Soheila Kashanian

Razi University | razi · Department of Applied Chemistry

Obesity has been linked to a low‐grade inflammatory process in the white adipose tissue. Our study aims to detect the relationship between cytokine levels of tumor necrosis factor‐alpha (TNF‐α), interleukin‐6 (IL‐6), and C‐reactive protein (CRP) in obese diabetics, compared to obese non‐diabetics, Iraqi individuals. Ninety Iraqi adults, 45 type 2 d...

Intranasal administration is a drug delivery approach to provide a non-invasive pharmacological response in the central nervous system with relatively small peripheral side effects. To improve the residence time of intranasal drug delivery systems in the nasal mucosa, mucoadhesive polymers (e.g., chitosan) can be used. Here, insulin-loaded chitosan...

Lateral flow tests are one of the most important types of paper-based point-of-care (POCT) diagnostic tools. It shows great potential as an implement for improving the rapid screening and management of infections in global pandemics or other potential health disorders by using minimally expert staff in locations where no sophisticated laboratory se...

Electrospinning is a well-known promising technique for the cost-effective and rapid fabrication of therapeutic-loaded nanofibers. Electrospun fibers have many merits that give them prospects in the production of therapeutic-loaded sutures. Despite the desirable properties of electrospun fibrous yarns, they have no prospective mechanical properties...

Controlling water and food contamination by pathogenic organisms requires quick, simple, and low-cost methods. Using the affinity between mannose and type I fimbriae in the cell wall of Escherichia coli (E. coli) bacteria as evaluation elements compared to the conventional plate counting technique enables a reliable sensing platform for the detecti...

Controlling water and food contamination by pathogenic organisms requires quick, simple, and low-cost methods. using affinity between mannose and type I fimbriae in the cell wall of Escherichia coli bacteria as evaluation elements compared to the conventional plate counting technique enables a reliable sensing platform for the detection of bacteria...

Mercury is a highly toxic and potentially bioaccumulative heavy metal ion that can cause severe health problems in humans even at very low concentrations. Thus, the development of a simple, rapid, and sensitive assay for the effective detection of mercury ions at trace levels is of great importance. Here, nitrogen and sulfur co-doped carbon quantum...

The management of diabetes, in contrast to the treatment of the disease, is basically aimed at controlling the blood glucose level. Besides the primary changes required in the lifestyle and diet of the patient, drug therapy can play a critical role in the diabetes management. Diabetic drugs are formulated in various forms to permit oral, transderma...

Elastomer electrospun fibers are suitable for biomedical applications due to more processability. Designing elastomer polymeric fibers with outstanding remedial effects has great practical importance in the healthcare system. For this purpose, we blended Propolis Ethanolic Extract (PEE) with poly-ε-caprolactone (PCL) and prepared elastomeric electr...

Statins are a class of widely prescribed drugs used to reduce low-density lipoprotein cholesterol (LDL-C) and important to prevent cardiovascular diseases (CVD). Most statin users are older adults with CVD, who are also at high risk of cognitive decline. It has been suggested that statins can alter cognitive performance, although their positive or...

A new Molecularly Imprinted Polymer (MIP)-based electrochemical sensor was used to detect neonatal jaundice in saliva and serum samples. The Bilirubin (BR) detection sensor is fabricated by 2-aminothiophenol (2-ATP) polymerization on MIP/AuFe2O3-GrCNT/GCE using a Glassy Carbon Electrode (GCE). BR is an important factor in the body. Excessive amount...

Evaluation of extracellular domain of human epidermal growth factor receptor-2 (HER2-ECD) oncomarker status is an impressive factor in screening, diagnosing and monitoring early-stage breast cancer (BC). Electrochemical aptamer-based nanobiosensor with high sensitivity and selectivity for quantitative and qualitative measurement of HER2-ECD oncomar...

Assessment of human epidermal growth factor receptor-2 (HER2) tumor marker status is an impressive factor in screening, diagnosing and monitoring breast cancer (BC). The electrochemical biosensor is a revolutionary method in cancer diagnosis, which is used in this research to detect HER2+ circulating tumor cells. The electrochemical activity, size,...

Enzymatic biofuel cell (EBFC) is a particular sort of fuel cell (FC) that oxidizes its fuel using enzymes as catalysts instead of valuable metals. The enzymes such as laccase (Lac) or bilirubin oxidase (BOD) in cathode compartment and glucose dehydrogenase (GDH) or glucose oxidase (GOD) in anode compartment can be applied as biocatalysts in EBFCs....

