Sombat Muengtaweepongsa

Thammasat University · Faculty of Medicine

Background: Acute ischemic stroke (AIS) retains a notable stance in global disease burden, with thrombolysis via recombinant tissue plasminogen activator (rtPA) serving as a viable management approach, albeit with variable outcomes and the potential for complications like hemorrhagic transformation (HT). The platelet-to-neutrophil ratio (P/NR) has...

Stroke results in many survivors experiencing limb dysfunction and functional disability. Early rehabilitation has shown promise in improving recovery. Traditional Thai Massage (TTM) is noted for potential benefits in aiding stroke recovery. Chaophya Abhaibhubejhr Hospital in Thailand has integrated TTM in treating various diseases and has develope...

Moyamoya disease (MMD), characterized by progressive internal carotid artery stenosis and collateral vessel formation, prompts cerebral perfusion complications and is stratified into idiopathic and Moyamoya syndrome subtypes. A multifaceted approach toward MMD management addresses cerebral infarctions through revascularization surgery and adjunctiv...

Background: Dyslipidemia is characterized by abnormal lipid concentrations in the bloodstream, heightening the risk of atherosclerosis. While statins are primarily prescribed to treat dyslipidemia, not all patients benefit from them for various reasons, such as intolerance, myopathy, and hepatotoxicity. Perilla frutescens (L.) Britton, traditionall...

Telemedicine and remote patient monitoring (RPM) systems have been gaining interest and received adaptation in healthcare sectors since the COVID-19 pandemic due to their efficiency and capability to deliver timely healthcare services while containing COVID-19 transmission. These systems were developed using the latest technology in wireless sensor...

Marchiafava-Bignami disease (MBD) is a rare condition characterized by demyelination of the corpus callosum. It is seen most often in patients with chronic alcoholism.

The novel coronavirus, SARS-CoV-2, can lead to potential neurological complications in COVID-19 patients. This study aims to assess the prevalence and associated risk factors of these complications among Thai individuals. We conducted a retrospective study on hospitalized adults with COVID-19 at Thammasat University Hospital from April 2020 to Sept...

The raw data of perilla seed pill

Introduction: Cannabidiol (CBD), a phytocannabinoid isolated from cannabis plants, is an interesting candidate for studying its anti-inflammatory effects, especially in the pre-clinical and animal models. Its anti-inflammatory effects, such as reduction of edema and arthritis, have been demonstrated in animal models. However, topical CBD administra...

Background : Saraburi province in central Thailand connects the capital to the north and northeast. A hospital-based model drives the Emergency Medical Service (EMS) system in Saraburi’s vicinity. We studied factors related to death within 24 hours of EMS patients. Methods: Patients who received EMS from the high-level operation team of Saraburi Ho...

Background: Cannabidiol (CBD), a non-psychoactive compound in cannabis, has various pharmacological advantages associated with clinical use, especially for reducing inflammatory arthritis and paw edema in animal models. This study evaluated the anti-inflammatory effects of various oral CBD doses (5-40 mg/kg) in rats after injecting 0.1 mL of carrag...

During the early six months after the onset of a stroke, patients usually remain disabled with limbs weakness and need intensive rehabilitation. An increased number of stroke patients is countered with a reduced number of physical therapists. The development of medical robots to substitute therapists' work should be helpful. We developed a prototyp...

Raw Data PNR in rtPA

Raw data neurologic COVID-19

Raw data oral CBD animal project

Our previous study showed the potential benefit of perilla seed oil for improving lipid profiles in the elderly. We conducted a post hoc data analysis of our previous study to investigate the efficacy of perilla seed oil for improving lipid profiles in the elderly after the 6-month treatment. A total number of 182 patients with mild to moderate dem...

Raw data

Motorcycle accidents accounted for the most common prevalence of Road traffic collision (RTC). Therefore, identifying the rider or passenger is crucial for ensuring fairness. However, patients who suffered from RTC frequently could not provide any information due to loss of consciousness, memory loss, or death. We aim to develop two separately mult...

Classification of normal sinus rhythm (NSR), paroxysmal atrial fibrillation (PAF), and persistent atrial fibrillation (AF) is crucial in order to diagnose and effectively plan treatment for patients. Current classification models were primarily developed by electrocardiogram (ECG) signal databases, which may be unsuitable for local patients. Theref...

Raw data of AF recording

Introduction: Cannabidiol (CBD) is a non-psychoactive compound of cannabis. Due to the therapeutic potential of CBD, there were given drugs through oral administration to treat pain and anti-inflammatory. The bioavailability of CBD has been reported to be poor when given through oral administration because of the high first-pass effect with cytochr...

Air embolic signals detected in the intracranial arteries using transcranial Doppler after intravenous injection of agitated saline bubbles indicate right-to-left cardiac shunting. They prove that emboli from venous sites can bypass the lungs and flow to the intracranial arteries. The Valsalva maneuver immediately after an intravenous injection of...

