Sofia Markoula

Sofia Markoula
University of Ioannina | UOI · Division of Neurology

Dr, Consultant Neurologist

About

101
Publications
10,760
Reads
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1,285
Citations
Citations since 2016
37 Research Items
798 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Additional affiliations
November 2009 - present
University Hospital of Ioannina
Position
  • Consultant
October 2007 - present
University of Ioannina
Position
  • Consultant Neurologist, in charge of Epilepsy Unit

Publications

Publications (101)
Article
Background: The aim of the present study was to compare the myocardial perfusion imaging (MPI) with [99mTc]tetrofosmin stress - rest single-photon emission computer tomography (SPECT) of patients with epilepsy with matched control individuals. Material and methods: All 29 adult epileptic patients were receiving antiepileptic drugs (AEDs) for epi...
Article
Full-text available
Epilepsy is a risk factor for the development of psychogenic non-epileptic seizures (PNES) and comorbid epilepsy is recognized as a comorbidity in about 10–30% of patients with PNES. The combination of epileptic and nonepileptic seizures poses a particular diagnostic challenge. In patients with epilepsy, additional PNES may be suspected on the basi...
Article
Full-text available
Brivaracetam (BRV) is the latest approved antiepileptic drug. The aim of the study was to evaluate the efficacy and tolerability of BRV in everyday clinical practice. In this retrospective, observational, multicenter study, data from epilepsy patients receiving BRV from January 2018 to July 2019 were analyzed. Patients with age ≥16 suffering from a...
Article
The aim of the present study was to review existing knowledge on the impact of epilepsy in reproductive health of both sexes. Extensive searches of relevant documentation published until February 2020 were retrieved from PubMed and Google Scholar literature in English or in other languages with an English abstract. In females, epilepsy may lead to...
Article
Background In cases undergoing epilepsy surgery, postoperative psychogenic nonepileptic seizures (PNES) may be underdiagnosed complicating the assessment of postsurgical seizures' outcome and the clinical management. We conducted a survey to investigate the current practices in the European epilepsy monitoring units (EMUs) and the data that EMUs co...
Article
Full-text available
The aim of the present study was to test whether inhibition of ovarian primordial follicles and subsequent activation can be achieved by transient mTOR inhibition. In this preclinical investigation, forty-five female immature Wistar rats were randomized in 5 groups. The control group received subcutaneous saline injections. The other groups receive...
Article
BACKGROUND: In cases undergoing epilepsy surgery, postoperative psychogenic nonepileptic seizures (PNES) may be underdiagnosed complicating the assessment of postsurgical seizures' outcome and the clinical management. We conducted a survey to investigate the current practices in the European epilepsy monitoring units (EMUs) and the data that EMUs c...
Article
Objective The aim of the present study was to explore the factors related to the severity of the adverse effects of antiepileptic drugs (AEDs), experienced by patients with epilepsy. Materials and methods A case study was conducted in adult patients with epilepsy and followed up at the Epilepsy Outpatients of the University Hospital of Ioannina in...
Article
Background/aim: The expression of reverse transcriptase (RT) in ovaries, testes, gametes and embryos highlights its critical role in cell growth and differentiation. We sought to investigate the effects of the potent RT inhibitor lamivudine in gametogenesis and mouse embryo preimplantation development. Materials and methods: Male and female FVB/...
Article
Objectives The aim of the study was to assess whether, male patients with epilepsy, switching from Valproic Acid (VPA) to levetiracetam (LEV) or lamotrigine (LMG) critically improves sperm counts and parameters, increasing chance of patients’ female partners to spontaneously conceive. Materials and methods This is an observational prospective stud...
Article
Full-text available
Limbic encephalitis is an inflammatory process involving the limbic structures of the brain, manifested with short-term memory deficits, confusion, depression and seizures. It is usually a paraneoplastic condition but it may also appear as a nonparaneoplastic syndrome. Patients with this condition may exhibit a variety of antibodies in their serum...