Determination of cholic acid concentration is a useful method to monitor liver diseases. We propose a rapid and simple method for measuring cholic acid. The development of a cholic acid electrochemical biosensor is described that is based on the modification of glassy carbon electrode surface using a mixture of carboxylated multiwalled carbon nanot...

There is no definite cure for Alzheimer’s disease (AD) due to its multifactorial origin. Drugs that inhibit acetylcholinesterase (AChE), such as rivastigmine, are promising symptomatic treatments for AD. Emerging evidence suggests that insulin therapy can hinder several aspects of AD pathology. Insulin has been shown to modify the activity of AChE,...

Integrating nanoparticles (NPs) as a smart and targeted tool for drug delivery with dissolving microneedle (DMN) patch, the non-invasive device for drug delivery, is a promising for future therapeutic delivery applications. Liraglutide (Lira) encapsulation in poly (lactic-co-glycolic acid) (PLGA) NPs provides a sustained release of Lira to 15 days...

Hydroquinone (HQ) sensitive electrochemical biosensing was performed using new nanocomposites of carboxylated graphene (GrCOOH) embedded in metal-organic coordination polymers (MOCPs) as efficient matrices for laccase (Lac) immobilization. GrCOOH nanosheets were used to pre-adsorbotion of HAuCl 4 and acted as anchor sites. They help to form MOCPs a...

As a noninvasive method of local and systemic drug delivery the administration of active pharmaceutical ingredients (APIs) via the pulmonary route represents an ideal approach for the therapeutic treatment of pulmonary diseases. The pulmonary route provides a number of advantages, including the rapid absorption which results from a high level of va...

The use of exogenous antioxidants or the combination of them during in vitro oocyte/embryo culture media is reasonable. Co-delivery by nanocarrier has been designed to overcome the limitations of combining them traditionally. In this work, amphiphilic chitosan nanocarrier (ACN) was applied to co-encapsulate melatonin (Mel) and tretinoin (TTN) by th...

In this study, molecular imprinting polymer (MIP) was used to develop selective active sites for low-cost and easy-to-build bilirubin (BR) detection because BR is known as an indicator of liver function. When the liver does not excrete BR properly, it causes jaundice, which is associated with liver diseases, especially in infants. High levels of BR...

Various nano-sized protein and lipid complexes are being investigated as drug delivery systems. The encapsulation of more than one drug in a single nanocomplex carrier could enhance the therapeutic potency and afford synergistic therapeutic effects. In this study, we developed a novel protein-lipid nanocomplex as a controlled drug delivery system f...

In this work the binding of artificial sweetener aspartame with human serum albumin (HSA) was studied at physiological pH. Binding studies of aspartame (APM) with HSA are useful to understand APM -HSA interaction, mechanism and providing guidance for the application and design of new and more efficient artificial sweeteners. The interaction was inv...

How to cite this article Noori T, Kashanian S, Rafipour R, Mansouri K, Nazari M. Dual-targeted drug delivery system based on dopamine functionalized human serum albumin nanoparticles as a carrier for methyltestosterone drug. Nanomed J. 2021; 8(2): 147-155. ABSTRACT Objective(s): This study aims to enhance 17 a-methyltestosterone loaded human serum...

Till date, several studies have reported magnetic drug targeting as well as passive drug delivery. In this study, the passive characteristic of PEGylated carriers with a neutral surface charge rather than chitosan (CS)-based nanoparticles (NPs) with a positive charge was proved using molecular docking. The complete and without flaw stealth CS-coate...

In this project, our research group has performed an interesting work in which interactions of acarbose (ACB) with normal human serum albumin (HSA) and glycated HSA (GHSA) have been investigated by chemometrics assisted-electrochemical and spectroscopic techniques. To have a deep insight to the interactions of ACB with HSA and GHSA, different elect...

Nanoparticles (NPs) show great promise as tools for designing formulations capable of meeting the challenge of targeted and non-targeted drug delivery to bone and cartilage tissue. NPs can also be employed to deliver regenerative materials, growth factors, and genes to bone and cartilage. Furthermore, the application of nanomaterials in tissue engi...

Aim Enhancement of anti-tumor activity of the chemotherapeutic agent CUR by redox-sensitive nanoparticle to get a deeper in-sight into cancer therapy. Background Tumor targetability and stimulus are widely used to study the delivery of drugs for cancer diagnosis and treatment because poor cellular uptake and inadequate intracellular drug release l...

