Sonia J Lupien

Sonia J Lupien
Université de Montréal | UdeM · Department of Psychiatry

About

276
Publications
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Introduction

Publications

Publications (276)
Article
Background and objectives: Stress is not inherently negative. As youth will inevitably experience stress when facing the various challenges of adolescence, they can benefit from developing a stress-can-be-enhancing mindset rather than learning to fear their stress responses and avoid taking on challenges. We aimed to verify whether a rapid interve...
Article
Full-text available
The onset of the COVID-19 pandemic was accompanied by an increase in alcohol use in a third of the population worldwide. To date, the literature shows that subjective reports of stress predicted increased alcohol use during the early stages of the pandemic. However, no studies have investigated the effect of physiological stress (via the stress hor...
Article
Full-text available
Background Studies report a growing tendency for students to experience state anxiety in schools. However, the combination of individual susceptibilities likely to trigger students’ anxious states remains unclear. Aims This study examined whether distinct profiles of students emerge regarding their susceptibility to anxiety sensitivity and/or test...
Article
The cortisol awakening response (CAR) is frequently assessed in psychobiological (stress) research. Obtaining reliable CAR data, however, requires careful attention to methodological detail. To promote best practice, expert consensus guidelines on the assessment of the CAR were published (Stalder et al., 2016, PNEC). However, it is unclear whether...
Article
Full-text available
This perspective article was written by invitation of the editors in chief as a summary and extension of the symposium entitled Psychoneuroendocrine Research in the Era of the Replication Crisis which was held at the virtual meeting of the International Society of Psychoneuroendocrinology 2021. It highlights the opportunities presented by the appli...
Article
Full-text available
Surveys report that about three-quarters of visits to general practitioners in America are for stress-related complaints. Animal and human studies have consistently demonstrated that exposure to acute and/or chronic stress leads to the activation of the autonomic nervous system (ANS) and/or hypothalamic-pituitary-adrenal (HPA) axis, and to the prod...
Article
Full-text available
Purpose: Sexual and gender minority (SGM) people are at increased risk for psychological distress compared with cisgender heterosexual people. Specific SGM subgroups include lesbian, gay, bisexual, gender diverse, and asexual people who each experience unique psychosocial challenges that can result in different mental health outcomes. The coronavir...
Article
Many studies show a general increase in stress hormones at the exposure to school entry, but inconsistencies among them due to small samples with varying methodologies and very few time-points, preclude robust conclusions. The current study aimed to describe the pattern of morning cortisol concentration in children across the transition from presch...
Article
Objective: Depression and anxiety symptoms are commonly observed among clinical populations, especially among women and maltreated individuals. Few investigations have, however, assessed the existence of distinct symptoms trajectories among clinical populations and how these relate to childhood maltreatment, sex differences, and stress physiology...
Article
Objective Self-reported maternal prenatal stress (MPS) has been associated with earlier febrile seizure (FS) age of onset in offspring. Studies are needed to understand how the biological systems associated with exposure to psychological MPS are linked to seizure disorders in children. The aim of this study was to investigate whether placental mark...
Preprint
Many studies showed a global acute increase in stress hormones at kindergarten entry, but inconsistencies among them due to small samples with varying methodologies and very few measurement points, preclude robust conclusions. The current study aimed to describe the pattern of morning cortisol concentration in children during the transition from pr...
Article
The prevalence of mental health problems represents a significant burden on school and community health resources as early as preschool. Reducing this burden requires a better understanding of the developmental mechanisms linking children’s early vulnerabilities with mental health after the transition to formal schooling. The 3D-Transition study (2...
Article
Full-text available
Exposure to early adversity (EA) is associated with long-lasting dysregulations in cognitive processes sustained by brain regions that are sensitive to stress hormones: the hippocampus, the amygdala, and the prefrontal cortex. The Life Cycle Model of Stress highlights the importance of considering the timing at which EA began, as these brain region...
Article
Early adversity (EA) modulates stress hormone secretion in mixed directions. The Accumulation Model suggests that the number of EA predicts patterns of cortisol dysregulations, while the Life Cycle Model of Stress highlights the importance of considering the timing at which EA began, given that brain regions sensitive to stress hormones follow dist...
