Somporn Swasdison

• Doctor of Dental Surgery, Ph.D
• Chulalongkorn University

In this study, electrospinning technique was used for ternary system to fabricate nanofiber mats from silk fibroin (SF):gelatin (G):chitosan (C) with various mass ratios i.e. 10:20:0, 10:20:0.5, 10:20:1, 10:20:1.5, 10:20:2, and 20:10:1. An increase in chitosan content of the mats was found to decrease average fiber diameter and with narrow size dis...

Fluoride varnish is a professionally applied product that prevents dental caries. However, fluoride varnishes do not provide sustained fluoride release. The objective of this study was to prepare fluoride varnish formulations containing various amounts of chitosan that would generate sustained fluoride release. We evaluated their chemical structure...

Objective: The aim of this study was to evaluate the effect of neutralizing agents on the shear bond strength of hydrofluoric (HF)-etched porcelain in nonaging and aging conditions. Subjects and methods: One hundred and twenty feldspathic porcelain specimens were prepared and divided into six groups to undergo different surface conditioning meth...

Curcuma aff. amada is used for treatment of poisoning, detoxification and anti-inflammation in Thai folk medicine. However, there is no scientific evidence supporting the potential antinociceptive and anti-inflammatory activities of this plant. To investigate the antinociceptive and anti-inflammatory effects of the ethanolic extract of Curcuma aff....

Silk fibroin, gelatin, and chitosan blended solution in formic acid with different composition ratios were electrospun. The fiber could be produced from SF:G : C blended solution at weight blending ratios (%wt: %wt: ml) of 10:20:0, 10:20:0.5, 10:20;1, 10:20:1.5, 10:20:2, and 20:10:1. When the chitosan content in blended solution increased, the aver...

Dentin hypersensitivity is treated using materials that occlude the dentinal tubules or release potassium ions that induce nerve desensitization. In this study we formulated a novel varnish containing potassium chloride and fluoridated hydroxyapatite and evaluated its physical properties and cytotoxicity. Potassium ion release from the varnish was...

Ameloblastoma is a benign, locally invasive odontogenic neoplasm with high recurrent rate after conservative treatment. It is the most common odontogenic tumor found in the mandible. However, the mechanism of tumor cell behaviors is still unclear. Objective: To investigate the ultrastructure of ameloblastoma tumor cells that might relate to the tum...

Biomimetic gelatin (gel)-hydroxyapatite (HA) composites have been prepared for studying hard tissue engineering scaffolds. However, the biocompatibility test of this form of material using these three cell types, which are periodontal ligament (PDL) fibroblast cells, human mesenchymal stromal cells (HMSc) and primary cells from human hip bone (HBc)...

Genes involved in apoptosis are important and over expression of these genes are thought to contribute to carcinogenesis. Aim: to evaluate the expression of anti-apoptotic factors in a series of epithelial malignancies and actinic keratosis using immunohistochemistry. Design: Laboratory microscopy of stained biopsy specimen. Materials and methods:...

The objective of this study was to evaluate clinically, histologically and radiographically a ridge preservation technique used on extraction sockets grafted with biphasic calcium phosphate (BCP) and a resorbable collagen membrane. Patients having a labial socket wall defect more than one-third in mesio-distal socket width after maxillary central i...

To conduct a clinicopathological review of oral squamous cell carcinoma (SCC) and to analyze it with respect to gender, age at diagnosis, clinical presentation, lesion location, and histological grading. Information on the clinicopathological characteristics of SCC was obtained from pathology reports of 342 cases. The male to female ratio was 1:1 a...

Objectives: Tissue engineering has been evolved to replace diseased or damaged tissue by using controlled scaffolds. The role of the scaffold is providing a matrix of a specific configuration in which seeded cells may grow to produce the desired tissue. To date, the ideal scaffold has not been developed. The aims of this study are to investigate th...

One main etiology for oral squamous cell carcinoma (OSCC) is inflammation. Inducible nitric oxide synthase (iNOS), vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) are the important molecules showing close relation to not only inflammation but also carcinogenesis and angiogenesis. Angiogenesis is defined as the formation of ne...

