Sohtaro Mine

Sohtaro Mine
National Institute of Allergy and Infectious Diseases | NIAID · Laboratory of Infectious diseases

Ph.D., MD., Pharm.D.

About

33
Publications
6,378
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
241
Citations
Additional affiliations
April 2012 - July 2014
National Center for Global Health and Medicine in Japan
Position
  • Pathologist

Publications

Publications (33)
Article
Full-text available
This is a review article based on the international symposium report of the "US-Japan Conference on Advances in Oncology: Cancer and Infectious Diseases" held online on June 25, 2021, which provided an update on the association between oncology and infectious disease research from cutting-edge basic science to high-impact clinical trials.
Article
Primary infection with Epstein-Barr virus (EBV) is associated with post-transplant lymphoproliferative disease and severe disease in patients with X-linked lymphoproliferative disease; no therapies are approved to prevent EBV infection in these patients. Hyperimmune globulin has been used to prevent some virus infections in immunocompromised person...
Article
Kaposi’s sarcoma-associated herpesvirus (KSHV) is an etiologic agent of Kaposi’s sarcoma as well as primary effusion lymphoma (PEL), an aggressive B-cell neoplasm which mostly arises in immunocompromised individuals. Lytic replication of KSHV is also associated with a subset of multicentric Castleman diseases. At present, there is no specific treat...
Preprint
Full-text available
Kaposi’s sarcoma-associated herpesvirus (KSHV) is an etiologic agent of Kaposi’s sarcoma as well as primary effusion lymphoma (PEL), an aggressive B-cell neoplasm which mostly arises in immunocompromised individuals. At present, there is no specific treatment available for PEL and its prognosis is poor. Lytic replication of KSHV is also associated...
Article
Full-text available
Renal manifestations of multiple myeloma (MM) including cast nephropathy, amyloidosis, and renal calcification have been widely recognized. However, the severity of histopathological findings has not been addressed so far, and the clinical significance of these pathological findings is unclear. We sought to clarify the relationship between the seve...
Article
Full-text available
Plasmablastic lymphoma (PBL) is a rare, highly aggressive subtype of non-Hodgkin lymphoma with plasma-cell differentiation occurring typically in immune-suppressed patients such as those with AIDS. This study reports the establishment and characterization of a new cell line, PBL-1, derived from a patient with AIDS-associated PBL. Morphological asse...
Article
Full-text available
Anti-tumor necrosis factor α (anti-TNFα) agents increase the risk of tuberculosis (TB), but cases are rarely fatal. This report concerns a patient who was undergoing treatment with infliximab and presented with acute respiratory distress syndrome due to miliary TB without a miliary shadow. The findings of a pathological autopsy revealed innumerable...
Data
Table S2. Numbers of annotated miRNA reads in each small RNA library.
Data
Table S1. Overview of small RNAs detected by NGS.
Article
Full-text available
Epstein–Barr virus (EBV) encodes 49 microRNAs (miRNAs) in the BART and BHRF1 regions of its genome. Although expression profiles of EBV-encoded miRNAs have been reported for EBV-positive cell lines and nasopharyngeal carcinoma, to date there is little information about total miRNA expression, including cellular and viral miRNAs, in the primary tumo...
Article
Full-text available
Background Primary effusion lymphoma is a rare distinct large B-cell neoplasm that is associated with Kaposi’s sarcoma–associated herpesvirus (KSHV) infection. Over recent years, 9 KSHV-positive/Epstein-Barr virus (EBV)-negative PEL cell lines have been established. Methods Tumor cells were collected from the pleural effusion of a 49-year-old male...
Article
A 65-year-old man with non-ischemic cardiomyopathy, underwent an autopsy 2 months after the successful ablation of a sustained left ventricular (LV) summit ventricular tachycardia (VT). The patient died due to interstitial pneumonia from amiodarone use. The earliest activation sites of the VT were documented from both inside the anterior interventr...
Article
Introduction: Multiple myeloma is a heterogeneous hematological malignancy. Investigation on the poor prognostic factors contributes the development of the effective stratified treatment. AF1q is an oncogene which expressed in leukemia cells, located in 1q21. The gene is well known as a one of the partner of 11q23. Recently, the association between...
Article
Background Extramedullary disease (EMD) is often observed in end stage of multiple myeloma (MM).However, central nervous system (CNS) involvement is very rare. Thus, little is known about CNS involvement of MM. We conducted clinicopathological analysis. Methods We reviewed medical records and pathological specimens of multiple myeloma cases between...
Article
Full-text available