Article
Objectives: Gendered inequalities in workplace stress are linked to sex-specific health trajectories that are poorly understood. Measuring gendered inequalities is challenging but necessary to better explain individual differences in occupational health. The aim of this exploratory, retrospective study was to create a measure of occupational gender...
Article
Objectives: Gendered inequalities in workplace stress are linked to sex-specific health trajectories that are poorly understood. Measuring gendered inequalities is challenging but necessary to better explain individual differences in occupational health. The aim of this exploratory, retrospective study was to create a measure of occupational gender...
Article
Objective Despite decades of research on the identification of specific characteristics of situations that trigger a physiological stress response (novelty, unpredictability, threat to the ego, and sense of low control [NUTS]), no integrative research has examined the validity of this framework applied to pain experiences. This study aimed to 1) ex...
Article
Stress associated with caring for a mentally ill spouse can adversely affect the health status of caregivers and their children. Adding to the stress of caregiving is the stigma often placed against spouses and children of people with mental illness. Contrary to mental illness, many physical disorders such as cancer may be less stigmatized (expect...
Article
Full-text available
Introduction Mild traumatic brain injury (mTBI) is highly prevalent, especially in children under 6 years. However, little research focuses on the consequences of mTBI early in development. The objective of the Kids’ Outcomes And Long-term Abilities (KOALA) study is to document the impact of early mTBI on children’s motor, cognitive, social and beh...
Article
Full-text available
Mental health problems related to chronic stress in workers appear to be sex-specific. Psychosocial factors related to work–life balance partly explain these sex differences. In addition, physiological markers of stress can provide critical information on the mechanisms explaining how chronic stress gets “under the skull” to increase vulnerability...
Article
Background and objectives: Anxiety and depression are prevalent psychopathologies that affect twice as many women than men. Although the role of biological factors has been investigated, it has been argued that gender roles – defined by the feminine and masculine characteristics that society attributes to men and women – should also be considered....
Article
Previous studies have reported a positive association between mobile phone use and psychological stress. However, the reasons why stressed out individuals use their cell phones more are not clear. To gain further insight on this relationship, we performed secondary analyses on a database of 87 healthy young adults aged 18‐35 years who self‐categori...
Article
Background Peer victimization has been associated with long‐lasting risks for mental health. Prior research suggests that stress‐related systems underlying adaptation to changing environments may be at play. To date, inconsistent findings have been reported for the hypothalamic–pituitary–adrenal (HPA) axis, and its end product cortisol. This study...
Article
Alzheimer's disease (AD) patients show high cortisol levels suggesting that biological mediators of stress may play a role in the neurodegenerative process of cognitive disorders. However, there is no consensus as to whether cortisol concentrations represent a risk factor for the development of cognitive impairment. We analyzed the potential associ...
Article
Living in the past, the present, or the future can affect stress and health. Our group has shown that acute stress (cortisol reactivity) is modulated by time perspectives, the ways we psychologically relate to time. Here, we expand this research with a comprehensive measure of multi-systemic chronic stress (allostatic load). Among 204 healthy adult...
Article
Stress exposure over the lifespan is robustly associated with accelerated cognitive decline in later life. Brain-derived neurotrophic factor (BDNF) is shown to regulate activity of the hypothalamic-pituitary-adrenal axis. The objective of this study was to evaluate the association betweenthe BDNF polymorphism and indices of stress among adults aged...
Article
Background: Studies suggest that the relationship between seizures and stress starts early in life. However, evidence of long-term altered stress reactivity following early-life seizures is lacking. Our objectives were to assess alterations in stress hormone reactivity in children with past febrile seizures (FS) and investigate how these alteratio...
Article
Full-text available
Background: People differ in their ability to regulate their physiological stress response. Individual differences in emotion regulation strategies such as suppression and reappraisal may explain this differential response to stress. Objective: The aim of the current study was to assess whether daily use of suppression and reappraisal as well as...
Article
Although a majority of people will be exposed to a traumatic event over the course of their lifespan, only a minority will develop post-traumatic stress disorder. Better understanding the factors contributing to the development of this psychopathology is of high importance and could significantly reduce the societal and human costs associated with...
