Sombat Muengtaweepongsa

Sombat Muengtaweepongsa
Thammasat University · Faculty of Medicine

Professor

About

163
Publications
78,415
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,034
Citations
Citations since 2017
77 Research Items
700 Citations
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
Additional affiliations
October 2010 - present
Thammasat University
Position
  • Integrated Sciences for Holistic Stroke Approach
January 2007 - present
Thammasat University
Education
September 2005 - October 2007
Saint Louis University
Field of study
  • Cerebrovascular and Critical care Neurology

Publications

Publications (163)
Preprint
Full-text available
Introduction: Cannabidiol (CBD) is a non-psychoactive compound of cannabis. Due to the therapeutic potential of CBD, there were given drugs through oral administration to treat pain and anti-inflammatory. The bioavailability of CBD has been reported to be poor when given through oral administration because of the high first-pass effect with cytochr...
Article
Full-text available
Air embolic signals detected in the intracranial arteries using transcranial Doppler after intravenous injection of agitated saline bubbles indicate right-to-left cardiac shunting. They prove that emboli from venous sites can bypass the lungs and flow to the intracranial arteries. The Valsalva maneuver immediately after an intravenous injection of...
Article
Full-text available
Background: Foot reflexology is a treatment with the hypothesis that such massage stimulation on the feet may cause a therapeutic effect which should be helpful for smoking cessation. However, its mechanism of action in the brain of smoking people remains unknown. Functional magnetic resonance imaging (fMRI) is helpful for real-time brain activity...
Article
Full-text available
The diverse clinical manifestation of essential tremor (ET) has led to the question whether the different phenotypes may affect the clinical outcome and progression. This study aimed to estimate the clinical characteristics and natural history of ET and ET-plus. A total of 221 patients with ET were included, 117 (52.9%) reclassified as ET and 104 (...
Chapter
Full-text available
After resuscitation from cardiac arrest, a combination of the complex patho-physiologic process, known as post-cardiac arrest syndrome (PCAS), is attributed to multiple organ damage. Global ischemic cascade occurs in the brain due to generalized ischemia during cardiac arrest and the reperfusion process after the return of spontaneous circulation (...
Article
Full-text available
The relationship between atrial fibrillation (AF) and distortion of autonomic function is reported in the literature. We aim to evaluate sample entropy (SampEn) and heart rate variability (HRV) in patients with persistent AF and compare them with patients suffering from paroxysmal AF. SampEn and HRV during the presentation of AF were analyzed. In p...
Article
Full-text available
The reticular activating system (RAS) is responsible for wakefulness. The RAS projects activation to either side of the hemisphere. The dysfunction of the RAS or insufficiency of its activation results in impairment of consciousness. Physicians classify levels of awareness into four levels, from normal status to most severe unconsciousness, these b...
Article
Full-text available
Many patients have significantly lower limb weakness after getting a stroke. Continuous regular physical therapy is essential to promote the improvement of the weakness and overall outcomes. Home rehabilitation provides motivation and enhances regular rehabilitation in stroke patients. The Do-It-Yourself (DIY) medical device is developed to fill th...
Article
Full-text available
The coronavirus 2019 (COVID-19) infection initially affects the respiratory system. However, nervous system involvement lately becomes a significant feature of COVID-19 infection. The neurologic manifestations can be direct and indirect viral effects or just the non-specific complications from critical illness. The prevalence of stroke in patients...
Data
antibiogram tuh 2021 (jan-jun)
Article
Full-text available
Importance Prior trials of dual antiplatelet therapy excluded patients with moderate ischemic stroke. These patients were included in the Acute Stroke or Transient Ischaemic Attack Treated With Ticagrelor and ASA for Prevention of Stroke and Death (THALES) trial, but results have not been reported separately, raising concerns about safety and effic...
Article
Full-text available
Central venous catheterization (CVC) remains a common practice in the emergency setting. Routine flushing 10–20 ml of normal saline to maintain the patency of CVC could affect the accuracy of laboratory tests. Typically, physicians require peripheral vein phlebotomy when more blood sampling is needed. One alternative method, the Pull-push method, c...