Background: Foot reflexology is a treatment with the hypothesis that such massage stimulation on the feet may cause a therapeutic effect which should be helpful for smoking cessation. However, its mechanism of action in the brain of smoking people remains unknown. Functional magnetic resonance imaging (fMRI) is helpful for real-time brain activity...

The diverse clinical manifestation of essential tremor (ET) has led to the question whether the different phenotypes may affect the clinical outcome and progression. This study aimed to estimate the clinical characteristics and natural history of ET and ET-plus. A total of 221 patients with ET were included, 117 (52.9%) reclassified as ET and 104 (...

Yahom-Navakot" (YN) is a Thai herbal remedy for treating fatigue and post-fever maladies ("Lom Plai Khai"). YN is composed of 55 plant materials based on a Thai essential medicines list. Extracts obtained by maceration with 95% ethanol (YNE) and water decoction (YNW) were analyzed by gas chromatography-mass spectrometry. Anti-bacterial activities o...

After resuscitation from cardiac arrest, a combination of the complex patho-physiologic process, known as post-cardiac arrest syndrome (PCAS), is attributed to multiple organ damage. Global ischemic cascade occurs in the brain due to generalized ischemia during cardiac arrest and the reperfusion process after the return of spontaneous circulation (...

The relationship between atrial fibrillation (AF) and distortion of autonomic function is reported in the literature. We aim to evaluate sample entropy (SampEn) and heart rate variability (HRV) in patients with persistent AF and compare them with patients suffering from paroxysmal AF. SampEn and HRV during the presentation of AF were analyzed. In p...

The reticular activating system (RAS) is responsible for wakefulness. The RAS projects activation to either side of the hemisphere. The dysfunction of the RAS or insufficiency of its activation results in impairment of consciousness. Physicians classify levels of awareness into four levels, from normal status to most severe unconsciousness, these b...

Many patients have significantly lower limb weakness after getting a stroke. Continuous regular physical therapy is essential to promote the improvement of the weakness and overall outcomes. Home rehabilitation provides motivation and enhances regular rehabilitation in stroke patients. The Do-It-Yourself (DIY) medical device is developed to fill th...

The coronavirus 2019 (COVID-19) infection initially affects the respiratory system. However, nervous system involvement lately becomes a significant feature of COVID-19 infection. The neurologic manifestations can be direct and indirect viral effects or just the non-specific complications from critical illness. The prevalence of stroke in patients...

antibiogram tuh 2021 (jan-jun)

Importance Prior trials of dual antiplatelet therapy excluded patients with moderate ischemic stroke. These patients were included in the Acute Stroke or Transient Ischaemic Attack Treated With Ticagrelor and ASA for Prevention of Stroke and Death (THALES) trial, but results have not been reported separately, raising concerns about safety and effic...

Central venous catheterization (CVC) remains a common practice in the emergency setting. Routine flushing 10–20 ml of normal saline to maintain the patency of CVC could affect the accuracy of laboratory tests. Typically, physicians require peripheral vein phlebotomy when more blood sampling is needed. One alternative method, the Pull-push method, c...

Rehabilitation is a crucial part of stroke recovery to help them regain use of their limb. The aim of this article was to compare the effectiveness of long-term training of mirror therapy with conventional rehabilitation therapy on neurological and recovery of upper limb in acute stroke patients. In this randomized and assessor-blinded control stud...

This paper aims to study the effectiveness of mirror therapy (MT) having treated to acute stroke patients. The subjects of 20 acute stroke patients, who possessed the ability to respond to verbal instructions were randomly blinded and allocated to a control group (n = 10, 59.2 ± 2.28 years) and a mirror group (n = 10, 53.8 ± 6.14 years). Both group...

To maintain the continuity of noncommunicable disease (NCD) services and ascertain the health outcomes of patients with NCDs during the COVID-19 (coronavirus disease 2019) outbreak in Thailand, various telemedicine services have been developed. To achieve this determination, the implementation framework has been constructed based on recommendations...

Background: Central venous catheterization (CVC) remains a common practice in the emergency setting. Routine flushing 10 - 20 ml of normal saline to maintain the patency of CVC could affect the accuracy of laboratory tests. Typically, physicians require peripheral vein phlebotomy when more blood sampling is needed. One of the alternative methods, t...

Medical treatment seems to be not entirely helpful in the treatment of Moyamoya disease. No evidence supports the benefits of any drug treatment in Moyamoya disease. The ischemic or hemorrhagic event in Moyamoya disease is not preventable with any medical treatment. However, most of the physicians still prescribe the antithrombotic drug for Moyamoy...

Objective: Targeted temperature management (TTM) is recommended for patients suffering a cardiac arrest after restoration of spontaneous circulation (ROSC). Heart rate variability (HRV), which reflects autonomic function, has been proposed as an outcome predictor but HRV measurement is not suitable for everyday practice. RR interval variation (RRIV...

