Sok Nicolas

Sok Nicolas
University of Burgundy | UB · AgroSup Dijon

PhD

About

31
Publications
4,785
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
481
Citations
Additional affiliations
September 2011 - present
UMR PAM Procédés Alimentaires et Microbiologiques
UMR PAM Procédés Alimentaires et Microbiologiques
Position
  • Professor (Assistant)
September 2011 - present
Institut national supérieur des sciences agronomiques, de l'alimentation et de l'environnement
Position
  • Professor (Associate)
September 2009 - September 2010
University of Burgundy
Position
  • Research Assistant

Publications

Publications (31)
Article
Molecularly imprinted polymers (MIPs), often referred to as “artificial” or “plastic” antibodies, are synthetic alternatives to natural receptors. Based on the “key-and-lock” principle, a template is imprinted into a polymer, which is then able to selectively bind to a target molecule. Over the past 50 years, MIPs have continued to attract attentio...
Article
SO2 reaction with electrophilic species present in wine, including in particular carbonyl compounds, is responsible for the reduction of its protective effect during wine aging. In the present study, direct ¹H NMR profiling used to monitor the reactivity of SO2 with acetaldehyde under wine-like oxidation conditions. The dissociation of acetaldehyde...
Article
Full-text available
Background: Plant-based foods such as hummus are alternative to animal protein, and when properly prepared, they help to alleviate nutritional iron deficiency that leads to anemia, a global health problem. Objective: The objective was to assess iron intake among Lebanese women and related participant’s characteristics, discern iron-rich dietary pat...
Article
Full-text available
Hummus, an iron-containing plant-based dish mainly made from chickpea purée, tahini, lemon juice and garlic, could be a valuable source of iron when bioavailable. Since the processing and formulation of food influence iron bioavailability, the present study investigated for the first time, their effects on hummus. Firstly, iron bioaccessibility was...
Article
Full-text available
For efficiently measuring copper (II) ions in the acidic media of white wine, a new chemosensor based on rhodamine B coupled to a tetraazamacrocyclic ring (13aneN4CH2NH2) was designed and synthesized by a one-pot reaction using ethanol as a green solvent. The obtained chemosensor was characterized via NMR, UV and fluorescent spectra. It was marked...
Article
Full-text available
Active films are produced by a grafting reaction based on the reactivity between chitosan amino groups and lignin hydroxyl groups. This opens a new route for the valorization of lignin, with the possibility of tuning the anti-oxidant activity.
Article
Iprodione is a fungicide widely used in viticulture in most agricultural countries. It was banned recently in the European community because of its carcinogenic and endocrine disrupting characters. In this work, a cheap analytical method able to monitor iprodione in a white wine was developed. Molecularly imprinted sol-gel polymers (MIS) specific t...
Article
An efficient route has been developed for the synthesis of multifunctional tetraazacycloalkanes (in particular 1,4,7,10‐tetraazacyclotridecane) incorporating an aminomethyl pendant arm on the carbon skeleton. Starting from the appropriate C‐functionalized bisaminal‐protected intermediate, the target macrocycles were easily obtained by means of a st...
Article
The acid gelation by glucono-δ-lactone of thermal protein aggregates from mixed pea globulin (Glob) and β-lactoglobulin (βlg), namely “mixed-aggregates”, was investigated at 25 °C in comparison to that of mixtures of thermal aggregates of each protein obtained beforehand separately (“mixtures of aggregates”). A phase diagram indicating thermal gela...
Article
Full-text available
We report herein an efficient and general method for the synthesis of new bismacrocyclic compounds, structural analogues of biscyclam AMD3100, in which the two macrocycles are linked together through carbon atoms of the cycles. Several representatives of this new class of biscyclic derivatives were prepared by reacting C-aminomethyl-13aneN4 with ar...
Article
We report herein an efficient synthesis of news naphtalimide-based fluorescent derivatives functionalized with an α,β-unsaturated carbonyl group. Probes were synthesized from reaction of an amino-naphtalimide precursor with maleic anhydride. Photophysical study of fluorescent probes and cells labelling were performed, and showed that the reactive d...
Article
