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Solomon Habtemariam

Solomon Habtemariam
Herbal Analysis Services UK

PhD
Drug discovery; Quality control of medicinal products and nutraceuticals; Pharmaceutical science education

About

307
Publications
117,043
Reads
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10,792
Citations
Citations since 2017
156 Research Items
8889 Citations
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201720182019202020212022202305001,0001,5002,0002,500
201720182019202020212022202305001,0001,5002,0002,500
Additional affiliations
January 2012 - present
CMS College Kottayam
January 2011 - present
Università degli Studi di Bari Aldo Moro
January 2010 - present
University of East London

Publications

Publications (307)
Article
Full-text available
The isolation of phlorizin from the bark of an apple tree in 1835 led to a flurry of research on its inhibitory effect on glucose transporters in the intestine and kidney. Using phlorizin as a prototype drug, antidiabetic agents with more selective inhibitory activity towards glucose transport at the kidney have subsequently been developed. In cont...
Article
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Background In late 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is responsible for coronavirus disease (COVID-19), was identified as the new pathogen to lead pneumonia in Wuhan, China, which has spread all over the world and developed into a pandemic. Despite the over 1 year of pandemic, due to the lack of an effecti...
Article
Given the importance of COVID-19-induced ARDS, recently, researchers have strived to determine underlying mechanisms involved in the inflammatory responses. In this regard, inflammasomes possess a distinct priority for cytokine storm occurrence and subsequently ARDS progression in ill patients with SARS-CoV-2 infection. In this mini-review, the cha...
Article
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Background: The existing drug treatments for trypanosomiases are limited and suffer from shortcomings due to their toxicity and the emergence of resistant parasites. Developing anti-trypanosomal compounds based on natural products is a promising way of fighting trypanosomiases. Objectives: This study aims to identify through scientific review a...
Article
Full-text available
Objective To examine the preventive effects of Aloe vera in colorectal cancer patients undergoing radiotherapy. Material and Method Twenty colorectal cancer patients, who received radiation, were randomized to receive Aloe vera 3% or placebo ointment, 1 g twice daily for 6 weeks. At weekly visits, acute radiation proctitis (ARP) was evaluated by R...
Article
Full-text available
Bryophyllum pinnatum is a well-known medicinal plant that has been used in many traditional systems of medicines. This includes treating fever, smallpox, otitis, cough, asthma, headache, convulsion, and general debility. The various secondary metabolites identified from B. pinnatum include steroids, flavonoids, terpenoids, fatty acid, bufadienolide...
Article
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Objective: The aim of this work was to evaluate the antioxidant potential of Datura metel. Materials and methods: Heart failure was induced in the frog's heart by continuous perfusion of hydrogen peroxide. Survival time and some heart tissue parameters of oxidative stress were recorded in the presence of aqueous extracts of the leaves and seeds...
Article
Hypothetical proteins (HPs) are non-predicted sequences that are identified only by open reading frames in sequenced genomes but their protein products remain uncharacterized by any experimental means. The genome of every species consists of HPs that are involved in various cellular processes and signaling pathways. Annotation of HPs is important a...
Article
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Neurodegenerative diseases (NDs) such as Alzheimer’s disease, Parkinson’s disease, Huntington disease, amyotrophic lateral sclerosis, and prion disease affect any part of the brain. The complete mechanism of ND is unknown, but there are some molecular mechanism and chemical process. Natural compounds have better compatibility with the human body al...
Article
Besides the common symptoms in COVID-19, it has been thought to be a more imperative measure to identify the extraordinary manifestations of the illness, which would be more helpful to improve clinical management. In the current report, a 39-year-old woman and a 44-year-old man showed reactive cervical and preauricular lymphadenopathies, respective...
Article
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PurposePrimary pediatric tumors are the most common solid tumors in children. There are limited reports on the management and outcome of these tumors in the developing countries. In recent years, advances have been done in the diagnosis, treatment, and outcome of these tumors. The aim of this study was to evaluate the histopathology, characteristic...
Preprint
Full-text available
Colchicine has shown clinical benefits in the management of COVID-19 via its anti-inflammatory effect. However, the exact role of colchicine in COVID-19 patients is unknown. The current clinical trial was performed on 202 patients with moderate to severe COVID-19. Patients were randomly assigned in a 1:1 ratio to receive up to a 3-day course of 0.5...
