Sofia MorazzoSt. Ann's University Hospital Brno | FNUSA-ICRC · International Clinical Research Center (ICRC)
PhD student in the Biomedical Sciences - Molecular Biology, Cancer Biology
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Currently focused in exploring the MAPK signaling pathway in breast cancer, particularly, MAPK6 (ERK3) in breast cancer cell invasiveness.
Mare endometrial function involves innumerous mediators as hormones (progesterone, estradiol, oxytocin, prostaglandins), cytokines, nitric oxide, enzymes and others. When this complex interaction is disrupted reproductive function is impaired. While some mares carry on a pregnancy to term, others develop recurrent post-breeding endometritis and chr...
Although proteases found in neutrophil extracellular traps (NETs) have antimicrobial properties, they also stimulate collagen type 1 (COL1) production by the mare endometrium, contributing for the development of endometrosis. Cathepsin G (CAT), a protease present in NETs, is inhibited by specific inhibitors, such as cathepsin G inhibitor I (INH; β-...
- To discover new signalling components of ERK3 pathway - To determine if ERK3 has a role in proliferative and/or migratory behavior of normal and cancer cells - To determine if ERK3 is an important component of invasive phenotype of cancer cells