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Publications (5)
We have synthesized two bipyridyl-based oligocationic cyclopeptides through solid phase peptide synthetic methods (SPPS) and studied their metal-binding, redox and biological properties in the presence of copper(II) ions in water media by several techniques. Remarkably, the studies performed indicate that, while the free cyclopeptides exhibit quite...
The use of light‐activated triphenylphosphonium‐based antimicrobials to tackle the emerging problem of antimicrobial resistance has been proposed in this study. Chemical modification of phenalenone and perylene with triphenylphosphonium cations enhances their photoantimicrobial activity up to 10⁷ times. Selective targeting of Gram‐positive bacteria...
Light‐mediated killing of pathogens by cationic photosensitisers is a promising antimicrobial approach that avoids the development of resistance inherent to the use of antimicrobials. In this study, we demonstrate that modification of different photosensitisers with the triphenylphosphonium cation yields derivatives with excellent photoantimicrobia...
Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only display excellent DNA binding properties, but also are endowed with new properties not found in their natural counterparts. Here we...
