Sönke Bartling

Universitätsmedizin Mannheim | UMM · Institute of clinical radiology and nuclear medicine

Since its launch just over a decade ago by the cryptocurrency Bitcoin, the distributed ledger technology (DLT) blockchain has followed a breathtaking trajectory into manifold application spaces. This study aper analyses how key factors underpinning the success of this ground-breaking “Internet of value” technology, such as staking of collateral (“s...

We outline the concept of an open technology platform that builds upon a publicly accessible library of fluidic designs, manufacturing processes, and experimental characterization, as well as virtualization by a "digital twin" based on modeling, simulation, and cloud computing. Backed by the rapidly emerging Web3 technology "Blockchain," we signifi...

Background Macrophages engulf particulate contrast media, which is pivotal for biomedical imaging. Purpose To introduce a macrophage ablation animal model by showing its power to manipulate the kinetics of imaging probes. Material and Methods The kinetics of a particulate computed tomography (CT) contrast media was compared in macrophage ablative...

An overwhelming majority of experts has been flagging for decades that "Saving the Planet" requires immediate, persistent and drastic action to curb a variety of catastrophic risks over the 21 st century. However, despite compelling evidence and a range of suggested solutions, transnational coordination of effective measures to protect our biospher...

Blockchain is a computer protocol involving cryptography, a new way to look at databases, and a socio-cultural-legal-political-economic (r)evolution and knowledge creation will be affected by it. Blockchain has the capacity to make digital goods immutable, transparent, externally provable, decentralized, valuable, and distributed (and potentially p...

Implementation of real-time, continuous, and three-dimensional imaging (4D intervention guidance) would be a quantum leap for minimally-invasive medicine. It allows guidance during interventions by assessing the spatial position of instruments continuously in respect to their surroundings. Recent research showed that it is feasible using X-ray and...

Blockchain technology has the capacity to make digital goods immutable, transparent, externally provable, decentralized, and distributed. Besides the initial experiment or data acquisition, all remaining parts of the research cycle could take place within a blockchain system. Attribution, data, data postprocessing, publication, research evaluation,...

Aims: To evaluate the incremental value of low endothelial shear stress (ESS) combined with high-resolution magnetic resonance imaging (MRI)- and computed tomography angiography (CTA)-based imaging for the prediction of inflamed plaque. Methods and results: Twelve hereditary hyperlipidaemic rabbits underwent quantitative analysis of plaque in th...

Objectives: Evaluation of absolute radiation exposure values for interventional radiologists (IR) using a multi-axis interventional flat panel C-arm cone-beam CT system (CBCT) with 3D laser guidance for biopsy in a triple-modality, abdominal phantom. Methods: In the phantom 8 lesions were punctured in two different angles (in- and out-of-plane)...

The objective of this publication is to provide guidance on radiological protection in the new technology of cone beam computed tomography (CBCT). Publications 87 and 102 dealt with patient dose management in computed tomography (CT) and multi-detector CT. The new applications of CBCT and the associated radiological protection issues are substantia...

Präsentationsart Vortrag (Wissenschaftliches Programm) Haupt-Thema Interventionelle Radiologie Experimentelle Radiologie Interventionelle Radiologie Neuroradiologie CT Es wurde bereits gezeigt, dass mittels neuartiger, tomografischer Rekonstruktionsverfahren eine 4D Interventionsführung (3 Raumdimensionen + Zeit) mit einer akzeptablen Strahlendos...

Purpose It was experimentally demonstrated, that by implementing novel, tomographic reconstruction techniques (such as prior knowledge and compressed sensing) the dose of truly 4D, real-time tomographic intervention guidance can be similarly low as in standard, projective, X-ray fluoroscopy. Here we provide an early stage assessment of this novel...

Citations of relevant works are an integral part of all scholarly papers. Collecting, reading, and integrating these references into a manuscript is a time-consuming process, and reference managers have facilitated this process for more than 25 years. In the past 5 years, we have seen the arrival of a large number of new tools with greatly expanded...

While Online Publishing has replaced most traditional printed journals in less than twenty years, today’s Online Publication Formats are still closely bound to the medium of paper. Collaboration is mostly hidden from the readership, and ‘final’ versions of papers are stored in ‘publisher PDF’ files mimicking print. Meanwhile new media formats origi...

Objectives: To determine impedance values and charge consumption following cochlear implantation post-meningitic deaf children depending on the grade of cochlear ossification and obliteration. Methods: Post-meningitic deaf (n=49) and control (n=43) children treated with cochlear implants were included in the study. Impedance and charge values we...