Article
Full-text available
Rehabilitation is a crucial part of stroke recovery to help them regain use of their limb. The aim of this article was to compare the effectiveness of long-term training of mirror therapy with conventional rehabilitation therapy on neurological and recovery of upper limb in acute stroke patients. In this randomized and assessor-blinded control stud...
Article
Full-text available
This paper aims to study the effectiveness of mirror therapy (MT) having treated to acute stroke patients. The subjects of 20 acute stroke patients, who possessed the ability to respond to verbal instructions were randomly blinded and allocated to a control group (n = 10, 59.2 ± 2.28 years) and a mirror group (n = 10, 53.8 ± 6.14 years). Both group...
Article
Full-text available
To maintain the continuity of noncommunicable disease (NCD) services and ascertain the health outcomes of patients with NCDs during the COVID-19 (coronavirus disease 2019) outbreak in Thailand, various telemedicine services have been developed. To achieve this determination, the implementation framework has been constructed based on recommendations...
Preprint
Full-text available
Background: Central venous catheterization (CVC) remains a common practice in the emergency setting. Routine flushing 10 - 20 ml of normal saline to maintain the patency of CVC could affect the accuracy of laboratory tests. Typically, physicians require peripheral vein phlebotomy when more blood sampling is needed. One of the alternative methods, t...
Chapter
Full-text available
Medical treatment seems to be not entirely helpful in the treatment of Moyamoya disease. No evidence supports the benefits of any drug treatment in Moyamoya disease. The ischemic or hemorrhagic event in Moyamoya disease is not preventable with any medical treatment. However, most of the physicians still prescribe the antithrombotic drug for Moyamoy...
Article
Full-text available
Objective: Targeted temperature management (TTM) is recommended for patients suffering a cardiac arrest after restoration of spontaneous circulation (ROSC). Heart rate variability (HRV), which reflects autonomic function, has been proposed as an outcome predictor but HRV measurement is not suitable for everyday practice. RR interval variation (RRIV...
Article
Full-text available
The cognitive impairment was documented in stroke patients, in addition to disability and might lead to dementia. Hence the proper cognitive program is important in the acute phase. This study is a quasi-experimental research design aimed to evaluate the effect of the family participation program in cognitive rehabilitation on the functional outcom...
Article
Background and purpose Postherpetic neuralgia (PHN) is a well-known painful syndrome. Acupuncture is a treatment for PHN. We aimed to compare the effectiveness of pain control between press needle and electroacupuncture (EA) in PHN patients. Materials and methods We conducted a retrospective cohort study by a review of PHN patients treated with th...
Article
Full-text available
Two major objectives of targeted temperature management (TTM) in critical care neurology are to provide neuroprotective treatment and to control intracranial pressure (ICP). TTM is the most promising neuroprotective therapy due to its multiple sites of action against hypoxic-ischemic cascade. TTM is useful for ICP reduction. Hypoxic-ischemic brain...
Article
Full-text available
Background The standard treatment of acute ischemic stroke patients is thrombolytic therapy within 60 minutes of a patient’s arrival in stroke center hospitals. Based on the policy of the Lampang Referral System Committee, blood samples of suspected stroke patients need to be collected before transfer to the stroke center (Lampang Hospital). It was...
Article
Full-text available
The purpose of this study was to determine the factors influencing the prioritization model for the treatment of patients with mobile computed tomography (mCT) scanning. The main research process entailed value innovation product planning (VIPP), which focuses on three steps: idea generation; idea screening; concept testing and development. This wa...
Chapter
Full-text available
Evoked potentials are the electrical signals generated by the nervous system in response to sensory stimuli. Auditory, visual, and somatosensory stimuli are used commonly for clinical evoked potential studies. Somatosensory evoked potentials (SEPs) consist of a series of waves that reflect sequential activation of neural structures along the somato...