Article
Over activation of the hypothalamo–pituitary–adrenal (HPA) axis in stress situations is known to influence learning and memory. In adults, an inverted-U shape relationship between acute stress, and learning and memory has been demonstrated. Whether this model fits learning performances in infants is unknown. In this study, we used EEG repetition su...
Article
Background: Converging evidence suggests that maltreated children suffer from depression at an early age and experience recurrent episodes of depression that persist over longer periods of time. However, the stress-related mechanisms hypothesized to be implicated in these associations remain to be specified. The present study tested the mediating...
Article
Oral contraceptive (OC) is the most common type of contraceptive method used in industrialized countries. A recent epidemiological study showed that OC use was associated with the onset of depression in young women. Mind wandering, a cognitive process associated with spontaneous thoughts unrelated to the task at-hand, has previously been associated...
Article
Oral contraceptive (OC) is the most common type of contraceptive method used in industrialized countries. A recent epidemiological study showed that OC use was associated with the onset of depression in young women. Mind wandering, a cognitive process associated with spontaneous thoughts unrelated to the task at-hand, has previously been associated...
Article
Objective: Individuals requiring psychiatric emergency services are often highly distressed and intoxicated. To provide an objective and comprehensive measure of their stress-related physiological dysregulations, we indexed allostatic load with 14 biomarkers collected within 24 hours of patients’ admission to the largest psychiatric hospital in the...
Article
This review examines the current state of knowledge regarding children's biological stress response during the transition from preschool to compulsory formal schooling, focusing on longitudinal studies that include repeated measures of cortisol concentrations in saliva or scalp hair. In all, eight independent studies (ten publications) were found a...
Article
Early experiences with parents may be particularly difficult for lesbian, gay, and bisexual (LGB) individuals who face stigma that is linked to potentially distinct stress-related biobehavioral profiles. This study examined the association between parental bonding in relation to acute stress (cortisol reactivity) and chronic stress (allostatic load...
Article
Full-text available
There is a relative consensus about the detrimental impact of childhood maltreatment on later mental health problems and behavioral difficulties. Prior research suggests that neurophysiological stress mechanisms may partly mediate this association. However, inconsistent findings regarding hypothalamic-pituitary-adrenal axis and sympathetic response...
Article
For the last five decades, science has managed to delineate the mechanisms by which stress hormones can impact on the human brain. Receptors for glucocorticoids are found in the hippocampus, amygdala and frontal cortex, three brain regions involved in memory processing and emotional regulation. Studies have shown that chronic exposure to stress is...
Article
Full-text available
This study of depressed outpatients (N = 43) examined daily stress-sadness reactivity and the cortisol awakening response (CAR) as moderators of the relationship between self-critical (SC) perfectionism and depression over one year. Participants completed perfectionism measures at baseline (Time 1), daily diaries and salivary sampling six months la...
Article
Full-text available
This study of depressed outpatients (N = 43) examined daily stress-sadness reactivity and the cortisol awakening response (CAR) as moderators of the relationship between self-critical (SC) perfectionism and depression over one year. Participants completed perfectionism measures at baseline (Time 1), daily diaries and salivary sampling six months la...
Article
Full-text available
Objective Hundreds of scientific publications are produced annually that involve the measurement of cortisol in saliva. Intra- and inter-laboratory variation in salivary cortisol results has the potential to contribute to cross-study inconsistencies in findings, and the perception that salivary cortisol results are unreliable. This study rigorously...
Article
Experimental and epidemiological studies suggested that exposure to lead (Pb) may influence the hypothalamic-pituitary-adrenal (HPA) axis. However, previous studies have yielded mixed results. We evaluated changes in basal salivary cortisol levels and acute cortisol responsivity to psychological stress in relation with blood Pb levels (BPb), in Cau...
Article
Objective Prenatal exposure to stress and fever are factors lowering seizure threshold in animal models. The fever effect on seizure threshold is well documented in human infants, however the consequences of perinatal stress on infants’ susceptibility to seizure is unknown. This is the first study to investigate longitudinally, in humans, the effec...
Article
Many youths who are victimized by peers suffer from depression symptoms. However, not all bullying victims show depression symptoms and individuals’ biological sensitivity may play an important moderating role in this regard. In line with this notion, peer victimization has been associated with increased depressive symptoms in youth with higher bas...