Computed tomography (CT) plays an important role in interventional procedures such as biopsy, abscess drainage, tumor ablation, catheter placement, and orthopedic instrumentation. All these procedures involve precise incremental advancement of a needle or a probe. This chapter reviews the current state of the art and advanced applications of CT in...

This manuscript provides a possible approach for overcoming the high uptake of applied particulate contrast agents into the RES. The engulfment of particulates by macrophages is a relevant problem in molecular imaging as well as theranostics. Our solution presents a way to deplete macrophages in mice models by employing clodronate-filled liposomes...

Cardiac perfusion studies using computed tomography are a common tool in clinical practice. Recent technical advances and the availability of dedicated small animal scanners allow the transfer of these techniques to the preclinical sector in general and to mouse models of cardiac diseases in particular. This necessitates new requirements for contra...

Modern information and communication technologies, together with a cultural upheaval within the research community, have profoundly changed research in nearly every aspect. Ranging from sharing and discussing ideas in social networks for scientists to new collaborative environments and novel publication formats, knowledge creation and dissemination...

In this introductory chapter we establish a common understanding of what are and what drives current changes in research and science. The concepts of Science 2.0 and Open Science will be introduced. As such we provide a short introduction to the history of science and knowledge dissemination. We explain the origins of our scientific culture which e...

Scientific publications—ranging from full papers, abstracts, and presentations to posters, including grant applications and blog posts—are usually written by one or a few authors and then corrected and reviewed by many authors. Collaboration on scientific publications is a cornerstone of science. Many novel tools exist that can be integrated and fa...

This book about novel publishing and collaboration methods of scholarly knowledge was itself created using novel and collaborative authoring tools. Google Docs as a collaborative authoring and text editing tool and Dropbox as a cloud storage solution were used. Our experience was a positive one and we think that it saved us a lot of organisational...

Purpose: Today's standard imaging technique in interventional radiology is the single- or biplane x-ray fluoroscopy which delivers 2D projection images as a function of time (2D+T). This state-of-the-art technology, however, suffers from its projective nature and is limited by the superposition of the patient's anatomy. Temporally resolved tomogra...

A movie of an unfolding stent protruding from the common carotid artery of a pig into the external carotid artery is shown. A volume rendering technique is used

Example of 4D intervention guidance of a guide wire in the right carotid artery of a full sized pig using colour-coded volume rendering. First the bent guide wire is visible in the external carotid artery, from which it is retracted into the common carotid artery. Here the guide wire tip is placed in front of the ostium of the ascending pharyngeal...

Image-guided interventions are an increasingly important part of clinical minimally invasive procedures. However, up to now they cannot be performed under 4D (3D + time) guidance due to the exceedingly high x-ray dose. In this work we investigate the applicability of compressed sensing reconstructions for highly undersampled CT datasets combined wi...

Objective: A new technology is introduced that enables real-time 4D (three spatial dimensions plus time) X-ray guidance for vascular catheter interventions with acceptable levels of ionising radiation. Methods: The enabling technology is a combination of low-dose tomographic data acquisition with novel compressed sensing reconstruction and use o...

Bismuth oxide nanoparticles of 12.1 ± 3.0 nm diameter were prepared by thermal decomposition of bismuth acetate dissolved in ethylene glycol in the presence of an oxidizing agent. Functionalization and stabilization of the hydrophobic Bi(2) O(3) nanoparticles was accomplished by coating these core nanoparticles with human serum albumin (HSA), via a...

Purpose: Mouse models of cardiac diseases have proven to be a valuable tool in preclinical research. The high cardiac and respiratory rates of free breathing mice prohibit conventional in vivo cardiac perfusion studies using computed tomography even if gating methods are applied. This makes a sacrification of the animals unavoidable and only allow...

PURPOSE To develop and test real-time volumetric (3D+time) radiological guidance of vascular interventions at the same low dose levels as conventional projection fluoroscopy (2D+time) and to demonstrate 3D vascular roadmapping. METHOD AND MATERIALS A flat-panel detector-based imaging chain that resembles current angiographic imaging chains was mou...

PURPOSE 4D angiography provides both morphological and functional information about the vasculature. Since the volume of interest (VOI) is irradiated multiple times, concerns about high radiation dose have prevented its routine clinical adoption. This first-in-man pilot study evaluates potential dose savings from prior-image constrained compressed...

Mouse models of cardiac diseases have proven to be a valuable tool in preclinical research. The rapid heart and respiratory rates of free breathing mice and the consequent technical challenges up to now prohibit in vivo perfusion studies, e.g. of the myocardium, even if gating methods are applied. This makes a sacrification of the animals unavoidab...

