Sofia P Beloka

Sofia P Beloka
KU Leuven | ku leuven · Hypertension & Cardiovascular Lifestyle

PhD Exercise Physiology

About

26
Publications
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222
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Introduction
Sofia P Beloka currently works at the Hypertension & Cardiovascular Lifestyle, University of Leuven. Sofia does research in Cardiology, Rehabilitation Medicine and Respiratory Medicine. Their current project is 'Sleep phases combined with exercise and caffeine intake on hypertension'.

Publications

Publications (26)
Article
Full-text available
If a competition between the oxygen demands of limb and respiratory muscles happens, hypoxia may favour redistribution of blood flow from peripheral to respiratory muscles during heavy exercise. This hypothesis was tested in eighteen lowlanders and 27 highlanders at 4,350 m altitude. During an incremental exercise, the regional tissue oxygen satura...
Article
Full-text available
Background: Chronic mountain sickness (CMS) is characterized by a combination of excessive erythrocytosis,severe hypoxemia, and pulmonary hypertension, all of which affect exercise capacity. Methods: Thirteen patients with CMS and 15 healthy highlander and 15 newcomer lowlander control subjects were investigated at an altitude of 4,350 m (Cerro...
Article
β2-Adrenergic receptor agonists are believed to present with ergogenic properties. However, how combined respiratory, cardiovascular and muscular effects of these drugs might affect exercise capacity remain incompletely understood. The effects of salbutamol were investigated in 23 healthy subjects. The study was randomised, placebo-controlled in do...
Article
Background: Hypertension is an important modifiable risk factor for stroke prevention; up to 50% of patients taking antihypertensive therapy at the time of stroke onset. It is uncertain whether pre-existing treatment should be continued or stopped following acute stroke; both hypertension and hypotension being associated with adverse prognosis. The...
Article
In patients with hypertension, β blockade decreases muscle sympathetic nerve activity (MSNA; micrographic technique) expressed in burst frequency (burst/min) but does not affect MSNA expressed in burst incidence (burst/100 heart beats), because reductions in blood pressure (BP) upon each diastole continue to deactivate the arterial baroreceptors, b...
Article
Blockade of the skeletal muscle Na+–K+-ATPase pump by digoxin could result in a more marked hyperkaliema during a forearm exercise, which in turn could stimulate the mechano- and metaboreceptors. In a randomized, double-blinded, placebo-controlled, and cross-over-design study, we measured mean blood pressure (MBP), heart rate (HR), ventilation (V E...
Article
The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 microg kg(-1)min(-1)) on cardiopulmonary exe...
Article
1. The contribution of peripheral chemoreceptors to the regulation of ventilation during exercise remains incompletely understood. Digoxin has been reported to increase chemoreflex sensitivity in humans. In the present randomized, cross-over, double-blind study, we tested the hypothesis that this increases the ventilatory response to exercise in no...
Article
Full-text available
Arterial stiffening is more accelerated in blacks than in whites. Whether this is attributed to an enhanced vascular reactivity to environmental stress stimulation remains unknown. We therefore decided to test the hypothesis that cold pressor test (CPT) elicits a greater increase in arterial stiffness and an enhanced sympathetic skin vasoconstricti...
Article
Exercise-induced dyspnea in patients with cardiopulmonary diseases may be related to sympathetic nervous system activation, with increased metabo- and/or chemosensitivities. Whether this mechanism plays a role in exercising normal subjects remains unclear. Muscle sympathetic nerve activity (MSNA), HR, ventilation (V(E)), O2 saturation (SpO2), and e...
Article
Full-text available
Spontaneous time domain BRS estimation is based on the SBP-RR slope, which can be computed from either baroreflex sequences (BS) or baroreflex events (BE). BRS analysis from BEs was recently shown be advantageous particularly in the cases of reduced BRS or when BS are not identified. Also, it offers a superior discrimination between lying and stand...
Article
The peripheral chemoreflex contributes to cardiovascular regulation and represents the first line of defence against hypoxia. The effects of nicotine on chemoreflex regulation in non-smoking humans are unknown. We conducted a prospective, randomized, crossover, and placebo-controlled study in 20 male non-smokers to test the hypothesis that nicotine...
Article
Full-text available
cAMP plays an important role in peripheral chemoreflex function in animals. We tested the hypothesis that the phosphodiesterase inhibitor and inotropic medication enoximone increases peripheral chemoreflex function in humans. In a single-blind, randomized, placebo-controlled crossover study of 15 men, we measured ventilatory, muscle sympathetic ner...
Article
Muscle metaboreceptors and peripheral chemoreceptors exert differential effects on the cardiorespiratory and autonomic responses following hypoxic exercise. Whether these effects are accompanied by specific changes in sympathetic and cardiac baroreflex control is not known. Sympathetic and cardiac baroreflex functions were assessed by intravenous n...
Chapter
Full-text available
Implantable devices were introduced as life-saving equipment for millions of people suffering from coronary heart disease. Nowadays, not only traditional antiarrhythmic pharmacological therapy has been shown to decrease sudden cardiac death, but also pacemakers and cardioverter defibrillators have proved their value in the treatment of life-threate...
Chapter
Cardiac rehabilitation (CR) has been defined as the sum of interventions required to ensure the best possible physical, psychological, and social conditions so that patients with subacute or chronic disease may, by their own efforts, preserve or resume as normal a place as possible in the life of the community.1–5

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Project (1)