Article
Full-text available
Epilepsy Behav. 2019 Nov 27;102:106647. doi: 10.1016/j.yebeh.2019.106647. [Epub ahead of print] Psychological distress symptoms and illness perception in patients with epilepsy in Northwest Greece. Siarava E1, Markoula S2, Pelidou SH2, Kyritsis AP2, Hyphantis T3. Author information 1 Department of Neurology, University of Ioannina, University Hospi...
Article
Full-text available
Objective: The purpose of the present study was to compare psychological distress between patients with epilepsy and healthy controls and to evaluate potentially related factors to psychological distress in patients with epilepsy. Furthermore, we assessed how psychological distress and other potential factors mediate illness perception in patients...
Poster
Full-text available
Purpose The de novo development of PNEA has been described after brain surgery [1]. De novo psychogenic non-epileptic attacks (PNEA) after epilepsy surgery has an estimated incidence of 1.8% to 8.8% [2,3] and is not well studied. This is a European multicenter retrospective cohort study to record patients with de novo psychogenic non-epileptic atta...
Article
Full-text available
Purpose The purpose of the present study was to compare depression and QoL between patients with epilepsy and healthy controls, evaluating potentially related factors to depression and QoL in patients with epilepsy in Northwest Greece. Methods A case study was conducted in adult patients with epilepsy followed up at the University Hospital of Ioan...
Article
Full-text available
Numerous types of cancer have been shown to be associated with either ischemic or hemorrhagic stroke. In this review, the epidemiology and pathophysiology of stroke in cancer patients is discussed, while providing vital information on the diagnosis and management of patients with cancer and stroke. Cancer may mediate stroke pathophysiology either d...
Article
Full-text available
Purpose: We set out to establish the clinical utility of EEG-correlated fMRI as part of the presurgical evaluation, by measuring prospectively its effects on the clinical decision. Methods: Patients with refractory extra-temporal focal epilepsy, referred for presurgical evaluation were recruited in a period of 18 months. The EEG-fMRI based local...
Conference Paper
Although the electroencephalogram (EEG) is the most commonly used means to monitor epileptic patients, public EEG datasets are very scarce making it difficult to develop and validate seizure detection algorithms. In this work an unsupervised seizure detection methodology is used to isolate ictal EEG segments without requiring any apriori informatio...
Conference Paper
As long-term EEG recordings are becoming more and more frequent in clinical practice, the volume of EEG data that require annotation by clinical experts is growing exponentially, highlighting the need for automated epileptic seizure detection systems. Supervised methodologies based on machine learning techniques have been proposed as a solution, bu...
Article
In this work an unsupervised methodology for the detection of epileptic seizures in long-term EEG recordings is presented. The design of the methodology exploits the available medical knowledge to tackle the lack of training data using a simple rule-based seizure detection logic, avoiding complex decision making systems, training and empirical thre...
Chapter
Epilepsy is a chronic neurological condition caused by abnormal electrical activity of the human brain that affects up to 1% of the global population. Since seizures may occur at any time, long-term EEG recordings are more suitable to record ictal activity. To assist the inspection process various automated seizure detection methodologies have been...
Article
In this work an unsupervised methodology for the detection of epileptic seizures in long-term EEG recordings is presented. The design of the methodology exploits the available medical knowledge to tackle the lack of training data using a simple rule-based seizure detection logic, avoiding complex decision making systems, training and empirical thre...
Article
Background: To assess the myocardial status in patients with stroke, employing myocardial perfusion imaging (MPI) with (99m)Technetium-tetrofosmin ((99m)Tc-TF)-single-photon emission computed tomography (SPECT). Methods: Fifty-two patients with ischemic stroke were subjected to (99m)Tc-TF-SPECT MPI within 1 month after stroke occurrence. None of...
Article
Purpose: The therapeutic equivalence of generic and brand antiepileptic drugs, based on studies performed on healthy volunteers, has been questioned. We compare, in a routine clinical setting, brand versus generic levetiracetam (LEV) bioequivalence in patients with epilepsy and also the clinical efficacy and tolerability of the substitution. Meth...
Article
Full-text available
Objective: To investigate the expression of long interspersed element (LINE) 1, human endogenous retrovirus (HERV) K10, and short interspersed element-VNTR-Alu element (SVA) retrotransposons in ejaculated human spermatozoa by means of reverse-transcription (RT) polymerase chain reaction (PCR) analysis as well as the potential incorporation of clon...