4D (=3D+time) interventional image guidance requires tomographic data acquisition during the whole intervention. However, the method, which is also called tomographic fluoroscopy or CT fluoroscopy, will be routinely accepted if the patient dose level can be kept as low as in 2D+time fluoroscopic guidance, which is the standard image guidance techni...

Intervention guidance using flat detector-based systems is becoming more and more common place Repetitive CT scans increase radiation dose. As shown in our previous work, novel reconstruction approaches using compressed sensing and prior knowledge can reduce the necessary radiation dose. While a potential, continous 4D intervention guidance might b...

PURPOSE Current state-of-the-art angiographic intervention guidance - namely biplane X-ray fluoroscopy - provides only projective 2D information – often leaving the radiologist with uncertainties about spatial relationships. In contrast to that CT-fluoroscopy would provide 3D information. However, a straightforward implementation would exceed accep...

Treatment of coronary bifurcation lesions remains challenging, beyond the introduction of drug eluting stents. Dedicated stent systems are available to improve the technical approach to the treatment of these lesions. However dedicated stent systems have so far not reduced the incidence of stent restenosis. The aim of this study was to assess the e...

The onset and spontaneous development of cystic fibrosis (CF) lung disease remain poorly understood. In the present study, we used volumetric computed tomography (VCT) as a new method for longitudinal in vivo monitoring of early lesions and disease progression in CF-like lung disease in β-epithelial Na(+) channel (ENaC)-transgenic (TG) mice. Using...

Ziele: Aktuell werden radiologische (Gefas-)interventionen mittels der Rontgenflouroskopie durchgefuhrt. In dieser planaren Darstellungsweise bleiben raumliche Verhaltnisse oft unklar. Eine 4D-Bildgebung mittels der CT-Flouroskopie, die dieses Problem lost, gilt als zu strahlungsintensiv. Hier wurde jedoch gezeigt, dass sich dies mittels neuer Sign...

Embolization therapy is gaining importance in the treatment of malignant lesions, and even more in benign lesions. Current embolization materials are not visible in imaging modalities. However, it is assumed that directly visible embolization material may provide several advantages over current embolization agents, ranging from particle shunt and r...

Objectives: Embolization therapy is gaining importance in the treatment of malignant and even more in benign lesions. Current embolization materials are not visible in imaging modalities. However, it is assumed that directly visible embolization material may provide several advantages over current embolization agents, ranging from particle shunt an...

A method is disclosed that provides 4D intervention guidance imaging without exceeding radiation dose levels of current intervention guidance methods

PURPOSE Within interventional radiology, embolization therapy is a key procedure. Current embolization materials are not visible (clinical) or solely visible either in X-ray/CT or MRI (research). Particles visible within MRI and X-ray/CT simultaneously would allow direct particle detection in multimodal setups at all times and could therefore be be...

Retrospective clinical study. Academic tertiary referral center at the Medical University of Hannover. Computed tomographic findings of 126 patients (95 children and 31 adults) profoundly deafened by meningitis during a period of 20 years were evaluated. Children were defined as up to 12 years old at the onset of meningitis. No patients showed any...

Core P(MAOETIB-GMA) microparticles of 40-200 microm were prepared by suspension copolymerization of the iodinated monomer 2-methacryloyloxyethyl (2,3,5-triiodobenzoate), MAOETIB, with a low concentration of the monomer glycidyl methacrylate, GMA, which formed hydrophilic surfaces on the particles. Magnetic gamma-Fe(2)O(3)/P(MAOETIB-GMA) core-shell...

The aim of this study was to assess the findings of chest radiography and high-resolution computed tomography in patients requiring intensive care unit treatment for severe H1N1 virus pneumonia. In 2009, 10 patients required treatment in an intensive care unit for confirmed H1N1 pneumonia. All patients underwent chest radiography and high-resolutio...

Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of peripheral lymph nodes. This study demonstrates the general...

A fully automated, intrinsic gating algorithm for small animal cone-beam CT is described and evaluated. A parameter representing the organ motion, derived from the raw projection images, is used for both cardiac and respiratory gating. The proposed algorithm makes it possible to reconstruct motion-corrected still images as well as to generate four-...

Purpose: To develop and test the first multimodal embolization particles being visible within CT and MRI. Its usage might be beneficial within multimodality angiography setups, therapy control, long-term follow-up of embolization therapy, future transition to interventional MRI and research of novel embolization concepts. Methods and Materials: CT...