Monosodium glutamate (MSG) is an example of food additive, which is used as a flavor enhancer in various foodstuffs. Because of its extensive use in food production, the toxicology and possible negative effects of MSG additive on albumin must be well investigated. Therefore, for the first time, the binding of BSA and MSG have been studied using mul...

microRNAs (miRNAs) are significant biomarkers either for probing cellular events or disease diagnosis. Compared to regular RNA, miRNAs possess short length and low abundance with sequence homology, which results in major challenges on the determination of these biomarkers. Thus, developing a simple, rapid, and effective technique for qualitative an...

In an attempt to describe how low-energy electrons (LEEs) damage the polypeptide chain at disulfide bridges, ab initio electronic structure estimates on LEE interactions with cysteine-cysteine (Cys-Cys) disulfide bond model have been performed. Here, the fundamental mechanisms in LEE impression on S-S and C-S bond ruptures in the Cys-Cys model have...

Novel reduction-responsive hyaluronic acid-chitosan-lipoic acid nanoparticles (HACSLA-NPs) were designed and synthesized for effective treatment of breast cancer by targeting Cluster of Differentiation 44 (CD44)-overexpressing cells and reduction-triggered 17α-Methyltestosterone (MT) release for systemic delivery. The effectiveness of these nanopar...

Chemotherapy using cytotoxic agents, such as letrozole (LTZ), is one of the most effective treatments for hormone-dependent breast cancer. Nevertheless, nonspecific targeting of the drug constructs several remarkable systemic toxicities. In this study, we synthesized solid lipid nanoparticles (SLNs) by solvent emulsification evaporation method as L...

Laccases are phenoloxidases that can oxidize the phenolic compounds. Catechol (1,2-dihydroxybenze) is one of the phenolic compounds broadly utilized in industry. Nanomaterials and conductive polymers can be utilized as a support medium for the laccase immobilization and phenolic biosensors. This paper describes a new enzymatic biosensor being devel...

Transdermal drug delivery (TDD) is an alternative method of drug administration for drugs whose delivery by conventional oral, topical, intravenous and intramuscular methods is of limited efficacy. Recent advances in TDD involve the use of nanoparticles (NPs), which exhibit a great potential to enhance drug permeation across the skin. NPs can also...

Background: Treatment of neurological diseases using systemic and non-surgical techniques presents a significant challenge in medicine. This challenge is chiefly associated with the condensation and coherence of the brain tissue. Methods: The coherence structure of the brain is due to the presence of the blood-brain barrier (BBB), which consists...

The safety of various food additives such as calcium lactate (CL) has become a challengeable subject in recent years because of their adverse effects on human health and their physiological effects study at the molecular level seems essential. Therefore, in this study, interactions of CL as food preservative with bovine serum albumin (BSA) in aqueo...

Aim In the present work, folic acid-modified human serum albumin conjugated to cationic solid lipid nanoparticles were fabricated as a novel carrier for mitoxantrone, a breast cancer therapeutic agent. Background Dual-targeted drug delivery is a new drug dosing strategy that is frequently used to enhance the therapeutic efficacy of anticancer drug...

In this work, we developed an ultrasensitive and ultraselective electrochemical biosensor for detection of a specific sequence DNA. It was fabricated based on a glassy carbon electrode (GCE) modified with Multi-walled carbon nanotubes (MWCNTs)-Chitosan (CHIT) nanocomposite and a thin film of gold nanoparticles (AuNPs). Immobilization is based on th...

Objective(s): Nanocarriers are drug delivery vehicles, which have attracted the attention of researchers in recent years, particularly in cancer treatment. The encapsulation of anticancer drugs using protein nanocages is considered to be an optimal approach to reducing drug side-effects and increasing the bioavailability of anticancer drugs. Epirub...

The current study investigated the binding of BSA and piperacillin at multifarious concentrations (1–128 μM) along with four different temperatures. To do this, three sensitive methods were employed including surface plasmon resonance (SPR), fluorescence spectroscopy and molecular docking (MD). In the SPR method, BSA immobilized on the carboxymethy...

We designed a hydrogen peroxide biosensor. The electrochemical detection of H2O2 was performed based on immobilization of cobalt nanoparticles–ferritin (CoNPs–Fer) onto multiwalled carbon nanotubes (MWCNTS) ensnared into chitosan (CS) matrices. Electrochemical techniques such as differential pulse voltammetry (DPV) and cyclic voltammetry (CV) was u...

