PhD student in the reseach groups BioPol4fun and Path at CICECO (Aveiro Institute of Materials) in University of Aveiro, Portugal. Her current interest of research and thesis is focused in the incorporation of novel formulations of deep eutectic solvents comprising active pharmaceutical ingredients into biopolymer-based drug deivery systems to develop novel therapeutic options.
Additional affiliations
July 2016 - July 2017
University of Aveiro
Position
  • Researcher
Education
October 2017 - October 2021
University of Aveiro
Field of study
  • Biochemistry
October 2016 - October 2016
University of Aveiro
Field of study
  • Molecular Immunology
September 2014 - July 2016
University of Aveiro
Field of study
  • Clinical Biochemistry

Publications

Publications (13)
Article
Introduction: Deep eutectic solvents comprising or acting as solvents of active pharmaceutical ingredients (API-DES) emerged as promising alternatives to improve therapeutic efficiency, with the additional possibility to integrate them in (bio)polymer-based systems to enhance their delivery. Areas covered: A critical review of the API-DES field evo...
Article
Full-text available
Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (AP...
Article
Full-text available
Ionic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. Due to their ionic character, most ILs present advantageous properties over conventional solvents, such as negligible volatility at atmospheric conditions and high thermal and chemical stabilities. The wide variety of IL anion–cation combinations...
Article
Full-text available
Deep eutectic solvents (DES) are eutectic mixtures that present a deviation from the ideal thermodynamic solid–liquid phase behavior, where a significant depression in the melting temperature occurs. If properly designed and chosen, DES may be liquid at room and the human body’s temperatures and display a biocompatible character, thus representing...
Article
The critical scenario of antimicrobial resistance to antibiotics highlights the need for improved therapeutics and/or formulations. Herein, we demonstrate that deep eutectic solvents (DES) formulations are very promising to remarkably improve the solubility, stability and therapeutic efficacy of antibiotics, such as ciprofloxacin. DES aqueous solut...
Article
Full-text available
The transdermal administration of nonsteroidal anti-inflammatory drugs (NSAIDs) is a valuable and safer alternative to their oral intake. However, most of these drugs display low water solubility, which makes their incorporation into hydrophilic biopolymeric drug-delivery systems difficult. To overcome this drawback, aqueous solutions of bio-based...
Article
The effect of water on the physicochemical properties of deep eutectic solvents (DES) is a trending research topic. In this work, inelastic neutron scattering (INS) spectroscopy, was used to probe intermolecular interactions in the water-deep eutectic solvent mixtures for the cases of choline chloride (the hydrogen bond acceptor) and three differen...
Chapter
The low solubility, permeation, and bioavailability of active pharmaceutical ingredients are the main factors affecting their delivery and therapeutic efficiency. Intensive research has pursuit new possibilities to overcome these drawbacks, in which polymers have played a major role in advances brought by drug delivery systems. Furthermore, the res...
Article
A series of novel analogues of glycine-betaine ionic liquids (AGB-ILs), viz. 1-(4-ethoxy-4-oxobutyl)-1-methylpyrrolidin-1-ium, N,N,N-tri(n-butyl)(4-ethoxy-4-oxobutyl)-1-phosphonium and N,N,N-trialkyl(4-ethoxy-4-oxobutyl)-1-aminium cations with ethyl, n-propyl and n-butyl alkyl chains, combined with the bromide anion, have been synthesized and chara...
Article
Full-text available
Aiming at designing effective and sustainable separation processes, herein we propose the use of carbohydrates combined with tetralkylphosphonium- and tetralkylammonium-based ionic liquids (ILs) to form aqueous biphasic systems (ABS). The formation of ABS composed of non-aromatic and non-fluorinated ILs with carbohydrates is here shown for the firs...

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