Background: The prevalence of candida esophagitis (CE) might be changing in an era of highly active antiretroviral therapy (HAART) among HIV-infected patients or today's rapidly aging society among non-HIV-infected patients. However, few studies have investigated long-term CE trends, and CE risk factors have not been studied in a large sample, cas...
Article
Full-text available
A 67-year-old man with elevated serum immunoglobulin G4 (IgG4) levels, systemic lymphadenopathy infiltrated by IgG4-positive plasma cells, and Coombs-positive autoimmune hemolytic anemia (AIHA) showed marked hypercalcemia. Although the intact parathyroid hormone (PTH) level was elevated, 99mTc-MIBI scintigraphy and thyroid ultrasonography revealed...
Article
NUT midline carcinoma (NMC) is a rare, lethal form of differentiated squamous cell carcinoma characterized by chromosomal rearrangement of the NUT gene. Its highly aggressive nature commonly leads to unresectable and metastatic lesions. We report on a case of endobronchial NMC in a middle-aged man who was treated by bronchoscopic electrocautery fol...
Article
Background Renal injury is a common complication in multiple myeloma (MM). Myeloma cast nephropathy is the most common lesion and this is caused by excessive light chains binding to uromodulin. Other than cast nephropathy, renal calcification, renal amyloidosis, and direct tumor cell involvement have been noticed. However seldom had previous report...
Article
Full-text available
Trichodysplasia spinulosa-associated polyomavirus (TSV) was identified in a seven-month-old girl with myocarditis. The number of TSV genomes detected was higher in the heart than in the other organs. The full-length TSV genome was cloned from the heart. This suggests a possible role of TSV infection in the pathogenesis of myocarditis in infants.
Article
Full-text available
Opportunistic infections and malignancies such as malignant lymphoma and Kaposi sarcoma are significant complications of human immunodeficiency virus (HIV) infection. However, following the introduction of antiretroviral therapy in Japan in 1997, the incidence of clinical complications has decreased. In the present study, autopsy cases of HIV infec...
Article
Full-text available
The introduction of combined antiretroviral therapy (ART) has reduced the mortality of patients with human immunodeficiency virus-1 infection worldwide. However, malignant lymphoma is a severe and frequent complication seen in patients with acquired immunodeficiency syndrome (AIDS). The diagnostic criteria for some categories of AIDS-related lympho...
Article
Objective : Primary effusion lymphoma (PEL), which is known to occur under immunosuppressive states, is characterized mainly by proliferation of malignant cells in body cavity fluids. In the third & fourth Edition of the Classification of Tumours of Haematopoietic and Lymphoid Tissues (WHO2008), the entity of PEL was renamed as malignant lymphoma c...
Article
Background Kidney injury and/or renal failure are common complication in multiple myeloma. Well known mechanism is deposition of free immunoglobulin light chains in renal tubules leading to cast nephropathy and renal failure. In addition, not only cast nephropathy, but also invasion of myeloma cells is frequently found in autopsied cases of multipl...
Article
Full-text available
Acquired immune deficiency syndrome (AIDS)-related lymphoma (ARL) remains the main cause of AIDS-related deaths in the highly active anti-retroviral therapy (HAART) era. Recently, rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma. Here, we report a rare case of gastrointestinal (GI)-ARL with MYC r...
Article
Full-text available
High-resolution white-light endoscopy showed nodular gastritis (NG). NG is an endoscopic indicator of Helicobacter pylori infection, particularly in young women. NG is characterized by unique small protruding lesions with a uniform distribution within the antrum. Biopsy specimens of these lesions reveal lymphoid follicles with active and chronic in...
Article
1832 Background Recent development of novel agents such as bortezomib, lenalidomide, and thalidomide improved the remission rate and survival of multiple myeloma. However, the end stage of myeloma is still uncontrollable. The extramedullary disease (EMD) progression of myeloma was frequently observed in heavily treated patients, whereas few data e...

Questions

Question (1)
Question
Are there any recommendations for lentiviral vectors and packaging systems?
It can be sold by a company or can be obtained from addgene etc..
I am currently using Invitrogen's pLenti6 series(6, 6.3 etc.), but packaging efficiency and titer are low, and in some cases integration may not be done.
I am looking for a lentivirus plasmids set to work reliably.
Also, I would like to know if there is a recommendation for outsourcing service.
Please let me know if you have recommendations.

Network

Cited By

Projects

Project (1)
Project
To determine human host factor(s) associated with severe Epstein-Barr virus disease.