Article
Currently, the world is facing a pandemic of the new coronavirus SARS-CoV-2 that causes COVID-19. Identifying key targets in the viral infection lifecycle is urgently needed for designing therapeutic strategies to combat the virus. Furin is a subtilisin-like proprotein convertase with diverse cellular functions. Emerging evidence suggests that furi...
Article
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Arglabin (l(R),10(S)-epoxy-5(S),5(S),7(S)-guaia-3(4),ll(13)-dien-6,12-olide), is a natural sesquiterpene γ-lactone which was first isolated from Artemisia glabella. The compound has been shown to possess anti-inflammatory activity through inhibition of the NLR Family pyrin domain-containing 3 (NLRP3) inflammasome and production of proinflammatory c...
Article
Infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) provokes acute inflammation due to extensive replication of the virus in the epithelial cells of the upper and lower respiratory system. The mammalian target of rapamycin (mTOR) is a l signalling protein with critical functions in cell growth, metabolism, and proliferatio...
Article
In this review, we discussed the biological targets of carnitine, its effects on immune function, and how L-carnitine supplementation may help critically ill patients. L-carnitine is a potent antioxidant. L-carnitine depletion has been observed in prolonged intensive care unit (ICU) stays, while L-carnitine supplementation has beneficial effects in...
Article
Recently, the medications used for the severe form of the coronavirus disease-19 (COVID-19) therapy are of particular interest. In this sense, it has been supposed that anti-VEGF compounds would be good candidates in the face of “cytokine storm” and intussuscepted angiogenesis due to having an appreciable anti-inflammatory effect. Therefore, they c...
Article
Mitochondria are ubiquitous membrane-bound organelles that not only play a key role in maintaining cellular energy homeostasis and metabolism but also in signaling and apoptosis. Aryl hydrocarbons receptors (AhRs) are ligand-activated transcription factors that recognize a wide variety of xenobiotics, including polyaromatic hydrocarbons and dioxins...
Article
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Rutin is a unique antioxidant flavonoid that is mainly found in fruit, vegetables, cereals, and many other plant-based human diets. This review aims to highlight the in vitro anticancer properties of rutin including combination therapeutic strategies. Literature resources were gathered through PubMed, Scopus, Web of Science, and Google Scholar data...
Article
Wound is defined as any injury to the body such as damage to the epidermis of the skin and disturbance to its normal anatomy and function. Since ancient times, the importance of wound healing has been recognized, and many efforts have been made to develop novel wound dressings made of the best material for rapid and effective wound healing. Medicin...
Article
Neurodegenerative disorders, particularly in the elderly population, represent one of the most pressing social and health-care problems in the world. Besides the well-established role of both oxidative stress and inflammation, alterations of the immune response have been found to be closely linked to the development of neurodegenerative diseases. I...
Article
Full-text available
Objective: To assess the patient's satisfaction rate during two distinct registry procedures in the emergency department. Methods: A cross-sectional study was conducted in educational hospitals with a high volume of patient's admission in Tabriz-Iran and Erzurum-Turkey. In this study, we used a Press Ganey questionnaire as a data collection tool...
Article
Full-text available
Citation: Milani, G.; Cavalluzzi, M.M.; Solidoro, R.; Salvagno, L.; Quintieri, L.; Di Somma, A.; Rosato, A.; Corbo, F.; Franchini, C.; Duilio, A.; et al. Molecular
Article
Decades of research have been put in place for developing sustainable routes of bioproduction of high commercial value natural products (NPs) on the global market. In the last few years alone, we have witnessed significant advances in the biotechnological production of NPs. The development of new methodologies has resulted in a better understanding...
Article
Full-text available
Berberine, the main bioactive component of many medicinal plants belonging to various genera such as Berberis, Coptis, and Hydrastis is a multifunctional compound. Among the numerous interesting biological properties of berberine is broad antimicrobial activity including a range of Gram-positive and Gram-negative bacteria. With the aim of identifyi...
Article
Ventilator-associated pneumonia (VAP) resulting from bacterial infection is a prevalent medical problem in intensive care units (ICUs). The purpose of this study was to systematically review available studies on oral products employed to control and reduce VAP in patients undergoing tracheal intubation. This study was based on a systematic review o...
Article
Adapted to effectively capture oxygen from inhaled air and deliver it to all other parts of the body, the lungs constitute the organ with the largest surface area. This makes the lungs more susceptible to airborne pathogens and pollutants that mediate pathologies through generation of reactive oxygen species (ROS). One pathological consequence of e...