The new ligand L was prepared, featuring a 13-membered tetraaza macrocyclic ring and a 1,8-naphtalimide fluorophore appended on a C atom of its backbone. The protonation constants of L as well as its complexation constants with Zn2+ have been determined in 1:1 water:methanol solution by potentiometric titrations. pH-fluorimetric titrations have bee...
Article
Full-text available
Bombesin (BBN) was covalently bound to graftable subphthalocyanine (SubPc) or to a cholesterol derivative, a component of a liposome that encapsulates non graftable SubPc. The latter bioconjugation approach was suitable to address the stability of SubPc and was achieved by copper-free click-chemistry on the outer-face of the liposome. Liposomes wer...
Article
A new synthetic method has been developed for the preparation of reinforced cyclams (1,4,8,11-tetraazacyclotetradecane) C-functionalized on the bridging unit, by using a one pot reaction starting from the appropriate bis-aminal cyclam intermediate. The high reactivity of quaternized aminal moiety toward nucleophilic agent has been used to elaborate...
Article
The present work investigates the formation of protein aggregates (85°C, 60 min incubation) upon heat-treatment of β-lactoglobulin (βlg) - pea globulins (Glob) mixtures at pH 7.2 and 5mM NaCl from laboratory-prepared protein isolates. Various βlg/Glob weight ratios were applied, for a total protein concentration of 2 wt% in admixture. Different ana...
Article
A new method based on 1H NMR spectroscopy was developed for monitoring transglutaminase crosslinking reaction with model molecules (CBZ-Gln-Gly and N-α-acetyl-lysine). The transglutaminase reaction led to the appearance of new resonances on NMR spectrum as well as significant decrease in others. The new observed resonances, originated from newly fo...
Article
This report focuses on cold-set gelation of pea (Pisum sativum L.) proteins and related globulin fractions, namely Vicilin 7S and Legumin 11S. Protein thermal denaturation and aggregation were investigated using differential scanning calorimetry (DSC) sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis, and sulfhydryl (S-)...
Article
The heat-induced denaturation and aggregation of mixed pea globulins (8 %, w/w) was investigated using differential scanning calorimetry (DSC), SDS-PAGE, and size-exclusion chromatography (SEC-HPLC). DSC data showed that the pea proteins denaturation temperature (Td) was heating-rate dependent. The Td value decreased of about 4°C by lowering the he...
Article
Full-text available
A silane-derivatized tetraazaCu2+ macrocyclic complex is prepared, which forms monolayers on glass surfaces, capable of allowing the further deposition of a stable monolayer of silver nanoparticles, obtaining by this, surfaces that display an enhanced antibacterial activity against Staphylococcus aureus and Escherichia coli.
Article
A powerful synthetic route for the preparation of new polyazamacrocycles, valuable precursors of bifunctional chelating agents with applications in nuclear medicine, is reported. The desired functional group was introduced onto the macrocycle backbone during the cyclization step, thus avoiding the tedious preparation of a C-functionalized synthon....
Article
A multitasking fluorescent device can be obtained by forming micelles of Triton X-100, containing a lipophilic macrocyclic Cu(2+) complex and the coordinating fluorophore Coumarin 343 (C343), which features a COOH moiety. At low pH the two micellised components do not interact, and the fluorescence of Courmarin 343 (C343) is intense. At intermediat...
Article
Full-text available
Three 13aneN4 macrocyclic ligands have been prepared bearing a -CH(2)NHR side arm (R = H, n-C(5)H(11), n-C(10)H(21)) on a carbon atom. When Cu(2+) is complexed in the macrocyclic ring, the amino group of the side arm undergoes an acid-base protonation equilibrium but it is not able to coordinate apically the metal cation even when it is deprotonate...
Article
Potentiometric titrations, fluorescence versus pH titrations, dynamic light scattering and fluorescence polarization anisotropy studies demonstrate that inside the nanodimensioned Triton X-100 micelles, 1-pyrenecarboxylic acid, PCOO(-), forms an apical complex with the Zn(2+) cation encircled by a lipophilic cyclen ligand and hugely increasing its...
Article
Potentiometric titrations, fluorescence versus pH titrations, dynamic light scattering and fluorescence polarization anisotropy studies demonstrate that inside the nanodimensioned Triton X-100 micelles, 1-pyrenecarboxylic acid, PCOO−, forms an apical complex with the Zn2+ cation encircled by a lipophilic cyclen ligand and hugely increasing its fluo...