Somia Shehzadi

• Doctor of Philosophy
• Professor (Assistant) at University of Lahore

Background Thalassemia, an inherited blood disease characterized by abnormal hemoglobin production, is a global health issue. Although the effects of thalassemia on human health are well-documented, less is known regarding its implications on pregnancy, particularly maternal outcomes. Analyzing thalassemia during pregnancy is crucial to understandi...

Marine ecosystems are a rich source of bioactive compounds, with carotenoids like astaxanthin, fucoxanthin, and zeaxanthin demonstrating significant antioxidant properties. These carotenoids neutralize reactive oxygen species (ROS), protecting against oxidative damage. This review examines their molecular structures, biosynthesis pathways, and mech...

Background The global challenge of Multidrug-resistant Tuberculosis (MDR-TB) presents a substantial public health concern, requiring extended and complex treatment regimens. Understanding the factors impacting treatment results, particularly sputum culture conversion and Body Mass Index (BMI), is crucial. This retrospective cohort investigation con...

Introduction The management of gastric cancer is challenging due to the complexities associated with its therapy and nursing care. This work aimed to elucidate the functions and processes of erythropoietin-producing hepatocellular carcinoma Receptor B4 (EphB4) in gastric cancer. Methods EphB4 expression in gastric cancer tissues and cell lines w...

Colorectal cancer (CRC) ranks as the third most prevalent malignant tumour behind breast and lung cancers, and it is the second foremost cause of cancer-related mortality. In recent years, the prevalence and death rates of colorectal cancer have continued to rise, with a decreasing age of start. Increasing research indicates that natural alkaloidal...

This study involved the synthesis, characterization, and assessment of fourteen pyridazine analogs (designated as 1–14) to investigate their efficacy in inhibiting the α‐amylase enzyme for potential diabetes treatment using an in vitro approach. Additionally, in silico molecular docking and molecular dynamic (MD) simulations were conducted to asses...

Sweet potatoes (Ipomoea batatas L.) are a key food crop in tropical and subtropical regions, notably Asia, Africa, and the Pacific. Asia and Africa account for 95% of global production. Sweet potatoes’ tendrils, leaves, tubers, and stems are rich in vitamins, minerals, fats, carbs, and proteins. Research indicates that bioactive compounds such as β...

Epigenetic machinery is a cornerstone in normal cell development, orchestrating tissue-specific gene expression in mammalian cells. Aberrations in this intricate landscape drive substantial changes in gene function, emerging as a linchpin in cancer etiology and progression. While cancer was conventionally perceived as solely a genetic disorder, its...

Background Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensiv...

Abstract: Hypoxia is a key component of the tumour microenvironment, and it is linked to cell proliferation, angiogenesis, metabolism, and the tumour immune response. All of these variables may accelerate tumour growth, increase tumour aggressiveness, raise tumour metastatic potential, and result in a poor prognosis. The goal of this trial was to d...

Purpose Oral squamous cell carcinoma (OSCC) personifies a worldwide problem for public health. Indeed, squamous cell carcinoma is the most common cancer in the oral cavity and one of the top ten cancers across the globe. According to GLOBOCAN2020, 264211 new cases of oral cancer were reported, and 125022 individuals died as a result of the disease....

Shikimate kinase is an enzyme that plays a crucial role in the biosynthesis of aromatic amino acids. It is integral to the fifth step of the shikimate pathway, transferring a phosphoryl group from ATP to shikimate, yielding ADP and shikimate-3-phosphate within Mycobacterium tuberculosis (Mtb). This enzyme is an attractive target for drug discovery,...

Background: Lung cancer (LC) incidence is rising globally and is reflected as a leading cause of cancer-associated deaths. Lung cancer leads to multistage carcinogenesis with gradually increasing genetic and epigenetic changes. Aims: Sanguinarine (sang) mediated the anticancer effect in LCC lines by involving the stimulation of reactive oxygen spe...

Depression, a global health concern with significant implications for suicide rates, remains challenging to treat effectively with conventional pharmacological options. The existing pharmaceutical interventions for these illnesses need daily dosing, are accompanied by various adverse effects, and may exhibit limited efficacy in certain cases. Howev...

Lung cancer (LC) is the leading cause of cancer-related death globally. Comprehensive knowledge of the cellular and molecular etiology of LC is perilous for the development of active treatment approaches. Hypoxia in cancer is linked with malignancy, and its phenotype is implicated in the hypoxic reaction, which is being studied as a prospective can...

Background: Saxitoxin (STX) stands as one of the most potent marine biotoxins, exhibiting high lethality. Despite its severity, current treatments remain ineffective, and existing detection techniques are limited due to ethical concerns and technical constraints. Methods: Herein, an innovative approach was constructed for STX detection, utilizing m...

Eph receptors and their Eph receptor-interacting (ephrin) ligands comprise a vital cell communication system with several functions. In cancer cells, there was evidence of bilateral Eph receptor signaling with both tumor-suppressing and tumor-promoting actions. As a member of the Eph receptor family, EphB4 has been linked to tumor angiogenesis, gro...

Background Saxitoxin (STX) stands as one of the most potent marine biotoxins, exhibiting high lethality. Despite its severity, current treatments remain ineffective, and existing detection techniques are limited due to ethical concerns and technical constraints. Methods Herein, an innovative approach was constructed for STX detection, utilizing me...

Background: Umbilical cord mesenchymal stem cells (UC-MSCs) are increasingly being utilized for immune-related disease therapies due to their low immunogenicity. However, the primary culture of UC-MSCs requires the supplementation of serum in the growth medium, which has posed a challenge due to ethical issues related to the collection method of th...

Liver is a vital organ and is routinely exposed to toxins. Carbon tetrachloride is one such noxious agent which cause toxicity in liver when CYP450 enzyme bio-activates it. Many hepatoprotective agents are available in market with severe side effects. Appropriate agent is required to combat such liver problems. Azole compounds have much therapeutic...

Tendinopathy or tendon degeneration in equine is an illness caused by inflammation or injury. Being a difficult tissue to repair, tendon damage can cause physical disabilities. Successful tendon regeneration requires an appropriate in-vitro model for tissue injury. The current study was planned to compare the effect of two inflammatory mediators: p...

Background Natural product with apoptotic activity could serve as potential new sources for anti-cancer medicine. Numerous phytochemicals from plants have shown to exert antineoplastic effects via programmed cell death (apoptosis). Cancer is one of the leading causes of death in the prosperous countries. The subject study was intended to evaluate t...

Undifferentiated types of cells found in multicellular organisms are called stem cells, having characteristic to differentiate into a range of different types of adult cells. These basic cells have the ability to self-renew them without any limit and are also considered as multipotent. These two main features make them potent for tissue engineering...

Objectives: The umbilical cord is proven as a potential source of adult stem cells, due to its abundance, harvesting, deficiency of ethical issues and wider potential of differentiation. Mesenchymal stromal cells (MSCs) derived from umbilical cord Wharton's jelly (WJ) are called as Wharton's jelly mesenchymal stromal cells (WJMSCs). Chronic kidney...

Wharton's Jelly mesenchymal stem cells (WJMSCs) have a vital property of migrating towards tumor sites and can be used as growth suppressor vector for tumor therapy. In this study, we hypothesized that, WJMSCs conditioned medium can significantly suppress the growth and can promote apoptosis of hepatocellular carcinoma (HepG2) and prostate cancer (...