Article
Full-text available
Background Levamisole has shown clinical benefits in the management of COVID-19 via its immunomodulatory effect. However, the exact role of Levamisole effect in clinical status of COVID-19 patients is unknown. We aimed to evaluate the efficacy of Levamisole on clinical status of patients with COVID-19 during their course of the disease. Methods Th...
Article
Background: Benign prostatic hyperplasia (BPH) is the most prevalent disease of the prostate in elderly men. Since Nigella sativa has been reported to show various pharmacological effects, this study was conducted to examine the effect of N. sativa seed oil on experimental BPH. Methods: The oil was extracted using the cold-pressing method. Fifty...
Article
The central dogma of molecular biology explains the flow of genetic information from DNA to functional products such as proteins. In most cases, a linear relationship with high correlation coefficient exists between the concentration of mRNA, the middle man, and the functional product. Untranslated regions (UTRs) of RNA form considerable base pairi...
Article
Full-text available
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters host cells through the endosomal and nonendosomal pathways. Although the relative contribu-tion of each mechanism could vary depending on host cell types, evidence from studies on related coronaviruses sug-gest that simultaneous targeting of both pathways could be an efficient...
Article
Full-text available
Myrianthus arboreus is use traditionally as an antidiabetic agent in Ghana. We reported the in vivo antidiabetic activity of its 70 % ethanol stem bark extract (MAB) which we found to be strongly concentrated in its EtOAc fraction using glucose uptake and enzyme inhibitory assays. The present study sought to investigate the in vivo hypoglycaemic an...
Article
Background Lignans are large group of polyphenols that are formed by the coupling of two coniferyl alcohol residues. Based on their origin, lignans are broadly grouped into plant lignans such as isolariciresinol, secoisolariciresinol diglucoside, lariciresinol, and matairesinol; and mammalian lignans such as enterodiol and enterolactone. Based on t...
Article
Full-text available
Interest in alkylamide, as a class of compound, has grown tremendously in recent years. This interest is due to the many presumed benefits in food, cosmetics, and medicine. This review focuses on the different alkylamides naturally occurring in many plant species. Several methods have been employed for their identification as well as isolation and...
Article
Under the hypothesis that cardioprotecting agents might benefit from a synergism between antiarrhythmic activity and antioxidant properties, a small series of mexiletine analogues were coupled with the 2,2,5,5‐tetramethylpyrroline moiety, known for its antioxidant effect, in order to obtain dual acting drugs potentially useful in the protection of...
Article
Full-text available
Letter to the Editor: Glucose-6-phosphate dehydrogenase deficiency and SARS- CoV-2 mortality: Is there a link and what should we do?
Article
In December 2019, an unprecedented outbreak of pneumonia associated with a novel coronavirus disease 2019 (COVID-19) emerged in Wuhan City, Hubei province, China. The virus that caused the disease was officially named by the World Health Organization (WHO) as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). According to the high tr...
Article
The global impact of the new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infection that caused COVID-19 has been evident in the last few months from the unprecedented socioeconomic disruption to more than 600,000 deaths. The lack of vaccine and effective therapeutic agents for the disease prompted world-wide effort to...
Article
Full-text available
Infection by human Coronaviruses (CoVs) such as HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1generally results in moderate to severe respiratory and intestinal infections in humans. The deadly human CoVs emerging in the last two decades however became the cause of great global concern. The severe acute respiratory syndrome (SARS) SARS-CoV, Middle East...
Article
Full-text available
What is known and objective This article summarizes the effects of sivelestat on acute lung injury/acute respiratory distress syndrome (ALI/ARDS) or ARDS with coagulopathy, both of which are frequently seen in patients with COVID‐19. Comment COVID‐19 patients are more susceptible to thromboembolic events, including disseminated intravascular coagu...
Article
Full-text available
The viral infection due to the new coronavirus or coronavirus disease 2019 (COVID-19), which was reported for the first time in December 2019, was named by the World Health Organization (WHO) as Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV2), because of the very similar genome and also its related symptoms to SARS-CoV1. The ongoing COV...
Article
The global spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes COVID19 has become a source of grave medical and socioeconomic concern to the human society. Since its first appearance in the Wuhan region of China in December 2019, the most effective measures of managing the spread of SARS-CoV-2 infection have been...
Conference Paper
Full-text available
The Book 2 of Proceedings, Ethnobotany Smposio, Cusco, Peru, is comprehensive of five papers that cover Current Research in Frontier Agroecology, Economic Botany Permaculture, and native production, in various environmental scenarios: Mexico, Peru, Greece. They constitute Models for sustainable Food Production in the forthcoming years.