Primary intraosseous squamous cell carcinoma derived from odontogenic cyst is an uncommon lesion and was designated as odontogenic carcinoma by the World Health Organization. About 60 welldocumented cases of this disease have been reported between 1938 and 2001. This report is of a patient with squamous cell carcinoma arising in a dentigerous cyst...

Oral cancer is the fourth most common cancer in males and the seventh most common cancer in females in Thailand. The survival rates and quality of life of oral cancer patients will significantly be improved if they receive treatment for lesions that are less advanced or premalignant. Early diagnosis is therefore of paramount importance. A number of...

The aim of this study was to determine the biologic profile of the adenomatoid odontogenic tumor (AOT) in a Thai population. Sixty-seven cases of AOT registered from January 1974 to May 2006 were studied retrospectively. Age, sex, variants of AOT, site and extent of tumors, associated impacted teeth, initial clinical diagnoses, clinical presentatio...

Osteopontin (OPN) is an adhesive, matricellular glycoprotein, whose expression is elevated in many types of cancer and has been shown to facilitate tumorigenesis in vivo. To understand the role of OPN in human skin cancer, this study is designed to determine whether OPN is expressed in premalignant [solar/actinic keratosis (AK)] and in malignant sk...

Adenomatoid odontogenic tumour (AOT) is a benign odontogenic jaw lesion. The aim of this study was to update the biological profile of AOT. Cases published in the literature and cases in files of co-authors were included. 550 new cases were retrieved, and of a total of 1082 cases analysed, 87.2% were found in the second and third decades. The M:F r...

The interaction between L929 cells and carboxymethylchitosan (CM-chitosan)-based hydrogels, hydrogels from pure CM-chitosan and its blends, was examined in this study. Cytotoxicity of all materials was also assessed. The cellular morphology and behavior on the surfaces of the hydrogels were observed by scanning electron microscopy (SEM). The effect...

The objectives of this study were to determine the prevalence, size, shape and location of the oral tori in 1,520 Thai dental patients and to investigate the relationship between the findings with age and gender. The prevalence rates were 60.5% for torus palatinus (TP) and 32.2% for torus mandibularis (TM). The concurrence of TP and TM was noted in...

We report the features of a central neurilemmoma in the mandible of a patient having an inflammatory apical dental (radicular) cyst in the same region. A 29-year-old woman complained of numbness on the right side of the lower lip of 3 months duration and noted following endodontic therapy to the right mandibular first molar tooth. Panoramic radiogr...

Objective: To evaluate the proliferative activity of odontogenic cysts and ameloblastomas.Patients and Methods: Ten radicular cysts, 10 dentigerous cysts, 10 odontogenic keratocysts, 14 ameloblastomas, 5 unicystic ameloblastomas, and 9 recurrent ameloblastomas were immunohistologically stained with antibody to proliferating cell nuclear antigen. Im...

Chitin grafted with poly(acrylic acid) (chitin-PAA) was prepared with the aim of obtaining a hydrogel characteristic for wound dressing application. The chitin-PAA films were synthesized at various acrylic acid feed contents to investigate its effect on water sorption ability. Acrylic acid (AA) was first linked to chitin, acting as the active graft...

Porphyromonas gingivalis, one of the important periodontal pathogens, exhibits many virulence properties. Among these, the adhesion to and invasion into host tissues are crucial for the initiation and progression of periodontal diseases. While evidence indicating the ability of this organism to adhere to and invade into epithelial cells as well as...

Dental rubber dams (RDs) were used as barrier membranes in guided tissue regeneration for the treatment of periodontal intraosseous defects with acceptable clinical results. The aim of the present study was to investigate the effects of autoclave sterilization on properties of RD as related to its use as a barrier membrane in guided tissue regenera...

The aim of this study was to compare connective tissue and bacterial deposits on silicone sheets (SS) and expanded polytetrafluoroethylene membranes (ePTFE) used as barrier membranes in guided tissue regeneration (GTR) for periodontal treatment. Eighteen intrabony periodontal lesions from 18 patients were first surgically treated by GTR and either...