Article
Full-text available
Retroelement transcripts are present in male and female gametes, where they are typically regulated by methylation, noncoding RNAs and transcription factors. Such transcripts are required for occurrence of retrotransposition events, while failure of retrotransposition control may exert negative effects on cellular function and proliferation. In ord...
Article
Aim: The role of UGT1A6 and UGT2B7 polymorphisms and the impact of total drug plasma concentration in valproic acid (VPA) pharmacogenomics. Patients & methods: A total of 134 Greek patients were recruited (76 adults). Patients were genotyped for UGT1A6 19T>G, 541A>G and 552A>C and UGT2B7 802T>C polymorphisms. Patients' demographic and clinical d...
Article
Full-text available
Scleromyxedema is a rare dermatologic disorder, characterized by erythematous or yellowish lichenoid waxy papules. Neurological manifestations are rare but well-recognized. A 51-year-old woman, diagnosed with scleromyxedema, was admitted to the hospital with status epilepticus, caused by brain lesions, as disclosed in a brain magnetic resonance ima...
Article
Full-text available
Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinders better clinical outcomes. Previous research efforts, by focusing on ex vivo UCB expansion capabilities have...
Article
Background: Holliday Junctions (HJs) constitute important intermediate structures for many cell functions such as DNA recombination and DNA repair. They derive from a 10 nucleotide degenerate sequence, with a 3 nucleotide-core motif. In this study, we explored the human genome whether the HJ degenerate sequence associates with transposable element...
Article
Background: The impact of Greece's economic crisis on healthcare is of great concern. The aim of the present study was to assess the impact of economic crisis on the prevention of cerebral ischemic events. Methods: Retrospective analysis of patients with ischemic stroke (IS) or transient ischemic attack (TIA) admitted to a tertiary neurological...
Conference Paper
An unsupervised methodology for the detection of Epileptic seizures in EEG recordings is proposed. The time-frequency content of the EEG signals is extracted using the Short Time Fourier Transform. The analysis focuses on the EEG energy distribution among the well-established delta, theta and alpha rhythms (2-13 Hz), as energy variations in these f...
Article
Full-text available
The usefulness of various pathways inhibitors, Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), Infliximab, a monoclonal antibody which blocks the tumor necrosis factor-a (TNF-a), Erlotinib, a tyrosine protein kinase inhibitor of the epidermal growth factor receptor (EGFR), Metformin, an activator of AMP-activated protein kinase en...
Article
Full-text available
To evaluate whether epilepsy or certain antiepileptic drugs render patients prone to develop low bone mineral density (BMD) and osteoporosis risk. Thirty-eight (27 males, 11 females) consecutive adult epileptic patients receiving antiepileptic drugs (AEDs) and 71 control individuals matched for race, gender, age and body mass index (BMI) were subje...
Chapter
DNA repeat motifs are common in eukaryotic and in prokaryotic organisms classified as interspersed, which originate mainly from transposons and tandem repeats. Tandem repeats (TRs) occur in DNA when a pattern of one, two or more nucleotides is repeated in a sequential and consistent way. Among the most prominent TRs with involvement in evolution, h...
Chapter
Epilepsy is a chronic neurological condition caused by abnormal electrical activity of the human brain that affects up to 1% of the global population. Since seizures may occur at any time, Long-Term EEG recordings are more suitable to record ictal activity. To assist the inspection process various automated seizure detection methodologies have been...
Article
Introduction: The cytokine tumor necrosis factor alpha (TNFα) is encoded by the TNFα gene and stimulates bone resorption. TNFα is involved in the pathogenesis of bone loss associated with estrogen deficiency. Polymorphisms in the TNFα gene have been associated with bone mineral density (BMD) in different populations. Objectives: The present study a...
Article
Aromatase is encoded by the CYP19 gene and catalyzes the conversion of androgens to estrogens, which in turn regulate skeletal homeostasis. CYP19 gene polymorphisms have been studied for their association with bone mineral density (BMD) in the general population with mixed results. To explore the influence of the CYP19 (TTTA)n repeat polymorphism o...