The cognitive impairment was documented in stroke patients, in addition to disability and might lead to dementia. Hence the proper cognitive program is important in the acute phase. This study is a quasi-experimental research design aimed to evaluate the effect of the family participation program in cognitive rehabilitation on the functional outcom...

Background and purpose Postherpetic neuralgia (PHN) is a well-known painful syndrome. Acupuncture is a treatment for PHN. We aimed to compare the effectiveness of pain control between press needle and electroacupuncture (EA) in PHN patients. Materials and methods We conducted a retrospective cohort study by a review of PHN patients treated with th...

Two major objectives of targeted temperature management (TTM) in critical care neurology are to provide neuroprotective treatment and to control intracranial pressure (ICP). TTM is the most promising neuroprotective therapy due to its multiple sites of action against hypoxic-ischemic cascade. TTM is useful for ICP reduction. Hypoxic-ischemic brain...

Background The standard treatment of acute ischemic stroke patients is thrombolytic therapy within 60 minutes of a patient’s arrival in stroke center hospitals. Based on the policy of the Lampang Referral System Committee, blood samples of suspected stroke patients need to be collected before transfer to the stroke center (Lampang Hospital). It was...

The purpose of this study was to determine the factors influencing the prioritization model for the treatment of patients with mobile computed tomography (mCT) scanning. The main research process entailed value innovation product planning (VIPP), which focuses on three steps: idea generation; idea screening; concept testing and development. This wa...

Evoked potentials are the electrical signals generated by the nervous system in response to sensory stimuli. Auditory, visual, and somatosensory stimuli are used commonly for clinical evoked potential studies. Somatosensory evoked potentials (SEPs) consist of a series of waves that reflect sequential activation of neural structures along the somato...

Background: Dementia is a common medical disorder in the elderly. Oxidative stress plays a major role in the process of cognitive decline in dementia. Perilla seed oil demonstrates its neuroprotective effects via anti-oxidative mechanisms against dementia. We investigate neuroprotective effects of perilla seed oil as an additional treatment in pati...

This work proposes an automated algorithm based on adaptive threshold and Adaptive Neuro-Fuzzy Inference System (ANFIS) to couple with transcranial Doppler ultrasound (TCD) in detecting cerebral embolic signal (ES). Our main objective is to support practical stroke risk monitoring in interventional procedures. Suspected ESs are captured in real-tim...

จุดมุ่งหมายสำคัญของการรักษาด้วย “การจัดการอุณหภูมิเป้าหมาย” (Targeted Temperature Management, TTM) คือ เพื่อช่วยกอบกู้หรือบรรเทาไม่ให้เนื้อเยื่อได้รับบาดเจ็บจากการขาดเลือดไปเลี้ยง และ เพื่อควบคุมความดันในกะโหลกศีรษะ TTM ได้รับการยอมรับให้เป็นการรักษาเพื่อช่วยกอบกู้หรือบรรเทาไม่ให้เนื้อเยื่อสมองได้รับบาดเจ็บจากการขาดเลือดไปเลี้ยงที่ได้ประสิทธิผลสูง...

Background and purpose: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional outcomes after stroke. Methods: Data from the CHInese Medicine NeuroAiD Efficacy on Stroke (CHI...

Background ROCKET AF and its East Asian subanalysis demonstrated that rivaroxaban was non‐inferior to warfarin for stroke/systemic embolism (SE) prevention in patients with non‐valvular atrial fibrillation (NVAF), with a favorable benefit–risk profile. XANAP investigated the safety and effectiveness of rivaroxaban in routine care in Asia‐Pacific....

[This corrects the article DOI: 10.1155/2018/1479850.].

Background Intravenous recombinant tissue plasminogen activator (i.v. rt-PA) is the milestone treatment for patients with acute ischemic stroke. Stroke Fast Track (SFT) facilitates time reduction, guarantees safety, and promotes good clinical outcomes in i.v. rt-PA treatment. Nursing case management is a healthcare service providing clinical benefi...

Dementia is a broad-spectrum terminology for a degenerate in cognitive function severe enough to intervene in activities of daily living. Oxidative stress plays a major role in the neurodegenerative cascade, leading to the irreversible mechanism in dementia. Perilla seed oil is extracted from its seeds and contains a high source of antioxidative su...

Background: Stroke disproportionately affects people in low-income and middle-income countries. Although improvements in stroke care and outcomes have been reported in high-income countries, little is known about practice and outcomes in low and middle-income countries. We aimed to compare patterns of care available and their association with pati...

Fat embolism syndrome (FES) is a life-threatening complication in patients with orthopedic trauma, especially long bone fractures. The diagnosis of fat embolism is made by clinical features alone with no specific laboratory findings. FES has no specific treatment and requires supportive care, although it can be prevented by early fixation of bone f...