Article
The novel coronavirus 2019-nCoV (SARS-CoV-2) infection that emerged in China in December 2019 has rapidly spread to become a global pandemic. This article summarizes the potential benefits of erythropoietin (EPO) in alleviating SARS-CoV-2 pathogenesis which is now called COVID-19. As with other coronavirus infection, the lethality of COVID-19 is as...
Article
Full-text available
Various interferon (IFN)-inducible transmembrane (IFITM) proteins are known to be expressed in human tissues though only IFITM 1–3 are inducible by IFN. Numerous studies have shown that activation of IFITM3 could suppress infection by influenza and coronaviruses such as the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). In view of the pot...
Article
Full-text available
Coriolus versicolor (L.) Quél. is a higher fungi or mushroom which is now known by its accepted scientific name as Trametes versicolor (L.) Lloyd (family Polyporaceae). The polysaccharides, primarily two commercial products from China and Japan as PSP and PSK, respectively, have been claimed to serve as adjuvant therapy for cancer. In this paper, r...
Article
Full-text available
Since the first human infection of SARS‐CoV‐2 was reported in the Hubei (Wuhan) province of China, the world has been facing a relentless degree of socioeconomic and medical crisis. The disease of SARS‐CoV‐2 infection which is now called the COVID‐19 pandemic has spread to several countries across the globe (Nicastri et al., 2020). This article is...
Article
The discovery of new drugs for treating the new coronavirus (SARS-CoV-2) or repurposing those already in use for other viral infections is possible through understanding of the viral replication cycle and pathogenicity. This article highlights the advantage of targeting one of the non-structural proteins, helicase (nsp13), over other SARS-CoV-2 pro...
Article
Full-text available
Readers are aware of the global emergency caused by the novel coronavirus SARS-CoV-2 (2019-nCoV) infection that results in COVID-19. With high rate of transmission and proven lethality, especially to the elderly, there is currently no vaccine or drug therapy to COVID-19. The century-old strategy currently practised around the world including sanita...
Article
Full-text available
Berberine is a quaternary isoquinoline alkaloid that has been isolated from numerous plants which are still in use today as medicine and herbal supplements. The great deal of enthusiasm for intense research on berberine to date is based on its diverse pharmacological effects via action on multiple biological targets. Its poor bioavailability result...
Article
Full-text available
The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currentl...
Article
Full-text available
Apart from differences in transmission and mortality rate, there are a lot of similarities in genetics, pathogenesis, clinical manifestation, etc. between SARS-CoV, MERS- Cov and SARS-CoV-2. Previous valuable lessons learned from other coronavirus outbreaks and a plethora of research data on this topic can help us to select the best treatment strat...
Article
Full-text available
Berberine is multifunctional natural product with potential to treat diverse pathological conditions. Its broad-spectrum anticancer effect through direct effect on cancer cell growth and metastasis have been established both in vitro and in vivo. The cellular targets that account to the anticancer effect of berberine are incredibly large and range...
Article
Berberine is a natural pentacyclic isoquinoline alkaloid that has been isolated as the principal component of many popular medicinal plants such as the genus Berberis, Coptis and Hydrastis. The multifunctional nature of berberine as a therapeutic agent is an attribute of its diverse effects on enzymes, receptors and cell signalling pathways. Throug...
Article
Full-text available
By using the streptozotocin- (STZ-) induced cytotoxicity in β-TC3 cells as an assay model, a bioassay-guided fractionation study was employed to isolate and characterize the potential antidiabetic principles of roots of Prosopis farcta. A combination of open column chromatography on reverse-phase silica gel using a water-ethanol gradient (10 : 90 t...
Article
Full-text available
Dictyophora indusiata (Vent. Ex. Pers.) Fischer or Phallus indusiatus is an edible member of the higher mushroom phylum of Basidiomycetes. Known for its morphological elegance that gave it the names bridal veil fungus, veiled lady or queen of the mushrooms, it has numerous medicinal values that are beginning to be acknowledged through pharmacologic...
Article
Full-text available
Dictyophora indusiata (Vent. Ex. Pers.) Fischer or Phallus indusiatus is an edible member of the higher mushroom phylum of Basidiomycetes. Known for its morphological elegance that gave it the names bridal veil fungus, veiled lady or queen of the mushrooms, it has numerous medicinal values that are beginning to be acknowledged through pharmacologic...
Article
Full-text available
Flavanones are a group of flavonoids that derive from their immediate chalcone precursors through the action of chalcone isomerase enzymes. The Aromatic A and B rings, C4-keto group, and the 15-carbon flavonoid skeleton are all evident in flavanones, but a notable absence of C2-C3 double bond and a lack of oxygenation at C-3 position of the C-ring...