Teeth have been recognized as providing a useful long-term record of lead (Pb2+) uptake. However, information regarding the effects of lead on dental pulp tissue cells that foster dentinogenesis is scarce. This study investigated the effects of lead on dental pulp tissue using human dental pulp fibroblasts in vitro. Dental pulp cells from the teeth...

The aim of this study was to compare the connective tissue and bacterial deposits on rubber dam sheets and expanded polytetrafluoroethylene membranes used as barrier membranes in guided tissue regeneration for periodontal treatment. Twenty patients having intrabony defects and/or furcation defects were surgically treated by guided tissue regenerati...

The aims of this study were to determine the prevalence, size, shape, and location of torus palatinus (TP) and torus mandibularis (TM), and to investigate their sex- and age-related differences in a Thai population. One thousand two hundred subjects were examined for the presence of both tori at the Faculty of Dentistry, Chulalongkorn University. T...

Characterization of a full length cDNA sequence for a chicken laminin beta chain is described which is most closely related to the mammalian beta 2 chain. Comparison with published sequences shows that the chicken beta 2-like chain corresponds to a fragment of a previously described laminin beta chain called B1-2 (O'Rear, 1992). The sequence of the...

Microfibrils were dissected from the zonular apparatus of the bovine eye, homogenized and used as an immunogen to prepare monoclonal antibodies. Initial screening of hybridomas was performed by immunoblotting to a sonicate of zonular fibrils and by immunolocalization to frozen sections of the zonular apparatus. Subsequently, monoclonal antibodies w...

Two methods were developed in which long-term cultures of quail skeletal muscle were established so that all of the muscle fibers develop in a highly oriented manner. The muscle fibers became spontaneously and vigorously contractile and established strong connections with the extracellular matrix at their ends that closely duplicate the structure o...

Monoclonal antibodies were prepared that were specific for chicken type I and type III collagens. The specificity of these antibodies was determined by ELISA, inhibition ELISA, and immunoblot assays. The results showed that the monoclonal antibodies were specific for their respective antigens without significant cross reactivity to other types of c...

Complex mechanical forces generated in the growing embryo play an important role in organogenesis. Computerized mechanical application of similar forces to differentiating skeletal muscle myoblasts in vitro generate three-dimensional artificial muscle organs. These organs contain parallel networks of long unbranched myofibers organized into fascicl...

The myotendinous junction (MTJ) and its associated cells and connective tissue are important structures involved in transmission of contractile force from skeletal muscle to tendon. A model culture system was developed to investigate the formation of the MTJ and its attachment to collagen fibers. Skeletal muscle cells were cultured in a well modele...

The distribution of several extracellular matrix macromolecules was investigated at the myotendinous junction of adult chicken gastrocnemius muscle. Localization using monoclonal antibodies specific for 3 basal lamina components (type IV collagen, laminin, and a basement membrane form of heparan sulfate proteoglycan) showed strong fluorescent stain...

Objective: To investigate the sealing ability and disintegration in water of newly developed temporary filling materials with four different zinc oxide and calcium sulfate ingredient ratios. Methods: Twenty specimens of each group of newly developed temporary filling materials and Cavit (controlled group) were tested for their sealing ability and...

Objectives: To investigate the fluoride release and the compressive strength of newly developed color changeable glass ionomer cement or thermochromic glass ionomer cement (tGIC). Methods: The thermochromogen (3 % by weight) was added into the liquid part of two commercial glass ionomer cements (Fuji IX and Ketac Molar). The cements were then pre...

Objective: To fabricate orthodontic elastomeric ligatures from epoxidized natural rubber and study the mechanical properties and biocompatibility of the fabricated products in comparison to the 7 commercially available orthodontic elastomeric ligatures. Methods: Four formulations of elastomeric ligatures were fabricated from epoxidized natural ru...

Recently, natural rubber has been used in several medical products. The purpose of this study was to develop a soft lining material from natural latex which had been improved its physical, mechanical and biological properties. Initially, natural latex was vulcanized by gamma irradiation. The vulcanized latex was then grafted with ethyl methacrylate...

Thesis (Ph. D.)--University of Alabama at Birmingham, 1991. Includes bibliographical references. Microfiche.