Article
Full-text available
Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data. The main objectives of the present study were to investigate the effects of dose, age, gender, and hepatic enzyme-inducing AEDs on the pharmacokinetics of L...
Article
Apolipropotein E(apoE) is a plasma protein exhibiting three common isoforms (E2, E3, E4). Its involvement in lipoprotein metabolism may have an impact on stroke occurrence. As results in the literature are inconclusive further studies are needed to elucidate its role. Our objective was to study the role of apoE isoforms and the interplay with envir...
Article
We retrospectively assessed all patients in a large cohort of patients with epilepsy surgery at the National Hospital for Neurology and Neurosurgery (NHNN) over 12 years, to identify patients with postoperative psychogenic nonepileptic attacks (PNEA). Twenty-nine patients (23 women) were identified of a total of 790 patients, a frequency of 3.7%. F...
Article
Abstract Several studies have examined the association of the PvuII polymorphism of the estrogen receptor alpha gene with the risk of stroke. Data linking the polymorphism with the severity and outcome of cerebrovascular disease are lacking. In this study, we evaluated 285 postmenopausal Caucasian patients suffering an acute stroke, hospitalized in...
Article
Introduction: Aromatase is encoded by the CYP19 gene and catalyzes the conversion of androgens to estrogens, which in turn regulate skeletal homeostasis. Polymorphisms in the CYP19 gene have been studied for their association with bone mineral density (BMD) in the general population with mixed results. Objectives: To explore the influence of the CY...
Article
Lacosamide (LCM) is a newer antiepileptic drug with a favorable safety profile used in partial epilepsy as adjunctive therapy. The most common side effects include dizziness, headache, confusion, diplopia, nausea, nasopharyngitis, and vomiting. Although sporadic cases of drug-induced psychosis have been reported for some antiepileptic drugs, this w...
Article
Familial defective apolipoprotein B (FDB) is an autosomal dominant genetic disorder causing hypercholesterolemia in affected patients. It is occurring due to mutation of apoB gene leading to a decreased low density lipoprotein (LDL) particles clearance. The R3527Q mutation is one of the disease’s causative mutations. Data support mutation’s origin...
Article
To establish an empirical systematic approach for the management of brain metastases from a variety of cancers. The English literature was reviewed from 2000 to 2011 and all clinical trials (phase II, phase III and retrospective studies) regarding therapy of brain metastases were selected for more detailed review. Some key articles published prior...
Article
Metabolism of valproic acid, a widely used drug, is only partially understood. It is mainly metabolized through glucuronidation and acts as a substrate for various UDP-glucuronosyltransferases (UGTs). UGTs metabolizing valproic acid in the liver are UGT1A3, UGT1A4, UGT1A6, UGT1A9 and UGT2B7, with UGT1A6 and UGT2B7 being the most prominent. Polymorp...
Article
Severe obesity constitutes the main public health crisis of the industrialised world. Bariatric surgery has been proposed as the most efficient treatment of obesity. In this study, we report the potential effects of bariatric surgery on semen parameters in male partners of couples undergoing assisted reproduction. These patients had been tested in...
Article
Raising interest towards genes implicates the effect of estrogen receptor-alpha (ESR1) gene on cerebrovascular disease, but data are lacking regarding the effect of estrogen receptor-beta (ESR2) gene. We assessed the hypothesis that AluI (G/A) polymorphism of the ESR2 gene (rs 4986938) is associated with ischemic stroke in a Caucasian population. F...
Article
Full-text available
Limbic encephalitis (LE) is rare, presents with memory impairment, seizures and behavioral disorder. We present a 44-year-old female with an agitation-depressive disorder associated with delusions and hallucinations, admitted to our hospital with the diagnosis of psychosis. A computed tomography (CT) scan of the brain and lumbar puncture on admissi...
Article
Endothelial nitric oxide synthase (eNOS) G894T polymorphism has been previously associated with vascular diseases including stroke, but often with conflicting results. Experimental evidence suggests that some eNOS modalities may be important in preventing stroke, while others may be important during the dynamic inflammatory processes triggered at t...