Article
Full-text available
Background: Dementia is a common medical disorder in the elderly. Oxidative stress plays a major role in the process of cognitive decline in dementia. Perilla seed oil demonstrates its neuroprotective effects via anti-oxidative mechanisms against dementia. We investigate neuroprotective effects of perilla seed oil as an additional treatment in pati...
Article
Full-text available
This work proposes an automated algorithm based on adaptive threshold and Adaptive Neuro-Fuzzy Inference System (ANFIS) to couple with transcranial Doppler ultrasound (TCD) in detecting cerebral embolic signal (ES). Our main objective is to support practical stroke risk monitoring in interventional procedures. Suspected ESs are captured in real-tim...
Article
Full-text available
จุดมุ่งหมายสำคัญของการรักษาด้วย “การจัดการอุณหภูมิเป้าหมาย” (Targeted Temperature Management, TTM) คือ เพื่อช่วยกอบกู้หรือบรรเทาไม่ให้เนื้อเยื่อได้รับบาดเจ็บจากการขาดเลือดไปเลี้ยง และ เพื่อควบคุมความดันในกะโหลกศีรษะ TTM ได้รับการยอมรับให้เป็นการรักษาเพื่อช่วยกอบกู้หรือบรรเทาไม่ให้เนื้อเยื่อสมองได้รับบาดเจ็บจากการขาดเลือดไปเลี้ยงที่ได้ประสิทธิผลสูง...
Article
Full-text available
Background and purpose: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional outcomes after stroke. Methods: Data from the CHInese Medicine NeuroAiD Efficacy on Stroke (CHI...
Article
Full-text available
Background ROCKET AF and its East Asian subanalysis demonstrated that rivaroxaban was non‐inferior to warfarin for stroke/systemic embolism (SE) prevention in patients with non‐valvular atrial fibrillation (NVAF), with a favorable benefit–risk profile. XANAP investigated the safety and effectiveness of rivaroxaban in routine care in Asia‐Pacific....
Article
Full-text available
Background Intravenous recombinant tissue plasminogen activator (i.v. rt-PA) is the milestone treatment for patients with acute ischemic stroke. Stroke Fast Track (SFT) facilitates time reduction, guarantees safety, and promotes good clinical outcomes in i.v. rt-PA treatment. Nursing case management is a healthcare service providing clinical benefi...
Article
Full-text available
Dementia is a broad-spectrum terminology for a degenerate in cognitive function severe enough to intervene in activities of daily living. Oxidative stress plays a major role in the neurodegenerative cascade, leading to the irreversible mechanism in dementia. Perilla seed oil is extracted from its seeds and contains a high source of antioxidative su...
Article
Background: Stroke disproportionately affects people in low-income and middle-income countries. Although improvements in stroke care and outcomes have been reported in high-income countries, little is known about practice and outcomes in low and middle-income countries. We aimed to compare patterns of care available and their association with pati...
Article
Full-text available
Fat embolism syndrome (FES) is a life-threatening complication in patients with orthopedic trauma, especially long bone fractures. The diagnosis of fat embolism is made by clinical features alone with no specific laboratory findings. FES has no specific treatment and requires supportive care, although it can be prevented by early fixation of bone f...
Article
Full-text available
Backgrounds Stroke is the leading cause of death and long-term disability. Oxidative stress is elevated during occurrence of acute ischemic stroke (AIS). Soluble LOX-1 (sLOX-1) and NO are used as biomarkers for vascular oxidative stress that can reflect stabilization of atherosclerotic plaque. Previous study showed that simvastatin can reduce oxida...
Article
Full-text available
Background The difficult intubation is associated with failure of emergency tracheal intubation. This study aimed to develop and validate a model for predicting difficult intubation in emergency department (ED). Methods A cross-sectional study was conducted in the ED. We collected data from all consecutive adult patients who underwent emergency tr...
Article
Full-text available
Background Mild traumatic brain injury (TBI) is a common condition at the Emergency Medicine Department. Head computer tomography (CT) scans in mild TBI patients must be properly justified in order to avoid unnecessary exposure to X-rays and to reduce the hospital/transfer costs. This study aimed to evaluate which clinical factors are associated wi...