Article
Full-text available
In diverse living organisms, signaling within the cell, chemical communication between cells or simply the fate of cells to survive or die is largely dependent on the intricate balance of control mechanisms related to reactive oxygen species (ROS)[...]
Article
Biotechnology Advances (in press) Resveratrol and the biosynthetically related stilbenes are plant secondary metabolites with diverse pharmacological effects. The versatile functions of these compounds in plant defense mechanisms as phytoalexins on one hand, and in human health as potential pharmaceutical agents on the other, have attracted lots...
Article
A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural products that have potential anti-cancer properties due to their proven a...
Book
Description Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just th...
Book
Inflammatory bowel disease is due to complex biological response of body tissues in colon and small intestine. Most common diseases are Crohn's disease, and Ulcerative colitis. The reason of IBD is unknown but Genetics and immune system problems are associated in formation. http://openaccessebooks.com/inflammatory-bowel-disease.html Open Access e...
Article
Full-text available
The common buckwheat, Fagopyrum esculentum Moench (Polygonaceae) is a gluten-free pseudocereal that has been gaining in popularity in recent years as a low-calorie and nutrient-rich healthy food option. Buckwheat farming is common in Eastern European countries and the Far East, while in the UK and other Western European countries, the plant has lim...
Article
Full-text available
Ursolic acid (UA) is a pentacyclic triterpene which is found in common herbs and medicinal plants that are reputed for a variety of pharmacological effects. Both as an active principle of these plants and as a nutraceutical ingredient, the pharmacology of UA in the CNS and other organs and systems has been extensively reported in recent years. In t...
Article
Full-text available
Despite extensive progress in understanding the pathology of Alzheimer’s disease (AD) over the last 50 years, clinical trials based on the amyloid–beta (Aβ) hypothesis have kept failing in late stage human trials. As a result, just four old drugs of limited clinical outcomes and numerous side effects are currently used for AD therapy. This article...
Article
Full-text available
Liver diseases such as hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma are one of the major health challenges in the world and many conditions such as inadequate nutrition, viral infection, ethanol and drug abuse, xenobiotic exposure, and metabolic diseases have been implicated in the development and progression of liver diseases. Seve...
Chapter
Bilberries and blueberries are represented by various species of the genus Vaccinum in the plant family of Ericaceae. Powered by their polyphenol composition which is largely dominated by anthocyanins, the numerous health benefits of these fruits including for treating type 2 diabetes (T2D) and associated diseases have been advocated in recent year...
Chapter
The dried flower bud of Syzygium aromaticum (Synonym, Eugenia caryophyllata) of the family Myrtaceae, known as clove, is one of the oldest spices ever to be used and traded by humans. This small flower bud of less than 2 cm is packed-full of essential oil dominated by eugenol, fixed oil dominated by oleic and linoleic acids; terpenoids dominated by...
Chapter
At least four species of pumpkin (Cucurbita pepo, C. moschata, C. ficifolia and C. maxima) are known to have antidiabetic, antiobesity and lipid lowering effects in the various animal and cellular models. This chapter exhibits the therapeutic potential of these common food and nutraceutical ingredients by looking into their distinct chemical compos...
Chapter
In this chapter, the chemistry of turmeric (rhizomes of Curcuma longa L.) including the curcuminoids and oil components are presented with special emphasis on biochemical mechanisms of turmeric extracts and compounds as therapeutic agents. An impressive list of in vitro protein-based and cellular assay systems, and chemically- and diet-induced as w...
Chapter
For thousands of years, medicinal plants have been used by mankind to treat numerous disease conditions including metabolic syndrome. In addition to common usage as herbs, spices, fruits, and beverages, there is now also a growing trend to employ many medicinal plants as dietary supplements. This chapter outlines the chemical and pharmacological ba...
Chapter
The goal of type 2 diabetes (T2D) therapy is to achieve outcomes that are associated with the diagnosis of the disease itself and centred at reversing the increased levels of blood glucose and glycated haemoglobin. The common approaches in T2D management are lifestyle changes such as dietary control and exercise regimens as well as pharmacotherapy...
Chapter
Native to the subtropics of South America, yerba maté (Ilex paraguariensis A.St.-Hil., Aquifoliaceae) has a long history of usage as a beverage plant far before the conquest of the region by the Spaniards. This chapter outlines the transformation of this local beverage as commercial product which