Article
Full-text available
In 2008, the National Institute of Mental Health (NIMH) announced that in the next few decades, it will be essential to study the various biological, psychological and social ‘signatures’ of mental disorders. Along with this new ‘signature’ approach to mental health disorders, modifications of DSM were introduced. One major modification consisted o...
Chapter
With an aging population on the rise, there is a projected exponential expansion in the prevalence of dementia, particularly Alzheimer's disease (AD). AD is the most common form of dementia, characterized by senile plaques and tangles in the brain. Although the pathophysiology and clinical symptoms are well described, the etiology and pathogenesis...
Article
Background This study investigated the potential environmental effects of peer victimization and the quality of relationships with parents and friends on diurnal cortisol secretion in mid-adolescence. Method This study used the monozygotic (MZ) twin-difference design to control for genetic effects and thus estimate the unique environmental influen...
Data
Full-text available
This Figure is a correction for the associated publication. All other information in-text is correct. However, the original Figure had the groups flipped for A1.
Conference Paper
The cortisol awakening response (CAR), the marked increase in cortisol secretion over the first 30–45 min after morning awakening, has been related to a wide range of psychosocial, physical and mental health parameters, making it a key variable for psychoneuroendocrinological research. The CAR is typically assessed from self-collection of saliva sa...
Article
Objectives: Beyond male/female binaries, gender roles represent masculine and feminine traits that we assimilate and enact throughout life span development. Bem proposed that "androgynous" individuals adeptly adapt to different contexts by alternating from a strong repertoire of both masculine and feminine gender roles. By contrast, "undifferentia...
Article
Full-text available
This study explored the mediating role of sleep in the relationship between personality traits and depressive symptoms in a group of community-dwelling men and women (Mage = 57.92, SD = 4.00). Participants completed the short form NEO Five Factor Inventory (NEO-FFI), Pittsburgh Sleep Quality Index (PSQI), and the Center for Epidemiologic Studies De...
Data
Dataset. Minimal dataset associated with this article. (SAV)
Article
Full-text available
Background: Negative effects of stress have pose one of the major threats to the health and economic well being of individuals independently of age and cultural background. Nevertheless, the term "stress" has been globally used unlinked from scientificevidence-based meaning. The discrepancies between scientific and public stress knowledge are focu...
Article
This study assessed sexual orientation and psychobiological stress indices in relation to salivary sex hormones as part of a well-validated laboratory-based stress paradigm. Participants included 87 healthy adults that were on average 25 years old who self-identified as lesbian/bisexual women (n = 20), heterosexual women (n = 21), gay/bisexual men...
Chapter
Many studies published over the last two decades show that chronic exposure to stress hormones, from the prenatal to aging period, can have deleterious effects on brain structures involved in cognition and mental health. In this selective review of the literature, we show that specific effects on the brain, behavior, and cognition emerge as a funct...
Chapter
Full-text available
Vulnerability and resilience are intertwined yet unraveling constructs in the allostatic load literature centered on stress-disease pathways. In examining this paradigm shift, this chapter focuses on allostatic load indices of multisystemic physiological dysregulations among marginalized populations. Social inequalities reviewed include early adver...
Article
Facebook(©) is changing the way people interact and socialize. Despite great interest in psychology and sociology, little is known about Facebook behaviors in relation to physiological markers of stress. Given that the brain undergoes important development during adolescence and that glucocorticoids-a major class of stress hormones-are known to mod...
Article
Introduction: By and large, studies have reported moderate contributions of genetic factors to cortisol secreted in the early morning and even smaller estimates later in the day. In contrast, the cortisol awakening response (CAR) has shown much stronger heritability estimates, which prompted the hypothesis that the etiology of cortisol secretion m...
Article
Salivary alpha-amylase (sAA) is a stress-sensitive biomarker the shows promise as an indirect proxy of sympathetic-adrenal-medullary axis activities that are otherwise difficult to discern non-invasively. This comprehensive study investigated diurnal sAA in association with numerous psychosocial characteristics related to mental health, work stress...
Article
Background: Inverse associations have been observed between memory performance and blood concentrations of cadmium (Cd) and lead (Pb). Low antioxidant cell activity has also been linked to decline in memory due to aging. However, it has not yet been established whether the heavy metal-memory relationship is mediated by differences in antioxidant a...