In this research, a novel glucose/O2 biofuel cell was developed with glucose dehydrogenase bioande and laccase biocathode. For the preparation of a bioanode, glassy carbon electrode was modified in a layer by layer structure of graphene oxide nano-sheets, glucose dehydrogenase, and nicotine amide adenine dinucleotide by electrostatic affinities and...

Chemotherapeutic agents have been used extensively in breast cancer remedy. However, most anticancer drugs cannot differentiate between cancer cells and normal cells, leading to toxic side effects. Also, the resulted drug resistance during chemotherapy reduces treatment efficacy. The development of targeted drug delivery offers the great promise in...

A new and simple procedure was applied to detect bisphenol A (BPA) based on a BPA aptamer and its complementary strand (Comp. Str.). An electrode was modified with a mixture of carboxylated multiwalled carbon nanotubes and chitosan. The Comp. Str. was immobilized on a modified-glassy carbon electrode (GCE) surface via covalent binding. After the in...

Biosensors research is one of the fastest growing fields in which tens of thousands of papers have been published over the years; even more, numerous biosensors have been developed for the detection of phenolic compounds, such as catechol which reacts with an appropriate enzymatic bioreceptor like laccase. A biosensing electrode for catechol detect...

Targeted drug delivery also known as smart drug delivery or active drug delivery is a subcategory of nanomedicine. Using this strategy, the medication is delivered into the infected organs in the patient’s body or for some medications to the exact parts inside the cells. In order to improve therapeutic efficiency and pharmacokinetic characteristics...

In this study, the simple, green and fast layer by layer modification of the glassy carbon electrode was mainly performed by electrodeposition of gold nanoparticles and then, addition of poly L‐arginine, and finally, laccase was covalently bonded to poly L‐arginine using glutaraldehyde. This type of fabrication is for the first time for catechol de...

Purpose The aim of this study is to show a new mesomicroscopic insight into Letrozole (LTZ) loaded nanocomplexes and their ex vivo characteristics as a drug delivery system. Methods The LTZ loaded hybrid chitosan-based carrier was fabricated using a modified ionic crosslinking technique and characterized in more detail. To understand the mechanism...

Silencing of tumor suppressor genes (E-cadherin) by promoter DNA methylation may lead to the development of invasive phenotypes in epithelial tissues. The authors describe an electrochemical nanobiosensor for early detection and screening of circulating methylated DNA as a biomarker for cancers. First, the antibody against 5-methylcytosine was phys...

Biosensors research is one of the fastest growing fields in which tens of thousands of papers have been published over the years; even more, numerous biosensors have been developed for the detection of phenolic compounds, such as catechol which reacts with an appropriate enzymatic bioreceptor like laccase. A biosensing electrode for catechol detect...

Epirubicin (Epr) is an effective chemotherapeutic drug; however, the clinical amenability of Epr is limited by its highly toxic interaction with normal cells. This toxicity can be decreased by utilizing nanocarriers and targeted drug delivery systems. This work describes an approach for the delivery of Epr via encapsulation in the horse spleen apof...

In this study, a new biosensor is developed with reliable and easy-to-use biodevice properties for catechol determination in real samples. A method is proposed for the fabrication of biosensors to sense catechol based on the adsorption method of laccase immobilization. Hence, a glassy carbon electrode was modified via graphene oxide nanosheets and...

Catechol and hydroquinone are two isomers of phenolics, which are widely used in various industries such as textiles, paints, plastics, oil refineries, cosmetics, pesticides, pharmaceuticals [1]. They are highly toxic to human health [2] and have been considered as well as environmental pollutants even at very low concentrations by Environmental Pr...

Dendrimers are nano-sized and three-dimensional macromolecules with well-defined globular architecture and are widely used in various aspects such as drug and gene delivery owing to multivalent and host-guest entrapment properties. However, dendrimers like other nanomaterials have some disadvantages for example rapid clearance by reticuloendothelia...

Chemically, lamivudine is amino-1-[(2R,5S)-2-(hydroxymethyl)-4,1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one, that commonly named 3TC, is a water soluble potent nucleoside analog reverse transcriptase inhibitor. The present protocol reports the covering of silica on the surface of Fe3O4 nanoparticles (NPs) using Stöber method via sol-gel process...