Article
Full-text available
Patients with mild head injuries, a GCS of 13–15, are at risk for intracranial hemorrhage. Clinical decision is needed to weigh between risks of intracranial hemorrhage and costs of the CT scan of the brain particularly those who are equivocal. This study aimed to find predictors for intracranial hemorrhage in patients with mild head injuries with...
Article
Full-text available
This study presented the image scanning U-tube viscometer technique to measure the whole blood viscosity. Two different constitutive models, power law and Casson, were selected to calculate blood viscosity. Results were compared with rotating viscometer. They had a good agreement at higher shear rates. Three constitutive models power law, Casson an...
Article
Full-text available
Background: Symptomatic intracranial hemorrhage (sICH) is common after intravenous thrombolysis in acute ischemic strokes (AISs). Available predictive scoring systems were derived mostly in the Western countries. Methods: Retrospective data in 1 provincial and 4 regional hospitals in the northern part of Thailand were reviewed. Patients with AIS...
Article
Objective: To compare the outcome of patients with acute ischemic stroke who received or did not receive intravenous fluid. Patients and methods: This study was a prospective, multicenter, randomized, open-label trial with blinded outcome assessment. We enrolled acute ischemic stroke patients without dehydration aged between 18 and 85 years with...
Conference Paper
Full-text available
This work investigated the potential of Deep Neural Network in detection of cerebral embolic signal (ES) from transcranial Doppler ultrasound (TCD). The resulting system is aimed to couple with TCD devices in diagnosing a risk of stroke in real-time with high accuracy. The Adaptive Gain Control (AGC) approach developed in our previous study is empl...
Article
Full-text available
Background: Patients with minor acute ischemic stroke or transient ischemic attack are at high risk for subsequent stroke, and more potent antiplatelet therapy in the acute setting is needed. However, the potential benefit of more intense antiplatelet therapy must be assessed in relation to the risk for major bleeding. The SOCRATES trial (Acute St...
Article
Full-text available
Targeted temperature management (TTM) shows the most promising neuroprotective therapy against hypoxic/ischemic encephalopathy (HIE). In addition, TTM is also useful for treatment of elevated intracranial pressure (ICP). HIE and elevated ICP are common catastrophic conditions in patients admitted in Neurologic intensive care unit (ICU). The most co...
Article
Full-text available
Background: Symptomatic intracranial hemorrhage (sICH) is a major complication after intravenous thrombolysis leading to severe disability and death. The incidence was higher in Asian than in western countries. Prognostic factors across ethnicities are presumably different. Studies in Asian populations are limited. Method: Clinical data from Jan...
Article
Full-text available
Reduced cerebrovascular reactivity (CVR) was found in patients with recent lacunar infarct. However, its mechanisms were controversial. The breath holding maneuver as vasodilatory stimulus is clinically useful for an estimation of cerebrovasomotor reactivity in well co-operative patients. Patients with lacunar infarct have no higher cortical dysfun...
Article
Full-text available
Background: Symptomatic intracranial hemorrhage (sICH) is the most unwanted adverse event in patients with acute ischemic stroke who received intravenous recombinant tissue plasminogen activator (i.v. rt-PA). Many tool scores are available to predict the probability of sICH. Among those scores, the Sugar, Early infarct sign, hyperDense middle cere...
Article
Full-text available
Background: Acute stroke can disturb autonomic regulation and promoting oxidative stress. Prolongation of QT interval is very common in stroke and related with stroke recurrent and sudden death. In this study, we hypothesize that neurovascular oxidative stress and autonomic modulation contribute to QT interval variation.
Article
Full-text available
Background: The Chinese Medicine NeuroAiD Efficacy on Stroke recovery - Extension (CHIMES-E) study is among the few acute stroke trials with long-term outcome data. We aimed to evaluate the recovery pattern and the influence of prognostic factors on treatment effect of MLC601 over 2 years. Methods: The CHIMES-E study evaluated the 2 years outcom...