A novel voltammetric sensor based on ZnO-Al2O3 ceramic nanofibers and gold nanoparticles (AuNPs) was used for simultaneous determination of catechol and hydroquinone. The sensor was fabricated using ZnO-Al2O3 ceramic nanofibers for modification of glassy carbon electrode (GCE). Ceramic nanofibers were electrodeposited onto the mixture of graphene o...

A copper(II) complex containing the ceftobiprole drug and 1,10-phenanthroline (phen) has been synthesized and characterized by UV-vis, FT-IR and mass spectra, and elemental analysis. The binding interaction between [Cu(cef)(phen)Cl2] complex and human serum albumin (HSA) was investigated using absorption, fluorescence emission and circular dichrois...

Purpose: Letrozole as a steroidal anticancer drug with hydrophobic nature is usually administrated by oral route for patient treatment and the injectable formulation for this drug has not still been reported. In this study, a new letrozole incorporated folate-conjugated polymer - lipid hybrid nanoparticles - is introduced for cancer treatment. Me...

Storage conditions seem to be important in the long-term stability of nanoparticles (NPs). This work studies the effects of surfactants and storage container on particle size distribution and zeta potential during long-term storage of acid hydrolyzed potato starch NPs. The NPs were prepared from potato starch using acid hydrolysis and high-intensit...

Objective: This study was performed to investigate a novel pH-responsive nanocarrier based on modified nano graphene oxide (nGO) to promote the acid-triggered intracellular release of a poorly soluble drug, FTY720. Methods: To synthesize a drug conjugated to modified nGO, firstly the polyethylene glycol (PEG) was conjugated to nGO, then the produce...

Biosensors could be used as digital devices to measure the sample infield. Consequently, computational programming along with experimental achievements are required. In this study, a novel biosensor/artificial neural network (ANN) integrated system was developed. Poly (3,4-ethylenedioxy-thiophene)(PEDOT), graphene oxide nano-sheets (GONs) and lacca...

Chitosan (CS) is a material derived from chitin, the most abundant biopolymer on the planet. It has shown potential among a wide variety of biomedical applications especially within the context of self-assembling nanocarriers usable in biomedical applications such as drug delivery, macroscopic injectables, tissue-engineering scaffolds, and nano-ima...

A novel electrochemical biosensing electrode for the determination of catechol was investigated by covalent immobilization of laccase on a glassy carbon electrode modified by conducting polymer built of Poly (3, 4-ethylenedioxythiophene), gold nanoparticles, and carbon nanotube. The fabrication process of the sensing surface was characterized by sc...

A novel electrochemical biosensing electrode for the determination of catechol was investigated by covalent immobilization of laccase on a modified glassy carbon electrode (GCE). Modification of GCE was performed by simultaneously electrodeposition of conducting polymer, poly (3, 4-ethylenedioxythiophene), gold nanoparticles, and carbon nanotube in...

A very sensitive and convenient nanobiosensor based on fluorescence resonance energy transfer (FRET) was developed for the detection of a 22-mer oligonucleotides sequence in Human Papillomavirus 18 virus (HPV18) gene. For this purpose, water-soluble CdTe quantum dots (QDs) were synthesized and, subsequently, amino-modified 11-mer oligonucleotide as...

In the present study, we developed a sensitive method based on fluorescence resonance energy transfer (FRET) for the determination of the BCR/ABL fusion gene, which is used as a biomarker to confirm the clinical diagnosis of both chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL). For this purpose, CdTe quantum dots (QDs) were...

The majority of anticancer drugs are hydrophobic and there is a big challenge to deliver them effectively to its target. One efficient way to overcome the challenge is to encapsulate them in an amphiphilic nanocarrier. This study will focus on the encapsulation of palmitic acid (PL) in chitosan nanoparticles by a two-step method, i.e., oil-in-water...

Chitosan (CS) has been investigated for its ability to be modified hydrophobically and self-assembled into nanocarriers. They can encapsulate drugs and protect them in a promising approach. However, loss of carrier stability against biological environments induces low bioavailability of encapsulated drugs after oral administration. The objective of...

The cellular targeting property of a biocompatible drug delivery system can widely increase the therapeutic effect against various diseases. Here, we report a dopamine conjugated nano graphene oxide (DA-nGO) carrier for cellular delivery of the anticancer drug, Methotrexate (MTX) into DA receptor positive human breast adenocarcinoma cell line. The...